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| 1 | 在 7T 的多原子的磁性的回声光谱学的应用显示文摘 AIM: To discuss the advantages of ultra-high field (7T) for 1H and 13C magnetic resonance spectroscopy (MRS) studies of metabolism.made at both 3 and 7T using 1H MRS. Measurements of glycogen and lipids in muscle were measured using 13C and 1H MRS respectively. RESULTS: In the brain, increased signal-to-noise ratio (SNR) and dispersion allows spectral separation of the amino-acids glutamate, glutamine and γ-aminobutyric acid (GABA), without the need for sophisticated editing sequences. Improved quantification of these me-tabolites is demonstrated at 7T relative to 3T. SNR was 36% higher, and measurement repeatability (% coefficients of variation) was 4%, 10% and 10% at 7T, vs 8%, 29% and 21% at 3T for glutamate, glutamine and GABA respectively. Measurements at 7T were used to compare metabolite levels in the anterior cingulate cortex (ACC) and insula. Creatine and glutamate levels were found to be significantly higher in the insula compared to the ACC (P < 0.05). In muscle, the increased SNR and spectral resolution at 7T enables interleaved studies of glycogen (13C) and intra-myocellular lipid (IMCL) and extra-myocellular lipid (EMCL) (1H) following exercise and refeeding. Glycogen levels were sig-nificantly decreased following exercise (-28% at 50% VO2 max; -58% at 75% VO2 max). Interestingly, levels of glycogen in the hamstrings followed those in the quadriceps, despite reduce exercise loading. No changes in IMCL and EMCL were found in the study. CONCLUSION: The demonstrated improvements in brain and muscle MRS measurements at 7T will increase the potential for use in investigating human metabolism and changes due to pathologies. | Mary C Stephenson Frances Gunner Antonio Napolitano Paul L Greenhaff Ian A MacDonald Nadeem Saeed William Vennart Susan T Francis Peter G Morris | 2011 | World Journal of Radiology2011，3，4： | 2 |
| 2 | Diversity and ecology of soil fungal communities:increased understanding through the application of molecular techniques显示文摘 | Ian C Anderson Johnw G Cairney | 2004 | Environmental Microbial2004，6，8： | 1 |
| 3 | Functional motor neurons differentiating from mouse multipotent spinal cord precursor cells in culture and after transplantation into transected sciatic nerve 显示文摘 | Stephen C Ian G Shawn H | 2003 | J Neurosurg2003，98，： | 1 |
| 4 | Tissue repair,con- traction,and the myofibroblast显示文摘 | Desmoul Iere A CHA Ponn IER C GABB IAN I G | 2005 | Wound Repair Regen2005，13，1： | 1 |
| 5 | ISCOMs:an adjuvant with multiple functions显示文摘 | Anders S John C C Ian G B | 1998 | Journal of Leukocyte Biology1998，12，： | 1 |
| 6 | Effects of yttrium on the sintering and microstructure of alumina-silicon carbide 'nanocomposites' 显示文摘 | ALEX M C IAN P S RICHARD I T STEVE G R | 2005 | J Am Ceram Soc2005，88，9： | 1 |
| 7 | A unified systems perspective of family firm performance显示文摘 | Timothy G Habbershon Mary Williams Ian C MacMillan | 2003 | Journal of Business Venturing2003，，4： | 1 |
| 8 | Ethanol vaponr treat- ment alleviates postharvest decay and maintains fruit quality in Chinese bayberry显示文摘 | ZHANG W S LI X WANG X X WANG G Y ZHENG J T ABERSINGHE Don C FERGUSON Ian B | 2007 | Postharvest Biology and Technology2007，46，2： | 1 |
| 9 | Review of Determination Instream Flow Requirements with Special Application to Australia显示文摘 | Khalid K Maureen E G Ian C G | 1995 | Water resources Bulletin1995，31，6： | 1 |
| 10 | Gap junctional communication in osteocytes is amplified by low intensity vibrations in vitro显示文摘 | Uzer G Pongkitwitoon S Ian C | 2014 | PLoS One2014，9，90： | 1 |
| 11 | 流行病学和临床研究中数据缺失的多重填补:机会和陷阱显示文摘许多研究都存在缺失数据。Jonathan | Jonathan A C Sterne Ian R White John B Carlin Michael Spratt Patrick Royston Michael G Kenward Angela M Wood James R Carpenter 张清(译) 张孔来(校) | 2009 | 英国医学杂志中文版2009，12，6： | 1 |
| 12 | Recent trends in glutathione biochemistry-glutathione-protein interactions:a molecular link between oxdative stress and cell proliferation? 显示文摘 | Ian A C Robert G G | 1998 | Biochem Biophy Res Commun1998，242，： | 1 |
| 13 | A unified systems perspective of family firm performance显示文摘 | Timothy G Habbershon Mary Williams Ian C MacMillan | 2003 | Journal of Business Venturing2003，，4： | 1 |
| 14 | Modeling and simulation of an electric arc furnace process显示文摘 | JOHANNES G B IAN K C PETRUS C P | 1999 | ISIJ International1999，39，1： | 1 |
| 15 | Top management team diversity, group process, and strategic consensus 显示文摘 | KN IGHTD PEARCE C L SMITH K G OL IAN J D SIMS H P SMITH K A FLOOD P | 1999 | Strategic Management Journal1999，20，3： | 1 |
| 16 | Industrial clusters,transactions costs and the institutional determinants of MNE location behaviour显示文摘 | PHILIP M C TOMOKAZU A IAN R G | 2002 | International Business Review2002，4，11： | 1 |
| 17 | Epigenetic programming by maternal behavior 显示文摘 | Ian C G Nadia C Frances A C | 2004 | Nat Neurosci2004，7，8： | 1 |
| 18 | Light-triggered theranostics based on photosensitizePconjugated carbon dots for sinm显示文摘 | Huang P IAn J Wang X S Wang Z Zhang C L He M Wang K Chen F Li Z M Shen G X | 2012 | Advanced Materials2012，24，37： | 1 |
| 19 | The influence of land transport on animal welfare in extensive farm- ing systems显示文摘 | Andrew D F Ian G C Caroline L | 2009 | Journal of Veterinary Behavior: Clini- cal Applications and Research2009，4，4： | 1 |
| 20 | Volumetric reductions in the subgenual anterior cingulate cortex in adolescents with bipolar I disorder显示文摘 | Manpreet K Singh Kiki D Chang Michael C Chen Ryan G Kelley Amy Garrett Myles M Mitsunaga Layla Bararpour Meghan Howe Allan L Reiss Ian H Gotlib | 2012 | Bipolar Disorders2012，，6： | 1 |
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