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| 1 | Single-center study comparing computed tomography colonography with conventional colonoscopy显示文摘AIM:To compare the results from computed tomography (CT) colonography with conventional colonoscopy in symptomatic patients referred for colonoscopy. METHODS: The study included 227 adult outpatients, mean age 60 years, with appropriate indications for colonoscopy. CT colonography and colonoscopy were performed on the same day in a metropolitan teaching hospital. Colonoscopists were initially blinded to the results of CT colonography but there was segmental unblinding during the procedure. The primary outcome measures were the sensitivity and specificity of CT colonography for the identification of polyps seen at colonoscopy (i.e. analysis by polyp). Secondary outcome measures included an analysis by patient, extracolonic findings at CT colonography, adverse events with both procedures and patient acceptance and preference. RESULTS: Twenty-five patients (11%) were excluded from the analysis because of incomplete colonoscopy or poor bowel preparation that affected either CT colonography, colonoscopy or both procedures. Polyps and masses (usually cancers) were detected at colonoscopy and CT colonography in 35% and 42% of patients, respectively. Of nine patients with a finaldiagnosis of cancer, eight (89%) were identified by CT colonography as masses (5) or polyps (3). For polyps analyzed according to polyp, the overall sensitivity of CT colonography was 50% (95% CI, 39%-61%) but this increased to 71% (95% CI, 52%-85%) for polyps ≥ 6 mm in size. Similarly, specificity for all polyps was 48% (95% CI, 39%-58%) increasing to 67% (95% CI, 56%-76%) for polyps ≥ 6 mm. Adverse events were uncommon but included one colonic perforation at colonoscopy. Patient acceptance was high for both procedures but preference favoured CT colonography. CONCLUSION: Although CT colonography was more sensitive in this study than in some previous studies, the procedure is not yet sensitive enough for widespread application in symptomatic patients. | Ian C Roberts-Thomson Graeme R Tucker Peter J Hewett Peter Cheung Ruben A Sebben EE Win Khoo Julie D Marker Wayne K Clapton | 2008 | World Journal of Gastroenterology2008，14，3： | 4 |
| 2 | 在 7T 的多原子的磁性的回声光谱学的应用显示文摘 AIM: To discuss the advantages of ultra-high field (7T) for 1H and 13C magnetic resonance spectroscopy (MRS) studies of metabolism.made at both 3 and 7T using 1H MRS. Measurements of glycogen and lipids in muscle were measured using 13C and 1H MRS respectively. RESULTS: In the brain, increased signal-to-noise ratio (SNR) and dispersion allows spectral separation of the amino-acids glutamate, glutamine and γ-aminobutyric acid (GABA), without the need for sophisticated editing sequences. Improved quantification of these me-tabolites is demonstrated at 7T relative to 3T. SNR was 36% higher, and measurement repeatability (% coefficients of variation) was 4%, 10% and 10% at 7T, vs 8%, 29% and 21% at 3T for glutamate, glutamine and GABA respectively. Measurements at 7T were used to compare metabolite levels in the anterior cingulate cortex (ACC) and insula. Creatine and glutamate levels were found to be significantly higher in the insula compared to the ACC (P < 0.05). In muscle, the increased SNR and spectral resolution at 7T enables interleaved studies of glycogen (13C) and intra-myocellular lipid (IMCL) and extra-myocellular lipid (EMCL) (1H) following exercise and refeeding. Glycogen levels were sig-nificantly decreased following exercise (-28% at 50% VO2 max; -58% at 75% VO2 max). Interestingly, levels of glycogen in the hamstrings followed those in the quadriceps, despite reduce exercise loading. No changes in IMCL and EMCL were found in the study. CONCLUSION: The demonstrated improvements in brain and muscle MRS measurements at 7T will increase the potential for use in investigating human metabolism and changes due to pathologies. | Mary C Stephenson Frances Gunner Antonio Napolitano Paul L Greenhaff Ian A MacDonald Nadeem Saeed William Vennart Susan T Francis Peter G Morris | 2011 | World Journal of Radiology2011，3，4： | 2 |
| 3 | Wireless multimedia sensor network: a survey显示文摘 | Ian F A Tommaso M Kaushik R C | 2007 | IEEE Wireless Communications2007，14，6： | 1 |
| 4 | Colorectal cancer metastasis in the surgeon's hand? 显示文摘 | Gary A Abhay C Ian M | 2005 | Int Semin Surg Oncol2005，2，5： | 1 |
| 5 | Terrain analysis:integration into the agricultural nonpoint source (AGNPS) pollution model显示文摘 | John C P Ian D M Larry A K | 1991 | J Soil and Water Conservation1991，，1： | 1 |
| 6 | Tissue repair,con- traction,and the myofibroblast显示文摘 | Desmoul Iere A CHA Ponn IER C GABB IAN I G | 2005 | Wound Repair Regen2005，13，1： | 1 |
| 7 | Improved techniques for particle size determination for quasi-elastic light scattering 显示文摘 | Ian D Morrison E F Grabowski C A Herb | 1985 | Langmuir1985，1，4： | 1 |
| 8 | A murine model of chronic inflammation-induced intestinal fibrosis down-regulated by antisense NF-κB显示文摘 | Ian C Lawrance Feng Wu André Z.A Leite Joseph Willis Gail A West Claudio Fiocchi Shukti Chakravarti | 2003 | Gastroenterology2003，，6： | 1 |
| 9 | NeXt generation/ dynamic spectrum access/cognitive radio wireless networks: A survey 显示文摘 | Ian F A Won- Yeol L Mehmet C V | 2006 | Computer Networks2006，，50： | 1 |
| 10 | Chemosensitivity testing of human tumors using a microplate adenosine triphosphate luminescence assay: clinical correlation for cisplatin resistance of ovarian carcinoma 显示文摘 | Peter E Ian A C Chrisfan M | 1995 | Cancer Research1995，55，： | 1 |
| 11 | Volatile constituents of cooked bullfrog (Rana catesbeiana) legs显示文摘 | IAN C C N CELENE S A ONOFRE M M | 2007 | Food Chemistry2007，102，1： | 1 |
| 12 | Ethyl carbamate in pot still cachacas (Brazilian sugar cane spirits): Influence of distillation and storage conditions 显示文摘 | Ian C C N6brega Jos A P Pereira Jos6 E Paiva | 2009 | Food Chemistry2009，，117： | 1 |
| 13 | Achieving controll ability of loads 显示文摘 | Duncan S C Ian A H | 2011 | Proceedings of the IEEE2011，99，1： | 1 |
| 14 | A comparison of different focus functions for use in autofocus algorithms显示文摘 | Frans C A Groen Ian T Young Guido Ligthart | 1985 | Cytometry1985，6，2： | 1 |
| 15 | 流行病学和临床研究中数据缺失的多重填补:机会和陷阱显示文摘许多研究都存在缺失数据。Jonathan | Jonathan A C Sterne Ian R White John B Carlin Michael Spratt Patrick Royston Michael G Kenward Angela M Wood James R Carpenter 张清(译) 张孔来(校) | 2009 | 英国医学杂志中文版2009，12，6： | 1 |
| 16 | Survey on Spectrum Management in Cognitive Radio Networks显示文摘 | Ian F A Lee W Y Megmet C V A | 2008 | IEEE Communications Magazine2008，46，04： | 1 |
| 17 | Recent trends in glutathione biochemistry-glutathione-protein interactions:a molecular link between oxdative stress and cell proliferation? 显示文摘 | Ian A C Robert G G | 1998 | Biochem Biophy Res Commun1998，242，： | 1 |
| 18 | Sequence Analysis and Editing for Bisulphite Genomic Sequencing Projects显示文摘 | Ian M C Elizabeth M A Sarah F | 2007 | Nucleic Acids Res2007，35，10： | 1 |
| 19 | A novel group of pumilio mutations affects the asymmetric division of germline stem cells in the Drosophila ovary 显示文摘 | IAN H SPRADLING A C | 1997 | Development1997，124，： | 1 |
| 20 | Top management team diversity, group process, and strategic consensus 显示文摘 | KN IGHTD PEARCE C L SMITH K G OL IAN J D SIMS H P SMITH K A FLOOD P | 1999 | Strategic Management Journal1999，20，3： | 1 |
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