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| 1 | Refining pathological evaluation of neoadjuvant therapy for adenocarcinoma of the esophagus显示文摘AIM:To assess tumour regression grade(TRG)and lymph node downstaging to help define patients who benefit from neoadjuvant chemotherapy.METHODS:Two hundred and eighteen consecutive patients with adenocarcinoma of the esophagus or gastro-esophageal junction treated with surgery alone or neoadjuvant chemotherapy and surgery between 2005and 2011 at a single institution were reviewed.Triplet neoadjuvant chemotherapy consisting of platinum,fluoropyrimidine and anthracycline was considered for operable patients(World Health Organization performance status≤2)with clinical stage T2-4 N0-1.Response to neoadjuvant chemotherapy(NAC)was assessed using TRG,as described by Mandard et al.In addition lymph node downstaging was also assessed.Lymph node downstaging was defined by cN1 at diagnosis:assessed radiologically(computed tomography,positron emission tomography,endoscopic ultrasonography),then pathologically recorded as N0 after surgery;ypN0 if NAC given prior to surgery,or pN0if surgery alone.Patients were followed up for 5 years post surgery.Recurrence was defined radiologically,with or without pathological confirmation.An association was examined between t TRG and lymph node downstaging with disease free survival(DFS)and a comprehensive range of clinicopathological characteristics.RESULTS:Two hundred and eighteen patients underwent esophageal resection during the study interval with a mean follow up of 3 years(median follow up:2.552,95%CI:2.022-3.081).There was a 1.8%(n=4)inpatient mortality rate.One hundred and thirty-six(62.4%)patients received NAC,with 74.3%(n=101)of patients demonstrating some signs of pathological tumour regression(TRG 1-4)and 5.9%(n=8)having a complete pathological response.Forty four point one percent(n=60)had downstaging of their nodal disease(cN1 to ypN0),compared to only 15.9%(n=13)that underwent surgery alone(pre-operatively overstaged:cN1 to pN0),(P<0.0001).Response to NAC was associated with significantly increased DFS(mean DFS;TRG 1-2:5.1years,95%CI:4.6-5.6 vs TRG 3-5:2.8 years,95%CI:2.2-3.3,P<0.0001).Nodal down-staging conferred a significant DFS advantage for those patients with a poor primary tumour response to NAC(median DFS;TRG 3-5 and nodal down-staging:5.533 years,95%CI:3.558-7.531 vs TRG 3-5 and no nodal down-staging:1.114 years,95%CI:0.961-1.267,P<0.0001).CONCLUSION:Response to NAC in the primary tumour and in the lymph nodes are both independently associated with improved DFS. | Fergus Noble Luke Nolan Adrian C Bateman James P Byrne Jamie J Kelly Ian S Bailey Donna M Sharland Charlotte N Rees Timothy J Iveson Tim J Underwood Andrew R Bateman | 2013 | World Journal of Gastroenterology2013，19，48： | 4 |
| 2 | Outcomes after arthroscopic repair of rotator cuff tears in the setting of mild to moderate glenohumeral osteoarthritis显示文摘BACKGROUND Rotator cuff pathology is a very common source of shoulder pain.Similarly,osteoarthritis of the glenohumeral joint can cause shoulder pain and produce similar symptoms.Surgical management can be indicated for both pathologies,however,outcomes data is limited when examining rotator cuff repair(RCR) in the setting of glenohumeral arthritis(GHOA).Thus,this study sought to determine outcomes for patients who undergo RCR in the setting of GHOA.AIM To evaluate if a relationship exists between outcomes of RCR in the setting of GHOA.METHODS This was a retrospective analysis of patients who underwent arthroscopic rotator cuff repair with concurrent glenohumeral osteoarthritis between 2010-2017.Patients were stratified based on rotator cuff tear size and glenohumeral osteoarthritis severity.Cohorts were paired 1:1 with patients without glenohumeral osteoarthritis.Patients included had a minimum two year follow-up.Rate of conversion to total shoulder arthroplasty,complication rates following initial surgery,and patient-reported outcome measures were collected.RESULTS A total of 142 patients were included.The number of patients that required total shoulder arthroplasty within two years after index surgery was low.2/71(2.8%) patients with GHOA,and 1/71(1.4%) without GHOA.Following rotator cuff repair,both groups showed favorable patientreported outcomes.CONCLUSION Patients with glenohumeral osteoarthritis who underwent arthroscopic rotator cuff repair showed comparable outcomes to patients without glenohumeral osteoarthritis. | Ian S Hong Allison J Rao Tyler L CarlLee Joshua D Meade Daniel J Hurwit Gregory Scarola David P Trofa Shadley C Schiffern Nady Hamid Patrick M Connor James E Fleischli Bryan Michael Saltzman | 2022 | World Journal of Orthopedics2022，13，7： | 2 |
| 3 | Wireless multimedia sensor network: a survey显示文摘 | Ian F A Tommaso M Kaushik R C | 2007 | IEEE Wireless Communications2007，14，6： | 1 |
| 4 | Operational evaluation of phoslock phosphorus locking technology in Laguna Niguel Lake, California 显示文摘 | WEST M B TERRY M IAN C | 2014 | Water Air & Soil Pollution2014，225，7： | 1 |
| 5 | Next Generation/Dynamic Spectrum Access/Cognitive Radio Wireless Networks: a Survey显示文摘 | Akyildiz Ian F Lee Won- Yeol Vuran M C | 2006 | Computer Networks2006，50，9： | 1 |
| 6 | Colorectal cancer metastasis in the surgeon's hand? 显示文摘 | Gary A Abhay C Ian M | 2005 | Int Semin Surg Oncol2005，2，5： | 1 |
| 7 | Terrain analysis:integration into the agricultural nonpoint source (AGNPS) pollution model显示文摘 | John C P Ian D M Larry A K | 1991 | J Soil and Water Conservation1991，，1： | 1 |
| 8 | Induction of heat shock proteins in differentiated human and rodent neurons by celastrol 显示文摘 | ARI M C IAN R B | 2007 | Cell Stress Chaperon2007，12，3： | 1 |
| 9 | Effects of yttrium on the sintering and microstructure of alumina-silicon carbide 'nanocomposites' 显示文摘 | ALEX M C IAN P S RICHARD I T STEVE G R | 2005 | J Am Ceram Soc2005，88，9： | 1 |
| 10 | XDR Tuberculosis-Implications for global public health显示文摘 | Mario C Raviglione Ian M Smith | 2007 | N Engl J Med2007，356，7： | 1 |
| 11 | Grid Services for Distributed System Integration显示文摘 | Ian Foster Kesselman C Jeffrey M | 2002 | Computer2002，35，6： | 1 |
| 12 | Chemosensitivity testing of human tumors using a microplate adenosine triphosphate luminescence assay: clinical correlation for cisplatin resistance of ovarian carcinoma 显示文摘 | Peter E Ian A C Chrisfan M | 1995 | Cancer Research1995，55，： | 1 |
| 13 | Volatile constituents of cooked bullfrog (Rana catesbeiana) legs显示文摘 | IAN C C N CELENE S A ONOFRE M M | 2007 | Food Chemistry2007，102，1： | 1 |
| 14 | The effect of vitamin E on blood pressure in individuals with type 2 diabetes: a randomized, double-blind, placebo-controlled trial显示文摘 | Natalie C Ward Jason HY Wu Michael W Clarke Ian B Puddey Valerie Burke Kevin D Croft Jonathan M Hodgson | 2007 | Journal of Hypertension2007，，1： | 1 |
| 15 | Cardiac collagen remodeling in the cardiomyopathic Syrian hamster and the effect of losarran显示文摘 | Haisong J Nicole L R | 1997 | J Mol Cell Cardiol1997，29，： | 1 |
| 16 | Mitochondrial ribosomal RNA mutation associated with both antibiotic2induced and non syndromic deafness 显示文摘 | PREZANT T R AGAP IAN J V BOHLMAN M C | 1993 | Nat Genet1993，4，： | 1 |
| 17 | BaTiO3-based ceramics for tunable microwave applications显示文摘 | Antonio Feteira Derek C Sinclair Ian M Reaney | 2004 | J Am Ceram Soc2004，2004，： | 1 |
| 18 | Opto-electronic sensor system for rapid evaluation of plan-ter seed spacing uniformity显示文摘 | KOCHER M F IAN Y CHEN C | 1998 | Transaction of ASAE1998，14，1： | 1 |
| 19 | 流行病学和临床研究中数据缺失的多重填补:机会和陷阱显示文摘许多研究都存在缺失数据。Jonathan | Jonathan A C Sterne Ian R White John B Carlin Michael Spratt Patrick Royston Michael G Kenward Angela M Wood James R Carpenter 张清(译) 张孔来(校) | 2009 | 英国医学杂志中文版2009，12，6： | 1 |
| 20 | Improvement in the energy density of lithium anode thermal batteries显示文摘 | ALASTAIR J C IAN M | 1993 | J Power Source1993，14，： | 1 |
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