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| 1 | 在没有危险因素的情况下,正常的低密度脂蛋白胆固醇水平与亚临床动脉粥样硬化相关显示文摘普遍认为缺乏心血管病危险因素(cardiovascular risk factors,CVRF)人群的动脉粥样硬化发生风险低,然而,无CVRF的个体仍然有心血管事件发生。为了确定无CVRF个体中亚临床动脉粥样硬化的预测因子, | Fernández-Friera L Fuster V López-Melgar B Oliva B García-Ruiz JM Mendiguren J Bueno H Pocock S Ibánez B Fernández-Ortiz A Sanz J 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，12： | 17 |
| 2 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 3 | Immediate and long-term outcomes in children with prenatal diagnosis of selected isolated congenital heart defects 显示文摘 | Fuchs IB Muller H Abdul-khaliq H | 2007 | Ultrasound Obstet Gynecol2007，29，1： | 1 |
| 4 | The influence of heart rate on augmentation index and central arterial pressure in humans 显示文摘 | Wilkinson IB MacCaUum H Flint L | 2000 | J Physiol2000，525，1： | 1 |
| 5 | Pennyroyal toxicity:measurement of toxicmetabolite levels in two cases and review ofthe literature显示文摘 | Anderson IB MullenW H Meeker JE etal | 1996 | Ann InternMed1996，124，8： | 1 |
| 6 | Impact of different antidopaminergic mechanisms on the dopaminergie control of prolactin secretion 显示文摘 | Veselinovic T Schorn H Vernaleken IB | 2011 | J Clin Psychopharmacol2011，31，31： | 1 |
| 7 | Protein kinase C beta enhances growth and expression of cyclin D1 in human breast cancer cells 显示文摘 | Li H Weinstein IB | 2006 | Cancer Res2006，66，11： | 1 |
| 8 | Exact state reconstructions in the recovery of messages encrypted by the states of nonlinear discretetime chaotic systems显示文摘 | Carlos A Ibá(n)ez H S Miguel S | 2002 | International Journal of Bifurcation and Chaos2002，12，1： | 1 |
| 9 | Differences in amino acid sequences of mistletoe lectin Ⅰ and Ⅲ B-subunits determining carbohydrate binding specificity显示文摘 | Pevzner IB Agapov II Niwa H | 2004 | Biochim Biophys Acta2004，1675，13： | 1 |
| 10 | FGF-23:More than a regulator of renal phosphate handling显示文摘 | Jüppner H Wolf M Salusky IB | | 0，，： | 1 |
| 11 | In vitro and in vivo release of albumin using a biodegradable MPEG-PCL diblock copolymer as an in situ gel- forming carrier显示文摘 | Hyun H Kim YH Song IB | 2007 | Biomacromolecules2007，8，4： | 1 |
| 12 | Effect of early chemoradiotherapy in patients with limited stage small cell lung cancer显示文摘 | Ha IB Jeong BK Jeong H | 2013 | Radiat Oncol J2013，31，4： | 1 |
| 13 | The resuits of digital replan- tations at the level of the distal interphalangeal joint and the distal phalanx 显示文摘 | Ozcelik IB Purisa H Sezer l | 2006 | Acta Orthop Traumatol Ture2006，40，： | 1 |
| 14 | Grain yield increase in cereal variety mixtures: A meta-analysis of field trials显示文摘 | Kiaer L P Skovgaard Ib M Osterg:rd H | 2009 | Field Crop Res2009，114，3： | 1 |
| 15 | Reduced rate of retinal detachment following silicone oil removal 显示文摘 | Bassat IB Desatnik H Alhalel A | 2000 | Retina2000，20，： | 1 |
| 16 | The influence of heart rate on augmentation index and central arterial pressure in humans 显示文摘 | Wilkinson IB MacCallum H Flint L | 2000 | J Physiol2000，525，： | 1 |
| 17 | Inhibition of basal ni- tric oxide synthesis increases aortic augmentation index and pulse wave velocity in vivo显示文摘 | Wilkinson IB MacCallum H Cockcroft JR | 2002 | Br J Clin Pharmacol2002，53，2： | 1 |
| 18 | Intensive insulin ther- apyin critically ill patients显示文摘 | H irsch IB Coviello A Mazuski J | 2002 | N Engl J Med2002，346，： | 1 |
| 19 | A phase III randomized trial of BAY 12-9566 (tanomastat) as maintenance therapy in patients with advanced ovarian cancer responsive to primary surgery and paclitaxel/ platinum containing chemotherapy: a National Cancer Institute of Canada Clinical Trials Group Study 显示文摘 | Hirte H Vergote IB Jeffrey JR | 2006 | Gynecol Oncol2006，102，： | 1 |
| 20 | Increase of chondregenic potentials in adipose - derived stromal cells by co - delivery of type Ⅰ and type Ⅱ TGFβ receptors encoding bicistronic vector system 显示文摘 | Kang SW Do H J Hart IB | 2012 | J NormaUed Release2012，160，： | 1 |
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