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| 1 | Preventive effect of a pectic polysaccharide of the common cranberry Vaccinium oxycoccos L. on acetic acid-induced colitis in mice显示文摘AIM: To study isolation and chemical characterization of pectin derived from the common cranberry Vaccinium oxycoccos L. (oxycoccusan OP) and the testing of its preventive effect on experimental colitis.METHODS: Mice were administrated orally with OP two days prior to a rectal injection of 5% acetic acid and examined for colonic damage 24 h later. Colonic inflammation was characterized by macroscopical injury and enhanced levels of myeloperoxidase activity measured spectrophotometrically with o-phenylene diamine as the substrate. The mucus contents of the colon were determined by the Alcian blue dye binding method. Vascular permeability was estimated using 4% Evans blue passage after i.p. injection of 0.05 mol/L acetic acid. RESULTS: In the mice treated with OP, colonic macroscopic scores (1.1 ± 0.4 vs 2.7, P < 0.01) and the total square area of damage (10 ± 2 vs 21 ± 7, P < 0.01) were significantly reduced when compared with the vehicle-treated colitis group. OP was shown to decrease the tissue myeloperoxidase activity in colons (42 ± 11 vs 112 ± 40, P < 0.01) and enhance the amount of mucus of colitis mice (0.9 ± 0.1 vs 0.4 ± 0.1, P < 0.01). The level of colonic malondialdehyde was noted to decrease in OP-pretreated mice (3.6 ± 0.7 vs 5.1 ± 0.8, P < 0.01). OP was found to decrease the inflammatory status of mice as was determined by reduction of vascular permeability (161 ± 34 vs 241 ± 21, P < 0.01). Adhesionof peritoneal neutrophils and macrophages was also shown to decrease after administration of OP (141 ± 50 vs 235 ± 37, P < 0.05).CONCLUSION: Thus, a preventive effect of pectin from the common cranberry, namely oxycoccusan OP, on acetic acid-induced colitis in mice was detected. A reduction of neutrophil infiltration and antioxidant action may be implicated in the protective effect of oxycoccusan. | Sergey V Popov Pavel A Markov Ida R Nikitina Sergey Petrishev Vasily Smirnov Yury S Ovodov | 2006 | World Journal of Gastroenterology2006，12，41： | 9 |
| 2 | Chronic pancreatitis and the heart disease:Still terra incognita?显示文摘BACKGROUND It has been suggested that chronic pancreatitis(CP)may be an independent risk factor for development of cardiovascular disease(CVD).At the same time,it seems that congestive heart failure(CHF)and CP share the responsibility for the development of important clinical conditions such as sarcopenia,cachexia and malnutrition due to development of cardiac cachexia and pancreatic exocrine insufficiency(PEI),respectively.AIM To explore the evidence regarding the association of CP and heart disease,more specifically CVD and CHF.METHODS A systematic search of MEDLINE,Web of Science and Google Scholar was performed by two independent investigators to identify eligible studies where the connection between CP and CVD was investigated.The search was limited to articles in the English language.The last search was run on the 1st of May 2019.The primary outcomes were:(1)Incidence of cardiovascular event[acute coronary syndrome(ACS),chronic coronary disease,peripheral arterial lesions]in patients with established CP;and(2)Incidence of PEI in patients with CHF.RESULTS Out of 1166 studies,only 8 were eligible for this review.Studies regarding PEI and CHF showed an important incidence of PEI as well as associated malabsorption of nutritional markers(vitamin D,selenium,phosphorus,zinc,folic acid,and prealbumin)in patients with CHF.However,after substitution of pancreatic enzymes,it seems that,at least,loss of appetite was attenuated.On the other side,studies investigating cardiovascular events in patients with CP showed that,in CP cohort,there was a 2.5-fold higher incidence of ACS.In another study,patients with alcohol–induced CP with concomitant type 3c diabetes had statistically significant higher incidence of carotid atherosclerotic plaques in comparison to patients with diabetes mellitus of other etiologies.Earlier studies demonstrated a marked correlation between the clinical symptoms in CP and chronic coronary insufficiency.Also,statistically significant higher incidence of arterial lesions was found in patients with CP compared to the control group with the same risk factors for atherosclerosis(hypertension,smoking,dyslipidemia).Moreover,one recent study showed that PEI is significantly associated with the risk of cardiovascular events in patients with CP.CONCLUSION Current evidence implicates a possible association between PEI and malnutrition in patients with CHF.Chronic pancreatic tissue hypoxic injury driven by prolonged splanchnic hypoperfusion is likely to contribute to malnutrition and cachexia in patients with CHF.On the other hand,CP and PEI seem to be an independent risk factor associated with an increased risk of cardiovascular events. | Sara Nikolic Ana Dugic Corinna Steiner Apostolos V Tsolakis Ida Marie Haugen Lofman J-Matthias Lohr Miroslav Vujasinovic | 2019 | World Journal of Gastroenterology2019，25，44： | 2 |
| 3 | Synthesis and CO_2 sorption properties of pure and modified lithium zirconate显示文摘 | Ida J Xiong R T Lin V S | | 0，，01： | 1 |
| 4 | Combination of ionomer cement and bone graft for ossicular reconstruction 显示文摘 | Miklos B Jozsef P Ida V | 2007 | Eur Arch Otorhinolaryngol2007，264，： | 1 |
| 5 | Fenton treatment of complex industrial wastewater: Optimization of process con- ditions by surface response method显示文摘 | Barbara B Ida D M Franeeseo V | 2011 | Journal of Hazard- ous Materials2011，，186： | 1 |
| 6 | Preparation of betulinic acid derivatives by chemical and biotransformation methods and determination of cytotoxicity against selected cancer cell lines 显示文摘 | LEOPOLDO C MARIANA V IDA C | 2013 | European Journal of Medicinal Chemistry2013，68，1： | 1 |
| 7 | Accuracy of panoramic radiography in assessing the dimensions of radiolucent jaw lesions with distinct or indistinct borders显示文摘 | Chuenchompoonut V Ida M Honda E | 2003 | Dentomaxillofac Radiol2003，32，： | 1 |
| 8 | Tailoring pore properties of MCM-48 silica for selective adsorption of CO2显示文摘 | Kim S Ida J Guliants V V | 2005 | J Phys Chem B2005，109，： | 1 |
| 9 | Tailoring pore properties of MCM-48 silica for select:ire adsorption of CO2 显示文摘 | Kim S Ida J Guliants V V | 2005 | J Phys Chem B2005，109，13： | 1 |
| 10 | Class 1 Intergon-Borne Multiple-Antibiotic resistance carried by incfl and incL/M plasmids in Salmonella emerica serotype 7 phimurium显示文摘 | FABIO T PAOLO V IDA L | 1998 | Antimicrobial Agents and Chemotherapy1998，42，12： | 1 |
| 11 | Accuracy of panoramic radiography in assessing the dimensions of radiolucent jaw lesions with distinct or in distinct borders 显示文摘 | Chuenchompoonut V Ida M Honda E | 2003 | Dentomaxillofac Radiol2003，32，7： | 1 |
| 12 | Shorter telomeres in dys- trophic muscle consistent with extensive regeneration in young chil- dren显示文摘 | Decary S Ham ida CB Manly V | 2000 | Neuromuscul Disord2000，10，2： | 1 |
| 13 | Tailoring pore properties of MCM-48silica for selective adsorption of CO2显示文摘 | Kim S Ida J Vadim V G | 2005 | Journal of Physical Chemistry B2005，109，13： | 1 |
| 14 | Effects of paradoxical sleep deprivation on blood parameters associated with cardiovascular risk in aged rats显示文摘 | Andersen ML Martins PJ Valm~ida V | | 0，，05： | 1 |
| 15 | Thermoelectricity principle显示文摘 | GOBBINI M Ida HAXBY James V | 2006 | Dry Research Bulletin2006，71，3： | 1 |
| 16 | Preparation of Betulinic Acid Derivatives by Chemical and Biotransformation Methods and Determination of Cytotoxicity against Selected Cancer Cell Lines显示文摘 | LEOPOLDO C MARIANA V IDA C | | 0，，01： | 1 |
| 17 | Prune-belly syndrome: case series and review of the literature regarding early prenatal diagnosis, epidemiology, genetic factors, treatment, and prognosis 显示文摘 | Tonni G Ida V Alessandro V | 2013 | Fetal Pediatr Pathol2013，31，1： | 1 |
| 18 | Neural response to the visual familiarity of faces显示文摘 | IDA M G HAXBY J V H | 2006 | Brain Research Bulletin2006，71，3： | 1 |
| 19 | Prtme-Belly Syndrome: Case Series and Review of the Literature Regarding Early Prenatal Diagnosis, Epidemiology, Genetic Factors, Treatment, and Prognosis 显示文摘 | Tonni G Ida V Alessandro V | 2013 | Fetal Pediatr Pathol2013，31，1： | 1 |
| 20 | Accuracy of panoramic radiography in assessing the dimensions of radiolucent jaw lesions with distinct or indistinct borders显示文摘 | Chnenchompoonut V Ida M Honda E | | 0，，02： | 1 |
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