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您的检索式：作者名="Igor Nikitin"
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| 1 | Simeprevir Increases Rate of Sustained Virologic Response Among Treatment-Experienced Patients With HCV Genotype-1 Infection: A Phase IIb Trial显示文摘 | Stefan Zeuzem Thomas Berg Edward Gane Peter Ferenci Graham R. Foster Michael W. Fried Christophe Hezode Gideon M. Hirschfield Ira Jacobson Igor Nikitin Paul J. Pockros Fred Poordad Jane Scott Oliver Lenz Monika Peeters Vanitha Sekar Goedele De Smedt Rekha | 2013 | Gastroenterology2013，，： | 1 |
| 2 | Boceprevir plus peginterferon/ribavirin for treatment ofchronic hepatitis C in Russia显示文摘AIM: to evaluate addition of boceprevir to peginterferon/ribavirin(PR) in Russian patients with chronic hepatitis C virus(HCV).METHODS: treatment-naive(t N) and treatmentexperienced(t E) patients(who had failed prior treatment with PR for ≥ 12 wk) with chronic HCV genotype 1 infection were enrolled in this placebocontrolled, double-blind study. All patients initially received PR for 4 wk. Patients randomized to control treatment then received PR for an additional 44 wk. t N patients randomized to triple therapy received boceprevir(800 mg three times daily) plus PR for 24 wk and then further therapy according to treatment week 8(t W8) HCV RNA levels. t E patients received boceprevir plus PR for 32 wk and then further therapy according to t W8 HCV RNA levels. treatment was discontinued for t N patients with detectable HCV RNA at t W24 and t E patients with detectable HCV RNA at t W12 because of futility. the primary efficacy end point was sustained virologic response(SVR) defined as undetectable HCV RNA 24 wk after completing all study therapy.RESULTS: SVR was 74.8% in the boceprevir plus PR arm compared with 46.2% in the control arm, with a stratification-adjusted treatment difference of 29.2%(95%CI: 16.4-41.5; P < 0.0001). Rates of SVR were higher in the boceprevir arm in both t N and t E patient groups(t N 78.4% vs 56.3%; t E 69.4% vs 30.0%). Within t E patients, the rates of SVR were higher with boceprevir plus PR compared with PR, regardless of treatment failure type(null responder, partial responder, and relapser). Most patients receiving boceprevir plus PR in both t N(86%) and t E(71%) populations were eligible for reduced treatment duration. Anemia was increased in patients receiving boceprevir plus PR vs PR alone(47.2% vs 24.4%); there was a corresponding increase in ribavirin dose reduction and erythropoietin use. Among patients receiving boceprevir plus PR, SVR rates were similar in patients with anemia(< 10 g/d L) and those without anemia(71.2% vs 77.4%).CONCLUSION: Regulatory approval has been obtained for boceprevir plus PR in Russian patients with HCV genotype 1 infection based on the results of this study. | Vasily Isakov Igor Nikitin Vladimir Chulanov Pavel Ogurtsov Ekaterina Lukyanova Jianmin Long JaniceWahl Frans A Helmond the P08160 Trial Investigators | 2016 | World Journal of Hepatology2016，8，6： | 0 |
| 3 | A 2D quadrangular pyramid photoelectric autocollimator with extended angle measurement range显示文摘A photoelectric autocollimator with high accuracy and extended measurement range based on the quadrangular pyramid is proposed,and the corresponding algorithms are also deduced.A new image processing algorithm has been proposed to improve the accuracy,and the corresponding errors are also estimated,the error does not exceed half a pixel when the distance between the marks more than two radii.The experimental results have verified that the measurement range of the proposed two-dimensional(2D)quadrangular pyramid photoelectric autocollimator can be increased 2 times than that of the flat mirror photoelectric autocollimator from 10′to 15′.The accuracy is better than 1″when the deflection is less than 15′. | Konyakhin Igor 黎人溥 周敏 Dang Dinh Duan Nikitin Mikhail 黄贵伏 杨嘉文 谭鑫 | 2021 | Optoelectronics Letters2021，17，8： | 0 |
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