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| 1 | Nitrogen regulation of root branching显示文摘 | Pia W L Igor I Ivanov S F | 2006 | Annals of Botany2006，97，5： | 1 |
| 2 | A molecular basis for cardiac arrhythmia: HERG mutations cause long QT syndrome显示文摘 | Mark E Curran Igor Splawski Katherine W Timothy G.Michael Vincen Eric D Green Mark T Keating | 1995 | Cell1995，，： | 1 |
| 3 | GUT baryogenesis after preheating: numerical study of the production and decay of X -bosons显示文摘 | Edward W Kolb Antonio Riotto Igor I Tkachev | 1998 | Physics Letters B1998，，3： | 1 |
| 4 | Genome sequence of the lignocellulose-biocenverting and xylose-fermenting yeast Pichia stipites显示文摘 | Jeffries T W Grigoriev Igor V Grimwood J | 2007 | Nature Biotechnology2007，25，3： | 1 |
| 5 | Alcapa(anomalous origin of the left coronary artery from the pulmonary artery)The 20 Year prince charles hosptital experience显示文摘 | Douglas W Jaifar S Igor K | 2007 | HearttLung and Circulation2007，16，5： | 1 |
| 6 | Spectrum of Mutations in Long - QT Syndrome Genes: KVLQT1, HERG, SCNSA, KCNE1, and KCNE2显示文摘 | Igor Splawski Jiaxiang Shen Katherine W | 2000 | Circulation2000，102，： | 1 |
| 7 | Phase formation,crystal chemistry,and properties in the system Bi2O3-Fe2O3-Nb2O5显示文摘 | Michael W L Terrell A V Ileana M P Igor L Robert S R Juan C N Virgil P Peter K S | | 0，，： | 1 |
| 8 | Recent changes of arctic multiyear sea ice coverage and the likely causes显示文摘 | IGOR V P JONE E W RONALD K | 2012 | American Meteorological Society2012，93，： | 1 |
| 9 | Incoherent combining of 100-W Yb-fiber laser beams by PTR Bragg grating 显示文摘 | Ciapurin Igor V Glebov Leonid B Glebova larissa W | 2003 | SPIE2003，4974，： | 1 |
| 10 | An Econometric Model of Serial Correlation and Illiquidity in Hedge Fund Re- turns 显示文摘 | Getmansky Mila Andrew W Lo Igor Makarov | 2004 | Journal of Financial Economics2004，74，3： | 1 |
| 11 | How do threshold firms sus- tain corporate entrepreneurship? The role of boards and absorp- tive capacity显示文摘 | SHAKER A Z IGOR F MIKE W | 2009 | Journal of Business Venturing2009，，24： | 1 |
| 12 | Two-step positioning of a cleavage furrow by cortexUlin and myosin Ⅱ显示文摘 | Igor W Ralph N Aiping Du | 2000 | Curr Biol2000，10，： | 1 |
| 13 | On the distribution and revocation of cryp tographic keys in sensor networks显示文摘 | CHAN H W IGOR D V PERR I A | 2005 | IEEE Transactions on Dependable and Secure and Secure Computing2005，2，3： | 1 |
| 14 | Progressive Multifocal Leukoencephalopathy: Why Gray and White Matter显示文摘 | Sarah Gheuens Christian Wüthrich Igor J. Koralnik | 2013 | Annual Review of Pathology: Mechanisms of Disease2013，，： | 1 |
| 15 | Synthesis and properties of urethane acrylate oligomers direct versus reverse addition显示文摘 | Kenneth W Swidersk I Igor V K | 2004 | Ind Eng Chem Res2004，43，： | 1 |
| 16 | No difference in graft - versus - host disease, relapse, and survival comparing peripheral stem cells to bone marrow using unrelated donors显示文摘 | Remberger M Ringden O Blau Igor - W | 2001 | Blood2001，98，6： | 1 |
| 17 | Numerical simulation of the effect of refractive turbulence on coherent lidar return statistics in the atmosphere显示文摘 | VIKTOR A B IGOR N S CHRISTIAN W | 2000 | Appl Opt2000，39，30： | 1 |
| 18 | Room-Temperature Synthesis and Characterization of Nanocrystalline CdS, ZnS, and CdxZn1-xS显示文摘 | Wang W Germanenko Igor Ei-Shall M S | 2002 | Chem Mater2002，14，： | 1 |
| 19 | Fractionation and characterization of biologically-active polysaccharides from Artemisia tripartita显示文摘 | Gang Xie Igor A Schepetkin Daniel W Siemsen | 2008 | Phytochemistry2008，69，： | 1 |
| 20 | Impact of preoperative antibiotics and other variables on integrated microbiome-host transcriptomic data generated from colorectal cancer resections显示文摘BACKGROUND Integrative multi-omic approaches have been increasingly applied to discovery and functional studies of complex human diseases.Short-term preoperative antibiotics have been adopted to reduce site infections in colorectal cancer(CRC)resections.We hypothesize that the antibiotics will impact analysis of multi-omic datasets generated from resection samples to investigate biological CRC risk factors.AIM To assess the impact of preoperative antibiotics and other variables on integrated microbiome and human transcriptomic data generated from archived CRC resection samples.METHODS Genomic DNA(gDNA)and RNA were extracted from prospectively collected 51 pairs of frozen sporadic CRC tumor and adjacent non-tumor mucosal samples from 50 CRC patients archived at a single medical center from 2010-2020.The 16S rRNA gene sequencing(V3V4 region,paired end,300 bp)and confirmatory quantitative polymerase chain reaction(qPCR)assays were conducted on gDNA.RNA sequencing(IPE,125 bp)was performed on parallel tumor and non-tumor RNA samples with RNA Integrity Numbers scores≥6.RESULTS PERMANOVA detected significant effects of tumor vs nontumor histology(P=0.002)and antibiotics(P=0.001)on microbialβ-diversity,but CRC tumor location(left vs right),diabetes mellitus vs not diabetic and Black/African Ancestry(AA)vs not Black/AA,did not reach significance.Linear mixed models detected significant tumor vs nontumor histology*antibiotics interaction terms for 14 genus level taxa.QPCR confirmed increased Fusobacterium abundance in tumor vs nontumor groups,and detected significantly reduced bacterial load in the(+)antibiotics group.Principal coordinate analysis of the transcriptomic data showed a clear separation between tumor and nontumor samples.Differentially expressed genes obtained from separate analyses of tumor and nontumor samples,are presented for the antibiotics,CRC location,diabetes and Black/AA race groups.CONCLUSION Recent adoption of additional preoperative antibiotics as standard of care,has a measurable impact on-omics analysis of resected specimens.This study still confirmed increased Fusobacterium nucleatum in tumor. | Sarah A Malik Chencan Zhu Jinyu Li Joseph F LaComb Paula I Denoya Igor Kravets Joshua D Miller Jie Yang Melissa Kramer W Richard McCombie Charles E Robertson Daniel N Frank Ellen Li | 2021 | World Journal of Gastroenterology2021，27，14： | 0 |
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