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| 1 | Claudin 1 mediates tumor necrosis factor alpha-induced cell migration in human gastric cancer cells显示文摘AIM:To investigate the role of claudin 1 in the regulation of genes involved in cell migration and tumor necrosis factor alpha(TNF-α)-induced gene expression in human gastric adenocarcinoma cells.METHODS:Knockdown experiments were conducted with claudin 1 small interfering RNA(si RNA),and theeffects on the cell cycle,apoptosis,migration and invasion were analyzed in human gastric adenocarcinoma MKN28 cells.The gene expression profiles of cells were analyzed by microarray and bioinformatics.RESULTS:The knockdown of claudin 1 significantly inhibited cell proliferation,migration and invasion,and increased apoptosis.Microarray analysis identified 245genes whose expression levels were altered by the knockdown of claudin 1.Pathway analysis showed that the top-ranked molecular and cellular function was the cellular movement related pathway,which involved MMP7,TNF-SF10,TGFBR1,and CCL2.Furthermore,TNFand nuclear frctor-κB were the top-ranked upstream regulators related to claudin 1.TNF-αtreatment increased claudin 1 expression and cell migration in MKN28 cells.Microarray analysis indicated that the depletion of claudin1 inhibited 80%of the TNF-α-induced m RNA expression changes.Further,TNF-αdid not enhance cell migration in the claudin 1 si RNA transfected cells.CONCLUSION:These results suggest that claudin 1 is an important messenger that regulates TNF-α-induced gene expression and migration in gastric cancer cells.A deeper understanding of these cellular processes may be helpful in establishing new therapeutic strategies for gastric cancer. | Atsushi Shiozaki Hiroki Shimizu Daisuke Ichikawa Hirotaka Konishi Shuhei Komatsu Takeshi Kubota Hitoshi Fujiwara Kazuma Okamoto Daisuke Iitaka Shingo Nakashima Yoshito Nako Mingyao Liu Eigo Otsuji | 2014 | World Journal of Gastroenterology2014，20，47： | 6 |
| 2 | Decrease in serum levels of thyroid hormone in patients with coronary heart disease显示文摘 | Miura S Iitaka M Suzuki S | 1996 | Endocr J1996，43，6： | 1 |
| 3 | PKC8 iPLA2-PGE2- PPAR3' signaling cascade mediates TNF-c~ induced C|audin Iexpression in human lung carcinoma cells显示文摘 | Iitaka D Moodley S Shimizu H | 2015 | Cell Signal2015，27，3： | 1 |
| 4 | A case of primary mucoepidermoid carcinoma of the thyroid:molecular evidence of its origin显示文摘 | Minagawa A Iitaka M Suzuki M | 2003 | Clin Endocrinol (Oxf)2003，58，1： | 1 |
| 5 | Increased serum vascular endothelial growth factor levels and intrathyroidal vascular area in patients with Gravestdisease and Hashimoto's thyroidiris显示文摘 | Iitaka M Miura S Yamanaka K | 1998 | J Clin Endocrinol Metab1998，83，： | 1 |
| 6 | Incidence of subacute thyroiditis recurrences after a prolonged latency:24-year survey显示文摘 | Iitaka M Momotani N Ishii J | 1996 | J Clin Endocrinol Metab1996，81，2： | 1 |
| 7 | The absolute structure of paeoniflorin, albiflorin, oxypaeoniflorin and benzoylpaeoniflorin isolated from Chinese paeony root显示文摘 | Kaneda M Iitaka Y Shibata S | 1972 | Tetrahedron1972，28，： | 1 |
| 8 | Incidence of sub acute thyroiditis recurrence after a prolonged latency : 24-year survey 显示文摘 | Iitaka M Monotuni N lshii J | 1996 | JClin Endocrinol Metab1996，81，2： | 1 |
| 9 | The elas- ticity of the MgSiOa post-perovskite phase :,n the Earth's lowermost mantie显示文摘 | Iitaka T Hirose K Kawamura K Murakami M | 2004 | Nature2004，430，： | 1 |
| 10 | The absolute structures of paeoniflorin,albifloron,oxypaeoniflorin and benzoylpaeoniflorin isolated from Chinese paeony root显示文摘 | Kaneda M Iitaka Y Shibata S | 1972 | Tetrahedron1972，28，16： | 1 |
| 11 | Incidence of subacute thy- roiditis recurrences after a prolonged latency :24 -year survey 显示文摘 | Iitaka M Momotani N Ishii J | 1996 | J Clin Endocrinol Metab1996，81，2： | 1 |
| 12 | The elasticity of the MgSiO post-perovskite phase in the Earth's lowermost mantle 显示文摘 | Iitaka T Hirose K Kawamura K | 2004 | Nature2004，430，6998： | 1 |
| 13 | The elasticity of the MgSiO3 post-perovskite phase in the earth's lowermost mantle显示文摘 | IITAKA T HIROSE K KAWAMURA K | 2004 | Nature2004，430，： | 1 |
| 14 | Induction of apoptosis and necrosis by zinc in human thyroid cancer cell lines显示文摘 | Iitaka M Kakinuma S Fujimaki S | 2001 | J Endocrinol2001，169，2： | 1 |
| 15 | The absolute structure of paeoniflorin, albiflorin, oxypaeoniflorin and benzoylpaeoniflorin isolated from Chinese paeony root显示文摘 | Kaneda M Iitaka Y Shibata S | 1972 | Tetrahedron1972，28，： | 1 |
| 16 | Increased serum vascular endothelial growth factor levels and intrathy- roidal vascular area in patients with Graves' disease and Hashimoto' s thyroiditis显示文摘 | IITAKA M MIURA S YAMANAKA K | 1998 | J Clin Endocrinol Metab1998，83，11： | 1 |
| 17 | Henoch - Schordein purpura with hypocom - plementemia in children 显示文摘 | Motoyama O Iitaka K | 2005 | Pediatr Int2005，47，： | 1 |
| 18 | A case of primary mucoepidermoid carcinoma of the thyroid:molecular evidence of its origin显示文摘 | MINAGAWA A IITAKA M SUZUKI M | 2002 | Clin Endocrinol2002，57，4： | 1 |
| 19 | The elasticity of the MgSiO3 post-perovskite phase in the Earth's lowermost mantle显示文摘 | Iitaka T Hirose K Kawamura K | 2004 | Nature2004，430，： | 1 |
| 20 | Decrease in serum levels of thyroid hormone in patients with coronary heart disease显示文摘 | Miura S Iitaka M Suzuki S | 1996 | Endocr J1996，43，6： | 1 |
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