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| 1 | Asymmetric dimethylarginine, a biomarker of cardiovascular complications in diabetes mellitus显示文摘Cardiovascular(CV) complications are an essential causal element of prospect in diabetes mellitus(DM), with carotid atherosclerosis being a common risk factor for prospective crisis of coronary artery diseases and/or cerebral infarction in DM subjects. From another point of view, asymmetric dimethylarginine(ADMA) has been established as an inhibitor of endogenous nitric oxide synthesis and the relationship between ADMA and arteriosclerosis has been reported. In our study with 87 type 2 DM(T2DM) patients, we have examined whether ADMA and other CV risk factors are the useful predictors of DMCV complications. After the measurement of the respective CV risk factors, we have followed the enrolled T2 DM patients for 5 years. We have finally analyzed 77 patients. DMCV complications developed in 15 cases newly within 5 years, and 4 cases recurred. The concentrations of ADMA in plasma were markedly more elevated in 19 DM patients with CV complications than in 58 DM patients without CV complications. Urinary albumin(U-Alb), mean intimal-medial thickness(IMT) and ankle brachial index(ABI) were also higher in patients with CV complications. Multiple regression analyses showed that U-Alb had an influence on the high level of ADMA(standardized β = 6.59, P = 0.00014) independently of age, systolic BP, fibrinogen, mean IMT, plaque score, and ABI. The review indicates what is presently known regarding plasma ADMA that might be a new and meaningful biomarker of CV complications in DM subjects. | Hiroyuki Konya Masayuki Miuchi Kahori Satani Satoshi Matsutani Yuzo Yano Taku Tsunoda Takashi Ikawa Toshihiro Matsuo Fumihiro Ochi Yoshiki Kusunoki Masaru Tokuda Tomoyuki Katsuno Tomoya Hamaguchi Jun-ichiro Miyagawa Mitsuyoshi Namba | 2015 | World Journal of Experimental Medicine2015，5，2： | 16 |
| 2 | Long-term outcome of percutaneous ethanol injection therapy for minimum-sized hepatocellular carcinoma显示文摘AIM: To evaluate long-term follow-up of minimum-sized hepatocellular carcinoma (HCC) treated with percutaneous ethanol injection (PEI). METHODS: PEI was applied to 42 lesions in 31 patients (23 male and eight female) with HCC < 15 mm in diameter, over the past 15 years. RESULTS: Overall survival rate was 74.1% at 3 years, 49.9% at 5 years, 27.2% at 7 years and 14.5% at 10 years. These results are superior to, or at least the same as those for hepatic resection and radiofrequency ablation. Survival was affected only by liver function, but not by sex, age, etiology of Hepatitis B virus or Hepatitis C virus, α-fetoprotein levels, arterial and portal blood flow, histological characteristics, and tumor multiplicity or size. Patients in Child-Pugh class A and B had 5-, 7- and 10-years survival rates of 76.0%, 42.2% and 15.8%, and 17.1%, 8.6% and 0%, respectively (P = 0.025). CONCLUSION: Treatment with PEI is best indicated for patients with HCC < 15 mm in Child-Pugh class A. | Miyuki Taniguchi Soo Ryang Kim Susumu Imoto Hirotsugu Ikawa Kenji Ando Keiji Mita Shuichi Fuki Noriko Sasase Toshiyuki Matsuoka Masatoshi Kudo Yoshitake Hayashi | 2008 | World Journal of Gastroenterology2008，14，13： | 16 |
| 3 | Advantages of using the CRISPR/Cas9 system of genome editing to investigate male reproductive mechanisms using mouse models显示文摘基因混乱技术长为男繁殖生物学的学习是有益的。因为包含的时间和费用,除了在专家实验室,然而,这种技术不是一个可行方法。基因混乱的 CRISPR/Cas9 系统的来临迎来了基因调查的一个新时代。现在,在很小的时间并且以很小的成本产生破坏基因的老鼠模型是可能的。这篇热点文章讨论这种技术的应用程序在一些能被用来揭示男繁殖机制的必要、非本质的基因部件的这个系统的未来使用学习男富饶和外表的遗传。 | Samantha AM Young R John Aitken Masahito Ikawa | 2015 | Asian Journal of Andrology2015，17，4： | 4 |
| 4 | Multistep hepatocarcinogenesis from a dysplastic nodule to well-differentiated hepatocellular carcinoma in a patient with alcohol-related liver cirrhosis显示文摘We describe a rare case of the transformation of a dysplastic nodule into well-differentiated hepato- cellular carcinoma (HCC) in a 56-year-old man with alcoholrelated liver cirrhosis. Ultrasound (US) disclosed a 10 mm hypoechoic nodule and contrast enhanced US revealed a hypovascular nodule, both in segment seven. US-guided biopsy revealed a high-grade dysplastic nodule characterized by enhanced cellularity with a high N/C ratio, increased cytoplasmic eosinophilia, and slight cell atypia. One year later, the US pattern of the nodule changed from hypoechoic to hyperechoic without any change in size or hypovascularity. US-guided biopsy revealed well-differentiated HCC of the same features as shown in the first biopsy, but with additional pseudoglandular formation and moderate cell atypia. Moreover, immunohistochemical staining of cyclase- associated protein 2, a new molecular marker of well- differentiated HCC, turned positive. This is the first case of multistep hepatocarcinogenesis from a dysplastic nodule to well-differentiated HCC within one year in alcohol-related liver cirrhosis. | Soo Ryang Kim Hirotsugu Ikawa Kenji Ando Keiji Mita Shuichi Fuki Michiie Sakamoto Yoshihiro Kanbara Toshiyuki Matsuoka Masatoshi Kudo Yoshitake Hayashi | 2007 | World Journal of Gastroenterology2007，13，8： | 4 |
| 5 | Real-time color holographic video reconstruction using multiple-graphics processing unit cluster acceleration and three spatial light modulators显示文摘We demonstrate real-time three-dimensional(3D)color video using a color electroholographic system with a cluster of multiple-graphics processing units(multi-GPU)and three spatial light modulators(SLMs)corresponding respectively to red,green,and blue(RGB)-colored reconstructing lights.The multi-GPU cluster has a computer-generated hologram(CGH)display node containing a GPU,for displaying calculated CGHs on SLMs,and four CGH calculation nodes using 12 GPUs.The GPUs in the CGH calculation node generate CGHs corresponding to RGB reconstructing lights in a 3D color video using pipeline processing.Real-time color electroholography was realized for a 3D color object comprising approximately 21,000 points per color. | Shohei Ikawa Naoki Takada Hiromitsu Araki Hiroaki Niwase Hiromi Sannomiya Hirotaka Nakayama Minoru Oikawa Yuichiro Mori Takashi Kakue Tomoyoshi Shimobaba Tomoyoshi Ito | 2020 | Chinese Optics Letters2020，18，1： | 4 |
| 6 | The mechanism of sperm-egg interaction and the involvement of IZUMO1 in fusion显示文摘 | Naokazu Inoue Masahito Ikawa Masaru Okabe | 2011 | Asian Journal of Andrology2011，13，1： | 3 |
| 7 | PNAS:科学家发现新的精子运动调节器显示文摘南京医科大学生殖医学国家重点实验室、基础医学院组织胚胎学系刘明兮课题组与贝勒医学院MartinM.Matzuk课题组、大阪大学MasahitoIkawa课题组等共同解析了一个精子运动调节基因TCTE1,结果发表于《美国科学院院刊》(PNAs)。 | Castaneda, Julio M. Hua, Rong Miyata, Haruhiko Oji, Asami Guo, Yueshuai Cheng, Yiwei Zhou, Tao Guo, Xuejiang Cui, Yiqiang Shen, Bin Wang, Zibin Hu, Zhibin Zhou, Zuomin Sha, Jiahao Prunskaite-Hyyrylainen, Renata Yu, Zhifeng Ramirez-Solis, Ramiro Ikawa, Masahito Matzuk, Martin M. Liu, Mingxi | 2017 | 现代生物医学进展2017，17，27： | 3 |
| 8 | The Class IV Semaphorin CD100 Plays Nonredundant Roles in the Immune System显示文摘 | Wei Shi Atsushi Kumanogoh Chie Watanabe Junji Uchida Xiaosong Wang Teruhito Yasui Kazunori Yukawa Masahito Ikawa Masaru Okabe Jane R Parnes Kanji Yoshida Hitoshi Kikutani | 2000 | Immunity2000，，5： | 2 |
| 9 | 'Green mice'as asource of ubiquitous green cells显示文摘 | Okabe M Ikawa M Kominami et a1 | 1997 | FEBS Lett1997，407，3： | 1 |
| 10 | E proteins and Notch signaling cooperate to promote T cell lineage specification and com- mitment显示文摘 | Ikawa T Kawamoto H Goldrath AW | 2006 | J Exp Med2006，203，5： | 1 |
| 11 | Microsatellite polymorphism in the human heme oxygenase-1 gene promoter and its application in association studies with Alzheimer and Parkinson disease显示文摘 | Teiko Kimpara A. Takeda Koichi Watanabe Yasuto Itoyama Shuntaro Ikawa Minro Watanabe Hiroyuki Arai Hidetada Sasaki Susumu Higuchi Naoshi Okita Sadao Takase Hiroshi Saito Kazuhiro Takahashi Shigeki Shibahara | 1997 | Human Genetics1997，，1： | 1 |
| 12 | Hashimoto ' s encephalopathy as a treatable adult-onset cerebellar ataxia mimicking spinocerebellar degeneration 显示文摘 | Matsunaga A Ikawa M Fuji A | 2013 | Eur Neurol2013，69，1： | 1 |
| 13 | Molecular dynamics analysis as compared with experimental results of micromachining显示文摘 | Ikawa N Ohmori G | 1992 | Annals of the CIRP1992，41，1： | 1 |
| 14 | The relationship between magneticresonance imagi,ag findings and clinical manifestations of hypothalamie hamartoma显示文摘 | Arita K Ikawa F Kurisu K | 1999 | J Neurosurg1999，91，2： | 1 |
| 15 | Deposition of dense isotropic carbon from acetylene in fluidized bed显示文摘 | Kobayashi F Ikawa K Iwamoto K | 1974 | Carbon1974，12，： | 1 |
| 16 | High-performance liq- uid chromatography with ultraviolet detection for real-timetherapeutic drug monitoring of meropenem in plasma 显示文摘 | Ikeda K Ikawa K Morikawa N | 2007 | J Chromatogr B Analyt Technol Biomed Life Sci2007，856，12： | 1 |
| 17 | Prostatic penetration of meropenem in humans,and dosage considerations for prostatitis based on a site-specific pharmacokinetic/pharmacodynamic evaluation显示文摘 | Nishikawa G Ikawa K Nakamura K | | 0，，03： | 1 |
| 18 | A general method forgene knockdown in mice by using lentiviral vectors expressingsmall interfering RNA显示文摘 | Tiscornia G Singer O Ikawa M | 2003 | Proc Natl Acad Sci USA2003，100，： | 1 |
| 19 | Gently north-dipping Median Tectonic Line (MTL) revealed by recent seismic reflection studies, Southwest Japan显示文摘 | Ito T Ikawa T Yamakita S | 1996 | Tectonophysics1996，264，： | 1 |
| 20 | Genotypic variability in phosphorus solubilizing activity of root exudates by pigeonpea grown in low-nutrient environments显示文摘 | ISH IKAWA S ADU-GYAM FI1 J J NAKAM URA T | 2002 | Plant and Soil2002，245，： | 1 |
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