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| 1 | Rectosigmoid findings are not associated with proximal colon cancer: Analysis of 6 196 consecutive cases undergoing total colonoscopy显示文摘AIM: To review the risk of proximal colon cancer in patients undergoing colonoscopy.METHODS: We estimated the risk of advanced proximal adenomas and cancers in 6 196 consecutive patients that underwent colonoscopy (mean age 60 years, 65% males,without prior history of colorectal examination). Neoplasms were classified as diminutive adenoma (5 mm or less),small adenoma (6-9 mm), advanced adenoma (10 mm or more, with villous component or high-grade dysplasia)and cancer (invasive adenocarcinoma). The sites of neoplasms were defined as rectosigmoid (rectum and sigmoid colon) and proximal colon (from cecum to descending colon).RESULTS: The trend of the prevalence of advanced proximal adenoma was to increase with severe rectosigmoid findings, while the prevalence of proximal colon cancer did not increase with severe rectosigmoid findings. Among the 157 patients with proximal colon cancer, 74% had no neoplasm in the rectosigmoid colon. Multivariate logisticregression analysis revealed that age was the main predictor of proximal colon cancer and existence of rectosigmoid adenoma was not a predictor of proximal colon cancer.CONCLUSION: Sigmoidoscopy is inadequate for colorectal cancer screening, especially in older populations. | Makoto Okamoto Takao Kawabe Yutaka Yamaji Jun Kato Tsuneo Ikenoue Goichi Togo Haruhiko Yoshida Yasushi Shiratori Masao Omata | 2005 | World Journal of Gastroenterology2005，11，15： | 3 |
| 2 | Inhibiting Cxcr2 disrupts tumor-stromal interactions and improves survival in a mouse model of pancreatic ductal adenocarcinoma显示文摘 | Ijichi Hideaki Chytil Anna Gorska Agnieszka E Aakre Mary E Bierie Brian Tada Motohisa Mohri Dai Miyabayashi Koji Asaoka Yoshinari Maeda Shin Ikenoue Tsuneo Tateishi Keisuke Wright Christopher V E Koike Kazuhiko Omata Masao Moses Harold L | 2011 | Journal of Clinical Investigation2011，，10： | 3 |
| 3 | Catalyst-free growth of ZnO nanowires on various-oriented sapphire substrates by pulsed-laser deposition显示文摘Catalyst-free growth of one-dimensional zinc oxide(ZnO) nanowires is reported. ZnO nanowires were synthesized on ZnO buffer layers deposited on various-oriented sapphire substrates. Syntheses of ZnO buffer layers and nanowires were performed by ultraviolet pulsed-laser deposition. ZnO nanowire's number density was the lowest in the case of using m-cut sapphire substrates. ZnO nanowires grown on a-cut sapphire substrates had vertical alignment with distances of tens to hundreds of nanometers. On the other hand, ZnO nanowires grown on c-cut sapphire substrates had the biggest nucleation rate. The dependence of crystalline orientation of ZnO buffer layers on the orientation of sapphire substrates were investigated by electron back scatter diffraction measurement.From their results, the growth models of ZnO buffer layers were suggested and the variations in morphological properties of ZnO nanowires were discussed. | Tetsuya Shimogaki Masahiro Takahashi Masaaki Yamasaki Taichi Fukuda Mitsuhiro Higashihata Hiroshi Ikenoue Daisuke Nakamura Tatsuo Okada | 2016 | Journal of Semiconductors2016，37，2： | 2 |
| 4 | Decreased Expression of the RAS-GTPase Activating Protein RASAL1 Is Associated With Colorectal Tumor Progression显示文摘 | Miki Ohta Motoko Seto Hideaki Ijichi Koji Miyabayashi Yotaro Kudo Dai Mohri Yoshinari Asaoka Motohisa Tada Yasuo Tanaka Tsuneo Ikenoue Fumihiko Kanai Takao Kawabe Masao Omata | 2009 | Gastroenterology2009，，1： | 2 |
| 5 | Cancer-derived VEGF plays no role in malignant ascites formation in the mouse显示文摘AIM: Vascular endothelial growth factor (VEGF) is a potent mediator of peritoneal fluid accumulation following tumor progression. This study investigated the role of VEGF secreted by cancerous cells in the formation of malignant ascites.METHODS: VEGF expression was eliminated byknockdown in the pancreas cancer cell-line PancO2 using vector-based short-hairpin type RNA interference (RNAi).Malignant ascites formation in the mouse was analyzed by intraperitoneal injection of PancO2 cells expressing VEGF or with expression knockdown.RESULTS: The VEGF knockdown PancO2 cell was successfully established. Knockdown of VEGF did not affect cancer cell proliferation in vitro or in vivo. The volume of ascites following peritoneal expansion of the tumor in VEGF knockdown cells and control cells did not differ statistically in this in vivo study. Moreover, the VEGF concentration in the ascites did not differ statistically.CONCLUSION: Malignant ascites formation might be mediated by VEGF production in noncancerous tissues,such as stromal compartments. An anti-VEGF strategy against malignant ascites could be applied to various tumors regardless of whether they secrete VEGF. | Bayasi Guleng Keisuke Tateishi Fumihiko Kanai Amarsanaa Jazag Miki Ohta Yoshinari Asaoka Hideaki Ijichi Yasuo Tanaka Jun Imamura Tsuneo Ikenoue Yasushi Fukushima Keita-Morikane Makoto Miyagishi Kazunari Taira Takao Kawabe Masao Omata | 2005 | World Journal of Gastroenterology2005，11，35： | 2 |
| 6 | The perinatal riskfactors of periventricularleukomalacia(PVL)in premature infants显示文摘 | Ibara S Ikenoue T Sameshima H | 1995 | Nippon Sanka Fujinka Gakkai Zashi1995，47，11： | 1 |
| 7 | Effect of lower dos- age of oral conjugated equine estrogen on inflammatory markers and endothelial function in healthy postmenopausal women 显示文摘 | Wakatsuki A Ikenoue N Shinohaza K | 2004 | Arterioseler Thromb Vase BioL2004，24，3： | 1 |
| 8 | Developmental effects on neonatal mortality and subsequent cerebral palsy in infants exposed to intrauterine infection 显示文摘 | Sameshima H Ikenoue T | 2007 | Early Hum Dev2007，83，8： | 1 |
| 9 | Fetal heart rate accelerations and late decelerations during the course of intrauterine death in chronically eatheterized rhesus monkeys 显示文摘 | Murata Y Martin CB Ikenoue T | 1982 | Am J Obstet Gynecol1982，144，： | 1 |
| 10 | Effect of medroxyprogesterone acetate on endothelium-dependent vasodilation in post- menopausal women receiving estrogen 显示文摘 | Wakatsuki A Okatani Y Ikenoue N | 2001 | Circulation2001，104，15： | 1 |
| 11 | Long - term magnesium sulfate treatment as protection against hypoxic - ischemic brain injury in seven - day - old rats 显示文摘 | Sameshima H Ikenoue T | 2001 | American Journal of Obstetrics & Gynecology2001，184，： | 1 |
| 12 | Functional analysis of PIK3CA gene mutations in human colorectal cancer显示文摘 | Ikenoue T Kanai F Hikiba Y | 2005 | Cancer Res2005，65，11： | 1 |
| 13 | Unselected low-risk pregnancies and the effect of continuous intrapartum fetal heart rate monitoring on umbilical blood gases and cerebral palsy 显示文摘 | Sameshima H Ikenoue T Ikeda T | 2004 | Am J Obstet Gynecal2004，190，1： | 1 |
| 14 | Effect of Lower Dosage of Oral Conjugated Equine Estrogen on Inflammatory Markers and Endothelial Function in Healthy Postmenopausal Women 显示文摘 | Wakatsuki A Ikenoue N Shinohara K | 2004 | Arterioscler Thromb Vasc Biol2004，24，3： | 1 |
| 15 | The perinatal risk factors of periventricular leukomalacia (PVL) in premature infants显示文摘 | Ibara S Ikenoue T Sameshima H | 1995 | Nippon Sanka Fujinka Gakkai Zasshi1995，47，11： | 1 |
| 16 | Studies on prostaglandin production relating to the mechanism of dysmenorrhea in endometriosis显示文摘 | Koike H Ikenoue T Mori N | | 0，，01： | 1 |
| 17 | Effect of me- droxyprogesterone acetate on endothelium-dependent vasodilation in postmenopausal women receiving estrogen 显示文摘 | Wakatsuki A Okatani Y Ikenoue N | 2001 | Circulation2001，104，15： | 1 |
| 18 | Systematic analysis of the TGF-β-Smad signaling pathway in gastrointestinal cancer cells显示文摘 | Ijichi H Ikenoue T Kato N | 2001 | Biochem Biophys Res Commun2001，289，2： | 1 |
| 19 | Rheb controls misfolded protein metabolism by inhibiting aggresome formation and autophagy显示文摘 | Zhou X Ikenoue T Chen X | 2009 | Proc Natl Acad Sci U S A2009，106，22： | 1 |
| 20 | Small low-density lipoprotein particles and endothelium-dependent vasodilation in postmenopausal women 显示文摘 | Wakatsukl A Ikenoue N Shinohara K | 2004 | Atherosclerosis2004，177，2： | 1 |
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