|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Assessment of the correlation between serum prolidase and alpha-fetoprotein levels in patients with hepatocellular carcinoma显示文摘AIM: To determine the predictive value of increased prolidase activity that reflects increased collagen turnover in patients with hepatocellular carcinoma(HCC).METHODS: Sixty-eight patients with HCC(mean age of 69.1 ± 10.1), 31 cirrhosis patients(mean age of59.3 ± 6.3) and 33 healthy volunteers(mean age of51.4 ± 12.6) were enrolled in this study. Univariate and multivariate analysis were used to evaluate the association of serum α-fetoprotein(AFP) values with HCC clinicopathological features, such as tumor size,number and presence of vascular and macrovascular invasion. The patients with HCC were divided into groups according to tumor size, number and presence of vascular invasion(diameters; ≤ 3 cm, 3-5 cmand ≥ 5 cm, number; 1, 2 and ≥ 3, macrovascular invasion; yes/no). Barcelona-clinic liver cancer(BCLC)criteria were used to stage HCC patients. Serum samples for measurement of prolidase and alphafetoprotein levels were kept at-80 ℃ until use.Prolidase levels were measured spectrophotometrically and AFP concentrations were determined by a chemiluminescence immunometric commercial diagnostic assay.RESULTS: In patients with HCC, prolidase and AFP values were evaluated according to tumor size, number,presence of macrovascular invasion and BCLC staging classification. Prolidase values were significantly higher in patients with HCC compared with controls(P <0.001). Prolidase levels were significantly associated with tumor size and number(P < 0.001, P = 0.002,respectively). Prolidase levels also differed in patients in terms of BCLC staging classification(P < 0.001).Furthermore the prolidase levels in HCC patients showed a significant difference compared with patients with cirrhosis(P < 0.001). In HCC patients grouped according to tumor size, number and BCLC staging classification, AFP values differed separately(P = 0.032,P = 0.038, P = 0.015, respectively). In patients with HCC, there was a significant correlation(r = 0.616; P< 0.001) between prolidase and AFP values in terms of tumor size, number and BCLC staging classification,whereas the presence of macrovascular invasion did not show a positive association with serum prolidase and AFP levels.CONCLUSION: Considering the levels of both serum prolidase and AFP could contribute to the early diagnosing of hepatocellular carcinoma. | Sevil Uygun Ilikhan Muammer Bilici Hatice Sahin Ayse Semra Demir Akca Murat Can Ibrahim Ilker Oz Berrak Guven M Cagatay Buyukuysal Yucel Ustundag | 2015 | World Journal of Gastroenterology2015，21，22： | 8 |
| 2 | Pegylated interferon-alpha plus taurine in treatment of rat liver fibrosis显示文摘AIM: To investigate the antif ibrotic effects of peginterferon- alpha 2b and taurine on oxidative stress markers and hepatocellular apoptosis. METHODS: Sixty rats with CCl4-induced liver fibrosis were divided into 4 groups (n = 15). Group 1 was left for spontaneous recovery (SR). Groups 2-4 received peginterferon-alpha 2b, taurine, and their combination, respectively, for four weeks. Histological f ibrosis scores, histomorphometric analysis, tissue hydroxyproline, tissue MDA, GPx and SOD activities were determined. Activated stellate cells and hepatocellular apoptosis were also evaluated. RESULTS: The degree of f ibrosis decreased in all treatment groups compared to spontaneous recovery group. Taurine alone and in combination with peginterferon-alpha 2b reduced oxidative stress markers, but peginterferon-alpha 2b alone did not. Apoptotic hepatocytes and activated stellate cells were higher in groups 2-4 than in group 1. Combined taurine and peginterferon-alpha 2b further reduced fibrosis and increased activated stellate cell apoptosis, but could not improve oxidative stress more than taurine alone.CONCLUSION: Peginterferon-alpha 2b exerts anti- f ibrotic effects on rat liver fibrosis. It seems ineffective against oxidative stress in vivo. Peginterferon-alpha 2b in combination with taurine seems to be an antif ibrotic strategy. | Ilker Tasci Mehmet Refik Mas Sevil Atalay Vural Salih Deveci Bilgin Comert Gunay Alcigir Nuket Mas Cemal Akay Mithat Bozdayi Cihan Yurdaydin Hakan Bozkaya Ozden Uzunalimoglu Ahmet Turan Isik Harun M Said | 2007 | World Journal of Gastroenterology2007，13，23： | 7 |
| 3 | Efficacy of ankaferd blood stopper application on nonvariceal upper gastrointestinal bleeding显示文摘AIM:To prospectively assess the hemostatic efficacy of the endoscopic topical use of ankaferd blood stopper(ABS) in active non-variceal upper gastrointestinal system(GIS) bleeding.METHODS:Endoscopy was performed on 220 patients under suspiciency of GIS bleeding.Patients with active non-variceal upper gastrointestinal bleeding(NVUGIB) with a spurting or oozing type were included.Firstly,8-10 cc of isotonic saline was sprayed to bleeding lesions.Then,8 cc of ABS was applied on lesions in which bleeding continued after isotonic saline application.The other endoscopic therapeutic methods were applied on the lesions in which the bleeding did not stop after ABS.RESULTS:Twenty-seven patients had an active NVUGIB with a spurting or oozing type and 193 patients were excluded from the study since they did not have non-variceal active bleeding.8 cc of ABS was sprayed on to the lesions of 26 patients whose bleeding continued after isotonic saline and in 19 of them,bleeding stopped after ABS.Other endoscopic treatment methods were applied to the remaining patients and the bleeding was stopped with these interventions in 6 of 7 patients.CONCLUSION:ABS is an effective method on NVUGIB,particularly on young patients with no coagulopathy.ABS may be considered as part of a combination treatment with other endoscopic methods. | Gokhan Gungor M Hakan Goktepe Murat Biyik Ilker Polat Tuncer Tuna Huseyin Ataseven Ali Demir | 2012 | World Journal of Gastrointestinal Endoscopy2012，4，12： | 5 |
| 4 | Adrenomed ullin reduces antioxidant defense system and enhances kid- ney tissue damage in cadmium and lead exposed rats 显示文摘 | Yurekli M Esrefoglu M Ilker Dogru M | 2009 | Environmental Toxicology2009，24，3： | 1 |
| 5 | Tuning the hemolytic and antibacterial activities of amphiphilic polynorbornene derivatives显示文摘 | ILKER M F NOSSLEIN K TEW G N | 2004 | J Am Chem Soc2004，126，15： | 1 |
| 6 | Three dimensional ultrasound observation of carotid artery plaque ulceration 显示文摘 | Schm inke U M otsch L H ilker L | 2000 | Stroke2000，31，7： | 1 |
| 7 | The impact of green product innovation on firm performance and competitive capability:The moderating role of managerial environmental concern显示文摘 | Ilker M A | 2012 | Procedia-Social and Behavioral Sciences2012，62，： | 1 |
| 8 | Revisiting internal waves and mixing in the Arctic Ocean 显示文摘 | John D G James H M Ilker F | 2013 | Journal of Geophysical Research: Oceans2013，118，8： | 1 |
| 9 | Inheritance and combining ability in some powdery mildew resistant wheat lines显示文摘 | Ilker E Tonk F A Tosun M | 2009 | Crop Breed Appl Biot2009，9，： | 1 |
| 10 | Alterations in the brain electrical activity in a rat model of sepsis- associated encephalopathy 显示文摘 | Ilker M Sinan B Murat U | 2010 | Brain research2010，1354，： | 1 |
| 11 | Hydrogen peroxide bleaching of cotton in ultrasonic energy显示文摘 | ILKER M S YUKSELOGˇLU MUGE S | 2005 | Uhrasonics2005，43，10： | 1 |
| 12 | Endocan, a novel marker of endothelial dysfunction in patients with essential hypertension: Comparative effects of amlodipine and valsartan显示文摘 | Turgay Cel&inodot k Sevket Balta Murat Karaman Sey&inodot t Ahmet Ay Sa&inodot t Dem&inodot rkol Ceng&inodot z Ozturk Mustafa D&inodot nc H&inodot lm&inodot U. Unal M. Ilker Y&inodot lmaz Sel&inodot m K&inodot l&inodot c Gulcan Kurt A. Tas At& | 2015 | Blood Pressure2015，，1： | 1 |
| 13 | Limbal-conjunctival autograft transplantation in cases with recurrent pterygium显示文摘 | Guler M Sobaci G Ilker S | 1994 | Acta Ophthalmol (Copenh)1994，72，6： | 1 |
| 14 | The impact of green product innovation on firm performance and competitive capability: The mod- erating role of managerial environmental concern 显示文摘 | Ilker M A | 2012 | Procedia-Social and Behavioral Sciences2012，62，24： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员