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| 1 | Helicobacter pylori-negative gastric mucosa-associated lymphoid tissue lymphomas: A review显示文摘Since Isaacson and Wright first reported on the extranodal marginal zone B-cell lymphoma of the stomach in 1983,following studies have clarified many aspects of this disease.We now know that the stomach is the most affected organ by this disease,and approximately90% of gastric mucosa-associated lymphoid tissue(MALT) lymphomas are related to Helicobacter pylori(H.pylori) infection.This implies that approximately 10% of gastric MALT lymphomas occur independent of H.pylori infection.The pathogenesis of these H.pylori-negative gastric MALT lymphomas remains unclear.To date,there have been several speculations.One possibility is that genetic alterations result in nuclear factor-kappa B(NF-κB) activation.Among these alterations,t(11;18)(q21;q21) is more frequently observed in H.pylori-negative gastric MALT lymphomas,and such translocation results in the synthesis of fusion protein API2-MALT1,which causes canonical and noncanonical NF-κB activation.Another possibility is infection with bacteria other than H.pylori.This could explain why H.pylori eradication therapy can cure some proportions of H.pylori-negative gastric MALT lymphoma patients,although the bacteria responsible for MALT lymphomagenesis are yet to be defined.Recent advances in endoscopy suggest magnifying endoscopy with narrow band imaging as a useful tool for both detecting gastric MALT lymphoma lesions and judging the response to treatment.A certain proportion of H.pylori-negative gastric MALT lymphoma patients respond to eradication therapy; hence,H.pylori eradication therapy could be considered as a first-line treatment for gastric MALT lymphomas regardless of their H.pylori infection status. | Naoki Asano Katsunori Iijima Tomoyuki Koike Akira Imatani Tooru Shimosegawa | 2015 | World Journal of Gastroenterology2015，21，26： | 7 |
| 2 | Stronger inhibition of gastric acid secretion by lafutidine, a novel H_2 receptor antagonist, than by the proton pump inhibitor lansoprazole显示文摘AIM: To compare the antisecretory activity and plasma drug concentrations of a single oral dose of 10 mg lafutidine, a novel H2 receptor antagonist, with those of the proton pump inhibitor lansoprazole (LPZ) 30 mg. METHODS: Ten volunteers without H pylori infection participated in this crossover study comparing lafutidine 10 mg with LPZ 30 mg. Intragastric pH was monitored for 6 h in all participants, and blood samples were collected from four randomly selected individuals after single-dose administration of each drug. RESULTS: The median intragastric pH was significantly higher in individuals who received lafutidine 10 mg than in those who received LPZ 30 mg 2, 3, 4, 5, and 6 h after administration. Maximal plasma drug concentration was reached more promptly with lafutidine 10 mg than with LPZ 30 mg. CONCLUSION: In H pylori-negative individuals, gastric acid secretion is more markedly inhibited by lafutidinethan by LPZ. | Hatsushi Yamagishi Tomoyuki Koike Shuichi Ohara Toru Horii Ryousuke Kikuchi Shigeyuki Kobayashi Yasuhiko Abe Katsunori Iijima Akira Imatani Kaori Suzuki Takanori Hishinuma Junichi Goto Tooru Shimosegawa | 2008 | World Journal of Gastroenterology2008，14，15： | 3 |
| 3 | A prospective comparative study of optical coherence tomography and EUS for tumor staging of superficial esophageal squamous cell carcinoma显示文摘 | Waku Hatta Kaname Uno Tomoyuki Koike Katsunori Iijima Naoki Asano Akira Imatani Tooru Shimosegawa | 2012 | Gastrointestinal Endoscopy2012，，3： | 2 |
| 4 | Early effects of Lansoprazole orally disintegrating tablets on intragastric pH in CYP2C19 extensive metabolizers显示文摘AIM: To compare rabeprazole (RPZ; 10 mg) with Lansoprazole orally disintegrating tablets (LPZ; 30 mg OD) in terms of antisecretory activity and blood drug concentration after a single dose. METHODS: Eight H pylori-negative cytochrome P450 (CYP) 2C19 extensive metabolizers were assigned to receive a single oral dose of RPZ 10 mg or LPZ 30 mg OD. Twelve hour intragastric pH monitoring was perform- ed on the day of treatment. Blood samples were also collected after the administration of each drug. RESULTS: LPZ 30 mg OD induced a significantly earlier rise in blood drug concentration than RPZ 10 mg; consequently, LPZ 30 mg OD induced a significantly earlier rise in median pH in the third and fourth hours of the study. CONCLUSION: In H pylori-negative CYP2C19 extensive metabolizers, LPZ 30 mg OD induced a significantly faster inhibition of gastric acid secretion than RPZ 10 mg. | Hatsushi Yamagishi Tomoyuki Koike Shuichi Ohara Toru Horii Ryousuke Kikuchi Shigeyuki Kobayashi Yasuhiko Abe Katsunori Iijima Akira Imatani Kaori Suzuki Takanori Hishinuma Junichi Goto Tooru Shimosegawa | 2008 | World Journal of Gastroenterology2008，14，13： | 2 |
| 5 | Prevalence of gastroesophageal reflux symptoms in a large unselected general population in Japan显示文摘AIM:To examine the prevalence of gastroesophageal reflux disease (GERD) symptoms in a large unselected general population in Japan. METHODS: In Japan, mature adults are offered regular check-ups for the prevention of gastric cancer. A notice was sent by mail to all inhabitants aged > 40 years. A total of 160 983 Japanese (60 774 male, 100 209 female; mean age 61.9 years) who underwent a stomach check up were enrolled in this study. In addition, from these 160 983 subjects, we randomly selected a total of 82 894 (34 275 male, 48 619 female; mean age 62.4 years) to evaluate the prevalence of abdominal pain. The respective subjects were prospectively asked to complete questionnaires concerning the symptoms of heartburn, dysphagia, and abdominal pain for a 1 mo period. RESULTS: The respective prevalences of the symptoms in males and females were: heartburn, 15.8% vs 20.7%; dysphagia, 5.4% vs 7.8%; and abdominal pain, 6.6% vs 9.6%. Among these symptoms, heartburn was significantly high compared with the other symptoms, and the prevalence of heartburn was significantly more frequent in females than in males in the 60-89-year agegroup. Dysphagia was also significantly more frequent in female patients. CONCLUSION: The prevalence of typical GERD symptoms (heartburn) was high, at about 20% of the Japan population, and the frequency was especially high in females in the 60-89 year age group. | Hatsushi Yamagishi Tomoyuki Koike Shuichi Ohara Shigeyuki Kobayashi Ken Ariizumi Yasuhiko Abe Katsunori Iijima Akira Imatani Yoshifumi Inomata Katsuaki Kato Daisuke Shibuya Shigemitsu Aida Tooru Shimosegawa | 2008 | World Journal of Gastroenterology2008，14，9： | 2 |
| 6 | Histatin 5 inhibits inflam matory cytokine induction from human gingival fibroblasts by Porphyromonas gingival显示文摘 | Imatani T Kato T Minaguchi K | 2000 | Oral Microbiol Immuno2000，15，6： | 1 |
| 7 | Custom AO small T plate for transcondylar fractures of the distal humerus in the elderly显示文摘 | Imatani J Ogura T Morito Y | 2005 | J Shoulder Elbow Surgery2005，14，6： | 1 |
| 8 | Identification of a novel NOTCH-4/ INT-3 RNA species encoding an activated gene product in certain human tumor cell lines显示文摘 | Imatani A Callahan R | 2000 | Oncogene2000，19，： | 1 |
| 9 | Incidence of reflux esophagitis and Helicobacter pylori infection in diabetic patients显示文摘AIM: To investigate the incidence of reflux esophagitis (RE) and H pylori infection in the diabetic patient. METHODS: The incidence of RE and H pylori infection were investigated in 85 patients with diabetes mellitus and the results were compared with controls. RESULTS: The incidence of RE in diabetic patients was 17.6%. Although this tended to be higher in diabetic patients, there were no statistically significant differences between diabetic patients and controls. The incidence of H pylori infection in diabetic patients was 53.7% but no statistically significant difference was seen between diabetic patients and controls in the incidence of H pylori infection. CONCLUSION: No significant differences could be seen between diabetic patients and controls in the incidence of RE and H pylori infection. | Ken Ariizumi Tomoyuki Koike Shuichi Ohara Yoshifumi Inomata Yasuhiko Abe Katsunori Iijima Akira Imatani Tomoyoshi Oka Tooru Shimosegawa | 2008 | World Journal of Gastroenterology2008，14，20： | 1 |
| 10 | Minimally invasive plate osteosynthesis for comminuted fractures of the metaphysic of the radius显示文摘 | Imatani J Noda T Morito Y | 2005 | J Hand Surg Br2005，30，2： | 1 |
| 11 | Acute, complete acromioclavicular separation显示文摘 | Imatani R J Hanlon JJ Cady GW | 1975 | J Bone Joint Surg(Am)1975，57，3： | 1 |
| 12 | The polymorphism interleukin 8 -251 A/T influences the susceptihility of Helicobacter pylori related gastric diseases in the Japanese population显示文摘 | Ohyauehi M Imatani A Yonechi M | 2005 | Gut2005，54，3： | 1 |
| 13 | Characterization of the Drosophila ortholog of mouse eIF-3p48/INT-6显示文摘 | Miyazaki S Rasmussen S Imatani A | 1999 | Gene1999，233，12： | 1 |
| 14 | Internal fixation for coronal shear fracture of the distal end of the humerus by the anterolateral approach显示文摘 | Imatani J Morito Y Hashizume H | 2001 | J Shoulder Elbow Surg2001，10，6： | 1 |
| 15 | Custom AO small T plate fortranscondylar fractures of the distal humerus in the elderly 显示文摘 | Imatani J Ogura T Morito Y | 2005 | Jshoulder Elbow Surg2005，14，： | 1 |
| 16 | Helicobacter pylori itself and interferon gamma suppresses the expression of a HMG box protein SOX2 through stat6-mediated in terleukin 4 signaling in gastric epithelial cells显示文摘 | Asonoma S Imatani A Asano N | 2006 | Gastro enterology2006，130，4： | 1 |
| 17 | Internal fixation for coronal shear fracture of the distal end of the humerus by the anterolateral approach显示文摘 | Imatani J Morito Y Hashizume H | 2001 | J Shoulder Elbow Surg2001，10，6： | 1 |
| 18 | Custom AO small T plate for transcondylar fractures of the distal humerus in the elderly显示文摘 | Imatani J Ogura T Morito Y | 2005 | J Shoulder Elbow Surg2005，14，： | 1 |
| 19 | Salivary cystatins induce interleukin-6 expression via cell surface molecules in human gingival fibroblasts 显示文摘 | Kato T Imatani T Minaguchi K | 2002 | Mol Immunol2002，39，78： | 1 |
| 20 | Cytoking inducing activity of family 2 cystatins显示文摘 | Kato T Imatani T Minaguchi K | 2000 | Biol Chem2000，381，11： | 1 |
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