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| 1 | Accuracy and responses of genomic selection on key traits in apple breeding显示文摘The application of genomic selection in fruit tree crops is expected to enhance breeding eficiency by increasing prediction accuracy,increasing selection intensity and decreasing generation interval.The objectives of this study were to assess the accuracy of prediction and selection response in commercial apple breeding programmes for key traits.The training population comprised 977 individuals derived from 20 pedigreed fllsib families.Historic phenotypic data were available on 10 traits related to productivity and fruit external appearance and genotypic data for 7829 SNPs obtained with an llumina 20K SNP array.From these data,a genome-wide prediction model was built and subsequently used to calculate genomic breeding values of five application fllsib families.The application families had genotypes at 364 SNPs from a dedicated 512 SNP array,and these genotypic data were extended to the high-density level by imputation.These five families were phenotyped for 1 year and their phenotypes were compared to the predicted breeding values.Accuracy of genomic prediction across the 10 traits reached a maximum value of 0.5 and had a median value of 0.19.The accuracies were strongly affected by the phenotypic distribution and heritability of traits.In the largest family,significant selection response was observed for traits with high heritability and symmetric phenotypic distribution.Traits that showed non-significant response often had reduced and skewed phenotypic variation or low heritability.Among the five application families the accuracies were uncorrelated to the degree of relatedness to the training population.The results underline the potential of genomic prediction to accelerate breeding progress in outbred fruit tree crops that still need to overcome long generation intervals and extensive phenotyping costs. | Hélène Muranty Michela Troggio Inès Ben Sadok Mehdi Al Rifaï Annemarie Auwerkerken Elisa Banchi Riccardo Velasco Piergiorgio Stevanato W.Eric van de Weg Mario Di Guardo Satish Kumar François Laurens Marco C.A.M.Bink | 2015 | Horticulture Research2015，2，1： | 14 |
| 2 | Guidelines forirradiation of blood and blood component post-trans-fusion graft-vs-host disease in Japan显示文摘 | ASAIL T IN ABA S’OHTO H | 2000 | Transfusion2000，10，： | 1 |
| 3 | 2显示文摘 | EVANS H K WYLIE A A MURPHY S K et akThe neuronatin gene resides in a micro-imprinted domain on human chromosome 20ql 1 | 2001 | Genomics2001，77，12： | 1 |
| 4 | Atherosclerosis in rheumatoid arthritis and systemic lupus erythematosus 显示文摘 | Haque S Mirjafari H Bruce IN | 2008 | Curr Opin Lipidol2008，19，4： | 1 |
| 5 | Corrigendum to mathematics and computa- tion 显示文摘 | KWON 0 M PARKJ H published papers in applied LEE S M | 2009 | Applied Mathematics and Computation2009，215，1： | 1 |
| 6 | Interleukin-lO suppresses atherosclerosis in hyperlipidemicmiee 显示文摘 | Han X Kitamoto S Wang overexpression in macrophages H | 2010 | FASEB J2010，24，8： | 1 |
| 7 | Mobilization of CD34^+CD38^- hematopoietic stem cells after priming in acute myeloid leukemia显示文摘AIM: To evaluate quantitatively and qualitatively the different CD34+cell subsets after priming by chemotherapy granulocyte colony-stimulating factor(± G-CSF)in patients with acute myeloid leukemia.METHODS: Peripheral blood and bone marrow sampleswere harvested in 8 acute myeloid leukemia patients during and after induction chemotherapy. The CD34/CD38 cell profile was analyzed by multi-parameter flow cytometry. Adhesion profile was made using CXC chemokine receptor 4(CXCR4)(CD184), VLA-4(CD49d/CD29) and CD47.RESULTS: Chemotherapy ± G-CSF mobilized immature cells(CD34+CD38 population), while the more mature cells(CD34+CD38lowand CD34+CD38+populations) decreased progressively after treatment. Circulating CD34+cells tended to be more sensitive to chemotherapy after priming with G-CSF. CD34+cell mobilization was correlated with a gradual increase in CXCR4 and CD47expression, suggesting a role in cell protection and the capacity of homing back to the marrow.CONCLUSION: Chemotherapy ± G-CSF mobilizes into the circulation CD34+bone marrow cells, of which, the immature CD34+CD38-cell population. Further manipulations of these interactions may be a means with which to control the trafficking of leukemia stem cells to improve patients' outcomes. | Adriana Plesa Eve Mattei Charles Dumontet Youcef Chelghoum Hélène Labussière Giovanna Cannas Mauricette Michallet Xavier Thomas Mohamed Elhamri Stéphane Morisset Inès Tagoug | 2013 | World Journal of Stem Cells2013，5，4： | 1 |
| 8 | Effects of substrate bias on electron energy distribution in magnetron sputtering system 显示文摘 | Seo S In J Chang H | 2004 | Physics of Plasmas2004，11，10： | 1 |
| 9 | The cutaneous lesions of Kikuchi’s disease: a comprehensive analysis of 16 cases based on the clinicopathologic, immunohistochemical, and immunofluorescence studies with an emphasis on the differential diagnosis显示文摘 | Kim J H Kim Y B In S I | 2010 | Hum Pathol2010，41，9： | 1 |
| 10 | Microstructure and situ synthesized TiC/Ti surface MMC on Ti-6Al-4V by laser cladding 显示文摘 | Man H C Zhang S Cheng formation mechanism of in F T | 2001 | Scripta Mater2001，44，： | 1 |
| 11 | Effect o f microbial inoculants on quality of alfalfa hay baled at high moisture and cattle performance显示文摘 | Emanuele S M H or ton G M J Aldw in J | 1992 | J Dairy Sci1992，75，： | 1 |
| 12 | Role of NADPH oxidase-derived superoxide in reduced size liver ischemia and reperfusion injury显示文摘 | Harada H Hines IN Flores S el al | 2004 | Arch Biochem Biophys2004，423，1： | 1 |
| 13 | Effects of a sheath boundary on electron energy distribution in Ar/He dc magnetron discharges 显示文摘 | Seo S In J Chang H | 2004 | J Appl Phys2004，96，1： | 1 |
| 14 | In vitro and prion protein oligomers 显示文摘 | Simoneau S Rezaei H in vivo neurotoxicity of Sale s N | 2007 | PLoS Pathogens2007，，3： | 1 |
| 15 | Rate of CD4 decline and HIV-RNA change fol- lowing HIV seroconversion in men who have sex with men: a comparison between the Beijing PRIMO and CASCADE cohorts 显示文摘 | Huang X Lodi S Fox Z Li W Phillips A Porter K Lut- sar I Kelleher A Li N Xu X Wu H Johnson AM Bei- jing PRIMO cohort study CASCADE Collaboration in EuroCoord | 2013 | J Acquir Immune Defic Syndr2013，62，4： | 1 |
| 16 | Semimembranosus release as the second step of soft tissue balancing in varus total kneearthroplasty显示文摘 | Koh H S In Y | 2013 | J Arthroplasty2013，28，2： | 1 |
| 17 | Effect of Overlayer Thickness of Hole Transport Material on Photovoltaic Performance in Solid-Sate Dye-Sensitized Solar Cell显示文摘 | Hui S K Chang R L In H J | 2012 | Bull Korean Chem Soc2012，33，2： | 1 |
| 18 | Transient are involved in gastric cancer cells 显示文摘 | Kim B J Nah S Y Jeon J H et receptor potential melastatin 7 channels ginsenoside Rg3 induced apoptosis in al | 2011 | Basic Clin Pharmacol Toxicol2011，109，4： | 1 |
| 19 | Characterization and biological potency of mono - to tetra-halogenated carbazoles 显示文摘 | Riddell N in U H Safe S | 2015 | Environmental Science & Technology2015，49，10： | 1 |
| 20 | Increased power generation with advective flow through the porous anode and reduced electrode spacing显示文摘 | Cheng S Liu H Logan in a continuous fow MFC B E | 2006 | Environmental Science Technology2006，40，7： | 1 |
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