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| 1 | An overview on recent in vivo biological application of cerium oxide nanoparticles显示文摘Cerium oxide nanoparticles(CNPs)possess a great potential as therapeutic agents due to their ability to self-regenerate by reversibly switching between two valences+3 and+4.This article reviews recent articles dealing with in vivo studies of CNPs towards Alzheimer’s disease,obesity,liver inflammation,cancer,sepsis,amyotrophic lateral sclerosis,acute kidney injury,radiation-induced tissue damage,hepatic ischemia reperfusion injury,retinal diseases and constipation.In vivo anti-cancer studies revealed the effectiveness of CNPs to reduce tumor growth and angiogenesis in melanoma,ovarian,breast and retinoblastoma cancer cell-induced mice,with their conjugation with folic acid,doxorubicin,CPM,or CXC receptor-4 antagonist ligand eliciting higher efficiency.After conjugation with triphenylphosphonium or magnetite nanoparticles,CNPs were shown to combat Alzheimer’s disease by reducing amyloid-β,glial fibrillary acidic protein,inflammatory and oxidative stress markers in mice.By improving muscle function and longevity,the citrate/EDTA-stabilized CNPs could ameliorate amyotrophic lateral sclerosis.Also,they could effectively reduce obesity in mice by scavenging ROS and reducing adipogenesis,triglyceride synthesis,GAPDH enzyme activity,leptin and insulin levels.In CCl4-induced rats,stress signaling pathways due to inflammatory cytokines,liver enzymes,oxidative and endoplasmic reticulum messengers could be attenuated by CNPs.Commercial CNPs showed protective effects on rats with hepatic ischemia reperfusion and peritonitis-induced hepatic/cardiac injuries by decreasing oxidative stress and hepatic/cardiac inflammation.The same CNPs could improve kidney function by diminishing renal superoxide,hyperglycemia and tubular damage in peritonitis-induced acute kidney injury in rats.Radiation-induced lung and testicular tissue damage could be alleviated in mice,with the former showing improvement in pulmonary distress and bronchoconstriction and the latter exhibiting restoration in spermatogenesis rate and spermatid/spermatocyte number.Through enhancement of gastrointestinal motility,the CNPs could alleviate constipation in both young and old rats.They could also protect rat from light-induced retinal damage by slowing down neurodegenerative process and microglial activation. | Baskaran Stephen Inbaraj Bing-Huei Chen | 2020 | Asian Journal of Pharmaceutical Sciences2020，15，5： | 6 |
| 2 | Cytotoxic action of juglone and plumbagin:a mechanistic study using HaCaT keratinocytes显示文摘 | Inbaraj J J Chignell C F | 2004 | Chem Res Toxicol2004，17，1： | 1 |
| 3 | Dye adsorption characteristics of magnetite nanoparticles coated with a biopolymer poly(γ-glutamic acid)显示文摘 | B. Stephen Inbaraj B.H. Chen | 2011 | Bioresource Technology2011，，19： | 1 |
| 4 | Analysis and formation of trans fatty acids in hydrogenated soybean oil during heating显示文摘 | LIU W H INBARAJ B S CHEN B H | 2007 | Food Chem2007，11，4： | 1 |
| 5 | Isolation of carotenoids,flavonoids and polysaccharides from Lycium barbarum L and evaluation of antioxidant activity显示文摘 | WANG C C CHANG S C INBARAJ B S | 2010 | Food Chemistry2010，120，1： | 1 |
| 6 | Use of Jackfruit Peel Carbon (JPC) for Adsorption of Rhodamine B,a Basic Dye fromAqueous Solution 显示文摘 | INBARAJ B S SULOCHANA N | 2006 | Indian Journal of Chemical Technology2006，13，1： | 1 |
| 7 | Adsorption of toxicmercury ( II) by an extracellular biopolymer poly ( ^-glutamicacid) 显示文摘 | INBARAJ B S WANG J S LU J F | 2009 | Bioresource Technology2009，100，1： | 1 |
| 8 | Textural and local spatial statistics for the object-oriented classification of urban areas using high resolution imagery显示文摘 | Wei Su Jing Li Yunhao Chen Zhigang Liu Jinshui Zhang Tsuey Miin Low Inbaraj Suppiah Siti Atikah Mohamed Hashim | 2008 | International Journal of Remote Sensing2008，，11： | 1 |
| 9 | Improved high performance liquid chromatographic method for determination of carotenoids in the microalga Chlorella pyrenoidosa显示文摘 | Inbaraj B S Chien J T Chen B H | 2006 | Journal of Chromatography A2006，1102，12： | 1 |
| 10 | Deter mination of chlorophylls and their derivatives in Gynostemma pentaphyllum Makino by liquid chromatography-mass spectrometry 显示文摘 | KAO T H HUANG S C STEPHEN INBARAJ B | 2008 | Journal of Pharmaceutical and Biomedical Analysis2008，48，1： | 1 |
| 11 | Determination of carotenoids and their esters in fruits of Lyciumbarbarum Lin- naeus by HPLC-DAD-APCI-MS显示文摘 | Inbaraj BS Lu H Hung CF | 2008 | Journal of Pharmaceutical and Biomedical Analysis2008，47，45： | 1 |
| 12 | Simultaneous determination of phenolic acids and flavonoids in Lycium bar- barum Linnaeus by HPLC-DAD-ESI MS显示文摘 | Inbaraj BS Lu H Kao TH | 2010 | Pharmaceutical and Biomedical Analysis2010，51，3： | 1 |
| 13 | Textural and local spatial statistics for the object-oriented classification of urban areas using high resolution imagery显示文摘 | Wei Su Jing Li Yunhao Chen Zhigang Liu Jinshui Zhang Tsuey Miin Low Inbaraj Suppiah Siti Atikah Mohamed Hashim | 2008 | International Journal of Remote Sensing2008，，11： | 1 |
| 14 | Analysis and formation of trans fatty acids in hydrogenated soybean oil during heating 显示文摘 | LIU W H STEPHEN INBARAJ B CHEN B H | 2007 | Food Chemistry2007，104，： | 1 |
| 15 | Adsorption of toxic mercury(II)byan extracellular biopolymer poly(-glutamic acid)显示文摘 | INBARAJ B S WANG J LU J | 2009 | Biore-source Technology2009，100，1： | 1 |
| 16 | Removal of cationic dyes from aqueous solution using an anionic poly-γ-glutamic acid-based adsorbent显示文摘 | Inbaraj B S Chiu C P Ho G H | 2006 | Hazardous Materials2006，137，1： | 1 |
| 17 | Synthesis,characterization and antibacterial activity of super paramagnetic nanoparticles modified with glycol chitosan 显示文摘 | Inbaraj B S Tsai T Y Chen B H | 2012 | Science and Technology of Advanced Materials2012，13，15： | 1 |
| 18 | Cytotoxic action of juglone and plumbagin: a mechanistic study using HaCaT keratino- cytes显示文摘 | Inbaraj JJ Chignell CF | 2004 | Chem Res Toxicol2004，17，1： | 1 |
| 19 | Improved high performance liquid chromatographic method for determination of carotenoids in the microalga Chlorella tryrenoidosa 显示文摘 | Inbaraj B S Chien J T Chen B H | 2006 | Journal of Chromatography A2006，，1102： | 1 |
| 20 | Cytotoxic action of juglone and plumbagin:amechanistic study using HaCaT keratinocytes显示文摘 | Inbaraj JJ Chignell CF | 2004 | Chem Res Toxicol2004，17，1： | 1 |
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