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1篇 您的检索式:作者名="Indong Jun"
    题名 作者 年代 出处 被引量
1Synergistic stimulation of surface topography and biphasic electric current promotes muscle regeneration显示文摘Developing a universal culture platform that manipulates cell fate is one of the most important tasks in the investigation of the role of the cellular microenvironment.This study focuses on the application of topographical and electrical field stimuli to human myogenic precursor cell(hMPC)cultures to assess the influences of the adherent direction,proliferation,and differentiation,and induce preconditioning-induced therapeutic benefits.First,a topographical surface of commercially available culture dishes was achieved by femtosecond laser texturing.The detachable biphasic electrical current system was then applied to the hMPCs cultured on laser-textured culture dishes.Laser-textured topographies were remarkably effective in inducing the assembly of hMPC myotubes by enhancing the orientation of adherent hMPCs compared with flat surfaces.Furthermore,electrical field stimulation through laser-textured topographies was found to promote the expression of myogenic regulatory factors compared with nonstimulated cells.As such,we successfully demonstrated that the combined stimulation of topographical and electrical cues could effectively enhance the myogenic maturation of hMPCs in a surface spatial and electrical field-dependent manner,thus providing the basis for therapeutic strategies.Indong Jun Na Li Jaehee Shin Jaeho Park Young Jun Kim Hojeong Jeon Hyuk Choi Jae-Gu Cho Byoung Chan Choi Hyung-Seop Han Jae-Jun Song 2022Bioactive Materials2022,7,5:0
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