|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Analysis of the phosphatidylinosit ol 3'-kinase signaling pathway in glioblastoma patients in vivo显示文摘Deregulated signaling through the p hosphatidylinositol 3-kinase(PI3K)pathway is common in many types of can cer,including glioblastoma.Dissecting the molecular events associated with activation of this pathway in glioblastoma p atients in vivo presents an important challenge that has implic ations for the development and clini cal testing of PI3K pathway inhibito rs.Using an immunohistochemical analysis appl ied to a tissue microarray,we performed hierarchical clustering and mul tidimensional scaling,as well as univariate and multivariate analyses,to dissect the PI3K pathway in v ivo.We demonstrate that loss of the t umor suppressor protein PTEN,which antagonizes PI3K pathwa y activation,is highly correlated w ith activation of the main PI3K effec tor Akt in vivo.We also show that Akt activation is signific antly correlated with phosphorylation of mammalian target of rapamycin(mTOR),the family of forkhead transcription factors(FOXO1,FOXO3a,and FOXO4),and S6,which are thought to promote its effects.Expression of the mutan t epidermal growth factor receptor vIII is also tightly correlated with phosphorylation of these effectors,d emonstrating an additional route to PI3K pathway activation in glioblastomas in vivo.These results provide the first dissection of the PI3K path way in glioblastoma in vivo and suggest an approach to stratifying patients for targeted kinase inhi bitor | Choe G Horvath S Cloughesy TF Crosby K Seligson D Palotie A Inge L Smith BL Sawyers CL Mischel PS | 2003 | 癌症2003，22，7： | 41 |
| 2 | Stimuli-responsive magnetic nanomicelles as multifunctional heat and cargo delivery vehicles 显示文摘 | Kim D H Vitol E A Liu | 2013 | Langmuir2013，29，24： | 1 |
| 3 | Pulmonary artery stents in the recent era: immediate and intermediate follow-up 显示文摘 | Ing FF Khan A Kobayashi D | 2014 | Catheter Cardiovasc Interv2014，84，7： | 1 |
| 4 | Polypoid gastrointestinal stromal tumor of small bowel metastasizing to mesenteric lymph nodes:a case report 显示文摘 | E1 Demellawy D Shokry P Ing A | 2008 | Pathol Res Pract2008，204，3： | 1 |
| 5 | Characterizing rule-based category learning deficitsin patients with Parkinson's disease显示文摘 | Filoteo J V Maddox W T Ing A D | | 0，，： | 1 |
| 6 | Delayed Feedback Disrupts the Procedural-learning System but not the Hypothesis-testing System in Perceptual Category Learning显示文摘 | Maddox W T Ing A D | 2005 | Journal of Experimental Psychology:Learning Memory and Ccognition2005，31，1： | 1 |
| 7 | Evidence for a Procedural-learning Based System in Perceptual Category Learning显示文摘 | Maddox W T Bohil C J Ing A D | 2004 | Psychonomic Bulletin & Review2004，11，5： | 1 |
| 8 | Using chlorophyll fluorescence to as- sess the fraction of absorbed light allocated to thermal dissipation of excess excitation 显示文摘 | Demmig-Adams B Adams W W Baker D H Logan B A Bowl- ing D R Verhoreven A S | 1996 | Physiol Plant1996，98，： | 1 |
| 9 | Disrupting Feedback Processing Interferes with Rule-based but not Information-integration Category Learning显示文摘 | Maddox W T Ashby F G Ing A D | 2004 | Memory & Cognition Austin2004，32，4： | 1 |
| 10 | Bubble detectors:A maturing technology显示文摘 | ING H NOULTY R A MCLEAN T D | 1997 | Radiat Means1997，27，1： | 1 |
| 11 | Platelet function in clopidogrel-treated patients with acute coronary syndrome 显示文摘 | Sibb ing D von B eckerath O Schm ig A | 2007 | Blood Coagul Fibrinolysis2007，18，4： | 1 |
| 12 | Polypoid gastrointestinal stromal tumor of small bowel metastasizing to mesenteric lymph nodes: a case report 显示文摘 | EL DEMELLAWY D SHOKRY P ING A | 2008 | Pathol Res Pract2008，204，3： | 1 |
| 13 | Cavitation erosion of plasma-sprayed NiTi coatings显示文摘 | STELLA J SCHULLER E HEβING C HAMED O A POHL M STOVER D | 2006 | Wear2006，260，： | 1 |
| 14 | Disrupting feed- back processing interferes with rule - based but not informa- tion - integration category learning 显示文摘 | Maddox W T Ashby F G Ing A D | 2004 | Memory & Cogni- tion2004，32，4： | 1 |
| 15 | Polypoid gastrointestinal stromal tumor of small bowel metastasizing to mesenterie lymph nodes: a case report 显示文摘 | El Demellawy D Shokry P Ing A | 2008 | Pathol Res Pratt2008，204，3： | 1 |
| 16 | Techniques for Reduc- Natural Convection Heat Losses in Annular Receiver Geometries 显示文摘 | Ratzel A Hickox C Gartling ing Thermal Conduction and D | 1979 | Journal of Heat Transfer1979，，02： | 1 |
| 17 | Gene expression in the spermatogenieally inactive 'Dark' and maturing 'Light' testicular tissues of the prepubertal colt显示文摘 | Ing N H Laughlin A M Varner D D | 2004 | J Androl2004，24，： | 1 |
| 18 | Bubble detectors- A maturing technology显示文摘 | ING H NOULTY R A MCLEAN T D | 1997 | Radiation Measurement1997，27，1： | 1 |
| 19 | Glass transi- tion behavior of latex interpenetrating polymer networks based on methaerylic/acrylic pairs显示文摘 | SPERI ING L H CldlU T W THOMAS D A | 1973 | Journal o1' Applied Polymer Science1973，17，8： | 1 |
| 20 | H ighly active ruthenium (II ) complex catalysts bearing an unsymmetrical N ,N ,N ligandinthe (asymmetric) transfer hyrogenation of ketones显示文摘 | Ye W enjing Zhao M iao D u W angm ing et a l | 2011 | Chem E ur J2011，17，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员