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| 1 | Trace element modeling of pelite- derived gTanites 显示文摘 | HARRIS N B W INGER S | 1992 | Contributions to Mineralogy and Petrology1992，110，： | 1 |
| 2 | Use of NMR in fish processing optimization: a review of recent progress显示文摘 | Ulf Erikson Inger B Standal Ida G Aursand Emil Veliyulin Marit Aursand | 2012 | Magn Reson Chem2012，，7： | 1 |
| 3 | Flocculation of colloidal silica with hydrolyzed aluminum:an Al solid state NMR investigation显示文摘 | BOTTERO J Y D REN INGER L S | 1997 | Langmuir1997，13，： | 1 |
| 4 | The Uniform Commercial Code in the of Comparative Law 显示文摘 | SCHLES INGER R B | 1959 | Inter - American Law Review1959，18，1： | 1 |
| 5 | Intravenous lidocaine relieves spinal cord injury pain:a randomized controlled trial显示文摘 | Nanna B Finnerup Fin Biering-S(o)rensen Inger L Johannesen | | 0，，05： | 1 |
| 6 | Evolution of pancreas transplantation:long-term results and perspectives from a high-volume center显示文摘 | Ol inger R Margreiter C B?smül er C | | 0，，05： | 1 |
| 7 | Targeting γ-secretase triggers the selective enrichment of oligomeric APP-CTFs in brain extracellular vesicles from Alzheimer cell and mouse models显示文摘Background:We recently demonstrated an endolysosomal accumulation of theβ-secretase-derived APP C-terminal fragment(CTF)C99 in brains of Alzheimer disease(AD)mouse models.Moreover,we showed that the treatment with theγ-secretase inhibitor(D6)led to further increased endolysosomal APP-CTF levels,but also revealed extracellular APP-CTF-associated immunostaining.We here hypothesized that this latter staining could reflect extracellular vesicle(EV)-associated APP-CTFs and aimed to characterize theseγ-secretase inhibitor-induced APPCTFs.Methods:EVs were purified from cell media or mouse brains from vehicle-or D6-treated C99 or APPswedish expressing cells/mice and analyzed for APP-CTFs by immunoblot.Combined pharmacological,immunological and genetic approaches(presenilin invalidation and C99 dimerization mutants(GXXXG))were used to characterize vesicle-containing APP-CTFs.Subcellular APP-CTF localization was determined by immunocytochemistry.Results:Purified EVs from both AD cell or mouse models were enriched in APP-CTFs as compared to EVs from control cells/brains.Surprisingly,EVs from D6-treated cells not only displayed increased C99 and C99-derived C83 levels but also higher molecular weight(HMW)APP-CTF-immunoreactivities that were hardly detectable in whole cell extracts.Accordingly,the intracellular levels of HMW APP-CTFs were amplified by the exosomal inhibitor GW4869.By combined pharmacological,immunological and genetic approaches,we established that these HMW APP-CTFs correspond to oligomeric APP-CTFs composed of C99 and/or C83.Immunocytochemical analysis showed that monomers were localized mainly to the trans-Golgi network,whereas oligomers were confined to endosomes and lysosomes,thus providing an anatomical support for the selective recovery of HMW APP-CTFs in EVs.The D6-induced APP-CTF oligomerization and subcellular mislocalization was indeed due toγ-secretase blockade,since it similarly occurred in presenilin-deficient fibroblasts.Further,our data proposed that besides favoring APP-CTF oligomerization by preventing C99 proteolysis,γ-secretase inhibiton also led to a defective SorLA-mediated retrograde transport of HMW APP-CTFs from endosomal compartments to the TGN.Conclusions:This is the first study to demonstrate the presence of oligomeric APP-CTFs in AD mouse models,the levels of which are selectively enriched in endolysosomal compartments including exosomes and amplified byγ-secretase inhibition.Future studies should evaluate the putative contribution of these exosome-associated APP-CTFs in AD onset,progression and spreading. | Inger Lauritzen Anaïs Bécot Alexandre Bourgeois Raphaëlle Pardossi-Piquard Maria-Grazia Biferi Martine Barkats Fréderic Checler | 2019 | Translational Neurodegeneration2019，8，1： | 1 |
| 8 | Food properties affecting the digestion and absorption of carbohydrates 显示文摘 | Inger B Yvonne B Helena L | 1994 | American Journal of Clinical Nutrition1994，，： | 1 |
| 9 | Quantitation of porcine circovirus type 2 isolated from serum/plasma and tissue samples of healthy pigs and pigs with postweaning muhisystemic wasting syndrome using a TaqMan-based real-time PCR 显示文摘 | INGER M B TORFINN M CHRISTINE M J | 2004 | J Virol Meth2004，122，： | 1 |
| 10 | Taylor Volatile Release from Aqueous Solutions under Dynamic Headspace Dilution Condition显示文摘 | MICHELE M INGER B ANDREW J | 1999 | J Agric Food Chem1999，47，： | 1 |
| 11 | Kirchhoff modeling, inversion for reflectivity, and subsurface illumination显示文摘 | Duquet B Marfurt J K Dell inger J A | 2000 | Geophysics2000，65，4： | 1 |
| 12 | The critical role of kinase activity of interleukin-1 receptor-associated kinase 4 in animal models of joint inflammation显示文摘 | Koziczak-Holbro M Littlewood-Evans A P?l inger B | | 0，，06： | 1 |
| 13 | Hypothyroidism is common in Turner syndrome: results of a five-year follow-up 显示文摘 | Mostafa EM Inger B Kerstin B | 2005 | J Clin Endocrinol Metab2005，90，4： | 1 |
| 14 | Nurses' development of professional self-from being a nursing student in a baccalaureate programme to an experience nurse显示文摘 | Monica B Elsy A Inger J | 2008 | J Clin Nurs2008，17，10： | 1 |
| 15 | Using nutrition for intervention and prevention against environmental chemical toxicity and associated diseases显示文摘 | Hennig B Et inger AS Jandacek RJ | | 0，，04： | 1 |
| 16 | Non-invasive Optical spectroscopy and imaging of human brain function显示文摘 | Vilh'inger A Chance B | 1997 | Trends in Neurosciences1997，20，10： | 1 |
| 17 | Cretaceous plutonism in central Tibet: an example of post-collision magmafism显示文摘 | Hams N B W Inger S Xu R | 1990 | Journal of Volcanology and Geothermal Research1990，44，： | 1 |
| 18 | Volatile release from aqueous solutions under dynamic headspace dilution condition显示文摘 | MICHELE M INGER B ANDREW J | 1999 | J Agric Food Chem1999，47，11： | 1 |
| 19 | GPX Pro198Leu and OGG1 Ser326Cys polymorphisms and risk of development of colorectal adenomas and colorectal cancer显示文摘 | Rikke Hansen Mona S?b? Camilla Furu Skjelbred Bj?rn Andersen Nex? Per Christian Hagen Günther Bock Inger Marie Bowitz Lothe Egil Johnson Steinar Aase Inger-Lise Hansteen Ulla Vogel Elin H. Kure | 2005 | Cancer Letters2005，，1： | 1 |
| 20 | Predictive value of cytokines for developing complications after polytrauma显示文摘AIM: To investigate posttraumatic cytokine alterations and their value for predicting complications and mortality in polytraumatized patients. METHODS: Studies on the use of specific cytokines to predict the development of complications and mortality were identified in MEDLINE, EMBASE, Web of Science and the Cochrane Library. Of included studies, relevant data were extracted and study quality was scored.RESULTS: Forty-two studies published between 1988 and 2015 were identified, including 28 cohort studies and 14 'nested' case-control studies. Most studies investigated the cytokines interleukin(IL)-6, IL-8, IL-10 and tumor necrosis factor(TNF-a). IL-6 seems related to muliorgan dysfunction syndrome, multiorgan failure(MOF) and mortality; IL-8 appears altered in acute respiratory distress syndrome, MOF and mortality; IL-10 alterations seem to precede sepsis and MOF; and TNF-a seems related to MOF. CONCLUSION: Cytokine secretion patterns appear to be different for patients developing complications when compared to patients with uneventful posttraumatic course. More research is needed to strengthen the evidence for clinical relevance of these cytokines. | Anne-Britt E Dekker Pieta Krijnen Inger B Schipper | 2016 | World Journal of Critical Care Medicine2016，5，3： | 1 |
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