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| 1 | Brain-gut-liver interactions across the spectrum of insulin resistance in metabolic fatty liver disease显示文摘Metabolic associated fatty liver disease(MAFLD),formerly named“nonalcoholic fatty liver disease”occurs in about one-third of the general population of developed countries worldwide and behaves as a major morbidity and mortality risk factor for major causes of death,such as cardio-vascular,digestive,metabolic,neoplastic and neuro-degenerative diseases.However,progression of MAFLD and its associated systemic complications occur almost invariably in patients who experience the additional burden of intrahepatic and/or systemic inflammation,which acts as disease accelerator.Our review is focused on the new knowledge about the brain-gut-liver axis in the context of metabolic dysregulations associated with fatty liver,where insulin resistance has been assumed to play an important role.Special emphasis has been given to digital imaging studies and in particular to positron emission tomography,as it represents a unique opportunity for the noninvasive in vivo study of tissue metabolism.An exhaustive revision of targeted animal models is also provided in order to clarify what the available preclinical evidence suggests for the causal interactions between fatty liver,dysregulated endogenous glucose production and insulin resistance. | Eleni Rebelos Patricia Iozzo Maria Angela Guzzardi Maurizia Rossana Brunetto Ferruccio Bonino | 2021 | World Journal of Gastroenterology2021，27，30： | 2 |
| 2 | Fibroblast growth factor-2显示文摘 | Nugent MA Iozzo RV | 2000 | Int J Biochem Cell Biol2000，32，2： | 1 |
| 3 | Biological functions of the small leucinerich proteoglycans:from genetics to signal transduction显示文摘 | Schaefer L Iozzo RV | 2008 | J Biol Chem2008，283，21： | 1 |
| 4 | Decorin is a biological ligand for the epidermal growth factor receptor显示文摘 | Iozzo RV Moscatello DK McQuillan DJ | 1999 | J Biol Chem1999，274，8： | 1 |
| 5 | Decorin is a biological ligand for the epidermal growth factor receptor显示文摘 | Iozzo RV Moscatello DK McQuillan DJ | 1999 | Biol Chem1999，274，8： | 1 |
| 6 | Fibroblast growth factor-2显示文摘 | Nugent MA Iozzo RV | 2000 | Int J Biochem Cell Biol2000，32，2： | 1 |
| 7 | Characterization of the complete genomic structure of the human WNT-SA gene, functional analysis of its promoter, chromosomal mapping ,and expression in early human embryogenesis 显示文摘 | Danielson KGS Pillarisetti J Iozzo RV | 1995 | J Biol Chem1995，270，31： | 1 |
| 8 | De novo expression of circulating biglycan evokes an innate inflammatory tissue response via MyD88/TRIF pathways显示文摘 | Jinyang Zeng-Brouwers Janet Beckmann Madalina-Viviana Nastase Renato V. Iozzo Liliana Schaefer | 2013 | Matrix Biology2013，，： | 1 |
| 9 | Matrix proteoglycans: from molecular design to cellular function显示文摘 | | 1998 | Annu Rev Biochem1998，67，： | 1 |
| 10 | A soluble ectodomain of LRIGlinhibits cancer cell growth by attenuating basal and ligand-dependent EGFR activity 显示文摘 | Goldoni S Iozzo RA Kay P | 2007 | Oncogene2007，26，3： | 1 |
| 11 | Decorin is a biological ligand for the epidermal growth factor显示文摘 | IOZZO R V MOSCATELLO D K MCQUILLAN D J | | 0，，08： | 1 |
| 12 | Endostatin and endorepellin,a common route of action for similar angiostatic cancer avengers 显示文摘 | Poluzzi C Iozzo R V Schaefer L | 2016 | Adv Drug Deliv Rev2016，97，： | 1 |
| 13 | Moleculas in focus: Heparin-binding fibroblast growth factor-2显示文摘 | Iozzo RV | 2000 | Int J Biochem Cell Biol2000，32，2： | 1 |
| 14 | Heparan sulfate proteoglycans:intricate molecules with intriguing functions显示文摘 | Iozzo RV | 2001 | J Clin Invest2001，108，2： | 1 |
| 15 | Decorin binds to a narrow region of the epidermal growth factor (EGF) receptor,partially overlapping but distinct from the EGF-binding epitope显示文摘 | Santra M Reed CC Iozzo RV | 2002 | J Biol Chem2002，277，35： | 1 |
| 16 | Decorin:a guardian from the ma- trix显示文摘 | Neill T Schaefer L Iozzo RV | 2012 | Am J Pathol2012，181，2： | 1 |
| 17 | Biological functions of the small leucine rich proteoglycans: from genetics to signal transduc tion显示文摘 | SCHAEFER L IOZZO R V | 2008 | The Journal of Biological Chemistry2008，283，21： | 1 |
| 18 | Suppression of tumorigenicity by adenovirus-mediated gene transfer of decorin显示文摘 | Reed CC Gauldie J Iozzo RV | 2002 | Oncogene2002，21，23： | 1 |
| 19 | Structural and functional characterization of the human decorin gene promoter显示文摘 | Santra M Danielson K G Iozzo R V | 1994 | J Biol Chem1994，269，1： | 1 |
| 20 | Aberrant expression of the growth factor Wnt-5A in human malignancy 显示文摘 | Iozzo R V Eichstetter I Danielson K G | 1995 | Cancer Res1995，55，16： | 1 |
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