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5篇 您的检索式：作者名="Isabel Fofana"

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		题名	作者	年代	出处	被引量
	1	Neutralizing antibodies in hepatitis C virus infection显示文摘Hepatitis C virus (HCV) is a major cause of hepatitis world-wide. The majority of infected individuals develop chronic hepatitis which can then progress to liver cirrhosis and hepatocellular carcinoma. Spontaneous viral clearance occurs in about 20%-30% of acutely infected individuals and results in resolution of infection without sequaelae. Both viral and host factors appear to play an important role for resolution of acute infection. A large body of evidence suggests that a strong, multispecific and long-lasting cellular immune response appears to be important for control of viral infection in acute hepatitis C. Due too the lack of convenient neutralization assays, the impact of neutralizing responses for control of viral infection had been less defined. In recent years, the development of robust tissue culture model systems for HCV entry and infection has finally allowed study of antibody-mediated neutralization and to gain further insights into viral targets of host neutralizing responses. In addition, detailed analysis of antibody-mediated neutralization in individual patients as well as cohorts with well defined viral isolates has enabled the study of neutralizing responses in the course of HCV infection and characterization of the impact of neutralizing antibodiesfor control of viral infection. This review will summarize recent progress in the understanding of the molecular mechanisms of antibody-mediated neutralization and its impact for HCV pathogenesis.	Mirjam B Zeisel Samira Fafi-Kremer Isabel Fofana Heidi Barth Franoise Stoll-Keller Michel Doffo■l Thomas F Baumert	2007	World Journal of Gastroenterology2007，13，36：	3
	2	Hepatitis C virus entry into hepatocytes: Molecular mechanisms and targets for antiviral therapies显示文摘	Mirjam B. Zeisel Isabel Fofana Samira Fafi-Kremer Thomas F. Baumert	2010	Journal of Hepatology2010，，3：	1
	3	Exosome-mediated transmission of hepatitis C virus between human hepatoma Huh7.5 cells显示文摘	Vedashree Ramakrishnaiah Christine Thumann Isabel Fofana Francois Habersetzer Qiuwei Pan Petra E. de Ruiter Rob Willemsen Jeroen A. A. Demmers Victor Stalin Raj Guido Jenster Jaap Kwekkeboom Hugo W. Tilanus Bart L. Haagmans Thomas F. Baumert Luc J. W. van	2013	Proceedings of the National Academy of Sciences2013，，32：	1
	4	Hepatitis C virus entry into hepatocytes: Molecular mechanisms and targets for antiviral therapies显示文摘	Mirjam B. Zeisel Isabel Fofana Samira Fafi-Kremer Thomas F. Baumert	2010	Journal of Hepatology2010，，3：	1
	5	Host-targeting agents for prevention and treatment of chronic hepatitis C – Perspectives and challenges显示文摘	Mirjam B. Zeisel Joachim Lupberger Isabel Fofana Thomas F. Baumert	2012	Journal of Hepatology2012，，：	1

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