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| 1 | Intravenous immune globulin suppresses angiogenesis in mice and humans显示文摘Human intravenous immune globulin(IVIg),a purified IgG fraction composed of~60%IgG1 and obtained from the pooled plasma of thousands of donors,is clinically used for a wide range of diseases.The biological actions of IVIg are incompletely understood and have been attributed both to the polyclonal antibodies therein and also to their IgG(IgG)Fc regions.Recently,we demonstrated that multiple therapeutic human IgG1 antibodies suppress angiogenesis in a target-independent manner via FcγRI,a high-affinity receptor for IgG1.Here we show that IVIg possesses similar anti-angiogenic activity and inhibited blood vessel growth in five different mouse models of prevalent human diseases,namely,neovascular age-related macular degeneration,corneal neovascularization,colorectal cancer,fibrosarcoma and peripheral arterial ischemic disease.Angioinhibition was mediated by the Fc region of IVIg,required FcγRI and had similar potency in transgenic mice expressing human FcγRs.Finally,IVIg therapy administered to humans for the treatment of inflammatory or autoimmune diseases reduced kidney and muscle blood vessel densities.These data place IVIg,an agent approved by the US Food and Drug Administration,as a novel angioinhibitory drug in doses that are currently administered in the clinical setting.In addition,they raise the possibility of an unintended effect of IVIg on blood vessels. | Reo Yasuma Valeria Cicatiello Takeshi Mizutani Laura Tudisco Younghee Kim Valeria Tarallo Sasha Bogdanovich Yoshio Hirano Nagaraj Kerur Shengjian Li Tetsuhiro Yasuma Benjamin J Fowler Charles B Wright Ivana Apicella Adelaide Greco Arturo Brunetti Balamurali K Ambati Sevim Barbasso Helmers Ingrid E Lundberg Ondrej Viklicky Jeanette HW Leusen J Sjef Verbeek Bradley D Gelfand Ana Bastos-Carvalho Sandro De Falco Jayakrishna Ambati | 2016 | Signal Transduction and Targeted Therapy2016，1，1： | 3 |
| 2 | Giant thermoelectric power factor in charged ferroelectric domain walls of GeTe with Van Hove singularities显示文摘Increasing the Seebeck coefficient S in thermoelectric materials usually drastically decreases the electrical conductivity σ,making significant enhancement of the thermoelectric power factor σS^(2) extremelly challenging.Here we predict,using first-principles calculations,that the extraordinary properties of charged ferroelectric domain walls(DWs)in GeTe enable a five-fold increase ofσS^(2) in the DW plane compared to bulk.The key reasons for this enhancement are the confinement of free charge carriers at the DWs and Van Hove singularities in the DW electronic band structure near the Fermi level. | Ðorđe Dangić Stephen Fahy Ivana Savić | 2020 | npj Computational Materials2020，，1： | 1 |
| 3 | Relations between mercury fractions and microbial community components in seawater under the presence and absence of probable phosphorus limitation conditions显示文摘Microbial transformations of toxic monomethylmercury(MMHg) and dissolved gaseous mercury(DGM) at the lower levels of the marine food web are not well understood, especially in oligotrophic and phosphorus-limited seas. To examine the effects of probable phosphorus limitation(~PP-limitation) on relations between mercury(Hg) fractions and microorganisms, we determined the total mercury(THg), total methylated mercury(MeHg), DGM, and microbiological and chemical parameters in the Central Adriatic Sea. Using statistical analysis, we assessed the potential microbial effects on Hg transformations and bioaccumulation. Only in the absence of ~PP-limitation conditions(^(NO–P)P-limitation) is MeHg significantly related to most chemical and microbial parameters, indicating metabolism-dependent Hg transformations.The heterotrophic activity of low nucleic acid bacteria(abundant in oligotrophic regions)seems responsible for most of Hg methylation under ^(NO–P)P-limitation. Under these conditions,DGM is strongly related to microbial fractions and chlorophyll a, indicating biological DGM production, which is probably not metabolically induced, as most of these relations are also observed underPP-limitation. MMHg biomagnification was observed through an increased bioaccumulation factor from microseston to mesozooplankton. Our results indicate that Hgtransformations and uptake might be enhanced under ^(NO–P)P-limitation conditions, emphasizing their impact on the transfer of Hg to higher trophic levels. | Igor ?ivkovi? Vesna Fajon Jo?e Kotnik Yaroslav Shlyapnikov Kristina Obu Vazner Ermira Begu Stefanija ?estanovi? Danijela ?anti? Ana Vrdoljak Slaven Jozi? Mladen ?oli? Jelena Lu?i? Jere Ve?a Grozdan Ku?pili? Marin Ordulj Frano Mati? Branka Grbec Natalia Bojani? ?ivana Nin?evi? Gladan Milena Horvat | 2019 | Journal of Environmental Sciences2019，31，1： | 1 |
| 4 | Modified MCM-41 as a drug delivery system for acetylsalicylic acid显示文摘 | Eli?ka Vysko?ilová Ivana Lu?tická Iva Paterová Libu?e Machová Libor ?erveny | 2014 | Solid State Sciences2014，，： | 1 |
| 5 | Optimized HTS current leads显示文摘 | Andrew V Gavrilin Victor E Keilin IvanA konalev | 1999 | IEEE Transactions on Applied Superconductivity1999，9，20： | 1 |
| 6 | Simultaneous determination of cadmium,lead copper and mercury ions using organofunctionalized SBA-15 nanostructured silica modified graphite-polyurethane composite electrode显示文摘 | IVANA C CAVALHEIRO E TG BRETT C M A | | 0，，01： | 1 |
| 7 | Reinitiation of cell division and polyamine and aromatic monoamine levels in alfalfa explants during the induction of somatic embryogenesis显示文摘 | MILENA C PAVLA B VERA C MILENA C PAVLA B VERA C JOSEF E IVANA C M | 1999 | Physiologia Plantarum1999，105，： | 1 |
| 8 | Determination of free amino acids in cheeses from the Czech market显示文摘 | Ivana Kabelova Mark e ta Dvoca kova HanaC i zkov a | 2009 | Czech J Food Sei2009，27，3： | 1 |
| 9 | Preparation and crossing of basidiospore-derlved monokaryons-a useful tool for obtaining laccase and other liguinolytic enzyme higher-producing dikaryotie strains of Pleurotus ostreatus 显示文摘 | Ivana E Ladislav H | 1999 | Antonie van Leeuwenhoek1999，75，： | 1 |
| 10 | Surface modifications of biometallic commercially pure Ti and Ti–13Nb–13Zr alloy by picosecond Nd:YAG laser显示文摘The effects of picosecond Nd:YAG laser irradiation on chemical and morphological surface characteristics of the commercially pure titanium and Ti–13Nb–13Zr alloy in air and argon atmospheres were studied under different laser output energy values.During the interaction of laser irradiation with the investigated materials,a part of the energy was absorbed on the target surface,influencing surface modifications.Laser beam interaction with the target surface resulted in various morphological alterations,resulting in crater formation and the presence of microcracks and hydrodynamic structures.Moreover,different chemical changes were induced on the target materials’surfaces,resulting in the titanium oxide formation in the irradiation-affected area and consequently increasing the irradiation energy absorption.Given the high energy absorption at the site of interaction,the dimensions of the surface damaged area increased.Consequently,surface roughness increased.The appearance of surface oxides also led to the increased material hardness in the surface-modified area.Observed chemical and morphological changes were pronounced after laser irradiation of the Ti–13Nb–13Zr alloy surface. | Slađana Laketić Marko Rakin MilošMomčilović Jovan Ciganović Đorđe Veljović Ivana Cvijović-Alagić | 2021 | International Journal of Minerals,Metallurgy and Materials2021，28，2： | 0 |
| 11 | The origin of the lattice thermal conductivity enhancement at the ferroelectric phase transition in GeTe显示文摘The proximity to structural phase transitions in IV-VI thermoelectric materials is one of the main reasons for their large phonon anharmonicity and intrinsically low lattice thermal conductivityκ.However,theκof GeTe increases at the ferroelectric phase transition near 700 K.Using first-principles calculations with the temperature dependent effective potential method,we show that this rise inκis the consequence of negative thermal expansion in the rhombohedral phase and increase in the phonon lifetimes in the high-symmetry phase.Strong anharmonicity near the phase transition induces non-Lorentzian shapes of the phonon power spectra.To account for these effects,we implement a method of calculatingκbased on the Green-Kubo approach and find that the Boltzmann transport equation underestimatesκnear the phase transition.Our findings elucidate the influence of structural phase transitions onκand provide guidance for design of better thermoelectric materials. | Đorđe Dangić Olle Hellman Stephen Fahy Ivana Savić | 2021 | npj Computational Materials2021，，1： | 0 |
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