|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Cloud computing and emerging IT platforms: Vision, hype, and reality for delivering computing as the 5th utility显示文摘 | Rajkumar Buyya Chee Shin Yeo Srikumar Venugopal James Broberg Ivona Brandic | 2008 | Future Generation Computer Systems2008，，6： | 5 |
| 2 | RANKL/RANK control Brca1 mutation-driven mammary tumors显示文摘 | Verena Sig Kwadwo Owusu-Boaitey Puma A Joshi Anoop Kavirayani Gerald Wimsberger Maria Novatchkova Ivona Kozieradzki Daniel Schramek Nnamdi Edokobi Jerome Hersl Aishia Sampson Ashley Odai-Afotey Conxi Lazaro Eva Gonzalez-Suarez Miguel A Pujaaa for CIMBA Holger Heyn Enrique Vidal Jennifer Cru. ickshank Hal Berman Renu Sarao Melita Tieevic Iris Uribesalgo Luigi Tortola Shuan Rao Yen Tan Georg Pfeiler Eva YHP Lee Zsuzsanna Bago-Horvath Lukas Kenner Helmuth Popper Christian Singer Rama Khokha LaundeRe P Jones Josef M Penninger | 2016 | Cell Research2016，26，7： | 3 |
| 3 | AIF-regulated oxidative phosphorylation supports lung cancer development显示文摘Cancer is a major and still increasing cause of death in humans. Most cancer cells have a fundamentally different metabolic profile from that of normal tissue. This shift away from mitochondrial ATP synthesis via oxidative phosphorylation towards a high rate of glycolysis, termed Warburg effect, has long been recognized as a paradigmatic hallmark of cancer, supporting the increased biosynthetic demands of tumor cells. Here we show that deletion of apoptosis-inducing factor (AIF) in a Kras^G12D-driven mouse lung cancer model resulted in a marked survival advantage, with delayed tumor onset and decreased malignant progression. Mechanistically, Aif deletion leads to oxidative phosphorylation (OXPHOS) deficiency and a switch in cellular metabolism towards glycolysis in non-transformed pneumocytes and at early stages of tumor development. Paradoxically, although Aif-deficient cells exhibited a metabolic Warburg profile, this bioenergetic change resulted in a growth disadvantage of Kras^G12D-driven as well as Kras wild-type lung cancer cells. Cell-autonomous re-expression of both wild-type and mutant AIF (displaying an intact mitochondrial, but abrogated apoptotic function) in Aif-knockout Kras^G12D mice restored OXPHOS and reduced animal survival to the same level as AIF wild-type mice. In patients with non-small cell lung cancer, high AIF expression was associated with poor prognosis. These data show that AIF-regulated mitochondrial respiration and OXPHOS drive the progression of lung cancer. | Shuan Rao Laura Mondragon Blanka Pranjic Toshikatsu Hanada Gautier Stoll Thomas Kocher Peng Zhang Alexander Jais Alexander Lercher Andreas Bergthaler Daniel Schramek Katharina Haigh Valentina Sica Marion Leduc Nazanine Modjtahedi Tsung-Pin Pai Masahiro Onji Iris Uribesalgo Reiko Hanada Ivona Kozieradzki Rubina Koglgruber Shane J. Cronin Zhigang She Franz Quehenberger Helmut Popper Lukas Kenner Jody J. Haigh Oliver Kepp Malgorzata Rak Kaican Cai Guido Kroemer Josef M. Penninger | 2019 | Cell Research2019，29，7： | 2 |
| 4 | Cloud computing and emerging IT platforms: Vision, hype, and reality for delivering computing as the 5th utility显示文摘 | Rajkumar Buyya Chee Shin Yeo Srikumar Venugopal James Broberg Ivona Brandic | 2008 | Future Generation Computer Systems2008，，6： | 2 |
| 5 | Early microbial translocation blockade reduces SIV-mediated inflammation and viral replication显示文摘 | Kristoff Jan Haret-Richter George Ma Dongzhu Ribeiro Ruy M Xu Cuiling Cornell Elaine Stock Jennifer L He Tianyu Mobley Adam D Ross Samantha Trichel Anita Wilson Cara Tracy Russell Landay Alan Apetrei Cristian Pandrea Ivona | 2014 | Journal of Clinical Investigation2014，，： | 1 |
| 6 | Cloud computing and emerging IT platforms: Vision, hype, and reality for delivering computing as the 5th utility显示文摘 | Rajkumar Buyya Chee Shin Yeo Srikumar Venugopal James Broberg Ivona Brandic | 2008 | Future Generation Computer Systems2008，，6： | 1 |
| 7 | Delivery of peptide and protein drugs over the blood-brain barrier显示文摘 | Brasnjevic Ivona Steinbusch Harry W M Schmitz Christoph | 2009 | Progress in Neurobiology2009，87，4： | 1 |
| 8 | Changes in speed and strength in female volleyball players during and after a plyometric training program显示文摘 | MICHAL L IVONA L MILAN E | | 0，，01： | 1 |
| 9 | Low-molecular-weight tumor necrosis factor receptor P55 controls induction of autoimmune heart disease显示文摘 | Kurt B Christian P Ivona K | 1997 | Ciculation1997，95，： | 1 |
| 10 | Expression of Extracellular Calcium (Ca 2+ o )-Sensing Receptor in Human Peripheral Blood Monocytes显示文摘 | Toru Yamaguchi Ivona Olozak Naibedya Chattopadhyay Robert R. Butters Olga Kifor David T. Scadden Edward M. Brown | 1998 | Biochemical and Biophysical Research Communications1998，，2： | 1 |
| 11 | Adsorption of Pb^2+ Cd^2+ Sr^2+ ions onto natural and acid-activated sepiolites显示文摘 | Slavica L Ivona J Dusan J | 2007 | Appl Clay Sci2007，37，1： | 1 |
| 12 | Transformation of petroleum saturated hydrocarbons during soil bioremediation experiments显示文摘 | Branimir Jovancicevic Malisa Antic Ivona Pavlovi(c) | 2008 | Water Air Soil Pollut2008，190，1： | 1 |
| 13 | Low-molecular-weigh tumor necrosis factor receptor Controls induction of autoimmune heart disease 显示文摘 | Kurt B Christian P Ivona K | 1997 | Ciculation1997，95，： | 1 |
| 14 | Depression and anxiety in patients on chronic Hemodialysis in University Clinical Hospital Mostar显示文摘 | Miro Ivona Boo | 2009 | M Klari2009，33，2： | 1 |
| 15 | Adsorption of Pb2+,Cd2+ and Sr2+ ions onto natural and acid-activated sepiolites显示文摘 | Slavica L Ivona J Dusan J | 2007 | Applied Clay Science2007，37，1： | 1 |
| 16 | Adsorption of Pb^2+, Cd^2+ and Sr^2+ ions onto natural and acid-activated sepiolites显示文摘 | Slavica Lazarevic Ivona Jankovic-Castvan Dusan Jovanovic | 2007 | Applied Clay Science2007，37，12： | 1 |
| 17 | Performance and cost analysis of the Supernova factory on the Amazon AWS cloud显示文摘 | Ivona Brandic Ioan Raicu Keith R. Jackson Krishna Muriki Lavanya Ramakrishnan Karl J. Runge Rollin C. Thomas | 2011 | Scientific Programming (-)2011，，2： | 1 |
| 18 | Adsorption of Pb2+,Cd2+,and Sr2+ions onto natural and acid-activated sepiolites显示文摘 | SLAVICA L IVONA J C J | 2007 | Applied Clay Science2007，37，： | 1 |
| 19 | Delivery of peptide and protein drugs over the blood brain barrier 显示文摘 | Ivona B Harry WMS Christoph S | 2009 | Prog Neurobiol2009，87，： | 1 |
| 20 | QoS support for time-critical grid workflow applications显示文摘 | Siegfried Benker | 2005 | Proceedings of the First International Conference on e-Science and Grid Computing2005，，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员