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| 1 | 尿钠排泄、血压、心血管病与死亡率的关系:社区前瞻性流行病学队列研究显示文摘WHO建议人群钠摄人<2 g/d作为预防心血管病的措施之一,但这一目标在任何国家都没有实现。该建议主要基于短期血压试验的个体水平数据,没有来自随机试验或观察性研究的关于低钠摄入与降低心血管事件的数据。前瞻性城市农村流行病学研究目前正在21个国家进行。该文对其中18个国家的数据进行分析,其中包含了临床结果数据。 | Mente A O'Donnell M Rangarajan S McQueen M Dagenais G Wielgosz A Lear S Ah STL Wei L Diaz R Avezum A Lopez-Jaramillo P Lanas F Mony P Szuba A Iqbal R Yusuf R Mohammadifard N Khatib R Yusoff K Ismail N Gulec S Rosengren A Yusufali A Kruger L Tsolekile LP Chifamba J Dans A Alhabib KF Yeates K Teo K Yusuf S 刘莉 叶鹏 | 2018 | 中华高血压杂志2018，26，12： | 29 |
| 2 | Small incision lenticule extraction (SMILE) history, fundamentals of a new refractive surgery technique and clinical outcomes显示文摘This review summarizes the current status of the small incision lenticule extraction(SMILE)procedure.Following the early work by Sekundo et al.and Shah et al.,SMILE has become increasingly popular.The accuracy of the creation of the lenticule with the VisuMax femtosecond laser(Carl Zeiss Meditec)has been verified using very high-frequency(VHF)digital ultrasound and optical coherence tomography(OCT).Visual and refractive outcomes have been shown to be similar to those achieved with laser in situ keratomileusis(LASIK),notably in a large population reported by Hjortdal,Vestergaard et al.Safety in terms of the change in corrected distance visual acuity(CDVA)has also been shown to be similar to LASIK.It was expected that there would be less postoperative dry eye after SMILE compared to LASIK because the anterior stroma is disturbed only by the small incision,meaning that the anterior corneal nerves should be less affected.A number of studies have demonstrated a lower reduction and faster recovery of corneal sensation after SMILE than LASIK.Some studies have also used confocal microscopy to demonstrate a lower decrease in subbasal nerve fiber density after SMILE than LASIK.The potential biomechanical advantages of SMILE have been modeled by Reinstein et al.based on the non-linearity of tensile strength through the stroma.Studies have reported a similar change in Ocular Response Analyzer(Reichert)parameters after SMILE and LASIK,however,these have previously been shown to be unreliable as a representation of corneal biomechanics.Retreatment options after SMILE are discussed.Tissue addition applications of the SMILE procedure are also discussed including the potential for cryo-preservation of the lenticule for later reimplantation(Mohamed-Noriega,Angunawela,Lim et al.),and a new procedure referred to as endokeratophakia in which a myopic SMILE lenticule is implanted into a hyperopic patient(Pradhan et al.).Finally,studies reporting microdistortions in Bowman’s layer and corneal wound healing responses are also described. | Dan Z Reinstein Timothy J Archer Marine Gobbe | 2014 | Eye and Vision2014，1，1： | 12 |
| 3 | Recent advances in the diagnostic evaluation of pancreatic cystic lesions显示文摘Pancreatic cystic lesions(PCLs)are becoming more prevalent due to more frequent abdominal imaging and the increasing age of the general population.It has become crucial to identify these PCLs and subsequently risk stratify them to guide management.Given the high morbidity associated with pancreatic surgery,only those PCLs at high risk for malignancy should undergo such treatment.However,current diagnostic testing is suboptimal at accurately diagnosing and risk stratifying PCLs.Therefore,research has focused on developing new techniques for differentiating mucinous from non-mucinous PCLs and identifying high risk lesions for malignancy.Cross sectional imaging radiomics can potentially improve the predictive accuracy of primary risk stratification of PCLs at the time of detection to guide invasive testing.While cyst fluid glucose has reemerged as a potential biomarker,cyst fluid molecular markers have improved accuracy for identifying specific types of PCLs.Endoscopic ultrasound guided approaches such as confocal laser endomicroscopy and through the needle microforceps biopsy have shown a good correlation with histopathological findings and are evolving techniques for identifying and risk stratifying PCLs.While most of these recent diagnostics are only practiced at selective tertiary care centers,they hold a promise that management of PCLs will only get better in the future. | Devarshi R Ardeshna Troy Cao Brandon Rodgers Chidiebere Onongaya Dan Jones Wei Chen Eugene J Koay Somashekar G Krishna | 2022 | World Journal of Gastroenterology2022，28，6： | 3 |
| 4 | Prolonged feeding with guanidinoacetate, a methyl group consumer, exacerbates ethanol-induced liver injury显示文摘AIM To investigate the hypothesis that exposure to guanidinoacetate(GAA, a potent methyl-group consumer) either alone or combined with ethanol intake for a prolonged period of time would cause more advanced liver pathology thus identifying methylation defects as the initiator and stimulator for progressive liver damage.METHODS Adult male Wistar rats were fed the control or ethanolLieber De Carli diet in the absence or presence of GAA supplementation. At the end of 6 wk of the feeding regimen, various biochemical and histological analyses were conducted. RESULTS Contrary to our expectations, we observed that GAA treatment alone resulted in a histologically normal liver without evidence of hepatosteatosis despite persistence of some abnormal biochemical parameters. This protection could result from the generation of creatine from the ingested GAA. Ethanol treatment for 6 wk exhibited changes in liver methionine metabolism and persistence of histological and biochemical defects as reported before. Further, when the rats were fed the GAA-supplemented ethanol diet, similar histological and biochemical changes as observed after 2 wk of combined treatment, including inflammation, macroand micro-vesicular steatosis and a marked decrease in the methylation index were noted. In addition, rats on the combined treatment exhibited increased liver toxicity and even early fibrotic changes in a subset of animals in this group. The worsening liver pathology could be related to the profound reduction in the hepatic methylation index, an increased accumulation of GAA and the inability of creatine generated to exert its hepato-protective effects in the setting of ethanol.CONCLUSION To conclude, prolonged exposure to a methyl consumer superimposed on chronic ethanol consumption causes persistent and pronounced liver damage. | Natalia A Osna Dan Feng Murali Ganesan Priya F Maillacheruvu David J Orlicky Samuel W French Dean J Tuma Kusum K Kharbanda | 2016 | World Journal of Gastroenterology2016，22，38： | 2 |
| 5 | DNA vaccination of infants in the presence of maternal antibody: a measles model in the primate显示文摘 | Mary Premenko-Lanier Paul A Rota Gary Rhodes David Verhoeven Dan H Barouch Nicholas W Lerche Norman L Letvin William J Bellini Michael B McChesney | 2003 | Virology2003，，1： | 2 |
| 6 | Using breath tests wisely in a gastroenterology practice: an evidence-based review of indications and pitfalls in interpretation显示文摘 | Joseph Romagnuolo Dan Schiller Robert J Bailey | 2002 | The American Journal of Gastroenterology2002，，5： | 2 |
| 7 | Cell polarity protein Par3 complexes with DNA-PK via Ku70 and regulates DNA double-strand break repair显示文摘分区有缺陷者 3 (Par3 ) ,在 conservedPar3/Par6/aPKC 建筑群的一个关键部件,在房间极性的戏基础角色。此处,我们报导 Ku70 和通过试管内绑定试金的蛋白质由液体层析双人脚踏车质谱法跟随了的 Ku80 同样新奇的交往 Par3 的鉴定。Ku70/Ku80 蛋白质是 DNA 依赖的蛋白激酶(DNA-PK ) 的二个关键规章的子单元,它在修理双海滨脱氧核糖核酸裂缝(DSB ) 起一个必要作用。我们决定 Par3 withKu70/Ku80 的原子协会被 y 照耀(红外) 提高,有势力 DSB inducer。而且, DNA-PKcs, DNA-PK 的催化子单元,响应红外与 Par3/Ku70/Ku80 建筑群交往了。Par3over 表示或击倒分别地能够 up- 或 downregulat-ing DNA-PK 活动。而且, Par3 击倒的房间被发现在随机的原生质标志集成有缺点,在 DSB 修理追随者红外有缺点、对射线敏感,类似于 Ku70knockdown 房间的显型。这些调查结果作为 DNA-PK 建筑群的一个新奇部件识别 Par3 并且含有到 DSB 修理的房间极性的一个意外连接。 | Longhou Fang YiGuo Wang Dan Du Guang Yang Tim Tak Kwok Siu Kai Kong Benjamin Chen David J Chen Zhengjun Chen | 2007 | Cell Research2007，17，2： | 2 |
| 8 | Nitrogen managemen strategies to nitrate leaching in tile-drained Mid- western soils 显示文摘 | Dana L D Douglas L K Dan B J | 2002 | Agronomy Journal2002，94，： | 1 |
| 9 | Effect of clay on the morphology and properties of PMMA/poly(styrene-co-acrylonitrile)/ day nanocomposites prepared by melt mixing显示文摘 | Lee M H Dan C H Kim J H | 2006 | Polymer2006，47，12： | 1 |
| 10 | Association of ambulatory arterial stiff- ness index and brachial pulse pressure is restricted to dippers显示文摘 | Baumann M Dan L Nurnberger J | 2008 | J Hyper- tens2008，26，2： | 1 |
| 11 | Peer review organizations: Promises and potential pitfalls显示文摘 | Dans P Weiner J Otter S | 1985 | N Engl J Med1985，313，： | 1 |
| 12 | Steady state pharmacokinetics of diltiazem and hydrochlorothiazide administered alone and in combination显示文摘 | Scott J Dan CD Robert CL | 1998 | Biopharm Drug Dispos1998，19，： | 1 |
| 13 | phosphorus speciation and sorption- desorption characteristics in heavily manured soils 显示文摘 | Dan Z X Ramberg C F Toth J D | 2009 | Soil Science Society of America2009，73，： | 1 |
| 14 | The role of albumin as a resuscitation fluid for patients with sepsis:a systematic review and meta-analysis显示文摘 | Delaney AP Dan A McCaffrey J | | 0，，02： | 1 |
| 15 | Clinical application of massively parallel sequencing-based prenatal noninvasive fetal trisomy test for trisomies 21 and 18 in 11, 105 pregnancies with mixed risk factors显示文摘 | Dan S Wang W Ren J | 2012 | Prenat Diagn2012，32，13： | 1 |
| 16 | Clinical application of massively parallel sequencing-based prenatal noninvasive fetal trisomy test for trisomies 21 and 18 in 11 105 pregnancies with mixed risk factors显示文摘 | Dan S Wang W Ren J H | 2012 | Prenatal Diagnosis2012，32，13： | 1 |
| 17 | Clinical application of massively parallel sequencing-based prenatal noninvasive fetal trisomy test for trisomies 21 and 18 in 11,105 pregnancies with mixed risk factors显示文摘 | Dan S Wang W Ren J | 2012 | Prenat Diagn2012，32，13： | 1 |
| 18 | Determination of Chemical Oxygen Demand in Fresh Waters Using Flow Injection With On-line UV-photocatalytic Oxidation and Spectrophotometric Detection显示文摘 | DAN De-zhong SANDFORD R C WORSFOLD P J | 2005 | The Analyst2005，130，2： | 1 |
| 19 | Characterization of petro physical flow units in carbonate reservoirs显示文摘 | Alden J M Stephen T S Dan J H | 1997 | AAPG Bulletin1997，81，5： | 1 |
| 20 | Green processing using ionic liquids and CO2 显示文摘 | Blanchard L A Hancu Dan Beckman E J | | Nature0，399，： | 1 |
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