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| 1 | The woodchuck as an animal model for pathogenesis and therapy of chronic hepatitis B virus infection显示文摘This review describes the woodchuck and the woodchuck hepatitis virus (WHV) as an animal model for pathogenesis and therapy of chronic hepatitis B virus (HBV) infection and disease in humans. The establishment of woodchuck breeding colonies, and use of laboratory-reared woodchucks infected with defined WHV inocula, have enhanced our understanding of the virology and immunology of HBV infection and disease pathogenesis, including major sequelae like chronic hepatitis and hepatocellular carcinoma. The role of persistent WHV infection and of viral load on the natural history of infection and disease progression has been firmly established along the way. More recently, the model has shed new light on the role of host immune responses in these natural processes, and on how the immune system of the chronic carrier can be manipulated therapeutically to reduce or delay serious disease sequelae through induction of the recovery phenotype. The woodchuck is an outbred species and is not well defined immunologically due to a limitation of available host markers. However, the recent development of several key host response assays for woodchucks provides experimental opportunities for further mechanistic studies of outcome predictors in neonatal- and adult-acquired infections. Understanding the virological and immunological mechanisms responsible for resolution of self-limited infection, andfor the onset and maintenance of chronic infection, will greatly facilitate the development of successful strategies for the therapeutic eradication of established chronic HBV infection. Likewise, the results of drug efficacy and toxicity studies in the chronic carrier woodchucks are predictive for responses of patients chronically infected with HBV. Therefore, chronic WHV carrier woodchucks provide a well-characterized mammalian model for preclinical evaluation of the safety and efficacy of drug candidates, experimental therapeutic vaccines, and immunomodulators for the treatment and prevention of HBV disease sequelae. | Stephan Menne Paul J Cote | 2007 | World Journal of Gastroenterology2007，13，1： | 22 |
| 2 | Hypersensitivity to local anaesthetics-update and proposal of evaluation algorithm显示文摘 | Thyssen JP Menn'e T Elberling J | 2008 | Contact Dermatitis2008，59，2： | 1 |
| 3 | Insulin resistance and renal disease 显示文摘 | Fliser D Kielstein JT Menne J | 2006 | Contrib Nephrol2006，151，： | 1 |
| 4 | Targeting the protein kinase C family in the diabetic kidney:lessons from analysis of mutant mice显示文摘 | Meier M Menne J Hailer H | 2009 | Diabeto- logia2009，52，5： | 1 |
| 5 | Dual inhibition of classical protein kinase C-α and protein kinase C-β isoforms protects against experimental murine diabetic nephropathy 显示文摘 | Menne J Shushakova N Bartels J | 2013 | Diabetes2013，62，4： | 1 |
| 6 | Human fetal hemoglobin expression is regulated by the developmental stage-specific re- pressor BCL1 IA显示文摘 | SANKARAN V G MENNE T F XU J | 2008 | Science2008，322，5909： | 1 |
| 7 | Awareness and behaviour of European physicians in relation to microalbuminuria and organ damage:an ESH-endorsed survey显示文摘 | Haller H Menne J Mancia G | 2010 | J Hypertens2010，28，11： | 1 |
| 8 | Deletion of protein ki- nase C-epsilon signaling pathway induces glomerulosclerosis and tubular interstitial fibrosis in vivo 显示文摘 | MEIER M MENNE J PARK J | 2007 | J Am Soc Nephrol2007，18，4： | 1 |
| 9 | Targeting the protein ki- nase C family in the diabetic kidney: lessons from analysis of mutant mice显示文摘 | MEIER M MENNE J HALLER H | 2009 | Diabetologia2009，52，5： | 1 |
| 10 | Insulin resistance and renal disease显示文摘 | Fliser D Kielstein JT Menne J | 2006 | Contrib Nephrol2006，151，： | 1 |
| 11 | Glucose-induced TGF-betal and TGF-beta receptor-I expression in vascular smooth muscle cells is mediated by protein kinase C-alpha 显示文摘 | Lindschau C Quass P Menne J | 2003 | Hypertension2003，42，3： | 1 |
| 12 | Interferon-gamma- associated responses to woodchuck hepatitis virus infection in neonatal woodchucks and virus-infected hepatocytes 显示文摘 | Wang Y Jacob J R Menne S | 2004 | J Viral Hepat2004，11，5： | 1 |
| 13 | Update on the ROADMAP clinical trial report:olmesartan for the prevention or delay of microalbuminuria development in type 2 diabetes显示文摘 | Chatzikyrkou C Menne J | 2012 | Expert Rev Cardiovasc Ther2012，10，9： | 1 |
| 14 | College studcot satisfaction in 10 public and private colleges and universities 显示文摘 | BETZ E L STARR A M MENNE J W | 1972 | Journal of Col- legeStudecnt Personnel1972，13，5： | 1 |
| 15 | Evaporation changes over the contiguous United States and the former USSR: A reassessment 显示文摘 | Menne M J Peterson T C Malone R W | 2001 | Geophysical Research Letters2001，28，： | 1 |
| 16 | Differences in college student satisfaction- academic dropouts, nonacademnic dropouts, and non- dropouts 显示文摘 | STARR A BETZ E L MENNE J | 1972 | Journal of Counseling Psychology1972，19，4： | 1 |
| 17 | Aerobic degradation of 1,1, 1-trichloro-2, 2-bis ( 4-chlorophenyl ) ethane ( DDT ) by alcaligenes eutrophus A5 显示文摘 | Nadeau L J Menn F M Breen A | 1994 | Applied and Environmental Microbiology1994，60，： | 1 |
| 18 | Targeting the protein kinase C family in the diabetic kidney: lessons from analysis of mutant mice 显示文摘 | M Meier J Menne H Haller | 2009 | Diabetologia2009，52，5： | 1 |
| 19 | Hypersensitivity to local anaesthetics-update and proposal of evaluation algo-rithm显示文摘 | Thyssen JP Menné T Elberling J | | 0，，02： | 1 |
| 20 | Postischemic acute renal failure is reduced by short-term statin treatment in a rat model显示文摘 | Fong S Prak JK Fiebeler A Menne J Elger M | 2002 | JAM Soc Nephrol2002，13，9： | 1 |
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