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| 1 | Two decades of variable retention in British Columbia: a review of its implementation and effectiveness for biodiversity conservation显示文摘Stand-level retention is an important component of sustainable forest management which aims to balance ecological,social and economic objectives.Long-term retention of mature forest structures at the time of harvesting(variable retention)is intended to produce future forest stands that more closely resemble conditions that develop after natural disturbances,thereby maintaining greater diversity of habitats for a variety of organisms.Structure includes features such as live and dead trees representing multiple canopy layers,undisturbed understory vegetation and coarse woody debris.Over the past two decades,variable retention has become common on forest lands in the temperate rainforests of coastal British Columbia(BC)and has been applied to a lesser extent in inland forest types.Our review of studies in BC and in similar forest types in our region indicates that both aggregated and dispersed retention can contribute to biodiversity conservation by providing short-term‘life-boating’habitat for some species and by enhancing the structural characteristics of future stands.For example,greater abundance of species present in the pre-harvest forest have been documented for vegetation,birds,carabid beetles,gastropods,ectomycorrhizal fungi and soil fauna in retention cutblocks compared to clearcuts.There are,however,some negative consequences for timber production such as wind damage to retained trees and reduced growth rates of tree regeneration compared to clearcuts.The authors suggest an adaptive management approach for balancing competing objectives when faced with uncertainty.This includes monitoring the implementation and effectiveness of various strategies for achieving goals.Over two decades of experience applying variable retention harvesting to industrial-scale management of forest lands in BC suggests that it is possible to balance production of wood with biodiversity conservation. | William J.Beese John Deal B.Glen Dunsworth Stephen J.Mitchell Timothy J.Philpott | 2019 | Ecological Processes2019，8，1： | 5 |
| 2 | 中国中北部的土地沙漠化及其改良治理显示文摘土地沙漠化是中国中北部的一个严重的环境问题。沙漠的发展是由于环境和土地管理因素的复杂的相互作用。据估计,沙漠目前正以每年1560km^2的速度扩展,其原因主要是人类活动。治理沙漠化的工作正在进行,这是由中国科学院沙漠研究所(IDRAS)组织协调的,土地改良技术以阻止沙漠发展和将沙漠化土地重新转变成生产用地为目标。这些技术包括建立防护林、用含有淤泥的河水灌溉、用草格子沙障和种植旱生植物固定沙丘、围沙造地、利用埋藏的古土壤以及化学处理等。在宁夏回族自治区沙坡头和盐池野外治沙站所进行的观察表明,治沙工作必须认真地、不懈地坚持6年以上,所治理的土地才会有明显的改良。如果工作不间断,那么土壤的物理、化学和生物性状就会得到比较快的改善。虽然治沙工作在技术上是可行的,但确实花费相当多的时间和相当大的代价。一个综合规划的治沙方案看起来是中国中北部最大希望之所在。 | Michael A.Fullen David J.Mitchell 杨柳春 | 1994 | 人类环境杂志1994，23，2： | 2 |
| 3 | Doxorubicin-conjugated siRNA lipid nanoparticles for combination cancer therapy显示文摘Evasion of apoptosis is a hallmark of cancer,attributed in part to overexpression of the antiapoptotic protein B-cell lymphoma 2(Bcl-2).In a variety of cancer types,including lymphoma,Bcl-2 is overexpressed.Therapeutic targeting of Bcl-2 has demonstrated efficacy in the clinic and is the subject of extensive clinical testing in combination with chemotherapy.Therefore,the development of co-delivery systems for Bcl-2 targeting agents,such as small interfering RNA(siRNA),and chemotherapeutics,such as doxorubicin(DOX),holds promise for enabling combination cancer therapies.Lipid nanoparticles(LNPs)are a clinically advanced nucleic acid delivery system with a compact structure suitable for siRNA encapsulation and delivery.Inspired by ongoing clinical trials of albumin-hitchhiking doxorubicin prodrugs,here we developed a DOX-siRNA co-delivery strategy via conjugation of doxorubicin to the surface of siRNAloaded LNPs.Our optimized LNPs enabled potent knockdown of Bcl-2 and efficient delivery of DOX into the nucleus of Burkitts'lymphoma(Raji)cells,leading to effective inhibition of tumor growth in a mouse model of lymphoma.Based on these results,our LNPs may provide a platform for the co-delivery of various nucleic acids and DOX for the development of new combination cancer therapies. | Kamila Butowska Xuexiang Han Ningqiang Gong Rakan El-Mayta Rebecca MHaley Lulu Xue Wenqun Zhong Wei Guo Karin Wang Michael J.Mitchell | 2023 | Acta Pharmaceutica Sinica B2023，13，4： | 1 |
| 4 | The influence of cognitive impairment on health‐related quality of life in neurological disease显示文摘 | Alex J.Mitchell StevenKemp JuliánBenito‐León MarkusReuber | 2010 | Acta Neuropsychiatrica2010，，1： | 1 |
| 5 | The Global Flat Tax Revolution:Lessons for Policy Makers显示文摘 | Daniel J.Mitchell | 2008 | 2008，，： | 1 |
| 6 | The mere acceptance eVect:Can it influence responses on racial Implicit Association Tests显示文摘 | Michael J.Sargent Todd A.Kahan Chris J.Mitchell | | 0，，： | 1 |
| 7 | Total Synthesis of Vancomycin显示文摘 | K. C.Nicolaou Helen J.Mitchell Nareshkumar F.Jain NicolasWinssinger RobertHughes ToshikazuBando | 2004 | 2004 (1‐2)2004，，1： | 1 |
| 8 | Acceptability of common screening methods used to detect distress and related mood disorders—preferences of cancer specialists and non‐specialists显示文摘 | Alex J.Mitchell StephenKaar ChrisCoggan JoanneHerdman | 2008 | Psycho‐Oncology2008，，： | 1 |
| 9 | 中国云南省的土壤侵蚀与保护显示文摘本文讨论了长江上游水源区云南境内土壤侵蚀的范围、程度和保持状况。长江发源于中国西部的青藏高原,横贯大陆西东,全长6380km,其源头位于地壳活动和地质不稳定的高原区,流域区是以水稻生产为主的、土地利用程度较高的农业主产区,所以,土壤侵蚀极其严重;随着三峡大坝的修建,土壤侵蚀产生泥沙淤积将降低水库的使用效率等问题,致使土壤保持成为该区必不可少的措施之一,土壤侵蚀问题正越来越受到关注。文章回顾了云南省的土壤保持工作,并以东川、寻甸为例,阐明了云南省的区域土壤保持措施。在云南农业大学农场正在进行的径流区实验被用于评估不同土壤保持措施的效果。试验选择种植当地的主要作物玉米(Zea mays),采取传统的栽培方法,在三个不同的坡度上,沿等高线种植和顺坡向下垂直种植等处理进行,试验地条件与生产上的坡耕地一致。1993~1996年的研究结果表明:一般情况下,沿等高线种植的地区,土壤侵蚀率较低,采取这种措施,平均侵蚀率为顺坡向种植的0.69;秸秆覆盖和沿等高线种植是比较有效的土壤保持措施。 | Micheal A.Fullen David J.Mitchell Andrew P.Barton Trevor J.Hocking 刘立光 吴伯志 郑毅 夏振远 | 1999 | 人类环境杂志1999，28，2： | 0 |
| 10 | 提高连续采煤机液压系统维修水平的故障诊断专家系统显示文摘在采矿工业中,产量减少和生产成本的增加大部分是由机器故障和维修耽搁造成的。美国矿业局正在开发将专家系统应用于采矿设备的故障诊断和预测维修技术,通过减少机器故障频率和维修时间而增加产量,减少生产成本。本文着重讨论美国矿业局在将专家系统技术应用于连续采煤机的液压系统故障诊断方面所作的工作。 | J.Mitchell 朱春林 张瑞鹤 | 1992 | 矿业译丛1992，，2： | 0 |
| 11 | 频繁着火的新热带松林上层林冠结构、实生苗成长特性与火之间的相互作用显示文摘加勒比海汇流区依赖于火的松林涵盖了广阔的区域,包括加勒比海和墨西哥湾的沿海平原,以及部分巴哈马群岛、古巴、伊斯帕尼奥拉岛(即海地岛)与洪都拉斯湾的一些岛屿。这些森林具有很高的保存价值,遗憾的是大部分仍未得到保护。此外,即使森林是依赖于火的,利用火进行森林管理也常常不被公众所理解,在一些国家还是法律所禁止的。在本文中,我们描述了这些生态系统中火灾与森林再生和森林持久性之间的根本联系。基于松树实生苗能否适应火灾而生存,我们确定了两个总体策略,并描述了这两个策略的管理意义。我们还提出了描述火、森林结构与再生间策略之间关系的概念模型。 | Joseph J.O'Brien J.Kevin Hiers Mac A.Callaham Robert J.Mitchell Steve B.Jack 高孟绪 | 2008 | AMBIO-人类环境杂志2008，37，7： | 0 |
| 12 | How Can Commodity Quality Be Ensured and Relevant Disputes Be Settled?显示文摘China,the big factory offering various commodities to companies and individuals all over the world,is attracting more and more merchants purchasing goods in various ways,through agents,on site,via modern communication,etc.One essential concern of these merchants is the quality of these commodities.How can the commodity quality be ensured?If there are | J.MITCHELL | 2016 | China's Foreign Trade2016，，4： | 0 |
| 13 | Evolving Values and How They Have Shaped the United States National Park System显示文摘As one of the oldest and best-known park systems,the US National Park System continues to influence park systems around the world.However,the origins and wide diversity of US national parks are often not fully understood as there is a long-lived misconception that the large western parks represent the entirety of the US National Park System.In fact,the establishment of the first US national parks was heavily influenced by large 19th-century picturesque urban parks that provided benefits to the public and society.The foundational concept of national parks serving a public purpose has never changed,however,the types of landscapes selected as national parks have changed as societal values have evolved and now the system provides public benefits beyond those originally envisioned.This paper examines the development of the US National Park System,emphasising the evolution of landscape values.The emergence of the cultural landscape concept illustrates the evolution of landscape values from their early antecedents in the late 19th century to their contributions to innovative conservation strategies today.Throughout the development of the US National Park System,international exchange has and continues to play a pivotal role,advancing the inter-linkages of culture and nature for the most effective conservation. | Cari Goetcheus Nora J.Mitchell Brenda Barrett | 2018 | Built Heritage2018，2，3： | 0 |
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