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| 1 | Effect of Storage Temperature on Vitamin C, Total Phenolics,UPLC Phenolic Acid Profile and Antioxidant Capacity of Eleven Potato(Solanum tuberosum) Varieties显示文摘Storage of potato tubers at low temperature affects their metabolism and may alter their phytochemical properties. There is a need to elucidate the changes in antioxidant compounds, activity and enzymes during storage of tubers. Eleven Indian potato varieties were evaluated for antioxidant parameters, after 0, 30, 60 and 90 days of storage at room temperature, 15 °C and 4 °C. Total phenolics(0.0786–0.1546 mg gallic acid equivalents·g^(-1)FW) and vitamin C content(0.0828–0.2416 mg·g^(-1)FW) varied among the varieties and were different with storage temperature; their levels fluctuated during storage but remained above the initial level until the last day of observation. Phenolic acid profiling by UPLC identified 12 compounds among which the most abundant was chlorogenic acid followed by gallic acid, sinapic acid and ellagic acid. Except para-coumaric acid which decreased at 4 °C, all the phenolic acids increased with storage. Caffeic acid, chlorogenic acid, protocatechuic acid and gallic acid mostly correlated with total phenolic content(r = 0.456, 0.482, 0.588 and 0.620, respectively). Antioxidant activity against both DPPH and ABTS radicals increased during the initial days of storage and then dropped to a level comparable or lower than the original value,irrespective of the storage temperature. Correlation study revealed that chlorogenic acid, gallic acid and ferulic acid mostly contributed to antioxidant activity. Activity of both antioxidant enzymes, superoxide dismutase and ascorbate peroxidase, increased initially but then decreased to values lower than the initial level and were not influenced by storage temperature. Correlation with antioxidant activity indicated that the enhancement of reactive oxygen scavenging species in cold stored tubers could result mainly from ascorbate peroxidase activity. Our results demonstrate that storage temperature adversely influences the metabolism and the content of antioxidant compounds in potato tubers, with subsequent increase on their antioxidant capacity. | Joseph Hubert Yamdeu Galani Pooja M.Mankad Avadh K.Shah Nilesh J.Patel Rajeshkumar R.Acharya Jayant G.Talati | 2017 | Horticultural Plant Journal2017，3，2： | 2 |
| 2 | Structure-function insights into the initial step of DNA integration by a CRISPR-Cas-Transposon complex显示文摘Dear Editor,CRISPR(clustered regularly interspaced short palindromic repeats)-Cas(CRISPR-associated genes)surveillance complexes are PNA-based adaptive immune systems employed by prokar-yotes against invading nudeic acids from bacteriophages and plasmids. | Ning Jia Wei Xie M.Jason de la Cruz Edward T.Eng Dinshaw J.Patel | 2020 | Cell Research2020，30，2： | 1 |
| 3 | TiO2 pigments can be partly replaced by calcium aluminium silicate extenders显示文摘 | CHINTANKUMAR J.PATEL ASHOK K.DIGHE HITESH K.HIRANI | | 0，，03： | 1 |
| 4 | CasX:a new and small CRISPR gene-editing protein显示文摘In a recent paper published in Nature,Liu et al.demonstrate the DNA cleavage characteristics of CasX(a newly identified dual-RNA-guided DNA targeting nuclease)and establish its capacity for genome editing in Escherichia coli and human cells.Furthermore,they capture structural snapshots of CasX in different states by cryo-EM and establish a model of RNA assembly,DNA targeting and sequential cleavage. | Hui Yang Dinshaw J.Patel | 2019 | Cell Research2019，29，5： | 1 |
| 5 | Cost‐utility analysis of bevacizumab versus ranibizumab in neovascular age‐related macular degeneration using a Markov model显示文摘 | Jignesh J.Patel Margaret A.S.Mendes MarkBounthavong Melissa L.D.Christopher DanielBoggie Anthony P.Morreale | 2012 | Journal of Evaluation in Clinical Practice2012，，2： | 1 |
| 6 | Fanzors: Striking expansion of RNA-guided endonucleases to eukaryotes显示文摘RNA-guided DNA endonucleases are broadly associated with and play critical roles in prokaryotic adaptive immunity-based CRISPR-Cas systems and IS200/605 family transposons.The Feng Zhang lab recently elucidated the phylogeny,enzymatic activity and DNA recognition mechanism of its eukaryotic counterpart Fanzor,while further reprogramming Fanzor for human genome editing applications,thereby highlighting a universal RNA-guided DNA cleavage mechanism spanning from prokaryotes to eukaryotes. | Hui Yang Dinshaw J.Patel | 2024 | Cell Research2024，34，2： | 0 |
| 7 | Keeping innate immune response in check: when cGAS meets the nucleosome显示文摘Cao et al.report on cryo-EM structures of human cyclic GMPAMP synthase(cGAS)sensor bound to the nucleosome core particle,thereby defining the molecular mechanism of how cGAS avoids activation by chromatinized self-DNA.Notably,disruption of cGAS dimer formation and prevention of dsDNA recognition by the sensor at the nucleosome level impede cGAS activation. | Wei Xie Dinshaw J.Patel | 2020 | Cell Research2020，30，12： | 0 |
| 8 | Structure-based evolutionary relationship between IscB and Cas9显示文摘In a recent study published in Science,Ailong Ke and coworkers determined the cryo-EM structure of the dsDNAbound IscBωRNA ribonucleoprotein(RNP)complex,which was supplemented with complementary biochemical experiments,revealing the architectural and mechanistic similarities for RNA-guided DNA recognition and activation-mediated cleavage by IscB and Cas9 RNPs.These findings highlight the evolutionary relationship between IscB and Cas9,and the potential for development of enhanced and programmable genome editing tools by capitalizing on IscB’s small size. | Ning Jia Dinshaw J.Patel | 2022 | Cell Research2022，32，10： | 0 |
| 9 | A structural platform for B cell receptor signaling显示文摘Three groups recently determined the cryo-EM structures of full-length transmembrane B cell receptor(BCR)in its resting state,representing a key advance toward our understanding of BCR signaling.These findings explain the molecular principles underlying BCR assembly and provide opportunities for structure-guided rational engineering of BCRs for the treatment of hematological and autoimmune diseases. | Wei Xie Kai Wucherpfennig Dinshaw J.Patel | 2023 | Cell Research2023，33，2： | 0 |
| 10 | 单细胞技术揭示肝癌免疫图谱与动态特征显示文摘文章简介肝细胞癌是世界范围内死亡率排名第三的癌症,其中中国的肝癌发病率居世界之先。肿瘤存在多种免疫逃逸机制,提出了研究肿瘤微环境中不同免疫细胞状态的重要性。而不同类型的单细胞测序技术则是研究不同类型免疫细胞的状态和动态的有力手段。本研究结合了两种单细胞测序技术,充分发挥不同数据类型的优势,获得高分辨率的肝癌免疫图谱。肿瘤中的树突状细胞是重要的抗原呈递细胞,除传统的树突状细胞外。 | Qiming Zhang Yao He Nan Luo Shashank J.Patel Yanjie Han Ranran Gao Madhura Modak Sebastian Carotta Christian Haslinger David Kind Gregory W.Peet Guojie Zhong Shuangjia Lu Weihua Zhu Yilei Mao Mengmeng Xiao Michael Bergmann Xueda Hu Sid P.Kerkar Anne B.Vogt Stefan Pflanz Kang Liu 彭吉润 任仙文 张泽民 | 2020 | 科学新闻2020，，2： | 0 |
| 11 | Programmed death 1 (PD-1) and ligand (PD-L1) inhibitors in head and neck squamous cell carcinoma: A meta-analysis显示文摘Background: PD-1 and PD-L1 inhibitors have emerged as promising treatments for patients with head and neck squamous cell carcinoma (HNSCC).Methods: Systematic review and meta-analysis of PD-1 and PD-L1 inhibitors in HNSCC. Outcomes: median overall survival (mOS), median progression-free survival (mPFS), Response Evaluation Criteria in Solid Tumors (RECIST) and treatment-related adverse events (TRAEs).Results: Eleven trials reported data on 1088 patients (mean age: 59.9 years, range: 18-90). The total mOS was 7.97 months (range: 6.0-16.5). Mean mPFS for all studies was 2.84 months (range: 1.9-6.5). PD-1 inhibitors had a lower rate of RECIST Progressive Disease than PD-L1 inhibitors (42.61%, 95% confidence interval [CI]: 36.29-49.06 vs. 56.79%, 95% CI: 49.18-64.19,P < 0.001). The rate of TRAEs of any grade (62.7%, 95% CI: 59.8-65.6) did not differ.Conclusions: Meta-analysis shows the efficacy of PD-1 and PD-L1 inhibitors in HNSCC and suggests a possible difference in certain RECIST criterion between PD-1 and PD-L1 inhibitors. Future work to investigate the clinical significance of these findings is warranted. | Dylan A.Levy Jaimin J.Patel Shaun A.Nguyen W.Nicholas Jungbauer David M.Neskey Ezra E.W.Cohen Chrystal M.Paulos John A.Kaczmar Hannah M.Knochelmann Terry A.Day | 2022 | World Journal of Otorhinolaryngology-Head and Neck Surgery2022，8，3： | 0 |
| 12 | Vented Individual Patient(VIP)Hoods for the Control of Infectious Airborne Diseases in Healthcare Facilities显示文摘By providing a means of separating the airborne emissions of patients from the air breathed by healthcare workers(HCWs),vented individual patient(VIP)hoods,a form of local exhaust ventilation(LEV),offer a new approach to reduce hospital-acquired infection(HAI).Results from recent studies have demonstrated that,for typical patient-emitted aerosols,VIP hoods provide protection at least equivalent to that of an N95 mask.Unlike a mask,hood performance can be easily monitored and HCWs can be alerted to failure by alarms.The appropriate use of these relatively simple devices could both reduce the reliance on personal protective equipment(PPE)for infection control and provide a low-cost and energy-efficient form of protection for hospitals and clinics.Although the development and deployment of VIP hoods has been accelerated by the coronavirus disease 2019(COVID-19)pandemic,these devices are currently an immature technology.In this review,we describe the state of the art of VIP hoods and identify aspects in need of further development,both in terms of device design and the protocols associated with their use.The broader concept of individual patient hoods has the potential to be expanded beyond ventilation to the provision of clean conditions for individual patients and personalized control over other environmental factors such as temperature and humidity. | J.Patel F.McGain T.Bhatelia S.Wang B.Sun J.Monty V.Pareek | 2022 | Engineering2022，8，8： | 0 |
| 13 | A typeⅢ-E CRISPR Craspase exhibiting RNase and protease activities显示文摘TypeⅢ-E CRISPR-Cas effector gRAMP/Cas7-11 is a RNA-guided RNA endonuclease associated with a putative caspase-like protease TRP-CHAT/Csx29,which targets endogenous protein substrate Csx30.In a recent paper published in Science,the Ailong Ke lab has captured cryo-EM snapshots of the nuclease–protease complex Craspase in both resting and different functional states;this paper together with four other related studies have elucidated the molecular mechanisms of both target RNA cleavage and RNA-mediated allosteric regulation of protease catalytic activity,thereby highlighting RNA-dependent protease-based programmed cell death. | Hui Yang Dinshaw J.Patel | 2022 | Cell Research2022，32，12： | 0 |
| 14 | ANTIMICROBIAL ACTIVITY OF COPOLYMERS OF 2,4-DICHLOROPHENYL ACRYLATE WITH STYRENE:SYNTHESIS,CHARACTERIZATION AND REACTIVITY RATIOS显示文摘Some copolymers of 2,4-dichlorophenyl acrylate (2,4-DCPA) with styrene (St) of different teed compositions were prepared by tree radical polymerization technique using 2,2′-azobisisobutyronitrile (AIBN) as an initiator,and the copolymers were characterized by IR spectroscopy.The copolymer composition obtained by UV-spectra led to determination of reactivity ratio by employing Fineman-Ross (F-R) and Kelen-Tudos (K-T) methods.Average molecular weight,as well as intrinsic viscosity,was obtained by vapor pre... | Hetal J.Patel Mitesh G.Patel Kirit H.Patel Arabinda K.Ray Rajni M.Patel | 2009 | Chinese Journal of Polymer Science2009，27，1： | 0 |
| 15 | The Transradial Approach for Cardiac Catheterization and Percutaneous Coronary Intervention:A Review显示文摘Cardiac catheterization and percutaneous coronary intervention play an important role in the management of coronary artery disease.Although the transfemoral approach has been the traditionally dominant method,there has been an increased utilization of the transradial approach.Multiple observational studies and randomized clinical trials have shown fewer bleeding complications,reduced morbidity and mortality,improved quality of life,and better economic outcomes when the transradial approach is utilized when compared to the transfemoral approach.Despite its many benefits,utilization of this approach in certain countries including the United States has been less than optimal due to a lower adoption rates mostly driven by lack of training opportunities and decreased awareness of clinical benefits of the transradial approach.In this review,the history,observational trends,efficacy,and technical aspects of transradial cardiac catheterization and percutaneous coronary intervention are discussed. | Dhaval Pau Nileshkumar J.Patel Nish Patel Mauricio G.Cohen | 2016 | Cardiovascular Innovations and Applications2016，，B05： | 0 |
| 16 | Atypical bacterial Argonautes regulate antiphage defense显示文摘Unusual Argonaute(Ago)proteins have been recently identified in prokaryotic immune systems,which upon binding to foreign nucleic acids,activate their associated NADase effectors.Recent cryo-EM structures of such unique Ago-associated TIR and SIR2 NADases revealed an unconventional nucleic acid binding-mediated NADase activation,adding to the repertoire of canonical cyclic second messenger-driven TIR and SIR2 activation mechanisms. | Arpita Chakravarti Dinshaw J.Patel | 2023 | Cell Research2023，33，9： | 0 |
| 17 | A‘warhorse-shaped’topology adopted by the m^(6)A RNA writer complex显示文摘The m^(6)A writer complex is a holoenzyme formed by catalytic MAC and regulatory MACOM subcomplexes that play a key role in the readout of this most prevalent epigenetic mark on RNA.Su et al.recently determined the cryo-EM structures of the MACOM complex at high resolution and the MAC–MACOM complex at medium resolution,thereby defining the composition and assembly of the core MACOM complex,as well as highlighting insights into the regulatory mechanism of m^(6)A RNA readout at the molecular level and its impact on function. | Wei Xie Dinshaw J.Patel | 2023 | Cell Research2023，33，1： | 0 |
| 18 | Higher Child-Reported Internalizing and Parent-Reported Externalizing Behaviors were Associated with Decreased Quality of Life among Pediatric Cardiac Patients Independent of Diagnosis:A Cross-Sectional Mixed-Methods Assessment显示文摘Background:Pediatric cardiology patients often experience decreased quality of life(QoL)and higher rates of mental illness,particularly with severe disease,but the relationship between them and comparisons across diagnostic groups are limited.This mixed-methods cross-sectional study assessed the association between QoL anxiety and behavior problems among children with structural heart disease,arrhythmia,or other cardiac diagnoses.Methods:Children(6–14 years,n=76,50%female)and their parents completed measures of QoL(PedsQL),behavior(BASC-2,subset of 19 children)and anxiety(MASC-2,children 8+years).Pearson correlations/regression models examined associations between QoL,behavior and anxiety,controlling for age,sex,diagnosis and condition severity.Student t-tests compared results to published normative values.Semi-structured interviews(15 children,13 parents)examined self-and parent-reported perceptions of the patient’s emotional health.Results:Child reported social QoL(95%CI difference:−11.0,−2.1),emotional well-being(95%CI difference:−12.5,−3.8)and adjustment skills(95%CI difference:−13.9,−3.0)were significantly below published norms(p<0.05).Neither age,sex,nor diagnosis were significantly related to questionnaire responses.Compared to children with mild conditions,child and parent-reported QoL was significantly lower in children with complex conditions(np2≥0.14,p<0.05).Lower QoL was strongly associated with more internalizing problems based on both child(r=−0.78,p<0.001)and parent(r=−0.67,p<0.001)reports.Interview responses suggested emotional distress was attributed to“normal”child problems rather than the child’s cardiac problem.Conclusion:Children with complex cardiac conditions,regardless of diagnosis,had diminished QoL.Using the PedsQL in clinical settings may help identify pediatric cardiology patients experiencing emotional distress(i.e.,anxiety and depression). | Jacqueline S.Lee Angelica Blais Julia Jackson Bhavika J.Patel Lillian Lai Gary Goldfield Renee Sananes Patricia E.Longmuir | 2021 | Congenital Heart Disease2021，16，3： | 0 |
| 19 | Cofactor-assisted dicing:insights from structural snapshots显示文摘Two recent cryo-EM publications in Nature by Su et al.and Yamaguchi et al.have captured snapshots of structures of Drosophila Dicer-2 bound to target dsRNA in the presence of protein cofactors Loquacious-PD or R2D2 along the small RNA biogenesis pathway,thereby highlighting the stepwise molecular mechanism underlying dicing-mediated precise small RNA production. | Jiamu Du Dinshaw J.Patel | 2022 | Cell Research2022，32，11： | 0 |
| 20 | Cochlear implantation in patients with Meniere’s disease:A systematic review显示文摘Background:Meniere’s disease(MD)is an idiopathic disorder of the inner ear,which manifests as cochleo-vestibular dysfunction.Hearing loss will progress to a profound levelin a subset of patients with MD,and vestibular interventions can independently cause loss of hearing.The aim of this study was to systematically review the published literature describing the safety and efficacy of CI in patients with MD.Materials and methods:A systematic literature review was conducted in accordance PRISMA guidelines to identify articles that assessed at least one functional outcome in patients with MD who underwent CI.Demographic information,disease history,MD symptoms,outcomes measures,and complications related to CI were extracted from included studies.Results:In total,17 studies were included,and 182 patients with MD underwent CI.The weighted-mean age was 61.9 years(range 27-85).Study objective and methodology varied,and there was significant heterogeneity in CI outcome measures reported.In total,179(98.3%)of 182 patients reported objective improvements in at least one hearing metric after CI.A total of 69 patients(37.9%)reported vertigo or severe dizziness prior to CI,compared to 22 patients(15.4%)postoperatively.Two studies reported significant reductions in postoperative Tinnitus Handicap Inventory score(THI).Quality of life assessments varied between studies.Complications rates were low with only nine patients(4.9%)reporting a serious CI-related complication.Conclusions:This systematic review evaluated 17 studies describing the safety and efficacy of CI in patients with MD and encountered many challenges due to small sample sizes,and heterogeneity in study design and outcomes measured.Despite these limitations,this study of 182 patients is to the best of our knowledge the largest systematic review evaluating the safety and efficacy of CI in MD.The results of this study support the need for a standardized approach to evaluating outcomes of CI in patients with MD in future studies. | Vincent M.Desiato Jaimin J.Patel Shaun A.Nguyen Ted A.Meyer Paul R.Lambert | 2021 | World Journal of Otorhinolaryngology-Head and Neck Surgery2021，7，4： | 0 |
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