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| 1 | Mycophenolate mofetil for maintenance of remission in steroid-dependent autoimmune pancreatitis显示文摘Systemic corticosteroids represent the standard treatment for autoimmune pancreatitis with IgG4-associated cholangitis.For steroid-dependent disease,azathioprine has been used for maintenance of remission.Mycophenolate mofetil has been used for transplant immunosuppression and more recently for autoimmune hepatitis;however,there are no case reports to date on the use of mycophenolate mofetil in adult patients with autoimmune pancreatitis.A patient with IgG4-mediated autoimmune pancreatitis and IgG4-associated cholangitis refractory to steroids and intolerant of azathioprine was treated with mycophenolate mofetil,which inhibits de novo guanosine synthesis and blockade of both B and T lymphocyte production.Introduction of mycophenolate mofetil and uptitration to 1000 mg by mouth twice daily over a treatment period of 4 mo was associated with improvement in the patient's energy level and blood glucose control and was not associated with any adverse events.The patient was managed without a biliary stent.However,there was a return of symptoms,jaundice,increase in transaminases,and hyperbilirubinemia when the prednisone dose reached 11 mg per day.In the first report of mycophenolate mofetil use in an adult patient with IgG4-associated autoimmune pancreatitis and IgG4-associated cholangitis,the introduction of mycophenolate mofetil was safe and well-tolerated without adverse events,but it did not enable discontinuation of the steroids.Mycophenolate mofetil and other immunomodulatory therapies should continue to be studied for maintenance of remission in the large subset of patients with refractory or recurrent autoimmune pancreatitis. | Jamie B Sodikoff Steven A Keilin Sheila J Bharmal Melinda M Lewis Gottumukkala S Raju Field F Willingham | 2012 | World Journal of Gastroenterology2012，18，18： | 6 |
| 2 | Refining pathological evaluation of neoadjuvant therapy for adenocarcinoma of the esophagus显示文摘AIM:To assess tumour regression grade(TRG)and lymph node downstaging to help define patients who benefit from neoadjuvant chemotherapy.METHODS:Two hundred and eighteen consecutive patients with adenocarcinoma of the esophagus or gastro-esophageal junction treated with surgery alone or neoadjuvant chemotherapy and surgery between 2005and 2011 at a single institution were reviewed.Triplet neoadjuvant chemotherapy consisting of platinum,fluoropyrimidine and anthracycline was considered for operable patients(World Health Organization performance status≤2)with clinical stage T2-4 N0-1.Response to neoadjuvant chemotherapy(NAC)was assessed using TRG,as described by Mandard et al.In addition lymph node downstaging was also assessed.Lymph node downstaging was defined by cN1 at diagnosis:assessed radiologically(computed tomography,positron emission tomography,endoscopic ultrasonography),then pathologically recorded as N0 after surgery;ypN0 if NAC given prior to surgery,or pN0if surgery alone.Patients were followed up for 5 years post surgery.Recurrence was defined radiologically,with or without pathological confirmation.An association was examined between t TRG and lymph node downstaging with disease free survival(DFS)and a comprehensive range of clinicopathological characteristics.RESULTS:Two hundred and eighteen patients underwent esophageal resection during the study interval with a mean follow up of 3 years(median follow up:2.552,95%CI:2.022-3.081).There was a 1.8%(n=4)inpatient mortality rate.One hundred and thirty-six(62.4%)patients received NAC,with 74.3%(n=101)of patients demonstrating some signs of pathological tumour regression(TRG 1-4)and 5.9%(n=8)having a complete pathological response.Forty four point one percent(n=60)had downstaging of their nodal disease(cN1 to ypN0),compared to only 15.9%(n=13)that underwent surgery alone(pre-operatively overstaged:cN1 to pN0),(P<0.0001).Response to NAC was associated with significantly increased DFS(mean DFS;TRG 1-2:5.1years,95%CI:4.6-5.6 vs TRG 3-5:2.8 years,95%CI:2.2-3.3,P<0.0001).Nodal down-staging conferred a significant DFS advantage for those patients with a poor primary tumour response to NAC(median DFS;TRG 3-5 and nodal down-staging:5.533 years,95%CI:3.558-7.531 vs TRG 3-5 and no nodal down-staging:1.114 years,95%CI:0.961-1.267,P<0.0001).CONCLUSION:Response to NAC in the primary tumour and in the lymph nodes are both independently associated with improved DFS. | Fergus Noble Luke Nolan Adrian C Bateman James P Byrne Jamie J Kelly Ian S Bailey Donna M Sharland Charlotte N Rees Timothy J Iveson Tim J Underwood Andrew R Bateman | 2013 | World Journal of Gastroenterology2013，19，48： | 4 |
| 3 | Characterization of a unique ethanologenic yeast capableof fermenting galactose显示文摘 | Jamie R Rodney J Bothast John N S Shawn D M | 2004 | Enzyme and Microbial Technology2004，35，： | 1 |
| 4 | Methane emission from free-ranging sheep:a comparison of two measurement methods显示文摘 | Leuning R Baker S K Jamie I M | 1999 | Atmospheric Environment1999，33，9： | 1 |
| 5 | The neglec- ted role of proaetive behavior and outcomes in newcomer socialization显示文摘 | Alan M S Jamie A G Helena C T | 2011 | Journal of Vocational Behavior2011，79，1： | 1 |
| 6 | Unconventional gas: a review of regional and global resource estimates显示文摘 | Christophe M Jamie S Steve S | 2013 | Energy2013，55，： | 1 |
| 7 | MCPH1 functions in an H2AX-dependent but MDCl-independent pathway in response to DNA damage 显示文摘 | Jamie W Namit S Georges M | 2007 | J Biol Chem2007，282，35： | 1 |
| 8 | Monoclonal antibodies directed to CD20 and HLA-DR can elicit homotypic adhesion followed by lysosome-mediated cell death in human lymphoma and leukemia cells显示文摘 | Ivanov Andrei Beers Stephen A Walshe Claire A Honeychurch Jamie Alduaij Waleed Cox Kerry L Potter Kathleen N Murray Stephen Chan Claude H T Klymenko Tetyana Erenpreisa Jekaterina Glennie Martin J Illidge Tim M Cragg Mark S | 2009 | Journal of Clinical Investigation2009，，8： | 1 |
| 9 | Isolation of tetranuclear orgunoantimony oxo clusters and hexa-decanuclear polyoxostibonates 显示文摘 | JAMI A K PRABHU M S R BASKAR V | 2010 | Organometallics2010，29，5： | 1 |
| 10 | The Kuh-e-Surmeh mineralization, a carbonate-hosted Zn-Pb deposit in the simply folded belt of the Zagros Mountains,SW Iran显示文摘 | Liaghat S Moore F Jami M | 2000 | Mineralium Deposita2000，35，： | 1 |
| 11 | Social Networking as a Marketing Tool:The Case of a Small Australian Company显示文摘 | Sharifah F S Jamie M | 2010 | Journal of Hospitality Marketing & Management2010，，19： | 1 |
| 12 | Methane emission from free-ranging sheep:a comparison of two measurement methods显示文摘 | LEUNING R BAKER S K JAMIE I M | 1999 | Atmospheric Environment1999，33，9： | 1 |
| 13 | Anisotropic structure deformation in the VO2 metal-insulator transition显示文摘 | JAMIE M B PHILIP S | 2009 | Am Phys Soc2009，103，08： | 1 |
| 14 | Adenosine kinase of Arabidopsis.Kinetic properties and gene expression显示文摘 | Barbara A M Li W Mike S A Yvonne Y S,Wensheng Q,Jamie S,Klaus V S | | 0，，： | 1 |
| 15 | Bovine lactoferricin induces caspase -independent apoptosis inhuman B -lymphoma cells and extends the survival of immunefacient mice bearing B-lymphoma xenografts 显示文摘 | Suzanne J Furlong Jamie S Mader David M Conrad | 2010 | Experimentaland Molecular Pathology2010，88，： | 1 |
| 16 | Quality clusters: Dimensions of email responses by luxury hotels 显示文摘 | Jamie M Roland S Doina O | 2007 | Hospitality Management2007，26，3： | 1 |
| 17 | Denosine kinase deficiency in associated with developmental abnormalities and reduced transmethylation显示文摘 | Barbara A M Yvonne Y S Mike S A Jamie D S,Luiz A P,Margarita I T,Peter S S,Elizabeth A W,Luke M M,Conrad W A | | 0，，： | 1 |
| 18 | Bovine lactoferricin selectively induces apoptosis in humanleukemia and carcinoma cell lines 显示文摘 | Jamie S Mader Jayme Salsman David M Conrad | 2005 | Mol Cancer Ther2005，，4： | 1 |
| 19 | Proteome analysis of the penicillin producer Penicillium chry- sogenurn: characterization of protein changes during the in- dustrial strain improvement 显示文摘 | JAMI M S BARREIRO C GARCIA-ESTRADA C | 2010 | Molecular Cellular Pro- teomics2010，9，6： | 1 |
| 20 | Mathane emission from free-ranging sheep:a comparison of two measurement methods显示文摘 | Leuning R Baker S K Jamie I M et ol | 1999 | Atmospheric Environment1999，33，： | 1 |
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