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| 1 | Crosstalk between gut microbiota and antidiabetic drug action显示文摘Type 2 diabetes (T2D) is a disorder characterized by chronic inflated blood glucose levels (hyperglycemia), at first due to insulin resistance and unregulated insulin secretion but with tendency towards global spreading. The gut microbiota is recognized to have an influence on T2D, although surveys have not formed a clear overview to date. Because of the interactions between gut microbiota and host homeostasis, intestinal bacteria are believed to play a large role in various diseases, including metabolic syndrome, obesity and associated disease. In this review, we highlight the animal and human studies which have elucidated the roles of metformin,α-glucosidase inhibitors, glucagon-like peptide-1 agonists, peroxisome proliferator-activated receptors γ agonists, inhibitors of dipeptidyl peptidase-4, sodium/glucose cotransporter inhibitors, and other less studied medications on gut microbiota. This review is dedicated to one of the most widespread diseases, T2D, and the currently used antidiabetic drugs and most promising new findings. In general, the gut microbiota has been shown to have an influence on host metabolism, food consumption, satiety, glucose homoeostasis, and weight gain. Altered intestinal microbiota composition has been noticed in cardiovascular diseases, colon cancer, rheumatoid arthritis, T2D, and obesity. Therefore, the main effect of antidiabetic drugs is on the microbiome composition, basically increasing the short-chain fatty acids-producing bacteria, responsible for losing weight and suppressing inflammation. | Yevheniia Kyriachenko Tetyana Falalyeyeva Oleksandr Korotkyi Nataliia Molochek Nazarii Kobyliak | 2019 | World Journal of Diabetes2019，10，3： | 9 |
| 2 | Synthesis and biological activity of novel N-(3-furan-2-yl-1-phenyl-1H-pyrazol-5-yl) amides derivatives显示文摘A series of novel N-(3-furan-2-yl-1-phenyl-1H-pyrazol-5-yl) amides derivatives were designed and synthesized. Their structures were confirmed by ~1H NMR, ^(13) C NMR and HRMS. All title compounds were evaluated for their herbicidal and antifungal activities. Preliminary bioassay results indicated that the title compounds showed good to moderate herbicidal activity at 1000 mg/L. Compound 6q presented the best activity against Digitaria sanguinalis(L) Scop., Amaranthus retroflexus L. and Arabidopsis thaliana with an inhibition degree of five. Compound 6d also showed an inhibition degree of five against D. sanguinalis.In addition, at 50 mg/L, most compounds exhibited good in vitro antifungal activity against Sclerotinia sclerotiorum, with compound 6c showing over 90% antifungal activity against S. sclerotiorum and Pellicularia sasakii. | Jing-Qian Huo Liu-Yong Ma Zhe Zhang Zhi-Jin Fan Jin-Lin Zhang Tetyana V. Beryozkina Vasiliy A. Bakulev | 2016 | Chinese Chemical Letters2016，27，9： | 7 |
| 3 | Genetic characterization of worldwide Prunus domestica(plum)germplasm using sequence-based genotyping显示文摘Prunus domestica commonly known as European plum is a hexaploid fruit tree species cultivated around the world.Locally it is used for fresh consumption,in jams or jellies,and the production of spirits while commercially the fruit is primarily sold dried(prunes).Despite its agricultural importance and long history of cultivation,many questions remain about the origin of this species,the relationships among its many pomological types,and its underlying genetics.Here,we used a sequence-based genotyping approach to characterize worldwide plum germplasm including the potential progenitor Eurasian plum species.Analysis of 405 DNA samples established a set of four clades consistent with the pomological groups Greengages,Mirabelles,European plums,and d’Agen(French)prune plums.A number of cultivars from each clade were identified as likely clonal selections,particularly among the“French”type prune germplasm that is widely cultivated today.Overall,there was relatively low genetic diversity across all cultivated plums suggesting they have been largely inbred and/or derived from a limited number of founders.The results agree with P.domestica having originated as an interspecific hybrid of a diploid P.cerasifera and a tetraploid P.spinosa that itself may have been an interspecific hybrid of P.cerasifera and an unknown Eurasian plum species.The low genetic diversity and lack of true wild-types coupled with the known cultivation history of Eurasian plums imply that P.domestica may have been a product of inter-specific cross breeding and artificial selection by early agrarian Eurasian societies. | Tetyana Zhebentyayeva Vijay Shankar Ralph Scorza Ann Callahan Michel Ravelonandro Sarah Castro Theodore DeJong Christopher A.Saski Chris Dardick | 2019 | Horticulture Research2019，6，1： | 4 |
| 4 | Modulation of protein tyrosine phosphorylation in gastric mucosa during re-epithelization processes显示文摘AIM:To investigate the role of protein tyrosine phosphorylation in gastric wound formation and repair following ulceration. METHODS:Gastric lesions were induced in rats using restraint cold stress.To investigate the effect of oxidative and nitrosative cell stress on tyrosine phosphorylation during wound repair,total activity of protein tyrosine kinase(PTK),protein tyrosine phosphatase (PTP),antioxidant enzymes,nitric oxide synthase (NOS), 2',5'-oligoadenylate synthetase,hydroxyl radical and zinc levels were assayed in parallel. RESULTS:Ulcer provocation induced an immediate decrease in tyrosine kinase(40% in plasma membranes and 56% in cytosol,(P<0.05) and phosphatase activity (threefold in plasma membranes and 3.3-fold in cytosol),followed by 2.3-2.4-fold decrease (P<0.05) in protein phosphotyrosine content in the gastric mucosa. Ulceration induced no immediate change in superoxide dismutase (SOD) activity,30% increase (P<0.05) in catalase activity,2.3-fold inhibition (P<0.05) of glutathione peroxidase,3.3-fold increase (P<0.05) in hydroxyl radical content,and 2.3-fold decrease (P<0.05) in zinc level in gastric mucosa.NOS activity was three times higher in gastric mucosa cells after cold stress. Following ulceration,PTK activity increased in plasma membranes and reached a maximum on day 4 after stress (twofold increase,P<0.05),but remained inhibited(1.6-3-fold decrease on days 3,4 and 5,P<0.05) in the cytosol.Tyrosine phosphatases remained inhibited both in membranes and cytosol(1.5-2.4-fold,P< 0.05).NOS activity remained increased on days 1,2 and 3(3.8-,2.6-,2.2-fold,respectively,P<0.05).Activity of SOD increased 1.6 times(P<0.05)days 4 and 5 after stress.Catalase activity normalized after day 2. Glutathione peroxidase activity and zinc level decreased (3.3-and 2-fold,respectively,P<0.05)on the last day. Activity of 2',5'-oligoadenylate synthethase increased 2.8-fold (P<0.05) at the beginning,and 1.6-2.3-fold (P<0.05) during ulcer recuperation,and normalized on day 5,consistent with slowing of inflammation processes. CONCLUSION:These studies show diverse changes in total tyrosine kinase activity in gastric mucosa during the recovery process.Oxidative and nitrosative stress during lesion formation might lead to the observed reduction in tyrosine phosphorylation during ulceration. | Olena V Bogdanova Larysa I Kot Kateryna V Lavrova Volodymyr B Bogdanov Erica K Sloan Tetyana V Beregova Ludmyla I Ostapchenko | 2010 | World Journal of Biological Chemistry2010，1，11： | 2 |
| 5 | Plasmon-Enhanced Photoluminescence of SiC Quantum Dots for Cell Imaging Applications显示文摘 | Yuriy Zakharko Tetiana Serdiuk Tetyana Nychyporuk Alain Gélo?n Mustapha Lemiti Vladimir Lysenko | 2012 | Plasmonics2012，，4： | 1 |
| 6 | Topsoil magnetic susceptibility mapping as a tool for pollution monitoring: repeatability of in situ measurements显示文摘 | Tetyana Boyko Robert Scholger Helge Stanjek | 2004 | Journal of Applied Geophysics2004，55，： | 1 |
| 7 | Hypoxia induces oxidative stress in tissues of a goby, the rotan Perccottus glenii显示文摘 | Volodymyr I L Tetyana V B | 2007 | Comp Bio- chem Physiol2007，，148： | 1 |
| 8 | The genetic and neurobiological etiology of anorexia nervosa显示文摘 | Tetyana P | 2009 | Journal of Undergraduate Life Sciences(JULS)2009，3，： | 1 |
| 9 | Angiomotin :an angiostatin binding protein that regulates endothelial cell migration and tube formation显示文摘 | Boris Troyanovsky Tetyana Levchenko Goran Mansson | 2001 | J Cell Biol2001，152，6： | 1 |
| 10 | Grafting of Polyfluorene by Surface‐Initiated Suzuki Polycondensation显示文摘 | Tetyana Beryozkina Ksenia Boyko Natalya Khanduyeva Volodymyr Senkovskyy Marta Horecha Ulrich Oertel Frank Simon Manfred Stamm Anton Kiriy | 2009 | Angew Chem Int Ed2009，，15： | 1 |
| 11 | Top soil magnetic susceptibility mapping as a tool for pollution monitoring:repeatability of in situ measurements 显示文摘 | TETYANA B ROBERT S HELGE S | 2004 | Journal of Applied Geophysics2004，，55： | 1 |
| 12 | Hepatic epigenetic phenotype predetermines individual susceptibility to hepatic steatosis in mice fed a lipogenic methyl-deficient diet显示文摘 | Igor P. Pogribny Volodymyr P. Tryndyak Tetyana V. Bagnyukova Stepan Melnyk Beverly Montgomery Sharon A. Ross John R. Latendresse Ivan Rusyn Frederick A. Beland | 2009 | Journal of Hepatology2009，，1： | 1 |
| 13 | Temperature increase results in oxidative stress in goldfish tissues. 1. Indices of oxidative stress显示文摘 | Volodymyr I. Lushchak Tetyana V. Bagnyukova | 2005 | Comparative Biochemistry and Physiology Part C2005，，1： | 1 |
| 14 | Ulipristal acetateversus Placebo for Fibroid Treatment before Surgery显示文摘 | Jacques D Tetyana FT Philippe B | 2012 | New Engl J Med2012，366，： | 1 |
| 15 | Development and characterization of attenuated metabolic mutants of Bordetella bronchiseptica for applications in vaccinology显示文摘 | Tetyana Yevsa Thomas Ebensen Barbara Fuchs Beata Zygmunt Rimma Libanova Roy Gross Kai Schulze Carlos A. Guzmán | 2012 | Environmental Microbiology2012，，1： | 1 |
| 16 | Monoclonal antibodies directed to CD20 and HLA-DR can elicit homotypic adhesion followed by lysosome-mediated cell death in human lymphoma and leukemia cells显示文摘 | Ivanov Andrei Beers Stephen A Walshe Claire A Honeychurch Jamie Alduaij Waleed Cox Kerry L Potter Kathleen N Murray Stephen Chan Claude H T Klymenko Tetyana Erenpreisa Jekaterina Glennie Martin J Illidge Tim M Cragg Mark S | 2009 | Journal of Clinical Investigation2009，，8： | 1 |
| 17 | Role ofanti-angiogenic factor endostatin in the pathogenesis of experimentalulcerative colitis显示文摘 | Tolstanova Ganna Deng Xiaoming Khomenko Tetyana | 2011 | Life Sciences2011，88，12： | 1 |
| 18 | Coordinated response of goldfish antioxidant defenses to environmental stress显示文摘 | Tetyana V Bagnyukova Oxana I Chahrak | 2006 | Aquatic Toxicology2006，78，4： | 1 |
| 19 | Gene expression and gene therapy in experimental duodenal ulceration显示文摘 | Sandor Szabo Xiaoming Deng Tetyana Khomenko Masashi Yoshida Martin R Jadus Zsuzsa Sandor Zoltan Gombos Hiroko Matsumoto | 2001 | Journal of Physiology - Paris2001，，1： | 1 |
| 20 | High yield synthesis of Ru-Pt mixed-metal cluster compounds 显示文摘 | Sophie H Tetyana K Brian F | 2001 | J Chem Soc Dalton Trans2001，，21： | 1 |
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