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| 1 | Bovine immunoglobulin protein isolates for the nutritional management of enteropathy显示文摘The gastrointestinal tract is responsible for a multitude of digestive and immune functions which depend upon the balanced interaction of the intestinal microbiota, diet, gut barrier function, and mucosal immune response. Disruptions in one or more of these factors can lead to intestinal disorders or enteropathies which are characterized by intestinal inflammation, increased gut permeability, and reduced capacity to absorb nutrients. Enteropathy is frequently associated with human immunodeficiency virus(HIV) infection, inflammatory bowel disease, autoimmune enteropathy, radiation enteritis, and irritable bowel syndrome(IBS), where pathologic changes in the intestinal tract lead to abdominal discomfort, bloating, abnormal bowel function(e.g., diarrhea, urgency, constipation and malabsorption). Unfortunately, effective therapies for the management ofenteropathy and restoring intestinal health are still not available. An accumulating body of preclinical studies has demonstrated that oral administration of plasmaor serum-derived protein concentrates containing high levels of immunoglobulins can improve weight, normalize gut barrier function, and reduce the severity of enteropathy in animal models. Recent studies in humans, using serum-derived bovine immunoglobulin/protein isolate, demonstrate that such protein preparations are safe and improve symptoms, nutritional status, and various biomarkers associated with enteropathy. Benefits have been shown in patients with HIV infection or diarrhea-predominant IBS. This review summarizes preclinical and clinical studies with plasma/serum protein concentrates and describes the effects on host nutrition, intestinal function, and markers of intestinal inflammation. It supports the concept that immunoglobulin-containing protein preparations may offer a new strategy for restoring functional homeostasis in the intestinal tract of patients with enteropathy. | Bryon W Petschow Anthony T Blikslager Eric M Weaver Joy M Campbell Javier Polo Audrey L Shaw Bruce P Burnett Gerald L Klein J Marc Rhoads | 2014 | World Journal of Gastroenterology2014，20，33： | 2 |
| 2 | Optimized FPGA- implementation of quadrature DDS 显示文摘 | FRANCISCO C T JAVIER V C | 2002 | Volume2002，5，： | 1 |
| 3 | Deter- mining Vulnerability Importance in Environmental Impact Assessment: The case of Colombia 显示文摘 | JAVIER T OSCAR D IGNACIO R | 2012 | Envi- ronmental Impact Assessment Review2012，32，1： | 1 |
| 4 | PARO:Supporting Dynamic Power Controlled Routing in Wireless Ad Hoc Networks显示文摘 | Javier Gomez Andrew T Campbell | 2003 | Wireless Networks2003，，9： | 1 |
| 5 | A simple evolutionary topology optimization procedure for compliant mechanism design显示文摘 | Rubén Ansola Estrella Veguería Javier Canales José A. Tárrago | 2007 | Finite Elements in Analysis & Design2007，，1： | 1 |
| 6 | Phase evolution by thermal treatment of equimolar cobalt-magnesium cordierite glass powders 显示文摘 | FRANCISCO J T JAVIER A | 2004 | J Eur Ceram Soc2004，24，： | 1 |
| 7 | Nanometal surface energy transfer in optical rulers, breaking the FRET barrier 显示文摘 | Yun C Javier A Jennings T | 2005 | Journal of the American Chemical Society2005，127，9： | 1 |
| 8 | A two-layers based approach of an enhanced-map for urban positioning support显示文摘 | Pinana-Diaz C Toledo-Moreo R Javier T | 2012 | Sensors2012，12，14： | 1 |
| 9 | A major secreted elastase It essential for pathogenicity of Aeromonas hydrophila 显示文摘 | Alberto C Javier Y Alejandro T | 2000 | Infection and Im- munity2000，68，6： | 1 |
| 10 | GPUs for Parallel On-board Hyper-sperctral Image Processing显示文摘 | Javier S Manuel P Christian T | 2008 | International Journal of High Performance Computing Applications2008，22，4： | 1 |
| 11 | Mechanism of crystallization of fast fired mullite-based glass-ceramic glazes for floor-tiles 显示文摘 | FRANCISCO J T ESHTER R S JAVIER A | 2006 | J Non-Crystalline Solids2006，352，： | 1 |
| 12 | Discriminating among subgroups of borderline personality disorder: An assessment of object representation显示文摘 | Geraid T Rafael A Javier& Mima C | 2003 | The American Journal of Psychoanaly- sis2003，63，2： | 1 |
| 13 | Transistor paint:high mobilities in small bandgap polymer semiconductor based on the strong acceptor,diketopyrrolopyrrole and strong donor,dithienopyrrole显示文摘 | Toby L N Tomasz M Y Jun Y L Mishra S P Belot J A Balliet C L Javier A E Kowalewski T McCullough R D | 2010 | Advanced Materials2010，22，41： | 1 |
| 14 | Internet Micromobility显示文摘 | Andrew T Campbell Javier Gomez Sanghyo Kim | 2002 | High Speed Networks2002，，11： | 1 |
| 15 | Molecular signatures of vascular injury are associated with early growth of intracerebral hemorrhage显示文摘 | YOLANDA S ROGELIO L JAVIER T | 2005 | Stroke2005，36，1： | 1 |
| 16 | Technological implications of addition of wheat dietary fiber to giant squid (Dosidicus gigas) surimi gels显示文摘 | Isabel Sanchez-Alonso Mariia T Solas Javier Borderias A | | 0，，02： | 1 |
| 17 | PARO:Supporting dynamic power controlled routing in wireless Ad hoc networks显示文摘 | Javier Gomez Andrew T Campbell | 2003 | Wire- less Networks2003，9，： | 1 |
| 18 | Discriminating among subgroups of borderline personality disorder: An assessment of object representation显示文摘 | Gerald T Rafael A Javier & Mima C | 2003 | The American Journal of Psychoanalysis2003，63，2： | 1 |
| 19 | Effects of varying sulphate concentrations on growth, physiology and of the green- house tomato显示文摘 | JAVIER L NICOLAS T WIM V | 1996 | Scientia Horticuhurae1996，67，： | 1 |
| 20 | A new approach to pruning Volterra models for power amplifiers 显示文摘 | CARLOS C C JAVIER R T MARIA J M A JEsus M C | 2010 | IEEE Transactions on Signal Processing2010，58，4： | 1 |
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