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| 1 | ALDH2 protects against stroke by clearing 4-HNE显示文摘(ALDH2 ) 醛脱氢酶 2 是使象 4-hydroxy-2-nonenal (4-HNE ) 那样的乙醇和有毒的醛产生代射变化的 mitochondrial 酶。用不偏的 proteomic 搜索,我们作为与自发地高血压的老鼠(SHR ) 相比在击容易的自发地高血压的老鼠(SHR-SP ) 识别了 ALDH2 缺乏。我们作为 overexpression 在 neuronal 损害结束了 ALDH2 缺乏的原因的角色或 ALDH2 的激活由清除 4-HNE 在授与 neuroprotection 在 vitro 研究。进一步, ALDH2 击倒的老鼠揭示了 PKCε 的 neuroprotective 效果的缺席;。被知道对击施加保护的中等乙醇管理被显示提高 4-HNE 的 detoxification,并且免于 ischemic 通过 PKCε 的服的损害; -ALDH2 小径。在 SHR-SP,浆液 4-HNE 水平固执地与 lifespan 相反地被提高并且相关。在在人的击的 4-HNE 的角色被它的血浆层次的坚持的举起也在击以后建议至少 6 个月。最后,我们观察到发展了的跟随 8 年的 1 242 个题目中的 21 个比没得中风的那些摸有的更高起始的血浆 4-HNE 层次。这些调查结果建议 ALDH2 小径的激活可以在击容易的题目的鉴定用作一个有用索引,并且 ALDH2 小径可以是在击的治疗学的干预的一个潜在的目标。 | Jin-Min Guo Ai-Jun Liu Pu Zang Wen-Zhe Dong Li Ying Wei W ang Pu Xu Xu-Rui Song Jun Cai She-Qing Zhang Jun-Li Duan Jawahar L Mehta Ding-Feng Su | 2013 | Cell Research2013，23，7： | 19 |
| 2 | Mitochondrial Autophagy and NLRP3 Inflammasome in Pulmonary Tissues from Severe Combined Immunodeficient Mice after Cardiac Arrest and Cardiopulmonary Resuscitation显示文摘 | Jing-Jun Lyu Jawahar L Mehta Yi Li Lu Ye Sheng-Nan Sun Hong-Shuang Sun Jia-Chang Li Dong-Mei Zhang Jie Wei | 2018 | Chinese Medical Journal2018，，10： | 12 |
| 3 | Aspirin resistance: Fact or fiction? A point of view显示文摘Aspirin is a wonder drug that has been used for well over 100 years for its analgesic and antipyretic effects. For the past three decades, it has increasingly been used for the prevention of primary and secondary cardiovascular events. Lately, it has been suggested that a significant number of individuals taking aspirin have become resistant to this drug. The phenomenon of 'aspirin resistance' is based on the observation of clinical events in some patients taking aspirin, and/or a diminished platelet aggregation inhibitory response to aspirin therapy. Unfortunately, laboratory assays used to monitor the efficacy of aspirin are far from accurate and the results are not reproducible. Furthermore, results of different platelet function tests are often not congruent. In addition, platelet aggregation studies show marked interindividual and intra-individual variability. Patients with coronary heart disease take many drugs that interfere with the effect of aspirin on platelet aggregation. Besides inhibiting formation of thromboxane A2 from arachidonic acid, aspirin has a host of platelet-independent effects that complement its platelet inhibitory effects. Laboratory assays designed to measure platelet function do not take into account these pleiotropic effects of aspirin. In our view, use of the term 'aspirin resistance' based on inadequate knowledge of imperfect laboratory tests does a disservice to physicians and patients. | Jawahar L Mehta Bhavna Mohandas | 2010 | World Journal of Cardiology2010，2，9： | 7 |
| 4 | Role of cardiac CTA in estimating left ventricular volumes and ejection fraction显示文摘Left ventricular ejection fraction(LVEF)is an impor-tant predictor of cardiac outcome and helps in makingimportant diagnostic and therapeutic decisions suchas the treatment of different types of congestive heartfailure or implantation of devices like cardiac resynchro-nization therapy-defibrillator.LVEF can be measuredby various techniques such as transthoracic echo-cardiography,contrast ventriculography,radionuclidetechniques,cardiac magnetic resonance imaging andcardiac computed tomographic angiography(CTA).Thedevelopment of cardiac CTA using multi-detector rowCT(MDCT)has seen a very rapid improvement in thetechnology for identifying coronary artery stenosis andcoronary artery disease in the last decade.During theacquisition,processing and analysis of data to studycoronary anatomy,MDCT provides a unique opportunityto measure left ventricular volumes and LVEF simulta-neously with the same data set without the need foradditional contrast or radiation exposure.The develop-ment of semi-automated and automated software to measure LVEF has now added uniformity,efficiency and reproducibility of practical value in clinical practice rather than just being a research tool.This article will address the feasibility,the accuracy and the limitations of MDCT in measuring LVEF. | Robin Man Singh Balkrishna Man Singh Jawahar Lal Mehta | 2014 | World Journal of Radiology2014，6，9： | 5 |
| 5 | Analysis of vibration signal responses on pre induced tunnel defects in friction stir welding using wavelet transform and empirical mode decomposition显示文摘Among many condition-monitoring systems in welding operation,Defect identification is an important method to ensure the precision in finishing operation.Friction stir welding is a solid state welding process used to join two metals without the use of electrode at lower temperatures.The aim of this present work is to identify and localize the tunnel defect in aluminum alloy and measure the distance of the defect zone in the time domain of the vibration signal during Friction stir welding.The vibration signals are captured from the experiments and the burst in the vibration signal is focused in the analysis.A signal-processing scheme is proposed to filter the noise and to measure the dimensional parameters of the defect area.The proposed technique consists of discrete wavelet transform(DWT),which is used to decompose the signal.The enveloping technique is applied on the decomposed zero padded signal.The continuous wavelet transform(CWT) has been implemented on detailed signal followed by a time marginal integration(TMI) of the CWT scalogram.Empirical mode decomposition(EMD) is used to replace the detailing coefficients from DWT with Intrinsic Mode Function(IMF).Statistical parameters such as mean,kurtosis,S.D and crest factor have been extracted from the final filtered signal for validating the defect welds from the control defect free welds.Results produced were found to be that kurtosis is 7.4402 for tunnel defect induced weld and 3.3862 for defect free welds.As the increase in kurtosis value predicts the defect zone impact in the signal.The measurement of the defect zone of the cut 1(voids) and cut 2(tunnel grooves) in correlation with the processed signal is found to produce a much redundant results with an error rate of 0.02. | J.Rabi T.Balusamy R.Raj Jawahar | 2019 | Defence Technology(防务技术)2019，15，6： | 4 |
| 6 | Effects of linagliptin and liraglutide on glucose- and angiotensin Ⅱ-induced collagen formation and cytoskeleton degradation in cardiac fibroblasts in vitro显示文摘瞄准:象 Glucagon 一样 peptide-1 (GLP-1 ) 收缩筋和 dipeptidyl peptidase-4 (DPP-4 ) 禁止者不能仅仅降低血葡萄糖层次,而且减轻在心肌的局部缺血和高血压以后的心脏的改变。在现在的学习,我们在葡萄糖上调查了一个 DPP-4 禁止者(linagliptin ) 和 GLP-1 使活跃之物(liraglutide ) 的效果 -- 并且血管收缩素 II (Ang II ) 在 vitro 在心脏的成纤维细胞导致了骨胶原形成和细胞骨架重组,并且阐明相关 mechanisms.Methods:心脏的成纤维细胞从 6-week-old C57BL/6 老鼠的心被孤立,然后为 24 h 暴露了到葡萄糖或 Ang II 的不同集中。fibrotic 的表达式发信号(象 ERK1/2 和 NF-κ 一样的 fibronectin, collagen-1, -3 和 -4), ;在成纤维细胞的 B-p65 用西方的弄污被检验试金。F 肌动朊降级在在成纤维细胞的共焦的显微镜与玫瑰精 phalloidin.Results 染色了的转换激光下面被检测:葡萄糖(1-40 mmol/L ) 和 Ang II (10 −8-10−5 mol/L ) dose-dependently 增加了 fibronectin,骨胶原, phospho-ERK1/2 和 phospho-NF-κ 的表示;在心脏的成纤维细胞的 B-p65。葡萄糖的高集中(≥ 40 mmol/L ) 并且 Ang II (≥ 10 −6 mol/L ) 引起了 F 肌动朊(更少的集会 F 肌动朊纤维和更多拆卸纤维) 的重要降级。ERK1/2 禁止者 U0126 (10 μ mol/L ) 并且 NF-κ B 禁止者 JSH-23 (10 μ mol/L ) 两个显著地压制了葡萄糖 -- 并且血管收缩素在心脏的成纤维细胞的导致 II 的 fibronectin 和骨胶原表情。而且,有 liraglutide (10-100 nmol/L ) 的预告的处理或 linagliptin (3 和 30 nmol/L ) 显著地减少了葡萄糖 -- 并且 fibrotic 信号, phospho-ERK1/2 和 phospho-NF-κ 的 Ang 导致 II 的表示;在心脏的成纤维细胞的 B-p65。而且,然而,有 liraglutide (30 nmol/L ) 的预告的处理或 liraglutide (100 nmol/L ) 显著地禁止了导致葡萄糖的 F 肌动朊降级仅仅 liraglutide 禁止的 Ang 导致 II 的 F 肌动朊 degradation.Conclusion:Linagliptin 和 liraglutide 禁止葡萄糖 -- 并且在经由 ERK/NF-κ 的激活的心脏的成纤维细胞的 Ang 导致 II 的骨胶原形成; B/pathway。Linagliptin 和 liraglutide 显著地也在心脏的成纤维细胞,而是仅仅 liraglutide 禁止导致葡萄糖的 F 肌动朊降级禁止 Ang 导致 II 的 F 肌动朊降级。 | Xian-wei WANG Fen-xi ZHANG Fen YANG Zu-feng DING Nidhi AGARWAL Zhi-kun GUO Jawahar L MEHTA | 2016 | Acta Pharmacologica Sinica2016，37，10： | 3 |
| 7 | Regulatory role of vitamin D receptor gene variants of Bsm I,Apa I,Taq I,and Fok I polymorphisms on macrophage phagocytosis and lymphoproliferative response to mycobacterium tuberculosis antigen in pulmonary tuberculosis显示文摘 | Selvaraj P Chandra G Jawahar MS | 2004 | J Clin Immunol2004，24，5： | 1 |
| 8 | Role of stereotactic radiosurgery as a primary treatment option in the management of newly diagnosed multiple (3-6) intracranial metastases显示文摘 | Jawahar A Shaya M Campbell P | 2005 | Surg Neurol2005，64，3： | 1 |
| 9 | Upregulation of endothelial receptor for oxidized LDL (Lox-1) by oxidized LDL and implications in apoptosis of human coronary artery endothelial cells: evidonce from use of antisense Lox mRNA and chemical in hibitors显示文摘 | Li D Jawahar L | 2000 | Arterioscler Thromb Vase Biol2000，19，4： | 1 |
| 10 | Toward a Descriptive Stakeholder Theory: An Organizational Life Cycle Approach显示文摘 | JAWAHAR I McLAUGHLIN G | 2001 | Academy of Management Review2001，，26： | 1 |
| 11 | Examining the relationship between work-family conflict and organisational role stress on life sat- isfaction among women professionals in Chennai city显示文摘 | Jawahar KR Muzhumathi R | 2012 | Eur J Bus Manage2012，4，15： | 1 |
| 12 | The significance of platelet-vessel wall prostag landing equilibriwm during exercise-Induced stress显示文摘 | Jawahar | 1983 | AM Heart J1983，105，6： | 1 |
| 13 | Assessment of pain control, quality of life, and predictors of success after gamma knife surgery for the treatment of trigeminal neuralgia 显示文摘 | Jawahar A Wadhwa R Berk C | 2005 | Neurosurg Focus2005，18，5： | 1 |
| 14 | Total disc arthroplasty does not affect the incidence of adjacent segment degeneration in cervical spine:results of 93 patients in three prospective randomized clinical trials显示文摘 | Jawahar A Cavanaugh DA Kerr EJ 3rd | 2010 | Spine J2010，10，12： | 1 |
| 15 | Development and Evaluation of a PCR Based Assay for Detection of the Toxic Dinoflagellate, Gymnodinium catenatum(Graham) in Ballast Water and Environmental Samples显示文摘 | Jawahar G. Patil Rasanthi M. Gunasekera Bruce E. Deagle Nicholas J. Bax Susan I. Blackburn | 2005 | Biological Invasions2005，，6： | 1 |
| 16 | Total disc arthroplasty does not affect the incidence of adjacent segment degeneration in cervical spine:results of 93 patients in three prospective randomized clinical trials 显示文摘 | Jawahar A Cavanaugh DA Kerr EJ 3rd | 2010 | Spine J2010，10，4： | 1 |
| 17 | Differential colonization of wheat cultivars by two biotypes of Russian wheat aphid (Homoptera: Aphididae)显示文摘易受影响并且抵抗小麦栽培变种, Triticum aestivum L,被介绍给俄语的小麦蚜虫的二遗传因子型, Diuraphis noxia (Mordvilko ) ,在到试金的多重选择测试他们的相对可接受程度是寄植物。apterae (第三和第四中间形态) 和有翼的成年人在 22 ±在不同栽培变种联合在二叶的阶段被提供植物 1 ℃并且 16:8 (L:D ) 小时光周期。Apterae 在测试植物的一个圆的中心被免除 Petri 盘子,而 alatae 从在在排安排的植物上安定的一个成熟蚜虫殖民地分散了。alatae 和两遗传因子型的无翅的美女乐意地开拓殖民地于测试的所有栽培变种:“ 2137 ”,“ Akron ”“ Ankor ”“暂停”“ Jagger ”“大草原红”“ Stanton ”“ TAM107 TAM110 Trego Yuma 和 Yumar1 apterae 回答了的更少遗传因子型(安定并且喂) 在包含的联合更抵抗(Dn4-expressing) 和表示 Dny ) 栽培变种,与联合相比,那有少数。颠倒为遗传因子型 2 apterae 是真的;更多的蚜虫在包含表示栽培变种的 Dn4 的最大的数字的联合反应了。栽培变种的 Differentialcolonization 在仅仅一联合被观察,在哪个遗传因子型在更大的数字的 2 apteraecolonized Akron 和 Yumar 一个分开的实验比他们做 Stanton 和 Yuma,证实了那,在群袭以后的 48 个小时,放弃的 2 apterae 比 Yumar 的植物 Yuma 种的更多的遗传因子型。这微分回答由于在 Yuma 包括 Dn4 表示的缺乏的 two'near isogenic' 线之间的基因差别是可能的。有 alatae 的选择测试没在测试的任何联合由任何一个遗传因子型导致栽培变种殖民的微分率。这些结果建议年轻小麦植物看起来缺乏任何有意义的 antixenosistoward D。noxia 尽管蚜虫看起来察觉,并且有时对作出回应,在栽培变种适用性的某些差别。 | JAWWAD A. QURESHI JAWAHAR L. JYOTI J. P. MICHAUD | 2005 | Insect Science2005，12，5： | 1 |
| 18 | Threshold Accepling and Ant-colony Optimization Algorithms for Scheduling M-machine Flow Shops with Lot Streaming显示文摘 | Marimuthu S Ponnambalam S G Jawahar N | 2009 | Journal of Materials Processing Technology2009，209，2： | 1 |
| 19 | Symptomatic adjacent segment disease after cervical total disc replacement:re-examining the clinical and radiological evidenee with established criteria显示文摘 | Nunley PD Jawahar A Cavanaugh DA | 2013 | Spine J2013，13，1： | 1 |
| 20 | A systematic review of pharmacological pain management in multiple sclerosis 显示文摘 | Jawahar R Oh U Yang S | 2013 | Drugs2013，73，15： | 1 |
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