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| 1 | Hospitalized ulcerative colitis patients have an elevated risk of thromboembolic events显示文摘AIM: To compare thromboembolism rates between hospitalized patients with a diagnosis of ulcerative colitis and other hospitalized patients at high risk for thromboembolism. To compare thromboembolism rates between patients with ulcerative colitis undergoing a colorectal operation and other patients undergoing colorectal operations. METHODS: Data from the National Hospital Discharge Survey was used to compare thromboembolism rates between (1) hospitalized patients with a discharge diagnosis of ulcerative colitis and those with diverticulitis or acute respiratory failure, and (2) hospitalized patients with a discharge diagnosis of ulcerative colitis who underwent colectomy and those with diverticulitis or colorectal cancer who underwent colorectal operations. RESULTS: Patients diagnosed with ulcerative colitis had similar or higher rates of combined venous thromboembolism (2.03%) than their counterparts with diverticulitis (0.76%) or respiratory failure (1.99%), despite the overall greater prevalence of thromboembolic risk factors in the latter groups. Discharged patients with colitis that were treated surgically did not have signifi cantly different rates of venous or arterial thromboembolism than those with surgery for diverticulitis or colorectal cancer.CONCLUSION: Patients with ulcerative colitis who do not undergo an operation during their hospitalization have similar or higher rates of thromboembolism than other medical patients who are considered to be high risk for thromboembolism. | Jennifer Y Wang Jonathan P Terdiman Eric Vittinghoff Tracy Minichiello Madhulika G Varma | 2009 | World Journal of Gastroenterology2009，15，8： | 8 |
| 2 | BCL2 inhibits cell adhesion, spreading, and motility by enhancing actin polymerization显示文摘BCL2 最好作为多功能的 anti-apoptotic 蛋白质被知道。然而,很少在房间粘合剂和活动性事件对它的角色被知道。这里,我们证明 BCL2 可以在房间粘附的规定起一个作用,传播,并且活动性。BCL2 什么时候是在有教养的鼠科、人的房间线,传播的房间,粘附,和活动性的 overexpressed,被损害。与这些结果一致, Bcl2 的损失导致了在 Bcl2 空的老鼠观察的更高的活动性与野类型相比的胚胎的成纤维细胞(MEF ) 房间。房间粘附和活动性的 BCL2 规定的机制可以包含包含 BCL2,肌动朊,和 gelsolin 的建筑群的形成,它看起来机能上地减少 gelsolin 的切断的活动。我们观察到从 overexpressed BCL2 提高了的 MCF-7 和 NIH3T3 房间的 lysate 肌动朊聚合在在 vitro 试金没有房间。BCL2 和 F 肌动朊的共焦的 immunofluorescent 本地化在一致地传播期间证明 BCL2 的那增加的表情导致了增加的 F 肌动朊聚合。因此, BCL2 和 gelsolin 建筑群的形成(它可能包含另外的蛋白质) 看起来在房间粘附和移植的规定起一个关键作用。与癌症转移给房间活动性的确定的关联,这结果可以解释在一些肿瘤房间类型的 BCL2 的表示为什么为转移减少潜力并且与改进耐心的预后被联系。 | Hengning Ke Vandy I Parron Jeff Reece Jennifer Y Zhang Steven K Akiyama John E French | 2010 | Cell Research2010，20，4： | 3 |
| 3 | Liver-specific deletion of mechanistic target of rapamycin does not protect against acetaminophen-induced liver injury in mice显示文摘Background:Acetaminophen(APAP)overdose can cause liver injury and liver failure,which is one of the most common causes of drug-induced liver injury in the United States.Pharmacological activation of autophagy by inhibiting mechanistic target of rapamycin(mTOR)protects against APAP-induced liver injury likely via autophagic removal of APAP-adducts and damaged mitochondria.In the present study,we aimed to investigate the role of genetic ablation of mTOR pathways in mouse liver in APAP-induced liver injury and liver repair/regeneration.Methods:Albumin-Cre(Alb-Cre)mice,mTOR^(f/f) and Raptor^(f/f) mice(C57BL/6J background)were crossbred to produce liver-specific mTOR knockout(L-mTOR KO,Alb Cret/-,mTOR^(f/f))and liver-specific Raptor KO(L-Raptor,Alb Cret/-,Raptor^(f/f))mice.Alb-Cre littermates were used as wild-type(WT)mice.These mice were treated with APAP for various time points for up to 48 h.Liver injury,cell proliferation,autophagy and mTOR activation were determined.Results:We found that genetic deletion of neither Raptor,an important adaptor protein in mTOR complex 1,nor mTOR,in the mouse liver significantly protected against APAP-induced liver injury despite increased hepatic autophagic flux.Genetic deletion of Raptor or mTOR in mouse livers did not affect APAP metabolism and APAP-induced c-Jun N-terminal kinase(JNK)activation,but slightly improved mouse survival likely due to increased hepatocyte proliferation.Conclusions:Our results indicate that genetic ablation of mTOR in mouse livers does not protect against APAP-induced liver injury but may slightly improve liver regeneration and mouse survival after APAP overdose. | Hua Sun Hong-Min Ni Jennifer M.McCracken Jephte Y Akakpo Sam Fulte Tara McKeen Hartmut Jaeschke Hua Wang Wen-Xing Ding | 2021 | Liver Research2021，5，2： | 3 |
| 4 | Identification of △^5-desaturase from mortierella alpina by heterologous extrusion in bakers' yeast and canola显示文摘 | Deborah S K Jennifer M T Huang Y S | 1998 | J Biol Chem1998，273，29： | 1 |
| 5 | Cloning of △^12-desaturases from Mortierella alpina and recombinant production of γ-linolenic acid in Sacharomyces cerevisae显示文摘 | Huang Y SH Sunita C Jennifer M T | 1999 | Lipids1999，34，7： | 1 |
| 6 | A New Classification System Predictive of Complications in Surgically Treated Pediatric Humeral Lateral Condyle Fractures 显示文摘 | Jennifer MW Sara G Scott Y | 2009 | J Pediatr Orthop2009，29，6： | 1 |
| 7 | TGF-β stimulation and inhibition of cell proliferation:new mechanistic insights 显示文摘 | Harold L Moses Edmund Y Yang Jennifer A Pletepol | 1990 | Cell1990，63，： | 1 |
| 8 | Wireless sensor network survey显示文摘 | Jennifer Y Biswanath M Dipak G | 2008 | Computer Networks2008，52，12： | 1 |
| 9 | Steroids are required for epidermal cell fate establishment in Arabidopsis roots显示文摘 | Kavitha T Kuppusamy Andrew Y Chen Jennifer L Nemhauser | 2009 | Proceedings of the National Academy of Sciences of the United States of America2009，，106： | 1 |
| 10 | Wireless sensor network survey 显示文摘 | Jennifer Y Biswanath M Dipak G | 2008 | Computer Networks2008，52，12： | 1 |
| 11 | Cloning of Δ12-desaturases from Mortierella alpina and recombinant production of γ-linolenic acid in Saccharomyces cerevisiae 显示文摘 | Huang Y SH Sunita C Jennifer M T | 1999 | Lipids1999，34，7： | 1 |
| 12 | Growth of Cu2O nanocubes from seed5 in microwells 显示文摘 | Jennifer Y | 2005 | Nanoseape2005，2，1： | 1 |
| 13 | Pletepol TGF-β stimulation and inhibition of cell proliferation: New Mechanistic Insights显示文摘 | Harold L M Edmund Y Y Jennifer A | 1990 | Cell1990，63，： | 1 |
| 14 | Wireless sensor network survey显示文摘 | Jennifer Y Biswanath M Dipak G | | 0，，12： | 1 |
| 15 | A tumor-specific kinase activity regulate the viral death protein apoptin显示文摘 | JENNIFER L ZHANG Y H REMCO IJM | 2002 | J Bio Chem2002，277，50： | 1 |
| 16 | Wireless Sensor Net- work Survey 显示文摘 | JENNIFER Y BISWANATH M DIPAK G | 2008 | Computer Networks2008，52，22： | 1 |
| 17 | Highly prolific Booroola sheep have a mutation in the intracellular kinase domain of bone morphogenetic protein IB receptor (ALK-6) that is expressed in both oocytes and granulosa cells显示文摘 | THERESA WILSON WU X Y JUENGEL JENNIFER L | 2001 | Biol Reprod2001，64，4： | 1 |
| 18 | Psychosocial stress during pregnancy显示文摘 | Woods SM Jennifer LM Guo Y | 2010 | Am J Obstet Gynecol2010，202，61： | 1 |
| 19 | Rhizoremediation of trichloroethylene by a recombinant, root-colonizing pseudomonas fluorescens strain expressing toluene ortho-monooxygenase constitutively 显示文摘 | Dennis C Y JENNIFER A A THOMAS K W | 1998 | Appl & Environ Microbiol1998，64，1： | 1 |
| 20 | Identification of 16S rRNA methylase-producing Acinetobacter baumannii clinical strains in North America显示文摘 | Yohei D Jennifer M A Kunikazu Y | 2007 | Antimicrob Agents Chemother2007，51，11： | 1 |
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