|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Effects of basic fibroblast growth factor on angiogenin expression and cell proliferation in H7402 human hepatoma cells显示文摘Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide. Basic fibroblast growth factor (bFGF), which is highly expressed in developing tissues and malignant cells, regulates cell growth, differentiation, and migration. Its expression is essential for the progression and metastasis of HCC. This study aims to investigate the effects of bFGF on the expression of angiogenin, another growth factor, which plays an important role in tumor angiogenesis, and on cell proliferation in H7402 human hepatoma cells. The bFGF sense cDNA or antisense cDNA was stably transfected into H7402 cells. Genomic DNA PCR analysis demonstrated that human bFGF sense cDNA or antisense cDNA was inserted into the genome. Furthermore, the expression of bFGF and angiogenin was examined by RT-PCR and Western blot assays. MTT and colony formation assays were employed to determine cell proliferation. Stable bFGF over-expressing and under-expressing transfectants were successfully established. Expression of angiogenin was decreased in the over-expressing bFGF cells (sense transfectants) and was increased in the under-expressing bFGF cells (antisense transfectants). Cell proliferation increased in the bFGF sense transfectants and decreased in the bFGF antisense transfectants. These results demonstrated that the endogenous bFGF may not only negatively regulate the angiogenin expression but also contribute to the overall cell proliferation in H7402 human hepatoma cells. This study may be helpful in finding a potential therapeutic approach to HCC. | Ji Wang, Jianli Yang, Dawei Yuan, Jun Wang, Jia Zhao, Li Wang* Institute of Genetics and Cytology, Northeast Normal University, Changchun 130024, China | 2009 | Journal of Genetics and Genomics2009，36，7： | 4 |
| 2 | Analysis of Mitochondrial DNA from the Ancient Tombs of Turfan显示文摘MtDNA was successfully extracted from ten individual bones (femurs) in the tombs of ancient Jushi in Turfan basin, dated back to the year about 3 000-2 500 years ago. By means of four overlapping primers, we got nucleotide sequence of the 218bp length. Ancient mtDNA was analyzed by the sequencing of hypervariable region Ⅰ of the mtDNA control region. The result shows that 9 haplotypes with 24 polymorphic sites were obtained. The phylogenetic analysis indicated that Mongolians and Altai are the population genetically closest to the Jushi groups and Jushi mtDNA pool being an admixture of eastern Asian and European lineages. So our preliminary data imply that an ancient mingling of Euro-Asian population had existed in Turfan basin prior to the early Iron Age. | CUI Yin-qiu 1,2, DUAN Ran-hui 1, LIU Shu-bai 1, JI Chao-neng 2,ZHU Hong 1, LI Wei 1, MAO Yu-min 2 and ZHOU Hui 1,**1. Ancient DNA Laboratory, College of Life Science, Jilin University, Changchun 130023,P. R. China 2. State Key Laboratory of Genetic Engineering, School of Life Science,Fudan University, Shanghai 200433, P. R. China | 2002 | Chemical Research in Chinese Universities2002，18，4： | 3 |
| 3 | Biosynthesis of Unsaturated Fatty Acids via Mortierella Isabellina Cultivated in a Medium Containing Butanol显示文摘Mortierella isabellina was found to accumulate large amounts of unsaturated fatty acids when it was grown in a medium containing butanol(5 g/L) and yeast extract(10 g/L) and cultivated at 25 ℃ for 5 d during which additional feeding butanol of 2 g/L was fed after being cultivated for 48 h . The resultant mycelial lipids accounted for 40 1% of the dry mycelia, while about 34% of butanol in the medium was converted. The mycelial lipids contained four kinds of unsaturated fatty acids, i.e ., palmitoleic(4 9%), oleic(54 1%), linoleic(10 4%) and linolenic(5 4%) acids. Those accounted for 74 8% of the total fatty acids. The effects of the culture conditions, such as cultivation temperature, initial pH of the medium and additional feeding butanol in the course of cultivation, on the production of mycelial lipids by M. isabellina were studied. | XIAN Mo 1, YAN Ji chang 2, CHENG Tie xin 1, KANG Yi jian 3, LI Wen xing 1, BI Ying li 1 and ZHEN Kai ji 1** 1. College of Chemistry, Jilin University, Changchun 130023, P. R. China 2. College of Chemistry, Northeast Normal University, C | 2002 | Chemical Research in Chinese Universities2002，18，3： | 3 |
| 4 | The Essential Spectrum and Banach Reducibility of Operator Weighted Shifts | Jue Xian LI Department of Mathematics,Jilin University,Changchun 130023,P.R.China Department of Mathematics.Liaoning University.Shenyang 110036.P.R.China E-mail:Lixli@263.netYou Qing JI Shan Li SUN Departmerit of Mathematics.Jilin University,Changchun 130023.P.R.China | 2001 | Acta Mathematica Sinica,English Series2001，17，3： | 3 |
| 5 | Study on Effect of Gd (III) Speciation on Ca (II) Speciationin Human Blood Plasma by Computer Simulation显示文摘Ca (II) speciation and effect of Gd (III) speciation on Ca (II) speciation in human blood plasma were studied by computer simulation. [CaHCO3]+ is a predominant compound species of Ca (II). Gd (III) can compete with Ca (II) for biological molecules. The presence of Gd (III) results in a increase of concentration of free Ca (II) and a decrease of concentration of Ca (II) compounds. | Yue WANG, Xing LU, Shu Yun WANG, Jing Fen HAN, Kui Yue YANG, Chun Ji NIU*, Jia Zuan NI Key Laboratory of Rare Earth Chemistry and Physics, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022 | 2001 | Chinese Chemical Letters2001，12，2： | 2 |
| 6 | Efficacy and safety of blood pricking and cupping for treating nonspecific low back pain: a systematic review and Meta-analysis显示文摘OBJECTIVE: To systematically evaluate the efficacy and safety of blood pricking and cupping in the treatment of nonspecific low back pain(NLBP).METHODS:The China National Knowledge Infrastructure Database(CNKI), Wanfang Med Online Database(Wanfang), China Science and Technology Journal Database(VIP), Pub Med, Web of Science,EMBase, and Cochrane Library databases were searched from inception to October 31, 2021, for randomized controlled trials(RCTs) of the treatment of NLBP by blood pricking and cupping. The quality of each included study was evaluated according to the Cochrane Systematic Assessor’s Manual evaluation criteria, while the Meta-analysis was performed using RevMan 5.4software.RESULTS: A total of 13 thirteen RCTs included a total of 1088 subjects. The visual analogue scale scores indicated that blood pricking and cupping was superior to the other treatments at relieving NLBP pain [mean difference(MD) =-1.43;95% confidence interval(CI):-2.31 to 0.54;Z = 3.15;P = 0.002). The Oswestry Disability Index score of blood pricking and cupping was superior to that of the control group in terms of improving NLBP dysfunction(MD =-6.25;95%CI:-8.37 to-4.31);Z = 5.77;P < 0.000 01). 7 RCTs mentioned no adverse reactions, while one study reported mild syncope [7%(n = 3), all in the 17-30 years group] that was gradually relieved after rest. CONCLUSIONS: Blood pricking and cupping therapy can safely and effectively reduce pain and improve functional impairment in patients with NLBP. However, this study included limited high-grade studies with a small overall sample size;therefore, further high-quality large-sample RCTs are needed to improve clinical evidence. | XIE Chaoju SUN Zhangyin JI Changchun YANG Jinsheng | 2022 | Journal of Traditional Chinese Medicine2022，42，6： | 2 |
| 7 | Magnetic functionalised carbon nanotubes as drug vehicles for cancer lymph node metastasis treatment显示文摘 | Feng Yang Chen Jin Dong Yang Yongjian Jiang Ji Li Yang Di Jianhua Hu Changchun Wang Quanxing Ni Deliang Fu | 2011 | European Journal of Cancer2011，，12： | 2 |
| 8 | Impact of Interleukin-28B Polymorphism on Response to Treatment in Chinese Hepatitis C Patients显示文摘The candidate polymorphism rs12979860 of interleukin 28B(IL28B) gene was genotyped by means of polymerase chain reaction(PCR) amplification and direct PCR sequencing, and then the role of this single nucleotide polymorphism(SNP) in the response to the treatment of 172 Chinese patients with hepatitis C virus(HCV) chronic infection was analyzed. The results show that the frequencies of major homozygotes(CC) and heterozygotes(CT) of rs12979860 were 0.84 and 0.16, respectively, and the minor homozygotes(TT) wasn't found in this cohort. A highly significant association was found between the CC genotype and sustained virological response(SVR) in HCV geno type 1 infected patients(P<0.001) but not in HCV non-genotype 1 infected patients. In addition, a strong association was found between rs12979860 CC genotype and rapid virological response(RVR) in both HCV genotype 1 infected patients(P<0.001) and non-genotype 1 infected patients(P<0.001). Taken together, these results indicate that IL28B polymorphism plays a key role in response to hepatitis C therapy in Chinese patients. Combine assessment of clinical predictors and the IL28B polymorphism may be beneficial to the individualized treatment decision in Asian chronic hepatitis C(CHC) patients. | Lü Jian-nan1, WANG Song2, XU Yan1, ZHANG Man-hua1, SIQING Tunala1, JI Shang-wei1, JIAO Jian1, WANG Xu1 and WANG Jiang-bin1 1. China-Japan Union Hospital of Jilin University, Changchun 130033, P. R. China 2. The Second Hospital of Jilin University, Changchun 130041, P. R. China | 2012 | Chemical Research in Chinese Universities2012，28，1： | 2 |
| 9 | Two Ultraviolet Radiation Datasets that Cover China显示文摘Ultraviolet(UV) radiation has significant effects on ecosystems, environments, and human health, as well as atmospheric processes and climate change. Two ultraviolet radiation datasets are described in this paper. One contains hourly observations of UV radiation measured at 40 Chinese Ecosystem Research Network stations from 2005 to 2015. CUV3 broadband radiometers were used to observe the UV radiation, with an accuracy of 5%, which meets the World Meteorology Organization's measurement standards. The extremum method was used to control the quality of the measured datasets. The other dataset contains daily cumulative UV radiation estimates that were calculated using an all-sky estimation model combined with a hybrid model. The reconstructed daily UV radiation data span from 1961 to 2014. The mean absolute bias error and root-mean-square error are smaller than 30% at most stations, and most of the mean bias error values are negative, which indicates underestimation of the UV radiation intensity. These datasets can improve our basic knowledge of the spatial and temporal variations in UV radiation. Additionally, these datasets can be used in studies of potential ozone formation and atmospheric oxidation, as well as simulations of ecological processes. | Hui LIU Bo HU Yuesi WANG Guangren LIU Liqin TANG Dongsheng JI Yongfei BAI Weikai BAO Xin CHEN Yunming CHEN Weixin DING Xiaozeng HAN Fei HE Hui HUANG Zhenying HUANG Xinrong LI Yan LI Wenzhao LIU Luxiang LIN Zhu OUYANG Boqiang QIN Weijun SHEN Yanjun SHEN Hongxin SU Changchun SONG Bo SUN Song SUN Anzhi WANG Genxu WANG Huimin WANG Silong WANG Youshao WANG Wenxue WEI Ping XIE Zongqiang XIE Xiaoyuan YAN Fanjiang ZENG Fawei ZHANG Yangjian ZHANG Yiping ZHANG Chengyi ZHAO Wenzhi ZHAO Xueyong ZHAO Guoyi ZHOU Bo ZHU | 2017 | Advances in Atmospheric Sciences2017，34，7： | 2 |
| 10 | Novel nanocrystalline PdNi alloy catalyst for methanol and ethanol electro-oxidation in alkaline media显示文摘 | Zhen Qi Haoran Geng Xiaoguang Wang Changchun Zhao Hong Ji Chi Zhang Junling Xu Zhonghua Zhang | 2011 | Journal of Power Sources2011，，： | 1 |
| 11 | A Theoretical Study of Nonlinear Second-Order Optical Properties of Substituted Silanes显示文摘ATheoreticalStudyofNonlinearSecond┐OrderOpticalPropertiesofSubstitutedSilanes*SupportedbytheNationalNaturalScienceFoundationo... | FENG Ji kang, WANG Hai chuan, WEI Jia you, XIAO Chang yong XU Wen guo and SUN Chia chung (Department of Chemistry and Institute of Theoretical Chemistry, Jilin University, Changchun, 130023) | 1997 | Chemical Research in Chinese Universities1997，13，1： | 1 |
| 12 | Study of the Contact Force in Free-form Surfaces Compliant EDM Polishing by Robot显示文摘With an elastic negative pole being driven by ultra so nic vibration and being moved along the surface of work-piece compliantly by ro bot, a new kind of effective EDM, the compliant EDM, cuts the electrically condu ctive materials away and polishes work-piece of free-form surface. The study o f the contact force between the end of polishing tool and the surface of work-p iece is the key for the compliant EDM to study its cutting mechanism and to make better use of it. This paper makes a model for the contact force and verifies i t by experiments and simulation based on the theory of elastic body kinetics and dynamic stress concentration. The research work shows that this contact force i s caused by both the electrical impulsion of EDM and the mechanical force of ult rasonic vibration, the discharge frequency of compliant EDM has a much more clos er connection with the vibration frequency of polishing tool rather than the fre quency of ultrasonic vibration. | ZHAN Jian-ming 1, ZHAO Ji 2, XU Shu-xin 1, ZHU Pei-xi ng 1 (1. College of Mechanical Science and Engineering, Jilin University, Changchun 130022, China 2. Office of Education Administration, Jilin University, Changchun 130012, Chin a) | 2002 | 厦门大学学报(自然科学版)2002，41，S1： | 1 |
| 13 | Study on the Surface Photovoltage and Fluorescence Properties of N, N-Bis(4-aminopheny)-1, 4 quinonenediimine Doped with H_4SiW_(12)O_(40)显示文摘Aniline oligomer composite materials using heteropolyacid H4SiW12O40 as dopant was synthesized, and the effect of the doping concentration on the photoluminescence and surface photovoltaic properties were investigated. | Jian GONG, Ji Hua YANG, Xiu Jun CUI, Zhong Min SU, Lun Yu QU* Faculty of Chemistry, Northeast Normal University, Changchun 130024 | 2002 | Chinese Chemical Letters2002，13，3： | 1 |
| 14 | SEPARATION OF FORMIC ACID-WATER AZEOTROPIC MIXTURES BY MEMBRANE DISTILLATION显示文摘The azeotrope disappeared when the formic acid-water mixtureswere treated by membrane distillation. Membrane distillation were used forseparation of formic acid-water azeotropic mixtures for the first time. | Ying KONG Yong Lie WU Ji Ping XU Changchun Institute of Applied Chemistry, Academia Sinica, Changchun 130022 | 1992 | Chinese Chemical Letters1992，3，6： | 1 |
| 15 | Novel Raney-like nanoporous Pd catalyst with superior electrocatalytic activity towards ethanol electro-oxidation显示文摘 | Xiaoguang Wang Weimin Wang Zhen Qi Changchun Zhao Hong Ji Zhonghua Zhang | 2011 | International Journal of Hydrogen Energy2011，，3： | 1 |
| 16 | Preparation and Properties of Water-based Conducting Polyaniline显示文摘IntroductionInthepastdecade,conjugatedconductingpolymerslikepolyaniline,polythiopheneandpolypyrolehavereceivedconsiderableate... | WANG Xian hong, GENG Yan hou, YU Lei, SUN Zai cheng Li Ji, JING Xia bin ** and WANG Fo song (Polymer Chemistry Lab, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022) LEE Chang jin and RHEE Suh bo | 1998 | Chemical Research in Chinese Universities1998，14，3： | 1 |
| 17 | Studies on the Factors Affecting on Somatic Embryogenesis in Soybean显示文摘The effects of the concentration of MS micro salts, 2,4-dichlorophenoxyacetic acid (2,4-D), 3-naphthalene acetic acid (NAA), proline and adenine on callus formation and somatic embryogenesis were investigated using orthogonal design with immature cotyledons of soybean. The results showed that the role of concentration of micro salts on frequency of callus formation and somatic embryogenesis were significant. MS medium supplemented with 2,4-D, NAA, proline and adenine could stimulate callus formation. The concentration of MS micro salts possessed obvious effects on somatic embryogenesis of soybean. The category and concentration of the hormone needed were different among genotypes when embryogenesis were induced. | WANG Ping, WANG Gang, LU Wen-he, JI Jing and YANG Qing-kai(Laboratory of Plant Molecular Biology, The Research Center of Plant Genetic Engineering, The Quartermaster University of PLA , Changchun 130062 , P.R. China Agricultural College , Northeast Agricultural University, Harbin 150030 , P.R. China) | 2002 | Agricultural Sciences in China2002，1，9： | 1 |
| 18 | Synthesis of Novel Cyclic Aryl Ether Thioether Ketone (Sulfone) Oligomers显示文摘Two kinds of macrocyc1ic oligomers containing aromatic sulfide linkages have been synthesized by the solution polycondensation in high yield. The cyclic compounds were characterized by 1H and 13C NMR, by and MALDI -TOF MS. | Ying Hua QI Tian Lu CHEN Hong Yan JIANG Hai Bo LI Ji Ping XU (Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022) | 1998 | Chinese Chemical Letters1998，9，7： | 1 |
| 19 | Preparation and characterization of multiresponsive polymer composite microspheres with core–shell structure显示文摘 | Jie Cai Jia Guo Minglei Ji Wuli Yang Changchun Wang Shoukuan Fu | 2007 | Colloid and Polymer Science2007，，14： | 1 |
| 20 | The race to the nociceptor: mechanical versus temperature effects in thermal pain of dental neurons显示文摘The sensing of hot and cold stimuli by dental neurons differs in several fundamental ways. These sensations have been characterized quantitatively through the measured time course of neural discharge signals that result from hot or cold stimuli applied to the teeth of animal models. Although various hypotheses have been proposed to explain the underlying mechanism, the ability to test competing hypotheses against experimental recorded data using biophysical models has been hindered by limitations in our understanding of the specific ion channels involved in nociception of dental neurons. Here we apply recent advances in established biophysical models to test the competing hypotheses. We show that a sharp shooting pain sensa-tion experienced shortly following cold stimulation cannot be attributed to the activation of thermosensitive ion channels, thereby falsifying the so-called neuronal hypothesis,which states that rapidly transduced sensations of coldness are related to thermosensitive ion channels. Our results support a central role of mechanosensitive ion channels and the associated hydrodynamic hypothesis. In addition to the hydrodynamic hypothesis, we also demonstrate that the long time delay of dental neuron responses after hot stimulation could be attributed to the neuronal hypothesis—that a relatively long time is required for the temperature around nociceptors to reach some threshold. The results are useful as a model of how multiphysical phenomena can be combined to provide mechanistic insight into different mechanisms underlying pain sensations. | Min Lin Fusheng Liu Shaobao Liu Changchun Ji Ang Li Tian Jian Lu Feng Xu | 2017 | Acta Mechanica Sinica2017，33，2： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员