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| 1 | Washed microbiota transplantation vs.manual fecal microbiota transplantation:clinical findings,animal studies and in vitro screening显示文摘Fecal microbiota transplantation(FMT)by manual preparation has been applied to treat diseases for thousands of years.However,this method still endures safety risks and challenges the psychological endurance and acceptance of doctors,patients and donors.Population evidence showed the washed microbiota preparation with microfiltration based on an automatic purification system followed by repeated centrifugation plus suspension for three times significantly reduced FMT-related adverse events.This washing preparation makes delivering a precise dose of the enriched microbiota feasible,instead of using the weight of stool.Intraperitoneal injection in mice with the fecal microbiota supernatant obtained after repeated centrifugation plus suspension for three times induced less toxic reaction than that by the first centrifugation following the microfiltration.The toxic reactions that include death,the change in the level of peripheral white blood cells,and the proliferation of germinal center in secondary lymphoid follicles in spleen were noted.The metagenomic next-generation sequencing(NGS)indicated the increasing types and amount of viruses could be washed out during the washing process.Metabolomics analysis indicated metabolites with pro-inflammatory effects in the fecal microbiota supernatant such as leukotriene B4,corticosterone,and prostaglandin G2 could be removed by repeated washing.Near-infrared absorption spectroscopy could be served as a rapid detection method to control the quality of the washingprocess.In conclusion,this study for the first time provides evidence linking clinical findings and animal experiments to support that washed microbiota transplantation(WMT)is safer,more precise and more quality-controllable than the crude FMT by manual. | Ting Zhang Gaochen Lu Zhe Zhao Yafei Liu Quan Shen Pan Li Yaoyao Chen Haoran Yin Huiquan Wang Cicilia Marcella Bota Cui Lei Cheng Guozhong Ji Faming Zhang | 2020 | Protein & Cell2020，11，4： | 44 |
| 2 | Root microbiota shift in rice correlates with resident time in the field and developmental stage显示文摘Land plants in natural soil form intimate relationships with the diverse root bacterial microbiota. A growing body of evidence shows that these microbes are important for plant growth and health. Root microbiota composition has been widely studied in several model plants and crops; however, little is known about how root microbiota vary throughout the plant's life cycle under field conditions. We performed longitudinal dense sampling in field trials to track the time-series shift of the root microbiota from two representative rice cultivars in two separate locations in China. We found that the rice root microbiota varied dramatically during the vegetative stages and stabilized from the beginning of the reproductive stage, after which the root microbiota underwent relatively minor changes until rice ripening. Notably, both rice genotype and geographical location influenced the patterns of root microbiota shift that occurred during plant growth. The relative abundance of Deltaproteobacteria in roots significantly increased overtime throughout the entire life cycle of rice, while that of Betaproteobacteria, Firmicutes, and Gammaproteobacteria decreased. By a machine learning approach, we identified biomarker taxa and established a model to correlate root microbiota with rice resident time in the field(e.g., Nitrospira accumulated from 5 weeks/tillering in field-grown rice). Our work provides insights into the process of rice root microbiota establishment. | Jingying Zhang Na Zhang Yong-Xin Liu Xiaoning Zhang Bin Hu Yuan Qin Haoran Xu Hui Wang Xiaoxuan Guo Jingmei Qian Wei Wang Pengfan Zhang Tao Jin Chengcai Chu Yang Bai | 2018 | Science China(Life Sciences)2018，61，6： | 24 |
| 3 | Vanadium recovery from clay vanadium mineral using an acid leaching method显示文摘包括直接酸的沥滤的一种技术,钒降水与碱,钠氢氧化物重新沥滤,杂质由由烤步调整 pH 价值,有铵氯化物的降水钒,和钒 pentoxide 搬迁根据 Xichuan 的特征被建议泥土钒矿物质。影响象温度和硫磺的酸的集中那样的沥滤的钒的因素被调查并且优化。试验性的结果显示 V2O5 的摘录比率能分别地在 3% 的钠氯酸盐比率和 3% 的锰二氧化物比率到达 94% 和 92% 。一个完全化学的降水方法被采用清除并且在酸的沥滤溶液充实钒。X 光检查衍射(XRD ) 模式和钒 pentoxide 的纯净分析显示最后的钒 pentoxide 的纯净能到达 99% 并且遇见标准说明。全部的恢复能到达大约 75% 。这种技术作为与传统的咸烤方法相比有简洁,更少的投资,和更多的环境安全的特征。 | LI Haoran FENG Yali LIANG Jianglong LUO Xiaobing DU Zhuwei | 2008 | Rare Metals2008，27，2： | 23 |
| 4 | Wet and dry deposition fluxes of heavy metals in Pearl River Delta Region(China):Characteristics,ecological risk assessment,and source apportionment显示文摘The atmospheric deposition of heavy metals poses serious risks to the ecological system and human health. To advance our knowledge of atmospheric dry/wet heavy metal deposition in the PRD region, monthly fluxes were examined based on soluble/insoluble fractions of five heavy metal elements(Cu, Pb, Cd, Cr and Zn) in samples collected from January 2014 to December 2015 at Guangzhou(urban) and Dinghushan(suburban) sites. The ratios of wet/dry deposition fluxes indicated that heavy metal deposition was governed by wet deposition rather than dry deposition in the PRD region. Affected by the shifting of the Asian monsoon, wet deposition fluxes exhibited significant seasonal variation between summer monsoon seasons(April to September) and winter monsoon seasons(October to February) in this region. Cd was classified as an extremely strong potential ecological risk based on solubility and the Hakanson ecological risk index. Source contributions to wet deposition were calculated by PMF, suggesting that dust, biomass burning, industries,vehicles, long-range transport and marine aerosol sources in Guangzhou, and Zn fertilizers,marine aerosol sources, agriculture, incense burning, biomass burning, vehicles and the ceramics industry in Dinghushan, were the potential sources of heavy metals. | Lyumeng Ye Minjuan Huang Buqing Zhong Xuemei Wang Qiulan Tu Haoran Sun Chao Wang Luolin Wu Ming Chang | 2018 | Journal of Environmental Sciences2018，30，8： | 20 |
| 5 | Fuzzy logic based coordinated control of battery energy storage system and dispatchable distributed generation for microgrid显示文摘Microgrid is a good option to integrate renewableenergy sources (RES) into power systems. Inorder to deal with the intermittent characteristics of therenewable energy based distributed generation (DG) units,a fuzzy-logic based coordinated control strategy of a batteryenergy storage system (BESS) and dispatchable DGunits is proposed for the microgrid management system(MMS). In the proposed coordinated control strategy, theBESS is used to minimize active power exchange at thepoint of common coupling of the microgrid for grid-connectedoperation, and is used for frequency control for islandoperation. The efficiency of the proposed controlstrategy was tested by case studies using DIgSILENT/PowerFactroy. | Haoran ZHAO Qiuwei WU Chengshan WANG Ling CHENG Claus Nygaard RASMUSSEN | 2015 | Journal of Modern Power Systems and Clean Energy2015，3，3： | 18 |
| 6 | THERMAL RATE TREATMENT AND ITS EFFECT ON MODIFICATION OF Al-Si ALLOYS显示文摘THERMALRATETREATMENTANDITSEFFECTONMODIFICATIONOFAlSiALLOYS①GengHaoran,MaJiaji,BianXoufangCollegeofMaterialsScienceandEnginer... | Geng, Haoran Ma, Jiaji Bian, Xoufang | 1997 | 中国有色金属学会会刊:英文版1997，7，1： | 15 |
| 7 | Single and competitive adsorption affinity of heavy metals toward peanut shell-derived biochar and its mechanisms in aqueous systems显示文摘Converting peanut shells into biochar by pyrolysis was considered an environmentally friendly and efficient method for agricultural solid waste disposal.The properties of peanut shell-derived biochar(PBC)under different temperature and its adsorption capacity of heavy metals were investigated.It was found that PBC400 exhibited the highest cumulative capability for heavy metals elimination in single solute because of its high specific surface area and rich functional groups.Furthermore,the competitive adsorption revealed that PBC had a substantial difference in adsorption affinity from diverse heavy metal ions,sorption capacity decreased as Pb2+>Cu2+>Cd2+>Ni2+>Zn2+,which was lower than in a single solute.The adsorption process using selected biochar was optimized with respect to p H,reaction time,adsorbent dose,and initial concentration of heavy metals.The kinetic data was well fitted with PSO model,and the Langmuir model was adopted for adsorption equilibrium data in both cases of single solutes and mixed solutes for all heavy metals,which indicated that the removal course was primarily explained by monolayer adsorption,and chemical adsorption occupied an important role.Therefore,peanut shells derived biochar could be a potential and green adsorbent for wastewater treatment. | Rui Shan Yueyue Shi Jing Gu YazhuoWang Haoran Yuan | 2020 | Chinese Journal of Chemical Engineering2020，28，5： | 14 |
| 8 | Heterologous biosynthesis of natural product naringenin by co-culture engineering显示文摘Co-culture engineering is an emerging approach for microbial biosynthesis of a variety of biochemicals.In this study,E.coli-E.coli co-cultures were developed for heterologous biosynthesis of the natural product naringenin.The co-cultures were composed of two independent E.coli strains dedicated to functional expression of different portions of the biosynthetic pathway,respectively.The co-culture biosynthesis was optimized by investigating the effect of carbon source,E.coli strain selection,timing of IPTG induction and the inoculation ratio between the co-culture strains.Compared with the monoculture strategy,the utilization of the designed co-cultures significantly improved the naringenin production,largely due to the reduction of metabolic stress,employment of proper hosts for improving pathway enzyme activities,and flexible adjustment of the relative biosynthetic strength between the coculture strains.The findings of this study extend the applicability of co-culture engineering in complex natural product biosynthesis. | Vijaydev Ganesan Zhenghong Li Xiaonan Wang Haoran Zhang | 2017 | Synthetic and Systems Biotechnology2017，2，3： | 13 |
| 9 | Catalpol ameliorates depressive-like behaviors in CUMS mice via oxidative stress-mediated NLRP3 inflammasome and neuroinflammation显示文摘The purpose of the present study was to investigate whether catalpol exhibited neuro-protective effects in chronic unpredictable mild stress(CUMS)mice through oxidative stress-mediated nucleotide-binding oligomerization domain,leucine-rich repeat,and pyrin-domain-containing 3(NLRP3)inflammasome and neuroinflammation. | Wu Haoran Wang Yalim Hu Juntao | 2021 | 解剖学杂志2021，44，S01： | 12 |
| 10 | High Temperature Strain Structures and Quartz C-Axis Fabrics from Mylonitic Rocks in the Ailaoshan-Red River Shear Zone,Yunnan,and Their Tectonic Implication显示文摘Ailaoshan 红的河(ASRR ) 砍地区是考虑了东方西藏的现在的构造框架的主要东南亚洲构造断绝之一。几座变形山岳沿着 shear 地区线性地是分布式的,例如从北方的 Xuelongshan, Diancangshan, Ailaoshan 和到南方的天 Nui 反对 Voi。他们为构造进化忍受证据的很多线东方在在不同构造舞台的不同外壳的层次西藏。争吵仍然沿着 ASRR 在有变态的变丑结构,微观结构和他们的关系上存在。在这,纸详细说明了微结构和 EBSD (电子 Backscattered 衍射) 从沿着 ASRR 的不同山岳的一些高度砍的花岗石的岩石的织物分析被进行。高温度结构和微观结构在 unsheared 片麻岩被保存,在微弱地砍的捕虏体或在高度砍的岩石(糜棱岩) 的一些部分。高温度石英 c 轴织物的几种类型显示出对称的模式或转变从对不均匀的模式对称。前者在在印第安人欧亚的构造相互作用的一个早阶段的地区性的弄短期间被归因于同轴的变丑,后者与从同轴的压缩的转变有关到在让侧面的 post-collisional ASRR 期间砍的 noncoaxial 砍。 | LIU Junlai TANG Yuan XIA Haoran GUO Qiang TRAN My Dung CAO Shuyun WU Hujun WU Wenbin ZHANG Zhaochong ZHAO Zhidan | 2010 | Acta Geologica Sinica(English Edition)2010，84，6： | 12 |
| 11 | Friend or foe: the role of microRNA in chemotherapy resistance显示文摘 | Haoran LI Burton B YANG | 2013 | Acta Pharmacologica Sinica2013，34，7： | 12 |
| 12 | First observation of tropospheric nitrogen dioxide from the Environmental Trace Gases Monitoring Instrument onboard the GaoFen-5 satellite显示文摘The Environmental Trace Gases Monitoring Instrument(EMI)is the first Chinese satellite-borne UV–Vis spectrometer aiming to measure the distribution of atmospheric trace gases on a global scale.The EMI instrument onboard the GaoFen-5 satellite was launched on 9 May 2018.In this paper,we present the tropospheric nitrogen dioxide(NO2)vertical column density(VCD)retrieval algorithm dedicated to EMI measurement.We report the first successful retrieval of tropospheric NO_(2) VCD from the EMI instrument.Our retrieval improved the original EMI NO_(2) prototype algorithm by modifying the settings of the spectral fit and air mass factor calculations to account for the on-orbit instrumental performance changes.The retrieved EMI NO_(2) VCDs generally show good spatiotemporal agreement with the satellite-borne Ozone Monitoring Instrument and TROPOspheric Monitoring Instrument(correlation coefficient R of ~0.9,bias<50%).A comparison with ground-based MAX-DOAS(Multi-Axis Differential Optical Absorption Spectroscopy)observations also shows good correlation with an R of 0.82.The results indicate that the EMI NO_(2) retrieval algorithm derives reliable and precise results,and this algorithm can feasibly produce stable operational products that can contribute to global air pollution monitoring. | Chengxin Zhang Cheng Liu Ka Lok Chan Qihou Hu Haoran Liu Bo Li Chengzhi Xing Wei Tan Haijin Zhou Fuqi Si Jianguo Liu | 2020 | Light(Science & Applications)2020，9，1： | 11 |
| 13 | The endocrine regulation network of growth hormone synthesis and secretion in fish: Emphasis on the signal integration in somatotropes显示文摘In teleosts, growth hormone (GH) production is governed by multiple neuroendocrine factors from the hypothalamus and other regulators from the pituitary and peripheral organs. Exploring the principles followed by pituitary somatotropes when differentiating and integrating the signals from these regulators at the cellular and intracellular level is essential for understanding the endocrine regulation network of growth hormone synthesis and secretion in fish. This paper discusses recent advances in the action mechanisms of GH regulation factors, including the neuroendocrine regulators, pituitary level factors and peripheral factors, primarily involved in their receptor systems as well as in post-receptor signal transduction pathways. | LI WenSheng & LIN HaoRan State Key Laboratory of Biocontrol, Institute of Aquatic Economic Animals and the Guangdong Provincial Key Laboratory for Aquatic Economic Animals, School of Life Sciences, Sun Yat-sen University, Guangzhou 510275, China | 2010 | Science China(Life Sciences)2010，53，4： | 11 |
| 14 | Comparison of microstructures and mechanical properties of composite extruded AZ31 sheets显示文摘The microstructures and mechanical properties of the composite extruded AZ31/AZ31 and AZ31/4047 Al sheets were investigated and made a comparison to the conventional extruded AZ31 sheet.Owing to the introduced intense shear deformation at the interface during the composite extrusion,grain refinement and tilted texture were detected in AZ31 layers of the AZ31/AZ31 and AZ31/4047 Al sheets,while the conventional extruded AZ31 sheet exhibited a relative coarse,inhomogeneous microstructure and strong basal texture.The compressiontension yield ratio was increased gradually from the AZ31 to the AZ31/AZ31 and AZ31/4047 Al sheets.Besides,the AZ31/4047 Al sheet could successfully accomplish the whole bending forming process at room temperature,while the AZ31 and AZ31/AZ31 sheets were both bend-formed to failure with significant cracks in the outer tensile region under the identical bending parameters.Moreover,under the same bending strain,both the outward offset degree of strain neutral layer and the sheet thickening were more serious in the AZ31/4047 Al composite sheet than those of the AZ31 and AZ31/AZ31 sheets.The foremost reason was the quite wide gap of material properties between Mg alloy AZ31 layer(tensile loading in the outer region)and Al 4047 layer(compressive loading in the inner region). | Yanfu Chai Yan Song Bin Jiang Jie Fu Zhongtao Jiang Qingshan Yang Haoran Sheng Guangsheng Huang Dingfei Zhang Fusheng Pan | 2019 | Journal of Magnesium and Alloys2019，7，4： | 11 |
| 15 | Effects of tourmaline on nitrogen removal performance and biofilm structures in the sequencing batch biofilm reactor显示文摘The effects of tourmaline on nitrogen removal performance and biofilm structures were comparatively investigated in two identical laboratory-scale sequencing batch biofilm reactors(SBBRs)(denoted SBBR1 and SBBR2) at different nitrogen loading rates(NLRs) varying from(0.24 ± 0.01) to(1.26 ± 0.02) g N/(L·day). SBBR1 was operated in parallel with SBBR2, but SBBR1 was filled with polyurethane foam loaded tourmaline(TPU) carriers and another(SBBR2) filled with polyurethane foam(PU) carriers. Results obtained from this study showed that the excellent and stable performance of SBBR1 was obtained. Ammonia nitrogen removal and total nitrogen removal were higher in SBBR1 than that in SBBR2 with increase of NLR. At an NLR of(0.24 ± 0.01) g N/(L·day), the majority of the spherical and elliptical bacteria were surrounded by the extracellular polymeric substance(EPS) and bacillus or filamentous bacteria in two SBBRs biofilms. When NLR increased to(1.26 ± 0.02) g N/(L·day), the clusters were more obvious in the SBBR1 biofilm than that in the SBBR2 biofilm. Bacteria in SBBR1 were inclined to synthesis more EPS, and the formed EPS could protect the bacteria from free ammonia(FA) under extreme condition NLR(1.26 ± 0.02) g N/(L·day). The results of polymerase chain reaction-denaturing gradient gel electrophoresis analysis showed that the microbial community similarity in SBBR2 decreased more obviously than that in SBBR1 with the increase of NLR, which the microbial community in SBBR1 was relatively stable. | Chong Tan Haoran Xu Di Cui Jinlong Zuo Junsheng Li Yubin Ji Shan Qiu Lin Yao Ying Chen Yingjie Liu | 2018 | Journal of Environmental Sciences2018，30，5： | 10 |
| 16 | Large-scale real-world radio signal recognition with deep learning显示文摘In the past ten years, many high-quality datasets have been released to support the rapid development of deep learning in the fields of computer vision, voice, and natural language processing. Nowadays, deep learning has become a key research component of the Sixth-Generation wireless systems(6G) with numerous regulatory and defense applications. In order to facilitate the application of deep learning in radio signal recognition, in this work, a large-scale real-world radio signal dataset is created based on a special aeronautical monitoring system-Automatic Dependent Surveillance-Broadcast(ADS-B). This paper makes two main contributions. First, an automatic data collection and labeling system is designed to capture over-the-air ADS-B signals in the open and real-world scenario without human participation. Through data cleaning and sorting, a high-quality dataset of ADS-B signals is created for radio signal recognition. Second, we conduct an in-depth study on the performance of deep learning models using the new dataset, as well as comparison with a recognition benchmark using machine learning and deep learning methods.Finally, we conclude this paper with a discussion of open problems in this area. | Ya TU Yun LIN Haoran ZHA Ju ZHANG Yu WANG Guan GUI Shiwen MAO | 2022 | Chinese Journal of Aeronautics2022，35，9： | 9 |
| 17 | The interfacial fracture behavior of foam core composite sandwich structures by a viscoelastic cohesive model显示文摘A sandwich beam model consisting of two face sheets and a foam core bonded by a viscoelastic adhesive layer is considered in order to investigate interfacial fracture behavior. Firstly, a cohesive zone model in conjunction with a Maxwell element in parallel, or with a Kelvin element in series, respectively, is employed to describe the characteristics of viscoelasticity for the adhesive layer. The models can be implemented into the implicit finite element code. Next, the parametric study shows that the in- fluences of loading rates on the cohesive zone energy and strength are quite different for different models. Finally, a sandwich double cantilever beam model is adopted to simulate the interface crack growth between the face sheet and core. Numerical examples are presented for various loading rates to demonstrate the efficacy of the rate-dependent cohesive models. | SUN ShiYong CHEN HaoRan | 2011 | Science China(Physics,Mechanics & Astronomy)2011，54，8： | 9 |
| 18 | Activated carbons and amine-modified materials for carbon dioxide capture- a review显示文摘 | Zhenhe CHEN Shubo DENG Haoran WEI Bin WANG Jun HUANG Gang YU | 2013 | Frontiers of Environmental Science & Engineering2013，7，3： | 9 |
| 19 | Signal propagations and linkages of subsurface temperature anomalies in the tropical Pacific and Indian Ocean显示文摘The propagation characteristics of signals along different zonal-time profiles are analyzed using surface and subsurface temperature anomalies over the tropical Pacific and Indian oceans. Analyses show that there are intrinsic relationships between El Nio events in the eastern equatorial Pacific and dipole events in the equatorial Indian Ocean. In the region of tropical North Pacific between the equator and 16°N, there is a circle of propagation of subsurface temperature anomalies. El Nio events only happen when the warm subsurface signals reach the eastern equatorial Pacific. Dipole events are characterized when a warm subsurface signal travels along off-equatorial Indian Ocean to the western boundary. From these analyses, we believe that subsurface temperature anomalies can be considered to be the oceanographic early signal to forecast El Nio events in Pacific Ocean and dipole events in Indian Ocean, respectively. | QIAN Weihong HU Haoran | 2005 | Progress in Natural Science:Materials International2005，15，9： | 8 |
| 20 | Simultaneous removal of chromium and arsenate from contaminated groundwater by ferrous sulfate:Batch uptake behavior显示文摘Chromium and/or arsenate removal by Fe(II) as a function of pH,Fe(II) dosage and initial Cr(VI)/As(V) ratio were examined in batch tests.The presence of arsenate reduced the removal efficiency of chromium by Fe(II),while the presence of chromate significantly increased the removal efficiency of arsenate by Fe(II) at pH 6-8.In the absence of arsenate,chromium removal by Fe(II) increased to a maximum with increasing pH from 4 to 7 and then decreased with a further increase in pH.The increment in Fe(II) dosage resulted in an improvement in chromium removal and the improvement was more remarkable under alkaline conditions than that under acidic conditions.Chromium removal by Fe(II) was reduced to a larger extent under neutral and alkaline conditions than that under acidic conditions due to the presence of 10 μmol/L arsenate.The presence of 20 μmol/L arsenate slightly improved chromium removal by Fe(II) at pH 3.9-5.8,but had detrimental effects at pH 6.7-9.8.Arsenate removal was improved significantly at pH 4-9 due to the presence of 10 μmol/L chromate at Fe(II) dosages of 20-60 μmol/L.Elevating the chromate concentration from 10 to 20 μmol/L resulted in a further improvement in arsenate removal at pH 4.0-4.6 when Fe(II) was dosed at 30-60 μmol/L. | Xiaohong Guan Haoran Dong Jun Ma Irene M. C. Lo | 2011 | Journal of Environmental Sciences2011，23，3： | 8 |
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