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| 1 | miR-182参与调节胶质母细胞瘤的凋亡、生长和分化(英文)显示文摘Glioblastoma multiforme(GBM)is a lethal,therapy-resistant brain cancer consisting of numerous tumor cell subpopulations,including stem-like glioma-initiating cells(GICs),which contribute to tumor recurrence following initial response to therapy.Here,we identified miR-182 as a regulator of apoptosis,growth,and differentiation programs whose expression level is correlated with GBM patient survival.Repression of Bcl2-like12(Bcl2L12),c-Met,and hypoxia-inducible factor 2α(HIF2A)is of central importance to miR-182 anti-tumor activity,as it results in enhanced therapy susceptibility,decreased GIC sphere size,expansion,and stemness in vitro.To evaluate the tumor-suppressive function of miR-182 in vivo,we synthesized miR-182-based spherical nucleic acids(182-SNAs);i.e.,gold nanoparticles covalently functionalized with mature miR-182 duplexes.Intravenously administered 182-SNAs penetrated the bloodbrain/blood-tumor barriers(BBB/BTB)in orthotopic GBM xenografts and selectively disseminated throughout extravascular glioma parenchyma,causing reduced tumor burden and increased animal survival.Our results indicate that harnessing the anti-tumor activities of miR-182 via safe and robust delivery of 182-SNAs represents a novel strategy for therapeutic intervention in GBM. | Kouri FM Hurley LA Daniel WL Day ES Hua Y Hao L Peng CY Merkel TJ Queisser MA Ritner C Zhang H James CD Sznajder JI Chin L Giljohann DA Kessler JA Peter ME Mirkin CA Stegh AH | 2015 | 中华神经外科疾病研究杂志2015，14，2： | 14 |
| 2 | 计算机辅助截骨术指导和预弯钛板改善面部不对称矫正手术的规划显示文摘本研究评估了计算机辅助截骨术和预弯钛板治疗面部不对称患者的手术效果和准确性。纳入13例面部不对称进行双颌手术的患者。如果需要,在术前三维模型上进行Le Fort I型截骨术,下颌支矢状劈开截骨术和颏成形术的虚拟模拟。 | Ji H Du W Xu C 赵泽亮 | 2019 | 中国口腔颌面外科杂志2019，17，2： | 3 |
| 3 | 美国地震学会通报(BSSA)2008年四川汶川地震专集介绍显示文摘 | Klinger Y Ji C Shen Z-K Bakun W H 李平恩(译) 左玉玲(校) | 2010 | 国际地震动态2010，，12： | 3 |
| 4 | A low glitch 10-bit 75-MHz CMOS video D/A converter显示文摘 | WU T JI H C | 1995 | IEEE Journal of Solid-State Circuits1995，30，1： | 2 |
| 5 | 纳米光子结构软膜紫外光固化纳米压印(英文)显示文摘紫外光固化纳米压印是实现纳米结构批量复制的一种新技术.其特点是低成本和高分辨,而且可以达到极高的套刻精度.为了得到大面积图案的均匀复制,可用聚二甲基硅氧烷(PDMS)制备透光的压印软模板.其母版图案可由高分辨率电子束曝光和反应离子刻蚀的方法在硅片基底上获得,然后用浇注的方法将图案转移到PDMS上.本实验特别发展了紫外光固化纳米压印适用于软膜压印的双层膜图型转移技术.该双层膜由廉价的光胶和聚甲基丙烯酸甲脂(PMMA)构成.对光胶层的压印可用普通的光学曝光仪实现.然后再将图案用反应离子刻蚀的方法转移到PMMA层中.为了证明方案的可行性,在两种不同材料的半导体基片上压印了三角晶格的光子晶体和准晶结构的图案,并用剥离的方法将它们转移到金属薄膜上,最后成功地进行了硅片刻蚀实验.相信这一纳米制做方法对大面积纳米光子结构和光学集成芯片的制造是普遍适用的. | SHI J WANG Z M BAO K PEROZ C BELOTTI M XU L P LUO C X SUN M H ZHANG B JI H OUYANG Q CHEN Y | 2006 | 纳米技术与精密工程2006，4，3： | 2 |
| 6 | Cryopreservation of kunming mouse oocytes using slow cooling, ultrarapid cooling and vitrifyication protocols显示文摘 | Men H S Chen J C Ji W Z | 1997 | Theriogenology1997，47，： | 2 |
| 7 | PI3K5 and PI3Kγ: partners in crime in inflammation in rheumatoid arthritis and beyond?显示文摘 | ROMMEL C CAMPS M JI H | 2007 | Nat Rev Immunot2007，7，3： | 1 |
| 8 | Sequence-based screening for putative polyketide synthase gene-harboring clones from a soil metagenome library 显示文摘 | JI S C KIM D YOON J H | 2006 | J Microbiol Biotechnol2006，16，： | 1 |
| 9 | Surface Status and Size Influences of Nickel Nanoparticles on Sulfur Compound Adsorption 显示文摘 | Chang H K Jung G P Ji C P | 2007 | Applied Surface Science2007，253，13： | 1 |
| 10 | Sexual dimorphism arid female reproductive characteristics in the oriental garden lizard, Calotes versicolor, from a population in Hainan, southern China显示文摘 | Ji X Qiu Q B Dong C H | 2002 | Journal of Herpetology2002，36，1： | 1 |
| 11 | PI3K+ and PI3K+/: partners in crime in inflammation in rheumatoid arthritis and beyond 显示文摘 | Rommel C Camps M Ji H | 2007 | Nat Rev Immunol2007，7，3： | 1 |
| 12 | A recursive least-squares algorithm for on-line 1-D inverse heat conduction estimation显示文摘 | JI C C TUAN P C JANG H Y | 1997 | International Journal of Heat and Mass Transfer1997，40，9： | 1 |
| 13 | Modified cost function for passive sensor data association 显示文摘 | Ouyang C Ji H | 2011 | Electronics Letters2011，47，6： | 1 |
| 14 | Effects of Lactobacillusjohn- sonii XS4 supplementation on reproductive performance, gut environment,and blood biochemical and immunological index in lactating sows显示文摘 | Wang J Ji H F Hou C L | 2014 | Livestock Sci2014，164，6： | 1 |
| 15 | CO2 reforming of methane to synthesis gas over sol-gel-made Co/γ-Al2O3 catalysts from organometallic precursors显示文摘 | JI L TANG S ZENG H C LIN J TAN K L | 2001 | Appl Catal A2001，207，12： | 1 |
| 16 | Crack damage detection in beam-like structures using RBF neural networks with experimental validation显示文摘 | Li H J He C J Ji J L | 2005 | International Journal of Innovative Computing Information and Control2005，1，4： | 1 |
| 17 | Autolysis of shrimp head by gradual temperature and nutritional quality of the result hydrolysates显示文摘 | Cao W Zhang C Hong P Ji H | 2009 | LWT-Food Science & Technology2009，42，： | 1 |
| 18 | Experimental Study of Air Entrainment Mode with Natural Ventilation using Shafts in Road Tunnel Fires 显示文摘 | FAN C G JI J GAO Z H | 2013 | International Journal of Heat and Mass Transfer2013，56，12： | 1 |
| 19 | Lectin-Based Nanoprobes Functionalized with Enzyme for Highly Sensitive Electrochemical Monitoring of Dynamic Carbohydrate Expression on Living Cells显示文摘 | Ding L Ji Q J Qian R C Cheng W Ju H X | | 0，，04： | 1 |
| 20 | Optimizing polyphase sequences for orthogonal netted radar显示文摘 | Khan H A Zhang Y Y Ji C L | 2006 | IEEE Transactions on Signal Processing Letters2006，13，10： | 1 |
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