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您的检索式：作者名="JIA Mengze"
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| 1 | Manganese salts function as potent adjuvants显示文摘Aluminum-containing adjuvants have been used for nearly 100 years to enhance immune responses in billions of doses of vaccines.To date,only a few adjuvants have been approved for use in humans,among which aluminum-containing adjuvants are the only ones widely used.However,the medical need for potent and safe adjuvants is currently continuously increasing,especially those triggering cellular immune responses for cytotoxic T lymphocyte activation,which are urgently needed for the development of efficient virus and cancer vaccines.Manganese is an essential micronutrient required for diverse biological activities,but its functions in immunity remain undefined.We previously reported that Mn^(2+) is important in the host defense against cytosolic dsDNA by facilitating cGAS-STING activation and that Mn^(2+)alone directly activates cGAS independent of dsDNA,leading to an unconventional catalytic synthesis of 2′3′-cGAMP.Herein,we found that Mn^(2+) strongly promoted immune responses by facilitating antigen uptake,presentation,and germinal center formation via both cGAS-STING and NLRP3 activation.Accordingly,a colloidal manganese salt(Mn jelly,MnJ)was formulated to act not only as an immune potentiator but also as a delivery system to stimulate humoral and cellular immune responses,inducing antibody production and CD4^(+)/CD8^(+)T-cell proliferation and activation by either intramuscular or intranasal immunization.When administered intranasally,MnJ also worked as a mucosal adjuvant,inducing high levels of secretory IgA.MnJ showed good adjuvant effects for all tested antigens,including T cell-dependent and T cell-independent antigens,such as bacterial capsular polysaccharides,thus indicating that it is a promising adjuvant candidate. | Rui Zhang Chenguang Wang Yukun Guan Xiaoming Wei Mengyin Sha Mengran Yi Miao Jing Mengze Lv Wen Guo Jing Xu Yi Wan Xin-Ming Jia Zhengfan Jiang | 2021 | Cellular & Molecular Immunology2021，18，5： | 7 |
| 2 | Solid-state[2+2] Photocycloaddition Reaction of Zinc(Ⅱ) Complex Based on Quaternized 1,2-Bis(4'-pyridyl) ethylene显示文摘Aphotoactive metal-organic complex[Zn2(BCbpe)2(p-DBC)2]∙5H2O(1) has been synthesized based on an olefin-containing pyridinium compound, 1-(4-carboxybenzyl)-4-[2-(4-pyridyl)-vinyl]pyridinium chloride(HBCbpeCl), and characterized by single-crystal X-ray diffraction, IR spectroscopy, powder X-ray diffraction and thermogravimetric analysis, respectively. In the solid state, the BCbpe ligands are packed in a head-to-tail manner through weak cation-π interaction, undergoing a photo-induced cycloaddition quantitatively upon UV-light irradiation. | JIA Mengze SUN Li CHEN Yunrui ZHANG Jie | 2022 | Chemical Research in Chinese Universities2022，38，1： | 0 |
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