|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Bidirectional differentiation of BMSCs induced by a biomimetic procallus based on a gelatin-reduced graphene oxide reinforced hydrogel for rapid bone regeneration显示文摘Developmental engineering strategy needs the biomimetic composites that can integrate the progenitor cells,biomaterial matrices and bioactive signals to mimic the natural bone healing process for faster healing and reconstruction of segmental bone defects.We prepared the gelatin-reduced graphene oxide(GOG)and constructed the composites that mimicked the procallus by combining the GOG with the photo-crosslinked gelatin hydrogel.The biological effects of the GOG-reinforced composites could induce the bi-differentiation of bone marrow stromal cells(BMSCs)for rapid bone repair.The proper ratio of GOG in the composites regulated the composites’mechanical properties to a suitable range for the adhesion and proliferation of BMSCs.Besides,the GOG-mediated bidirectional differentiation of BMSCs,including osteogenesis and angiogenesis,could be activated through Erk1/2 and AKT pathway.The methyl vanillate(MV)delivered by GOG also contributed to the bioactive signals of the biomimetic procallus through priming the osteogenesis of BMSCs.During the repair of the calvarial defect in vivo,the initial hypoxic condition due to GOG in the composites gradually transformed into a well-vasculature robust situation with the bi-differentiation of BMSCs,which mimicked the process of bone healing resulting in the rapid bone regeneration.As an inorganic constituent,GOG reinforced the organic photo-crosslinked gelatin hydrogel to form a double-phase biomimetic procallus,which provided the porous extracellular matrix microenvironment and bioactive signals for the bi-directional differentiation of BMSCs.These show a promised application of the bio-reduced graphene oxide in biomedicine with a developmental engineering strategy. | Delong Jiao Ao Zheng Yang Liu Xiangkai Zhang Xiao Wang Jiannan Wu Wenjun She Kaige Lv Lingyan Cao Xinquan Jiang | 2021 | Bioactive Materials2021，6，7： | 1 |
| 2 | 环形RNA结构与降解调控PKR激活和天然免疫反应显示文摘文章简介环形RNA(circ RNA)来自RNA聚合酶II的转录本并以共价键形成闭环结构。虽然在哺乳动物细胞中普遍表达,但是绝大部分环形RNA的功能仍不清楚。外显子反向剪接成环发生效率很低,但产生的环形RNA非常稳定。该研究证明环形RNA分子倾向于形成长度为16-26bp双链RNA茎环结构,可以结合并抑制天然免疫因子PKR的活性。 | 刘楚霄 李响 南芳 Shan Jiang Xiang Gao Si-Kun Guo Wei Xue Yange Cui Kaige Dong Huihua Ding Bo Qu Zhaocai Zhou 沈南 杨力 陈玲玲 | 2020 | 科学新闻2020，，2： | 0 |
| 3 | Experimental Investigation on Compressive Properties of Fiber Recycled Aggregate Concrete显示文摘This paper presents an experimental study to explore the compressive properties of fiber recycled aggregate concrete.A total of 75 specimens with the replacement rate of recycled coarse aggregate and fiber type were conducted under a uniaxial compressive test.The failure modes,stress-strain whole curves,peak stress,peak strain,and energy dissipation capacity were systematically observed and revealed.Test results indicate that steel fiber has the best modification effect on energy dissipation capacity and the toughness index of recycled concrete,corresponding to the enhancement of 81.75% and 22.90% on average.The addition of polyvinyl alcohol fiber can effectively improve the compressive strength and energy dissipation capacity of recycled aggregate concrete by 28.49% and 29.43% on average,respectively.The compressive strength and energy dissipation capacity of recycled aggregate concrete is increased by an average of 16.5% and 24.4% by incorporating carbon fiber.The energy dissipation capacity of recycled aggregate concrete is increased by an average of 13.5% with the incorporation of polypropylene fiber.However,the addition of carbon fiber results in a slight reduction of toughness by 16.97%,and the effect of polyvinyl alcohol fiber on the energy dissipation capacity is limited.Besides,with the increase in replacement rate,the compressive strength and the energy dissipation capacity of recycled coarse aggregate concrete with fiber decreased,and toughness first decreased and then increased.Finally,based on the analysis of test data,a segment-based stress-strain model of fiber recycled aggregate concrete was proposed,which shows good agreement with the test results. | Guiwu Lin Kaige Liu Yuliang Chen Yunpeng Ji Rui Jiang | 2023 | Journal of Renewable Materials2023，11，11： | 0 |
| 4 | Belief reliability modeling and analysis for planetary reducer considering multi-source uncertainties and wear显示文摘The planetary reducer is a common type of transmission mechanism,which can provide high transmission accuracy and has been widely used,and it is usually required with high reliability of transmission characteristics in practice.During the manufacturing and usage stages of planetary reducers,uncertainties are ubiquitous and wear is inevitable,which affect the transmission characteristics and the reliability of planetary reducers.In this paper,belief reliability modeling and analysis considering multi-uncertainties and wear are proposed for planetary reducers.Firstly,based on the functional principle and the influence of wear,the performance margin degradation model is established using the hysteresis error as the key performance parameter,where the degradation is mainly caused by the accumulated wear.After that,multi-source uncertainties are analyzed and quantified separately,including manufacturing errors,uncertainties in operational and environmental conditions,and uncertainties in performance thresholds.Finally,the belief reliability model is established based on the performance margin degradation model.A case study of a planetary reducer is applied and the reliability sensitivity analysis is implemented to show the practicability of the proposed method.The results show that the proposed method can provide some suggestions to the design and manufacturing phases of the planetary reducer. | LI Yun JIANG Kaige ZENG Ting CHEN Wenbin LI Xiaoyang LI Deyong ZHANG Zhiqiang | 2021 | Journal of Systems Engineering and Electronics2021，32，5： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员