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| 1 | Derivation of Non-Integration Induced Pluripotent Stem Cells from Fibroblast of Severe Deafness Patients with GJB2 Mutation显示文摘在所有的连接蛋白相关的人类疾病,耳聋是一种高频率的最重要的疾病。穆均GJB2(间隙连接蛋白β2,也被称为连接蛋白26,Cx26)与非综合征性或综合性的结构rineural听力损失也占相当大的比例,在许多研究人群的先天性耳聋患者基因链接(卡斯蒂略和卡斯蒂略,2011)。例如,在235de1c GJB2突变显示约1%的频率,在东亚人群的最常见的突变(燕等人。,2003)。很多的努力已投入的研究在小鼠模型和人类GJB2基因的功能。在小鼠,GJB2广泛缺失导致胚胎致死性由于降低胎盘葡萄糖的摄取,这是没有发现在人类(高田和平野,1997;加布里埃尔等人。,1998)。在人类,GJB2基因缺陷不能使胚胎致死(.D.等人。,2002)。然而,GJB2相关听力损失的研究是许多困难阻碍,如无法获得人类耳蜗神经组织和声学,因此GJB2相关听力损失是潜在的机制仍不清楚。 | Xiaofeng Jin Rui Fu Wanwan Zhu Zhengxin Liu Tiantian Gu Guanyi Jiao Hua Yang Qi Zhou Zhiqiang Gao Xiao-Yang Zhao | 2015 | Journal of Genetics and Genomics2015，42，8： | 1 |
| 2 | Flow characteristics of mixed particles with a simulated cold state in moving bed reactor显示文摘The funnel flow of high-temperature circulating ash and coal in moving bed with height restrictions directly influences the efficiency of coal pyrolysis and scale-up design of reactor.It is one of the technical bottlenecks in the use of moving bed.In order to provide data support for the particle flow and pyrolysis model close to the actual working conditions in the future,this study describes the flow characteristics of solid-solid mixed particles in a cold two-dimensional moving bed.The results indicate that flow char-acteristics of mixed particles in the quartz sand-coal system are better than those in the cold circulating ash-coal system.The optimized conditions were obtained,the insert half angle is 20° and a heat carrier to coal ratio of 6:1.As the mixture progressed downstream,secondary separation of the heat carrier and coal become apparent.Furthermore,mixture residence time has been investigated to explore the relationship between regional residence time and to predict accurately the actual pyrolysis progress in pyrolyzer. | Yaqing Zhang Jialong Zhu Peng Liang Tiantian Jiao Xiangping Li | 2022 | Particuology2022，，12： | 1 |
| 3 | The folding dynamics and infrared spectra of a photo cleaved tetrapeptide predicted by theoretical simula- tions显示文摘 | JIAO Tiantian GAO Lianghui CHEN Xuebo | 2012 | Journal of Physical Chemistry B2012，116，14： | 1 |
| 4 | A novel and low-toxic peptide DR3penA alleviates pulmonary fibrosis by regulating the MAPK/miR-23b-5p/AQP5 signaling axis显示文摘Pulmonary fibrosis(PF)is a pathological change caused by repeated injuries and repair dysfunction of the alveolar epithelium.Our previous study revealed that the residues Asn3 and Asn4 of peptide DR8(DHNNPQIR-NH_(2))could be modified to improve stability and antifibrotic activity,and the unnatural hydrophobic amino acids a-(4-pentenyl)-Ala and D-Ala were considered in this study.DR3penA(DHa-(4-pentenyl)-ANPQIR-NH_(2))was verified to have a longer half-life in serum and to significantly inhibit oxidative damage,epithelial-mesenchymal transition(EMT)and fibrogenesis in vitro and in vivo.Moreover,DR3penA has a dosage advantage over pirfenidone through the conversion of drug bioavailability under different routes of administration.A mechanistic study revealed that DR3penA increased the expression of aquaporin 5(AQP5)by inhibiting the upregulation of miR-23b-5p and the mitogen-activated protein kinase(MAPK)pathway,indicating that DR3penA may alleviate PF by regulating MAPK/miR-23b-5p/AQP5.Safety evaluation showed that DR3penA is a peptide drug without obvious toxicity or acute side effects and has significantly improved safety compared to DR8.Thus,our findings suggest that DR3penA,as a novel and low-toxic peptide,has the potential to be a leading compound for PF therapy,which provides a foundation for the development of peptide drugs for fibrosis-related diseases. | Dan Wang Bochuan Deng Lu Cheng Jieru Li Jiao Zhang Xiang Zhang Xiaomin Guo Tiantian Yan Xin Yue Yingying An Bangzhi Zhang Wenle Yang Junqiu Xie Rui Wang | 2023 | Acta Pharmaceutica Sinica B2023，13，2： | 0 |
| 5 | Sinus histiocytosis with massive lymphadenopathy Author(s)显示文摘Sinus histiocytosis with massive lymphadenopathy is a benign lymphoproliferative disorder.In 1969, Rosai and Dorfman[1] made detailed research on it, so it was also called Rosai DorfnlRn disease (rosai.dorfmandisease, RDD).The clinical manifestations were fever, neck lymph node enlargement, leukocytosis and high gamma globulin.Histopathological findings showed that lymph node involvement was present in group RDD, and the infiltration of the cells was predominant, especially the phagocytosis of the histiocytic cells.About 43% of RDD patients have lymph node involvement in[2], in which the skin is the most common extranodal organs involved.About 10% of patients with skin damage, skin rash and morphological diversity, is easy to be misdiagnosed.In this paper, through the analysis of a case of RDD and EB virus infection, in clinical in patients with special infection can be early detection and treatment. | Jianying Feng Tiantian Han Fuyong Jiao | 2018 | Journal of Pediatric Diseases2018，2，1： | 0 |
| 6 | An injectable bioactive dressing based on platelet-rich plasma and nanoclay:Sustained release of deferoxamine to accelerate chronic wound healing显示文摘Delayed diabetic wound healing has placed an enormous burden on society.The key factors limiting wound healing include unresolved inflammation and impaired angiogenesis.Platelet-rich plasma(PRP)gel,a popular biomaterial in the field of regeneration,has limited applications due to its non-injectable properties and rapid release and degradation of growth factors.Here,we prepared an injectable hydrogel(DPLG)based on PRP and laponite by a simple one-step mixing method.Taking advantages of the non-covalent interactions,DPLG could overcome the limitations of PRP gels,which is injectable to fill irregular injures and could serve as a local drug reservoir to achieve the sustained release of growth factors in PRP and deferoxamine(an angiogenesis promoter).DPLG has an excellent ability in accelerating wound healing by promoting macrophage polarization and angiogenesis in a full-thickness skin defect model in typeⅠdiabetic rats and normal rats.Taken together,this study may provide the ingenious and simple bioactive wound dressing with a superior ability to promote wound healing. | Jiao Zhang Qian Luo Qian Hu Tiantian Zhang Jingyu Shi Li Kong Dehao Fu Conglian Yang Zhiping Zhang | 2023 | Acta Pharmaceutica Sinica B2023，13，10： | 0 |
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