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| 1 | A Collinearity-Incorporating Homology Inference Strategy for Connecting Emerging Assemblies in the Triticeae Tribe as a Pilot Practice in the Plant Pangenomic Era显示文摘Plant genome sequencing has dramatically increased,and some species even have multiple high-quality reference versions.Demands for clade-specific homology inference and analysis have increased in the pangenomic era.Here we present a novel method,GeneTribe(http://gffzz6c7fcf032cb94ff5sfccnxf5ob05c6bw0.ffgz.tsg.suse.edu.cn/genetribe/),for homology inference among genetically similar genomes that incorporates gene collinearity and shows bet-ter performance than traditional sequence-similarity-based methods in terms of accuracy and scalability.The Triticeae tribe is a typical allopolyploid-rich clade with complex species relationships that includes many important crops,such as wheat,barley,and rye.We built Triticeae-GeneTribe(http://gffzzaeec8df70e7c4b21hfccnxf5ob05c6bw0.ffgz.tsg.suse.edu.cn/TGT/),a homology database,by integrating 12 Triticeae genomes and 3 outgroup model genomes and implemented versatile analysis and visualization functions.With macrocollinearity analysis,we were able to construct a refined model illustrating the structural rearrangements of the 4A-5A-7B chromosomes in wheat as two major translocation events.With collinearity analysis at both the macro-and microscale,we illustrated the complex evolutionary history of homologs of the wheat vernalization gene Vm2,which evolved as a combined result of genome translocation,duplication,and polyploidization and gene loss events.Our work provides a useful practice for connecting emerging genome assemblies,with awareness of the extensive polyploidy in plants,and will help researchers efficiently exploit genome sequence re-sources. | Yongming Chen Wanjun Song Xiaoming Xie Zihao Wang Panfeng Guan Huiru Peng Yuannian Jiao Zhongfu Ni Qixin Sun Weilong Guo | 2020 | Molecular Plant2020，13，12： | 14 |
| 2 | In situ self-assembled organoid for osteochondral tissue regeneration with dual functional units显示文摘The regeneration of hierarchical osteochondral units is challenging due to difficulties in inducing spatial,directional and controllable differentiation of mesenchymal stem cells(MSCs)into cartilage and bone compartments.Emerging organoid technology offers new opportunities for osteochondral regeneration.In this study,we developed gelatin-based microcryogels customized using hyaluronic acid(HA)and hydroxyapatite(HYP),respectively for inducing cartilage and bone regeneration(denoted as CH-Microcryogels and OS-Microcryogels)through in vivo self-assembly into osteochondral organoids.The customized microcryogels showed good cytocompatibility and induced chondrogenic and osteogenic differentiation of MSCs,while also demonstrating the ability to self-assemble into osteochondral organoids with no delamination in the biphasic cartilage-bone structure.Analysis by mRNA-seq showed that CH-Microcryogels promoted chondrogenic differentiation and inhibited inflammation,while OS-Microcryogels facilitated osteogenic differentiation and suppressed the immune response,by regulating specific signaling pathways.Finally,the in vivo engraftment of pre-differentiated customized microcryogels into canine osteochondral defects resulted in the spontaneous assembly of an osteochondral unit,inducing simultaneous regeneration of both articular cartilage and subchondral bone.In conclusion,this novel approach for generating self-assembling osteochondral organoids utilizing tailor-made microcryogels presents a highly promising avenue for advancing the field of tissue engineering. | Zhen Yang Bin Wang Wei Liu Xiaoke Li Kaini Liang Zejun Fan Jiao Jiao Li Yudi Niu Zihao He Hui Li Du Wang Jianjing Lin Yanan Du Jianhao Lin Dan Xing | 2023 | Bioactive Materials2023，，9： | 2 |
| 3 | Stability assessment of an ancient landslide crossed by two coal mine tunnels显示文摘 | JIAO Yuyong WANG Zihao WANG Xinzhi | 2013 | Engineering Geology2013，159，： | 1 |
| 4 | Reprogrammed siTNFα/neutrophil cytopharmaceuticals targeting inflamed joints for rheumatoid arthritis therapy显示文摘Rheumatoid arthritis(RA)is an autoimmune disease characterized by severe synovial inflammation and cartilage damage.Despite great progress in RA therapy,there still lacks the drugs to completely cure RA patients.Herein,we propose a reprogrammed neutrophil cytopharmaceuticals loading with TNFα-targeting-siRNA(siTNFα)as an alternative anti-inflammatory approach for RA treatment.The loaded siTNFαact as not only the gene therapeutics to inhibit TNFαproduction by macrophages in inflamed synovium,but also the editors to reprogram neutrophils to anti-inflammatory phenotypes.Leveraging the active tendency of neutrophils to inflammation,the reprogrammed siTNFα/neutrophil cytopharmaceuticals(siTNFα/TP/NEs)can rapidly migrate to the inflamed synovium,transfer the loaded siTNFαto macrophages followed by the significant reduction of TNFαexpression,and circumvent the pro-inflammatory activity of neutrophils,thus leading to the alleviated synovial inflammation and improved cartilage protection.Our work provides a promising cytopharmaceutical for RA treatment,and puts forward a living neutrophil-based gene delivery platform. | Yijun Chen Kaiming Li Mengying Jiao Yingshuang Huang Zihao Zhang Lingjing Xue Caoyun Ju Can Zhang | 2023 | Acta Pharmaceutica Sinica B2023，13，2： | 0 |
| 5 | Effects of Different Slow-release Fertilizers on Growth and Yield of Ratooning Rice显示文摘The effect of slow-release fertilizer application on reducing the fertilization times of ratooning rice was explored by carrying out plot experiments using different slow-release fertilizer formulas.The results showed that compared with conventional fertilization of farmers(TCK),there were no significant differences in plant heights of the first rice crop and ratoon rice crop and the number of tillers was slightly increased,by applying different ratios and types of slow-release fertilizers,indicating that reducing fertilization times did not affect rice growth.Compared with the TCK,the yields of treatments T1,T2,T3 and T4 of slow-release fertilizers increased to a certain extent.The yield of the first rice crop increased by 14.7%,16.7%,23.5% and 17.5%,respectively,the yields of the ratoon rice crop increased by 6.3%,5.8%,7.4% and 8.1%,respectively,and the yields of the two rice crops increased between 10.8% and 16.1%,indicating that reasonable combined application of slow-release nitrogen and fast-acting nitrogen fertilizer could meet the nutrient requirements of ratooning rice at different growth stages,and the application of slow-release fertilizers could reduce the fertilization times of ratooning rice.Based on the combination of rice yield and slow-release fertilizer cost in the first rice crop and ratoon rice crop,the T 3 formula was preferred,that is,urea-formaldehyde slow-release nitrogen fertilizer was used as the base and tillering fertilizer,and polyurethane-coated slow-release nitrogen fertilizer was used as the panicle-sprouting fertilizer. | Weiping JIAO Tonghua LI Xianshun REN Zihao WANG | 2020 | Agricultural Biotechnology2020，9，4： | 0 |
| 6 | Photochemical Systems for Solar‑to‑Fuel Production显示文摘The photochemical system,which utilizes only solar energy and H_(2)O/CO_(2) to produce hydrogen/carbon-based fuels,is considered a promising approach to reduce CO_(2) emissions and achieve the goal of carbon neutrality.To date,numerous photochemical systems have been developed to obtain a viable solar-to-fuel production system with sufficient energy efficiency.However,more effort is still needed to meet the requirements of industrial implementation.In this review,we systematically discuss a typical photochemical system for solar-to-fuel production,from classical theories and fundamental mechanisms to raw material selection,reaction condition optimization,and unit device/system advancement,from the viewpoint of ordered energy conversion.State-of-the-art photochemical systems,including photocatalytic,photovoltaic-electrochemical,photoelectrochemical,solar thermochemical,and other emerging systems,are summarized.We highlight the existing bottlenecks and discuss the developing trend of this technology.Finally,optimization strategies and new opportunities are proposed to enhance photochemical systems with higher energy efficiency. | Ya Liu Feng Wang Zihao Jiao Shengjie Bai Haoran Qiu Liejin Guo | 2022 | Electrochemical Energy Reviews2022，5，3： | 0 |
| 7 | A 16-bit,±10-V Input Range SAR ADC with a 5-V Supply Voltage and Mixed-Signal Nonlinearity Calibration显示文摘This paper presents a high-precision,successive approximation register(SAR)analog-to-digital converter(ADC)with resistive analog front-end for lowvoltage and wide input range applications.To suppress the serious nonlinearity brought by the voltage coefficients of analog front-end without deteriorating differential nonlinearity performance,a mixed-signal calibration scheme based on piecewise-linear method with calibration digital-to-analog converter is proposed.A compensation current is designed to sink or source from the reference to keep it independent of input signal,which greatly improves the linearity performance.Fabricated in a 0.5-μm CMOS process,the proposed ADC achieves 88-dB signalto-noise-and-distortion ratio and 103-dB spurious free dynamic range with 5-V supply voltage and 2.5-V reference voltage,and the total power consumption is 37.5 mW. | LUO Hongrui ZHAO Xianlong JIAO Zihao ZHANG Jie WANG Xiaofei ZHANG Ruizhi ZHANG Hong | 2022 | Chinese Journal of Electronics2022，31，4： | 0 |
| 8 | Technological innovations on direct carbon mitigation by ordered energy conversion and full resource utilization显示文摘Coal consumption leads to over 15 billion tons of global CO_(2) emissions annually,which will continue at a considerable intensity in the foreseeable future.To remove the huge amount of CO_(2),a practically feasible way of direct carbon mitigation,instead of capturing that from dilute tail gases,should be developed;as intended,we developed two innovative supporting technologies,of which the status,strengths,applications,and perspective are discussed in this paper.One is supercritical water gasification-based coal/biomass utilization technology,which orderly converts chemical energy of coal and low-grade heat into hydrogen energy,and can achieve poly-generation of steam,heat,hydrogen,power,pure CO_(2),and minerals.The other one is the renewables-powered CO_(2) reduction techniques,which uses CO_(2) as the resource for carbon-based fuel production.When combining the above two technical loops,one can achieve a full resource utilization and zero CO_(2) emission,making it a practically feasible way for China and global countries to achieve carbon neutrality while creating substantial domestic benefits of economic growth,competitiveness,well-beings,and new industries. | Liejin Guo Zhisong Ou Ya Liu Zhiwei Ge Hui Jin Guobiao Ou Mengmeng Song Zihao Jiao Wenhao Jing | 2022 | Carbon Neutrality2022，1，1： | 0 |
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