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| 1 | Unlocking the door to highly efficient Ag-based nanoparticles catalysts for NaBH4-assisted nitrophenol reduction显示文摘Ag-based nano particles(NPs)catalysts have recently attracted in creasi ng atte ntion in NaBH4-assisted n itrophe nol reducti on,especially in 4?n itrophe nol(4?NP)reducti on.Moreover,Ag-based NPs catalysts are con sidered to be very promising for practical applicati ons because of their fascinating advantages,e.g.,easy preparation,relatively low cost and less toxicity,high activity and good stability.Basically,the size and shape of Ag NPs are well known as the key factors for achieving highly efficient catalytic reduction of 4-NP.In this review,three highly efficient Ag-based NPs catalysts(supported Ag NPs,anisotropic Ag NPs and bimetallic Ag NPs)are highlighted for the 4-NP reduction,in eluding the catalytic mecha nism and reactio n rate caused by their adjustments in size and shape.Although high catalytic activity has bee n demonstrated by several Ag-based NPs catalysts,further improvement in the catalytic performance is still desired.In terms of the most recent progress in Ag-based NPs catalysts for 4?NP reduction,this review provides a comprehensive assessment on the material selection,synthesis and catalytic characterizations of these catalysts.Moreover,this review aims to correlate the catalytic performance of Ag-based NPs catalysts with their size and shape,guiding the development of novel cost-effective and high-performance catalysts. | Guangfu Liao Yan Gong Liu Zhong Jiasheng Fang Li Zhang Zushun Xu Haiyang Gao Baizeng Fang | 2019 | Nano Research2019，12，10： | 9 |
| 2 | A direct real-time polymerase chain reaction assay for rapid high-throughput detection of highly pathogenic North American porcine reproductive and respiratory syndrome virus in China without RNA purification显示文摘Background:Porcine reproductive and respiratory syndrome virus(PRRSV),and particularly its highly pathogenic genotype(HP-PRRSV),have caused massive economic losses to the global swine industry.Results:To rapidly identify HP-PRRSV,we developed a direct real-time reverse transcription polymerase chain reaction method(dRT-PCR) that could detect the virus from serum specimen without the need of RNA purification.Our dRT-PCR assay can be completed in 1.5 h from when a sample is received to obtaining a result.Additionally,the sensitivity of dRT-PCR matched that of conventional reverse transcription PCR(cRT-PCR) that used purified RNA.The lowest detection limit of HP-PRRSV was 6.3 TCID_(50) using dRT-PCR.We applied dRT-PCR assay to 144 field samples and the results showed strong consistency with those obtained by cRT-PCR.Moreover,the dRT-PCR method was able to tolerate 5-20%(v/v) serum.Conclusions:Our dRT-PCR assay allows for easier,faster,more cost-effective and higher throughput detection of HP-PRRSV compared with cRT-PCR methods.To the best of our knowledge,this is the first report to describe a real-time RT-PCR assay capable of detecting PRRSV in crude serum samples without the requirement for purifying RNA.We believe our approach has a great potential for application to other RNA viruses. | Kang Kang Keli Yang Jiasheng Zhong Yongxiang Tian Limin Zhang Jianxin Zhai Li Zhang Changxu Song Christine Yuan Gou Jun Luo Deming Gou | 2015 | Journal of Animal Science and Biotechnology2015，6，1： | 2 |
| 3 | Longitudinal virological changes and underlying pathogenesis in hospitalized COVID-19 patients in Guangzhou,China显示文摘Prolonged viral RNA shedding and recurrence of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)in coronavirus disease 2019(COVID-19)patients have been reported.However,the clinical outcome and pathogenesis remain unclear.In this study,we recruited 43 laboratory-confirmed COVID-19 patients.We found that prolonged viral RNA shedding or recurrence mainly occurred in severe/critical patients(P<0.05).The average viral shedding time in severe/critical patients was more than 50 days,and up to 100 days in some patients,after symptom onset.However,chest computed tomography gradually improved and complete absorption occurred when SARS-CoV-2 RT-PCR was still positive,but specific antibodies appeared.Furthermore,the viral shedding time significantly decreased when the A1,430G or C12,473T mutation occurred(P<0.01 and FDR<0.01)and increased when G227A occurred(P<0.05 and FDR<0.05).High IL1R1,IL1R2,and TNFRSF21 expression in the host positively correlated with viral shedding time(P<0.05 and false discovery rate<0.05).Prolonged viral RNA shedding often occurs but may not increase disease damage.Prolonged viral RNA shedding is associated with viral mutations and host factors. | Zhengtu Li Yinhu Li Ruilin Sun Shaoqiang Li Lingdan Chen Yangqing Zhan Mingzhou Xie Jiasheng Yang Yanqun Wang Airu Zhu Guoping Gu Le Yu Shuaicheng Li Tingting Liu Zhaoming Chen Wenhua Jian Qian Jiang Xiaofen Su Weili Gu Liyan Chen Jing Cheng Jincun Zhao Wenju Lu Jinping Zheng Shiyue Li Nanshan Zhong Feng Ye | 2021 | Science China(Life Sciences)2021，64，12： | 1 |
| 4 | Effects of temperature, pH and light on the stability of aloin A and characterisation of its major degradation products显示文摘 | WENJING DING XIAOFANG WU JIASHENG ZHONG | 2014 | IntJ Food Sci Technol2014，49，7： | 1 |
| 5 | Chemi- cal constituents of Aloe barbadensis Miller and theirin- hibitory effects on phosphodiesterase-4D 显示文摘 | Jiasheng Zhong Yiyou Huang Wenjing Ding | 2013 | Fitoterapia2013，，91： | 1 |
| 6 | Development of cost-effective nanocrystalline multi-component(Ce,La,Y)-Fe-B permanent magnetic alloys containing no critical rare earth elements of Dy,Tb,Pr and Nd显示文摘Here we first report the fully abundant rare earth(RE)-based nanocrystalline multi-component(Ce,La,Y)-Fe-B alloys containing no critical RE elements of Nd,Pr,Dy,and Tb by melt-spinning technique.The roles of La and Y substitutions for Ce have been fully understood.La plays a positive role on both thermal stability and room-temperature(RT)magnetic properties.The enhanced coercivity H_(cj)by partial substitution of La is attributed to the increases of anisotropy field H_A and the formation of continuously distributed grain boundaries resulting from the suppre s sion of CeFe_(2)phase.Although Y substitution is not benefit for H_(cj),both remanent polarization J_r and thermal stability have been effectively improved since Y_(2)Fe_(14)B shows relatively high saturation magnetization M_s and a positive temperature coefficient of HA over a certain temperature range.In addition,RE element segregation has been confirmed,La prefers to enter into the grain boundaries than Ce and Y prefers to remain in the 2:14:1 phase.Based on these understanding,a series of melt-spun(Ce,La,Y)-Fe-B alloys have been designed.A relatively good combination of magnetic properties with maximum energy product(BH)_(max)=7.4 MGOe,H_(Cj)=400 kA/m,and J_r=0.63 T has been obtained in[(Ce_(0.8)La_(0.2))_(0.7)Y_(0.3)]_(17)Fe_(78)B_6 alloy,together with high Curie temperature(T_c=488 K)and low temperature coefficients of remanence(α=-0.255%/K)and coercivity(β=-0.246%/K). | Xuefeng Liao Jiasheng Zhang Jiayi He Wenbing Fan Hongya Yu Xichun Zhong Zhongwu Liu | 2021 | Journal of Materials Science & Technology2021，，17： | 0 |
| 7 | A Novel Method for the Prenatal Diagnosis of Cleft Palate Based on Amniotic Fluid Metabolites显示文摘Background and purpose The prenatal diagnosis of cleft palate is an important component of sequential therapy,but the relevant diagnostic methods are still limited.We aimed here,to explore the possibility of an early prenatal diagnosis of cleft palate by assessing metabolites in pregnant mice.Methods Twenty-four inseminated females were randomly divided into retinoic acid(RA)-treated(treated with retinoic acid at 10.5 gestation days)and control groups.The metabolites of the embryonic palatal tissue,maternal amniotic fluid,and serum were characterized using 9.4T magnetic resonance spectroscopy in vitro.Then,a predictive model was established through the principal component analysis(PCA),and the correlations between the metabolites of amniotic fluid and palatal tissue were explored using orthogonal-2 partial least squares(O2-PLS).Results The incidences of cleft palate were 100%and 0%in the RA-treated and control groups,respectively.A predictive PCA model with a high specificity and sensitivity was established for the early prenatal diagnosis of isolated cleft palate using amniotic fluid metabolic data.Between RA-treated and control mice,we found that two metabolites in the amniotic fluid and palatal tissue were correlated.Creatinine showed the same trend in the palatal tissue and amniotic fluid,while choline showed opposite trends in the two tissues.However,the data for serum metabolites could not be used to establish a prediction model.Conclusion This study indicates that assessing the metabolites of amniotic fluid is a potential approach for the prenatal diagnosis of isolated cleft palate. | Wancong ZHANG Lewen JIANG Zhiwei SHEN Jiasheng CHEN Xiaoping ZHONG Weiping ZENG Jianda ZHOU Zhihao HE Shijie TANG | 2020 | Chinese Journal Of Plastic and Reconstructive Surgery2020，2，2： | 0 |
| 8 | Omicron:a chimera of two early SARS-CoV-2 lineages显示文摘Dear Editor,The outbreak of the COVID‐19 that occurred in late 2019 has posed a remarkable threat to public health around the world.It is known that SARS-CoV-2 is a genetically diverse group that mutates continuously,leading to the emergence of multiple variants.1 Potential variants of concern(VOCs),variants of interest(VOIs),or variants under monitoring(VUMs)are regularly assessed based on the risk posed to global public health.Following the identification of a novel variant in South Africa on 24 November 2021,WHO designated Omicron(clade GRA,PANGO lineage B.1.1.529 and descendants BA.1 and BA.2)as the fifth SARS-CoV-2 VOC 2 days later due to its large number of variations. | Xiuliang Liu Jiasheng Xiong Zhong Sun Jingjing Hu Karuppiah Thilakavathy Mingquan Chen Qi Zhao Yi Feng Qingwu Jiang Chenglong Xiong | 2022 | Signal Transduction and Targeted Therapy2022，7，4： | 0 |
| 9 | Efficacy of early prone or lateral positioning in patients with severe COVID-19:a single-center prospective cohort显示文摘Background:Position intervention has been shown to improve oxygenation,but its role in non-invasively ventilated patients with severe COVID-19 has not been assessed.The objective of this study was to investigate the efficacy of early position intervention on non-invasively ventilated patients with severe COVID-19.Methods:This was a single-center,prospective observational study in consecutive patients with severe COVID-19 managed in a provisional ICU at Renmin Hospital of Wuhan University from 31 January to 15 February 2020.Patients with chest CT showing exudation or consolidation in bilateral peripheral and posterior parts of the lungs were included.Early position intervention(prone or lateral)was commenced for>4 hours daily for 10 days in these patients,while others received standard care.Results:The baseline parameters were comparable between the position intervention group(n=17)and the standard care group(n=35).Position intervention was well-tolerated and increased cumulative adjusted mean difference of SpO_(2)/FiO_(2)(409,95%CI 86 to 733)and ROX index(26,95%CI 9 to 43)with decreased Borg scale(−9,95%CI−15 to−3)during the first 7 days.It also facilitated absorption of lung lesions and reduced the proportion of patients with high National Early Warning Score 2(≥7)on days 7 and 14,with a trend toward faster clinical improvement.Virus shedding and length of hospital stay were comparable between the two groups.Conclusions:This study provides the first evidence for improved oxygenation and lung lesion absorption using early position intervention in non-invasively ventilated patients with severe COVID-19,and warrants further randomized trials. | Zhong Ni Kaige Wang Ting Wang Yuenan Ni Wei Huang Ping Zhu Tao Fan Ye Wang Bo Wang Jun Deng Zhicheng Qian Jiasheng Liu Wenhao Cai Shanling Xu Yu Du Gang Wang Zongan Liang Weimin Li Jianfei Luo Fengming Luo Dan Liu | 2020 | Precision Clinical Medicine2020，3，4： | 0 |
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