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| 1 | Tumor neoantigens: Novel strategies for application of cancer immunotherapy显示文摘Neoantigen-targeted immunotherapy is a rapidly advancing field that holds great promise for treating cancer.The recognition of antigens by immune cells is a crucial step in tumor-specific killing,and neoantigens generated by mutations in cancer cells possess high immunogenicity and are selectively expressed in tumor cells,making them an attractive therapeutic target.Currently,neoantigens find utility in various domains,primarily in the realm of neoantigen vaccines such as DC vaccines,nucleic acid vaccines,and synthetic long peptide vaccines.Additionally,they hold promise in adoptive cell therapy,encompassing tumor-infiltrating cells,T cell receptors,and chimeric antigen receptors which are expressed by genetically modified T cells.In this review,we summarized recent progress in the clinical use of tumor vaccines and adoptive cell therapy targeting neoantigens,discussed the potential of neoantigen burden as an immune checkpoint in clinical settings.With the aid of state-of-the-art sequencing and bioinformatics technologies,together with significant advancements in artificial intelligence,we anticipated that neoantigens will be fully exploited for personalized tumor immunotherapy,from screening to clinical application. | HANYANG GUAN YUE WU LU LI YABING YANG SHENGHUI QIU ZHAN ZHAO XIAODONG CHU JIASHUAI HE ZUYANG CHEN YIRAN ZHANG HUI DING JINGHUA PAN YUNLONG PAN | 2023 | Oncology Research2023，31，4： | 1 |
| 2 | A review of modeling,simulation,and control technologies of altitude ground test facilities for control application显示文摘As the pivotal test equipment of aero-engines design,finalization,improvement,modification,etc.,the Altitude Ground Test Facilities(AGTF)plays an important role in the research and development of the aero-engines.With the rapid development of advanced high-performance aeroengine,the increasing demand of high-altitude simulation test is driving AGTF to improve its test ability and level of automation and intelligence.The modeling method,simulation tool,and control technology are the key factors to support the improvement of the AGTF control system.The main purpose of this paper is to provide an overview of modeling methods,simulation tools,and control technologies in AGTF control system for future research.First,it reviews the evolution of AGTF in the world,from the early formative stage to integration stage.Then,the mathematical modeling method of AGTF for control application is overviewed.Furthermore,the simulation tools used in the AGTF control system are overviewed from numerical simulation to hardware-in-loop simulation and further to semi-physical simulation.Meanwhile,the control technologies used in the AGTF control system are summarized from single-variable control to multivariable integrated control,and from classical control theory to modern control theory.Finally,recommendations for future research are outlined.Therefore,this review article provides extensive literature information for the modeling,simulation,and control design of AGTF for control application. | Xitong PEI Xi WANG Jiashuai LIU Meiyin ZHU Zhihong DAN Ai HE Keqiang MIAO Louyue ZHANG Zheng XU | 2023 | Chinese Journal of Aeronautics2023，36，9： | 0 |
| 3 | Targeting FAPα-positive lymph node metastatic tumor cells suppresses colorectal cancer metastasis显示文摘Lymphatic metastasis is the main metastatic route for colorectal cancer, which increases the risk of cancer recurrence and distant metastasis. The properties of the lymph node metastatic colorectal cancer(LNM-CRC) cells are poorly understood, and effective therapies are still lacking. Here, we found that hypoxia-induced fibroblast activation protein alpha(FAPα) expression in LNM-CRC cells. Gain-or loss-function experiments demonstrated that FAPα enhanced tumor cell migration, invasion, epithelial-mesenchymal transition, stemness, and lymphangiogenesis via activation of the STAT3 pathway. In addition, FAPα in tumor cells induced extracellular matrix remodeling and established an immunosuppressive environment via recruiting regulatory T cells, to promote colorectal cancer lymph node metastasis(CRCLNM). Z-GP-DAVLBH, a FAPα-activated prodrug, inhibited CRCLNM by targeting FAPα-positive LNM-CRC cells. Our study highlights the role of FAPα in tumor cells in CRCLNM and provides a potential therapeutic target and promising strategy for CRCLNM. | Shuran Fan Ming Qi Qi Qi Qun Miao Lijuan Deng Jinghua Pan Shenghui Qiu Jiashuai He Maohua Huang Xiaobo Li Jie Huang Jiapeng Lin Wenyu Lyu Weiqing Deng Yingyin He Xuesong Liu Lvfen Gao Dongmei Zhang Wencai Ye Minfeng Chen | 2024 | Acta Pharmaceutica Sinica B2024，14，2： | 0 |
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