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| 1 | Viral effector protein manipulates host hormone signaling to attract insect vectors显示文摘 | Dewei Wu Tiancong Qi Wan-Xiang Li Haixia Tian Hua Gao Jiaojiao Wang Jin Ge Ruifeng Yao Chunmei Ren Xian-Bing Wang Yule Liu Le Kang Shou-Wei Ding Daoxin Xie | 2017 | Cell Research2017，27，3： | 20 |
| 2 | Targeted delivery of chlorogenic acid by mannosylated liposomes to effectively promote the polarization of TAMs for the treatment of glioblastoma显示文摘Tumor-associated macrophages(TAMs)generally display an immunosuppressive M2 phenotype and promote tumor progression and metastasis,suggesting their potential value as a target in cancer immunotherapy.Chlorogenic acid(CHA)has been identified as a potent immunomodulator that promotes the polarization of TAMs from an M2 to an M1 phenotype.However,rapid clearance in vivo and low tumor accumulation have compromised the immunotherapeutic efficacy of CHA in clinical trials.In this study,mannosylated liposomes are developed for targeted delivery of CHA to TAMs.The immunoregulatory effects of CHA,along with the overall antitumor efficacy of CHA-encapsulated mannosylated liposomes,are investigated through in vitro and in vivo experiments.The prepared CHA-encapsulated mannosylated liposomes exhibit an ideal particle size,favorable stability,and preferential accumulation in tumors via the mannose receptor-mediated TAMs-targeting effects.Further,CHA-encapsulated mannosylated liposomes inhibit G422 glioma tumor growth by efficiently promoting the polarization of the pro-tumorigenic M2 phenotype to the anti-tumorigenic M1 phenotype.Overall,these findings indicate that CHA-encapsulated mannosylated liposomes have great potential to enhance the immunotherapeutic efficacy of CHA by inducing a shift from the M2 to the M1 phenotype. | Jun Ye Yanfang Yang Jing Jin Ming Ji Yue Gao Yu Feng Hongliang Wang Xiaoguang Chen Yuling Liu | 2020 | Bioactive Materials2020，5，3： | 9 |
| 3 | EBV-Induced Human CD8^+ NKT Cells Synergise CD4^+ NKT Cells Suppressing EBV-Associated Tumours upon Induction of Thl-Bias显示文摘 | Wei Xiao Li Li Rui Zhou Ruijing Xiao Yujuan Wang Xiang Ji Mengjun Wu Lan Wang Wei Huang Xiaoling Zheng Xinti Tan Lang Chen Tao Xiong Jie Xiong Youxin Jin Jinquan Tan Yuling He | 2009 | Cellular & Molecular Immunology2009，6，5： | 5 |
| 4 | Vascularized bone regeneration accelerated by 3D-printed nanosilicate-functionalized polycaprolactone scaffold显示文摘Critical oral-maxillofacial bone defects,damaged by trauma and tumors,not only affect the physiological functions and mental health of patients but are also highly challenging to reconstruct.Personalized biomaterials customized by 3D printing technology have the potential to match oralmaxillofacial bone repair and regeneration requirements.Laponite(LAP)nanosilicates have been added to biomaterials to achieve biofunctional modification owing to their excellent biocompatibility and bioactivity.Herein,porous nanosilicate-functionalized polycaprolactone(PCL/LAP)was fabricated by 3D printing technology,and its bioactivities in bone regeneration were investigated in vitro and in vivo.In vitro experiments demonstrated that PCL/LAP exhibited good cytocompatibility and enhanced the viability of bone marrow mesenchymal stem cells(BMSCs).PCL/LAP functioned to stimulate osteogenic differentiation of BMSCs at the mRNA and protein levels and elevated angiogenic gene expression and cytokine secretion.Moreover,BMSCs cultured on PCL/LAP promoted the angiogenesis potential of endothelial cells by angiogenic cytokine secretion.Then,PCL/LAP scaffolds were implanted into the calvarial defect model.Toxicological safety of PCL/LAP was confirmed,and significant enhancement of vascularized bone formation was observed.Taken together,3D-printed PCL/LAP scaffolds with brilliant osteogenesis to enhance bone regeneration could be envisaged as an outstanding bone substitute for a promising change in oral-maxillofacial bone defect reconstruction. | Xiongcheng Xu Long Xiao Yanmei Xu Jin Zhuo Xue Yang Li Li Nianqi Xiao Jing Tao Quan Zhong Yanfen Li Yuling Chen Zhibin Du Kai Luo | 2021 | Regenerative Biomaterials2021，8，6： | 3 |
| 5 | CALTPP:A general program to calculate thermophysical properties显示文摘A program CALTPP(CALculation of ThermoPhysical Properties)is developed in order to provide various thermophysical properties such as diffusion coefficient,interfacial energy,thermal conductivity,viscosity and molar volume mainly as function of temperature and composition.These thermophysical properties are very important inputs for microstructure simulations and mechanical property predictions.The general structure of CALTPP is briefly described,and the CALPHAD-type models for the description of these thermophysical properties are presented.The CALTPP program contains the input module,calculation and/or optimization modules and output module.A few case studies including(a)the calculation of diffusion coefficient and optimization of atomic mobility,(b)the calculation of solid/liquid,coherent solid/solid and liquid/liquid interfacial energies,(c)the calculation of thermal conductivity,(d)the calculation of viscosity,and(e)the establishment of molar volume database in binary and ternary alloys are demonstrated to show the features of CALTPP.It is expected that CALTPP will be an effective contribution in both scientific research and education. | Yuling Liu Cong Zhang Changfa Du Yong Du Zhoushun Zheng Shuhong Liu Lei Huang Shiyi Wen Youliang Jin Huaqing Zhang Fan Zhang George Kaptay | 2020 | Journal of Materials Science & Technology2020，42，7： | 2 |
| 6 | Syntheses and Crystal Structures of Benzyl-and Cyclopentyl-Cyclopentadienyl Sodium Tetrahydrofuranate Complexes显示文摘The present paper covers syntheses and crystal structures of benzyl- and cy-clopentyl-cyclopentadienyl sodium tetrahydrofuranate complexes C6H5CH2C5H4Na·THF (1) and C5H9C5H4Na°THF (2). X-ray diffraction data of the title compounds were collected at a low temperature (about 210K). Structures of both the crystals belong to monoclinic space group P21/n with α=0. 9316(3) nm, b=1. 5161(4) nm, c= 0.9791(3) nm, β=91. 06(3)°Z=4 for (1) and α=1. 6120(7) nm, b=0. 9370(3) nm, c=1. 8475(7) nm, β=109.52(3)°Z = 8 for (2). Both structures were solved by using direct methods and refined by block-matrix least-squares to final values of R = 0. 044 for 520 observed reflections (1) and R = 0. 067 for 921 observed reflections (2). In the crystals the tetrahydrofuranate complexes C6H5CH2C5H4Na·THF and C5H9C5H4Na·THF adopt a puckered chain structure with η5-(C6H5CH2)C5H4 and η5-(C5H9)C5H4 rings connected by a bridge Na (THF) unit. | Zhang Bin (Department of Chemistry, Heilongjiang University, Haerbin)Jin Zhongsheng, Wang Yuling, Wei Gecheng and Chen Wenqi (Changchun Institute of Applied Chemistry, Chinese. Academy of Sciences, Changchun) | 1992 | Chemical Research in Chinese Universities1992，8，1： | 1 |
| 7 | Transcriptional and post‑transcriptional regulation of RNAi‑related gene expression during plant‑virus interactions显示文摘As sessile organisms,plants encounter diverse invasions from pathogens including viruses.To survive and thrive,plants have evolved multilayered defense mechanisms to combat virus infection.RNAi,also known as RNA silencing,is an across-kingdom innate immunity and gene regulatory machinery.Molecular framework and crucial roles of RNAi in antiviral defense have been well-characterized.However,it is largely unknown that how RNAi is transcriptionally regulated to initiate,maintain and enhance cellular silencing under normal or stress conditions.Recently,insights into the transcriptional and post-transcriptional regulation of RNAi-related genes in different physiological processes have been emerging.In this review,we integrate these new findings to provide updated views on how plants modulate RNAi machinery at the(post-)transcriptional level to respond to virus infection. | Qian Gong Yunjing Wang Zhenhui Jin Yiguo Hong Yule Liu | 2022 | Stress Biology2022，2，1： | 1 |
| 8 | Aesculetin induced apoptosis through ROS-mediated mitochondrial dysfunction pathway in human cervical cancer cells显示文摘 | Jin Yang Yuling Xiao Xianran He etal | 2010 | J Asian Nat Prod Res2010，12，3： | 1 |
| 9 | Oxidized galectin-1 in SLE fails to bind the inhibitory receptor VSTM1 and increases reactive oxygen species levels in neutrophils显示文摘Inhibitory immune receptors set thresholds for immune cell activation,and their deficiency predisposes a person to autoimmune responses.However,the agonists of inhibitory immune receptors remain largely unknown,representing untapped sources of treatments for autoimmune diseases.Here,we show that V-set and transmembrane domain-containing 1(VSTM1)is an inhibitory receptor and that its binding by the competent ligand soluble galectin-1(Gal1)is essential for maintaining neutrophil viability mediated by downregulated reactive oxygen species production.However,in patients with systemic lupus erythematosus(SLE),circulating Gal1 is oxidized and cannot be recognized by VSTM1,leading to increased intracellular reactive oxygen species levels and reduced neutrophil viability.Dysregulated neutrophil function or death contributes significantly to the pathogenesis of SLE by providing danger molecules and autoantigens that drive the production of inflammatory cytokines and the activation of autoreactive lymphocytes.Interestingly,serum levels of glutathione,an antioxidant able to convert oxidized Gal1 to its reduced form,were negatively correlated with SLE disease activity.Taken together,our findings reveal failed inhibitory Gal1/VSTM1 pathway activation in patients with SLE and provide important insights for the development of effective targeted therapies. | Xu Jiang Xinyue Xiao Hao Li Yiyi Gong Min Wang Huaxia Yang Lidan Zhao Ying Jiang Yanping Wei Chongchong Zhao Jin Li Yuling Chen Shan Feng Haiteng Deng Shiliang Ma Yue Xu Yudong Liu George C.Tsokos Minghong Jiang Xuan Zhan | 2023 | Cellular & Molecular Immunology2023，20，11： | 1 |
| 10 | Rare earth elements of aeolian deposits in Northern China and their implications for determining the provenance of dust storms in Beijing显示文摘 | Xiaoping Yang Yongsheng Liu Chaozhu Li Yuling Song Heping Zhu Xindi Jin | 2006 | Geomorphology2006，，4： | 1 |
| 11 | Application of visual evoked potential in the evaluation of visual field deffects due to chiasmal lesions显示文摘 | Wang Jin Chen Binghuan Tan Yuling | 1988 | Chin Med J1988，101，4： | 1 |
| 12 | Application of visual evoked potential in the in Lhe evaluation of visual field defects due to chiasmal lesions显示文摘 | Wan g Jin Chen Binghuan Tan Yuling | 1988 | Chin Med J1988，101，4： | 1 |
| 13 | Research on net- work security situation awareness technology hased on AIS 显示文摘 | LIU Sun-iun YULe YANG Jin | 2011 | International Journal of Knowledge and Language Processing2011，2，2： | 1 |
| 14 | Study of the spangle size of 55% Al- Zn- Si steel显示文摘The spangle size of the 55% Al-Zn-Si steel is affected by the composition of the zinc pot,the cooling capacity after plating,and the substrate. According to previous studies,the size of spangles can be reduced by increasing the cooling ability after plating,and by adding Ti in the zinc pot. However,these two methods cannot reduce the spangle size smaller than 1. 5 mm. Therefore,in this study,we have focused on the influence of substrates on the formation of spangles of 55% Al-Zn-Si steel by comparing and analyzing substrates with different surface roughness,composition,morphology,crystal orientation,and alloy layers. | REN Yuling WEN Naimeng ZHU Ziping GU Jin | 2014 | Baosteel Technical Research2014，8，4： | 1 |
| 15 | Dynamic patterns of gene expression during leaf initiation显示文摘The establishment of leaf dorsoventral(adaxial-abaxial)polarity conditions flattening of the leaf,an essential feature of land plants that optimizes light absorbance.Leaf primordia initiate from peripheral zone(PZ)at the flank of the shoot apical meristem(SAM),which maintains stem cells in the shoot apex.Soon after initiation,asymmetries in leaves become established.Extensive molecular genetic studies have identified a transcriptional regulatory network of adaxial-and abaxial-promoting genes,which | Ting Yu Chunmei Guan Jin Wang Muhammad Sajjad Lingjian Ma Yuling Jiao | 2017 | Journal of Genetics and Genomics2017，44，12： | 1 |
| 16 | A comparative analysis of academic dissertation management systems in China显示文摘The paper is to do a comparative evaluation on the four major digital theses and dissertations management systems used in the China's Mainland,which are TRS,TPI,TASi and IDL-ETD.The evaluation analysis is primarily based on the systematic tests on these systems conducted by DUT(Dalian University of Technology)Library.Special focuses are on the distinctive features of each system such as their performance in terms of stability,reliability,openness,capacity of backdating,copyright protection,service monitoring,document conversion and release automation,log management,statistical tabulations,vendor’s technical support and so on.In addition,authors provide a statistics on the choice of academic dissertation system of most 985a)colleges and universities in China. | GAO Min JIN Yuling WANG Zhengjun DAI Yumei WANG Ruiyun | 2010 | Chinese Journal of Library and Information Science2010，，2： | 0 |
| 17 | Achieving high dielectric energy-storage properties through a phase coexistence design and viscous polymer process in BNT-based ceramics显示文摘In the last few decades,dielectric capacitors have gotten a lot of attention because they can store more power and charge and discharge very quickly.But it has a low energy-storage density(Wrec),efficiency(h),and temperature stability.By adding Pb(Mg1/3Nb2/3)O3(PMN)and(Bi0$1Sr0.85)TiO3(BST)to a nonstoichiometric(Bi0$51Na0.5)TiO3(BNT)matrix,the goal is to change the phase transition properties and make the material more relaxor ferroelectric(RFE)by lowering the remnant polarization Pr and keeping the maximum polarization Pmax.A viscous polymer process(VPP)is used to improve the electric breakdown strength,which is also a key part of being able to store energy.By working together,ceramics with the formula 0.79[0.85BNT-0.15PMN]-0.21BST(BP-0.21BST)are made.The phase structure has been changed from a rhombohedral phase to a rhombohedral-tetragonal coexisted phase.This is beneficial for RFE properties and gives a Wrec of 6.45 J/cm^(3) and a h of 90%at 400 kV/cm.Also,the energy-storage property is very temperature stable between 30 and 150C.These results show that process optimization and composition design can be used to improve the energy storage properties,and that the dielectric ceramic materials made can be used in high-powder pulse dielectric capacitors. | Yule Yang Juanjuan Wang Ruiyi Jing Wenjing Shi Leiyang Zhang Chao Li Xinyu Zeng Fukang Chen Gang Liu Xiaolian Chao Yan Yan Li Jin | 2023 | Journal of Materiomics2023，9，6： | 0 |
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