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| 1 | Role of PRMTs in cancer: Could minor isoforms be leaving a mark?显示文摘Protein arginine methyltransferases(PRMTs) catalyze the methylation of a variety of protein substrates, many of which have been linked to the development, progression and aggressiveness of different types of cancer. Moreover, aberrant expression of PRMTs has been observed in several cancer types. While the link between PRMTs and cancer is a relatively new area of interest, the functional implications documented thus far warrant further investigations into its therapeutic potential. However, the expression of these enzymes and the regulation of their activity in cancer are still significantly understudied. Currently there are nine main members of the PRMT family. Further, the existence of alternatively spliced isoforms for several of these family members provides an additional layer of complexity. Specifically, PRMT1, PRMT2, CARM1 and PRMT7 have been shown to have alternative isoforms and others may be currently unrealized. Our knowledge with respect to the relative expression and the specific functions of these isoforms is largely lacking and needs attention. Here we present a review of the current knowledge of theknown alternative PRMT isoforms and provide a rationale for how they may impact on cancer and represent potentially useful targets for the development of novel therapeutic strategies. | R Mitchell Baldwin Alan Morettin Jocelyn C té | 2014 | World Journal of Biological Chemistry2014，5，2： | 14 |
| 2 | Effect of alcohol exposure on hepatic superoxide generation and hepcidin expression显示文摘AIM: To understand the role of mitochondrial-produced superoxide(O 2 ?) in the regulation of iron-regulatory hormone, hepcidin by alcohol in the liver. METHODS: For alcohol experiments, manganese superoxide dismutase knockout mice heterozygous for Sod2 gene expression(Sod2 +/) and age-matched littermate control mice(LMC), expressing Sod2 gene on both alleles, were exposed to either 10%(w/v) ethanol in the drinking water or plain water(control) for 7 d. Total cellular O 2 ? levels in hepatocytes isolated from the livers of mice were measured by electron paramagnetic resonance spectroscopy. The mitochondrial-targeted, O 2 ?-sensitive fluorogenic probe, MitoSOX Red and flow cytometry were utilized to measure O 2 ? in mitochondria. Gene and protein expression were determined by Taqman Real-time quantitative PCR and Western blotting, respectively. RESULTS: Sod2 +/- mice expressed 40% less MnSOD protein(SOD2) in hepatocytes compared to LMC mice. The deletion of Sod2 allele did not alter the basal expression level of hepcidin in the liver. 10% ethanol exposure for 1 wk inhibited hepatic hepcidin mRNA expression three-fold both in Sod2 +/ and LMC mice. O 2 ? levels in hepatocytes of untreated Sod2 +/ mice were three-fold higher than in untreated LMC mice, as observed by electron paramagnetic resonance spectroscopy. O 2 ? levels in mitochondria of Sod2 +/ mice were four-fold higher than in mitochondria of untreated LMC mice, as measured by MitoSOX Red fluorescence and flow cytometry. Alcohol induced a two-fold higher increase in O 2 ? levels in hepatocytes of LMC mice than in Sod2 +/ mice compared to respective untreated counterparts. In contrast, 1 wk alcohol exposure did not alter mitochondrial O 2 ? levels in both Sod2 +/- and control mice. CONCLUSION: Mitochondrial O2 ? is not involved in the inhibition of liver hepcidin transcription and thereby regulation of iron metabolism by alcohol. These findings also suggest that short-term alcohol consumption significantly elevates O 2 ? levels in hepatocytes, which appears not to originate from mitochondria. | Duygu Dee Harrison-Findik Sizhao Lu Emily M Zmijewski Jocelyn Jones Matthew C Zimmerman | 2013 | World Journal of Biological Chemistry2013，4，4： | 2 |
| 3 | Induction of CTGF by TGF-β1 in normal and radiation enteritis human smooth muscle cells: Smad/Rho balance and therapeutic perspectives显示文摘 | Valérie Haydont Denis Mathé Céline Bourgier Jalil Abdelali Jocelyne Aigueperse Jean Bourhis Marie-Catherine Vozenin-Brotons | 2005 | Radiotherapy and Oncology2005，，2： | 2 |
| 4 | Recent advance in techniques for hyperspectral image processing显示文摘 | Antonio P Jon A B Joseph W B Jason B Lorenzo B Gustavo C V Jocelyn C Mathieu F Paolo G Anthony G Mattia M James C T Giovanna T | 2009 | Remote Sensing of Environment2009，113，： | 1 |
| 5 | The low temperature oxidation of DME and mutual sensitization of the oxidation of DME and nitric oxide: experimental and detailed kinetic modeling显示文摘 | Philippe D Jocelyn I Michel C | 2001 | Combustion Science and Technology2001，165，： | 1 |
| 6 | Newton-GMRES Algorithm Applied to Compressible Flows显示文摘 | REMI C JOCELYNE E | 1998 | International Journal for Numerical Methods in Fluids1998，23，2： | 1 |
| 7 | Spectral and Spatial Classification of Hyperspectral Data Using SVMs and Morphological Profiles显示文摘 | Mathieu F Jon A B Jocelyn C | | 0，，11： | 1 |
| 8 | ESTs, cDNA microarray, and gene expression profiling : tools for dissecting plant physiology and development显示文摘 | AIBA R FEI Z J PAYTON P LIU Y MOORE S L DEBBIE P COHN J D'ASCENZO M GORDON J S JOCELYN K C ROSE MARTIN G TANKSLEY S D BOUZAYEN M JAHN M M GIOVANNONI J | 2004 | Plant Journal2004，39，5： | 1 |
| 9 | A critical evaluation of sample extraction techniques for enhanced proteomic analysis of recalcitrant plant tissues 显示文摘 | Ramu S Jocelyn K C | 2004 | Proteomics2004，4，9： | 1 |
| 10 | A critical evaluation of sample extraction techniques for enhanced proteomic analysis of recalcitrant plant tissues 显示文摘 | Ramu S Saravanan Jocelyn K C R | 2004 | Proteomics2004，，4： | 1 |
| 11 | Cholesterol reduction rapidlyimproves endothelial function after acute coronary syndrome显示文摘 | Jocelyn D Jean CT Prter C | 1999 | Circulation1999，99，： | 1 |
| 12 | Cholesterol reduction rapidly improves endothelial function after acute coronary syndrome 显示文摘 | Jocelyn D Jean CT Prter C | 1999 | Circulation1999，99，： | 1 |
| 13 | Runtime Monitoring of Web Service Conversation显示文摘 | Jocelyn S Yuan G Marsha C | 2009 | IEEE Transaction on Services Compu- ting2009，2，3： | 1 |
| 14 | The diagnosis of gastroesophageal reflux disease显示文摘 | Brian EL Kirsten W Jocelyn C | 2010 | Am J Med2010，123，7： | 1 |
| 15 | Spectral and spatial classification of hyperspectral data using SVMs and morphologi- cal profiles 显示文摘 | Mathieu F J6n A B Jocelyn C | 2008 | IEEE Transactions on Geoscience and Remote Sensing2008，46，11： | 1 |
| 16 | Bioeleetrical impedance analysis to estimate body composition, and change in adiposity, in overweight and obese adolescents: comparison with dual-energy x-ray absorptiometry显示文摘 | CHING S W LEIGH C W JOCELYN H | 2014 | BMC Pediatr2014，14，1： | 1 |
| 17 | Colonoscopy in the elderly: worse preparation,better tolerability显示文摘 | Kinesh PP Jocelyn LA Kuldeep C | 2008 | Gastrointest Endosc2008，67，5： | 1 |
| 18 | Reduced pulmonary clearance of endothelin-1in pulmonary hypertension显示文摘 | Peter C Jean-C T | 1998 | Am Heart J1998，135，： | 1 |
| 19 | Colonoscopy in the elderly:worse preparation,better tolerability显示文摘 | Kinesh PP Jocelyn LA Kuldeep C | | 0，，05： | 1 |
| 20 | Head-to-head and head-to-tail multilayer n -alkylsilsesquioxane films显示文摘 | Lingli Ni Séverinne Rigolet Abraham Chemtob Céline Croutxé-Barghorn Jocelyne Brendlé Lo?c Vidal | 2013 | Comptes rendus - Chimie2013，，： | 1 |
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