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| 1 | Schistosoma mansoni proteins attenuate gastrointestinal motility disturbances during experimental colitis in mice显示文摘AIM:To investigate the therapeutic effect of Schistosoma mansoni(S.mansoni) soluble worm proteins on gastrointestinal motility disturbances during experimental colitis in mice. METHODS:Colitis was induced by intrarectal injection of trinitrobenzene sulphate(TNBS) and 6 h later,mice were treated ip with S.mansoni proteins.Experiments were performed 5 d after TNBS injection.Inflammationwas quantified using validated inflammation parameters. Gastric emptying and geometric center were measured to assess in vivo gastrointestinal motility.Peristaltic activity of distal colonic segments was studied in vitro using a modified Trendelenburg set-up.Cytokine profiles of T-lymphocytes isolated from the colon were determined by real time reverse transcriptase-polymerase chain reaction. RESULTS:Intracolonic injection of TNBS caused severe colitis.Treatment with S.mansoni proteins significantly ameliorated colonic inflammation after 5 d.TNBS did not affect gastric emptying but significantly decreased the geometric center and impaired colonic peristaltic activity 5 d after the induction of colitis.Treatment with S.mansoni proteins ameliorated these in vivo and in vitro motility disturbances.In addition,TNBS injection caused a downregulation of effector T cell cytokines after 5 d,whereas a S.mansoni protein effect was no longer observed at this time point. CONCLUSION:Treatment with S.mansoni proteins attenuated intestinal inflammation and ameliorated motility disturbances during murine experimental colitis. | Nathalie E Ruyssers Benedicte Y De Winter Joris G De Man Natacha D Ruyssers Ann J Van Gils Alex Loukas Mark S Pearson Joel V Weinstock Paul A Pelckmans Tom G Moreels | 2010 | World Journal of Gastroenterology2010，16，6： | 11 |
| 2 | Hepatic ischemic preconditioning increases portal vein flow in experimental liver ischemia reperfusion injury显示文摘BACKGROUND: Ischemic preconditioning(IPC) has been shown to decrease liver injury and to increase hepatic microvascular perfusion after liver ischemia reperfusion. This study aimed to evaluate the effects of IPC on hemodynamics of the portal venous system. METHODS: Thirty-two rats were randomized into two groups: IPC group and control group. The rats of the IPC group underwent IPC by 10 minutes of liver ischemia followed by 10 minutes of reperfusion before liver ischemia, and the rats of the control group were subjected to 60 minutes of partial liver ischemia. Non-ischemic lobes were resected immediately after reperfusion. The animals were studied at 4 hours and 12 hours after reperfusion. Mean arterial pressure, heart rate, portal vein flow and pressure were analyzed. Blood was collected for the determination of the levels of aspartate aminotransferase, alanine aminotransferase, calcium, lactate, pH, bicarbonate, and base excess. RESULTS: IPC increased the mean portal vein flow at 4 hours and 12 hours after reperfusion. IPC recovered 78% of the meanportal vein flow at 12 hours after reperfusion. IPC decreased the levels of aspartate aminotransferase, alanine aminotransferase and lactate, and increased the levels of ionized calcium, bicarbonate and base excess at 12 hours after reperfusion. CONCLUSIONS: This study demonstrated that IPC increases portal vein flow and enhances hepatoprotective effects in liver ischemia reperfusion. The better recovery of portal vein flow after IPC may be correlated with the lower levels of transaminases and with the better metabolic profile. | Estela RR Figueira Joel A Rocha-Filho Mauro Nakatani Marcelo FS Buto Eduardo R Tatebe Vitor O Andre Ivan Cecconello Luiz AC D'Albuquerque | 2014 | Hepatobiliary & Pancreatic Diseases International2014，13，1： | 6 |
| 3 | Imaging of the temporomandibular joint: An update显示文摘Imaging of the temporomandibular joint(TMJ) is continuously evolving with advancement of imaging technologies. Many different imaging modalities are currently used to evaluate the TMJ. Magnetic resonance imaging is commonly used for evaluation of the TMJ due to its superior contrast resolution and its ability to acquire dynamic imaging for demonstration of the functionality of the joint. Computed tomography and ultrasound imaging have specific indication in imaging of the TMJ. This article focuses on state of the art imaging of the temporomandibular joint. Relevant normal anatomy and biomechanics of movement of the TMJ are discussed for better understanding of many TMJ pathologies. Imaging of internal derangements is discussed in detail. Different arthropathies and commontumors are also discussed in this article. | Asim K Bag Santhosh Gaddikeri Aparna Singhal Simms Hardin Benson D Tran Josue A Medina Joel K Curé | 2014 | World Journal of Radiology2014，6，8： | 5 |
| 4 | Pentoxifylline enhances the protective effects of hypertonic saline solution on liver ischemia reperfusion injury through inhibition of oxidative stress显示文摘BACKGROUND:Liver ischemia reperfusion(IR)injury triggers a systemic inflammatory response and is the main cause of organ dysfunction and adverse postoperative outcomes after liver surgery.Pentoxifylline(PTX)and hypertonic saline solution(HTS)have been identified to have beneficial effects against IR injury.This study aimed to investigate if the addition of PTX to HTS is superior to HTS alone for the prevention of liver IR injury. | Vinicius Rocha-Santos Estela RR Figueira Joel A Rocha-Filho Ana MM Coelho Rafael Soraes Pinheiro Telesforo Bacchella Marcel CC Machado Luiz AC D'Albuquerque | 2015 | Hepatobiliary & Pancreatic Diseases International2015，14，2： | 3 |
| 5 | Economic Incentives in Budgetary Control Systems显示文摘 | Joel S D Gerald A F | 1978 | The Accounting Review1978，，2： | 1 |
| 6 | Introduction:Ecology versus strategy or strategy and ecology 显示文摘 | Stanislav D Dobrev Joel A C Baum | 2006 | Advances in Strategic Management2006，23，： | 1 |
| 7 | Transparent conducting Nnc oxide thin films doped with aluminum and molybdenum显示文摘 | JOEL N D TIMOTHY A G DAVID M W TERESA M B MATTHEW Y BOBBY T TIMOTHY J C | 2007 | Journal V-acuum Society Technology2007，25，4： | 1 |
| 8 | The development of fear of falling among community-living older women:Predisposing factors and subsequent fall events显示文摘 | SUSAN L M JOEL A D THOMAS M G | 2003 | J Gerontol A Biol Sci Mad Sci2003，58，10： | 1 |
| 9 | Update 1 of: Proteases universally recognize beta strands in their active sites显示文摘 | Praveen K Madala Joel D A Tyndall Tessa Nall | 2011 | Chemical Reviews2011，110，6： | 1 |
| 10 | Estradiol and phorbol ester cause phosphorylation of serine 118 in the human estrogen receptor 显示文摘 | Joel P B Traish A M Lannigan D A | 1995 | Mol Endocrinol1995，9，： | 1 |
| 11 | Violacein/β- cyclodextrin inclusion complex formation studied by measurements of diffusion coefficient and circular dichroism显示文摘 | MariANgela B M D A Joel B A Antonio C S | 2000 | Journal of Inclusion Phenomena and Macrocyclic Chemistry2000，37，1： | 1 |
| 12 | Biological activities of violacein, a new antitumoral indole derivative, in an inclusion complex with β-cyclodextrin显示文摘 | Mariangela B M D A Joel A Jaime A R | 2000 | Journal of Inclusion Phenomena and Macroeyclic Chemistry2000，37，1： | 1 |
| 13 | Analysis of integral membrance protein contributions to the deformability and stability of the human erythrocyte membrance显示文摘 | DAVID W K JOEL A C | 2001 | Biological Chemistry2001，276，46： | 1 |
| 14 | Advanced Manufacturing Technology: Organizational Design and Strategic Flexibility 显示文摘 | Lei David Michael A Hilt Joel D Goldhar | 1997 | Organizational Studies1997，，3： | 1 |
| 15 | 显示文摘 | CODERRE J A JOEL D D MICCA P L | 1992 | Radiat Res1992，129，： | 1 |
| 16 | Robust linear quadratic designs with real parameter uncertainty 显示文摘 | Michael A | 1994 | IEEE Trans Automat Contr1994，39，1： | 1 |
| 17 | Kinesin-1 structural organization and conformational changes revealed by FRET stoichiometry in live cells 显示文摘 | Dawen C Adam D H Joel A S | 2007 | J Cell Bid2007，176，1： | 1 |
| 18 | Detecting and differentiating white from red coronary thrombus by angiography in angina pectoris and in acute myocardial infarction显示文摘 | George S Abela Joel D Eisenberg Murray A Mittleman Richard W Nesto David Leeman Stuart Zarich Sergio Waxman Alejandro R Prieto Karen S Manzo | 1999 | The American Journal of Cardiology1999，，： | 1 |
| 19 | MMP-9/Gelatinase B Is a Key Regulator of Growth Plate Angiogenesis and Apoptosis of Hypertrophic Chondrocytes显示文摘 | Thiennu H Vu J.Michael Shipley Gabriele Bergers Joel E Berger Jill A Helms Douglas Hanahan Steven D Shapiro Robert M Senior Zena Werb | 1998 | Cell1998，，3： | 1 |
| 20 | Preliminary ob- servations on the effects of holding temperature on reproduc- tive performance of female white sturgeon, Acipenser trans- montanus Richardson 显示文摘 | Molly A H W Joel P V E Serge I D | 1999 | Aquaculture1999，176，： | 1 |
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