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| 1 | Schistosoma mansoni proteins attenuate gastrointestinal motility disturbances during experimental colitis in mice显示文摘AIM:To investigate the therapeutic effect of Schistosoma mansoni(S.mansoni) soluble worm proteins on gastrointestinal motility disturbances during experimental colitis in mice. METHODS:Colitis was induced by intrarectal injection of trinitrobenzene sulphate(TNBS) and 6 h later,mice were treated ip with S.mansoni proteins.Experiments were performed 5 d after TNBS injection.Inflammationwas quantified using validated inflammation parameters. Gastric emptying and geometric center were measured to assess in vivo gastrointestinal motility.Peristaltic activity of distal colonic segments was studied in vitro using a modified Trendelenburg set-up.Cytokine profiles of T-lymphocytes isolated from the colon were determined by real time reverse transcriptase-polymerase chain reaction. RESULTS:Intracolonic injection of TNBS caused severe colitis.Treatment with S.mansoni proteins significantly ameliorated colonic inflammation after 5 d.TNBS did not affect gastric emptying but significantly decreased the geometric center and impaired colonic peristaltic activity 5 d after the induction of colitis.Treatment with S.mansoni proteins ameliorated these in vivo and in vitro motility disturbances.In addition,TNBS injection caused a downregulation of effector T cell cytokines after 5 d,whereas a S.mansoni protein effect was no longer observed at this time point. CONCLUSION:Treatment with S.mansoni proteins attenuated intestinal inflammation and ameliorated motility disturbances during murine experimental colitis. | Nathalie E Ruyssers Benedicte Y De Winter Joris G De Man Natacha D Ruyssers Ann J Van Gils Alex Loukas Mark S Pearson Joel V Weinstock Paul A Pelckmans Tom G Moreels | 2010 | World Journal of Gastroenterology2010，16，6： | 11 |
| 2 | Osteoclastic and pleomorphic giant cell tumors of the pancreas:A review of clinical,endoscopic,and pathologic features显示文摘Giant cell tumors of the pancreas come in three varieties-osteoclastic,pleomorphic,and mixed histology.These tumors have distinctive endoscopic,clinical,and cytological features.Giant cell tumors have a controversial histogenesis,with some authors favoring an epithelial origin and others favoring a mesenchymal origin.The true origin of these lesions remains unclear at this time.These are also very rare tumors but proper identification and differentiation from more common pancreatic adenocarcinoma is important.The risk factors of these tumors and the prognosis may be different from those associated with standard pancreatic adenocarcinoma.Recognition of these differences can significantly affect patient care.These lesions have a unique appearance when imaged with endoscopic ultrasound(EUS),and these lesions can be diagnosed via EUS guided Fine Needle Aspiration(FNA).This manuscript will review the endoscopic,clinical,and pathologic features of these tumors. | Jill C Moore Joel S Bentz Kristen Hilden Douglas G Adler | 2010 | World Journal of Gastrointestinal Endoscopy2010，2，1： | 7 |
| 3 | Multimodality imaging of ovarian cystic lesions: Review with an imaging based algorithmic approach显示文摘Ovarian cystic masses include a spectrum of benign, borderline and high grade malignant neoplasms. Imaging plays a crucial role in characterization and pretreatment planning of incidentally detected or suspected adnexal masses, as diagnosis of ovarian malignancy at an early stage is correlated with a better prognosis. Knowledge of differential diagnosis, imaging features, management trends and an algorithmic approach of such lesions is important for optimal clinical management. This article illustrates a multi-modality approach in the diagnosis of a spectrum of ovarian cystic masses and also proposes an algorithmic approach for the diagnosis of these lesions. | Ashish P Wasnik Christine O Menias Joel F Platt Usha R Lalchandani Deepak G Bedi Khaled M Elsayes | 2013 | World Journal of Radiology2013，5，3： | 7 |
| 4 | Peripancreatic collections in acute pancreatitis: Correlation between computerized tomography and operative fi ndings显示文摘AIM: To evaluate the ability of contrast-enhanced computerized tomography (CECT) to characterize the nature of peripancreatic collections.METHODS: Twenty five patients with peripancreatic collections on CECT and who underwent operative intervention for severe acute pancreatitis were retrospectively studied. The collections were classified into (1) necrosis without frank pus; (2) necrosis with pus; and (3) fluid without necrosis. A blinded radiologist assessed the preoperative CTs of each patient for necrosis and peripancreatic fluid collections. Peripancreatic collections were described in terms of volume, location, number, heterogeneity, fluid attenuation, wall perceptibility, wall enhancement, presence of extraluminal gas, and vascular compromise.RESULTS: Fifty-four collections were identif ied at operation, of which 45 (83%) were identif ied on CECT. Of these, 25/26 (96%) had necrosis without pus, 16/19 (84%) had necrosis with pus, and 4/9 (44%) had fluid without necrosis. Among the study characteristics, fluid heterogeneity was seen in a greater proportion of collections in the group with necrosis and pus, compared to the other two groups (94% vs 48% and 25%, P = 0.002 and 0.003, respectively). Among the wall characteristics, irregularity was seen in a greater proportion of collections in the groups with necrosis with and without pus, when compared to the group with fluid without necrosis (88% and 71% vs 25%, P = 0.06 and P < 0.01, respectively). The combination of heterogeneity and presence of extraluminal gas had a specif icity and positive likelihood ratio of 92% and 5.9, respectively, in detecting pus. CONCLUSION: Most of the peripancreatic collections seen on CECT in patients with severe acute pancreatitis who require operative intervention contain necrotic tissue. CECT has a somewhat limited role in differentiating the different types of collections. | Santhi Swaroop Vege Joel G Fletcher Rupjyoti Talukdar Michael G Sarr | 2010 | World Journal of Gastroenterology2010，16，34： | 5 |
| 5 | Sonohysterography: Principles, technique and role in diagnosis of endometrial pathology显示文摘Sonohysterography (SHG), which provides enhanced endometrial visualization during standard transvaginal ultrasonography, is a relatively safe procedure for the evaluation of endometrial pathology. It can be used to evaluate patients with abnormal vaginal bleeding or infertility. This modality offers real time imaging of the endometrium without exposure to ionizing radiation. SHG is typically used in patients for whom standard transvaginal ultrasonography does not show the endometrium well, show a potential abnormality for which further imaging is required, or in patients without endometrial pathology defined on routine transvaginal imaging but in whom there is a strong clinical suspicion of an abnormality. This article will discuss the utility of the sonohysterogram in evaluation of various endometrial pathologies. Imaging examples of these pathological entities will be illustrated as well. | Thomas Yang Amit Pandya Leonardo Marcal Ronald O Bude Joel F Platt Deepak G Bedi Khaled M Elsayes | 2013 | World Journal of Radiology2013，5，3： | 5 |
| 6 | Species-specific responses of plant communi-ties to altered carbon and nutrient availability显示文摘 | Joel G Chapin F S Chiariello N R | 2001 | Global Change Biology2001，7，： | 1 |
| 7 | Evolution of Resistance to High Temperature in Ectotherms显示文摘 | Raymond B Huey Joel G K | 1993 | The American Naturalist1993，142，： | 1 |
| 8 | Metabolic syndrome and its components as predictors of incident type 2 diabetes mellitus in an Aboriginal community显示文摘 | Ley Sylvia H Harris Stewart B Mamakeesick Mary Noon Tina Fiddler Edith Gittelsohn Joel Wolever Thomas M S Connelly Philip W Hegele Robert A Zinman Bernard Hanley Anthony J G | 2009 | Canadian Medical Association. Journal2009，，6： | 1 |
| 9 | Homocysteine lower ing therapy and stroke risk, severity, and disability additional findings from the HOPE 2 trial 显示文摘 | Gustavo Saposnik Joel G Ray | 2009 | Stroke2009，40，4： | 1 |
| 10 | Mod-seq:A high-throughput method for probing ma secondary structure显示文摘 | LIN Y MAY G E JOEL MCMANUS C | 2015 | Methods Enzymol2015，558，： | 1 |
| 11 | Bt toxin resistance from loss of a putative carbohydrate2 modifying enzyme 显示文摘 | Joel S G Johanna L W Daniel E S | 2001 | Science2001，293，3： | 1 |
| 12 | Transparent conducting Nnc oxide thin films doped with aluminum and molybdenum显示文摘 | JOEL N D TIMOTHY A G DAVID M W TERESA M B MATTHEW Y BOBBY T TIMOTHY J C | 2007 | Journal V-acuum Society Technology2007，25，4： | 1 |
| 13 | Protein identification methods in proteomics 显示文摘 | KRIS G JOEL Vandekerckhove | 2000 | Electrophoresis2000，21，： | 1 |
| 14 | Species-specific re-sponses of plant communities to altered carton and nutrient availability显示文摘 | Joel G Chanpin III S Chinariello N R | 2001 | Global Change Biol2001，，7： | 1 |
| 15 | Health risks posed by use of di-2-ethylhexyl phthalate (DEHP) in PVC medical devices: a critical review显示文摘 | Ted S Tee G | 2001 | Am J Ind Med2001，39，： | 1 |
| 16 | Aluminum-27 nuclear magnetic resonance study of the room-temperature melt AlCl3/n-butylpyridinium chloride显示文摘 | Joel L G Gary E M | 1981 | Journal of American Chemical Society1981，103，24： | 1 |
| 17 | Multiple UAV coalitions for a search and prosecute mission显示文摘 | Joel G M Sujit P B Beard R W | | 0，，62： | 1 |
| 18 | MGF mediated alteration of NF KappaB binaing activity after partial immunolesions to eatcholinergic basal forebrain neurons显示文摘 | Tracy TK Joel G | 2000 | Int Dev Neurosci2000，18，45： | 1 |
| 19 | Colonography: current status, research directions and challenges 显示文摘 | Joel G F Thomas J V | 2002 | Eur Radiol2002，12，： | 1 |
| 20 | Autoimmune pancreatitis differentiation from pancreatic carcinoma and normal pancreas on the basis of enhancement characteristics at dual phase CT显示文摘 | Naoki Takahashi Joel G Fletcher | 2009 | AJR2009，193，2： | 1 |
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