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| 1 | Vanishing bile duct syndrome in human immunodeficiency virus infected adults:A report of two cases显示文摘Vanishing bile duct syndrome(VBDS) is a group of rare disorders characterized by ductopenia,the progressive destruction and disappearance of intrahepatic bile ducts leading to cholestasis.Described in association with medications,autoimmune disorders,cancer,transplantation,and infections,the specific mechanisms of disease are not known.To date,only 4 cases of VBDS have been reported in human immunodeficiency virus(HIV) infected patients.We report 2 additional cases of HIV-associated VBDS and review the features common to the HIV-associated cases.Presentation includes hyperbilirubinemia,normal liver imaging,and negative viral and autoimmune hepatitis studies.In HIV-infected subjects,VBDS occurred at a range of CD4+ T-cell counts,in some cases following initiation or change in antiretroviral therapy.Lymphoma was associated with two cases;nevirapine,antibiotics,and viral co-infection were suggested as etiologies in the other cases.In HIV-positive patients with progressive cholestasis,early identification of VBDS and referral for transplantation may improve outcomes. | Ana Paula Oppenheimer Christopher Koh Mary McLaughlin John C Williamson Thomas D Norton Jennifer Laudadio Theo Heller David E Kleiner Kevin P High Caryn G Morse | 2013 | World Journal of Gastroenterology2013，19，1： | 8 |
| 2 | Worldwide spread of the Ponseti method for clubfoot显示文摘The Ponseti method has become the gold standard for the treatment of idiopathic clubfoot. Its safety and efficacy has been demonstrated extensively in the literature, leading to increased use around the world over the last two decades. This has been demonstrated by the increase in Ponseti related Pub Med publications from many countries. We found evidence of Ponseti activity in 113 of 193 United Nations members. The contribution of many organizations which provide resources to healthcare practitioners in low and middle income countries, as well as Ponseti champions and modern communication technology, have helped to spread the Ponseti method around the world. Despite this, there are many countries where the Ponseti method is not being used, as well as many large countries in which the extent of activity is unknown. With its low rate of complication, low cost, and high effectiveness,this method has unlimited potential to treat clubfoot in both developed and undeveloped countries. Our listing of countries who have not yet shown presence of Ponseti activity will help non-governmental organizations to target those countries which still need the most help. | Lior Shabtai Stacy C Specht John E Herzenberg | 2014 | World Journal of Orthopedics2014，5，5： | 7 |
| 3 | Clinical outcomes following salvage Gamma Knife radiosurgery for recurrent glioblastoma显示文摘Glioblastoma multiforme(GBM) is the most common malignant primary brain tumor with a survival prognosis of 14-16 mo for the highest functioning patients. Despite aggressive, multimodal upfront therapies, the majority of GBMs will recur in approximately six months. Salvage therapy options for recurrent GBM(r GBM) are an area of intense research. This study compares recent survival and quality of life outcomes following Gamma Knife radiosurgery(GKRS) salvage therapy. Following a Pub Med search for studies usingGKRS as salvage therapy for malignant gliomas, nine articles from 2005 to July 2013 were identified which evaluated rG BM treatment. In this review, we compare overall survival following diagnosis, overall survival following salvage treatment, progression-free survival, time to recurrence, local tumor control, and adverse radiation effects. This report discusses results for rG BM patient populations alone, not for mixed populations with other tumor histology grades. All nine studies reported median overall survival rates(from diagnosis, range:16.7-33.2 mo; from salvage, range:9-17.9 mo). Three studies identified median progression-free survival(range:4.6-14.9 mo). Two showed median time to recurrence of GBM. Two discussed local tumor control. Six studies reported adverse radiation effects(range:0%-46% of patients). The greatest survival advantages were seen in patients who received GKRS salvage along with other treatments, like resection or bevacizumab, suggesting that appropriately tailored multimodal therapy should be considered with each rG BM patient. However, there needs to be a randomized clinical trial to test GKRS for rG BM before the possibility of selection bias can be dismissed. | Erik W Larson Halloran E Peterson Wayne T Lamoreaux Alexander R MacKay Robert K Fairbanks Jason A Call Jonathan D Carlson Benjamin C Ling John J Demakas Barton S Cooke Christopher M Lee | 2014 | World Journal of Clinical Oncology2014，5，2： | 5 |
| 4 | Sofosbuvir with pegylated interferon alfa-2a and ribavirin for treatment-naive patients with hepatitis C genotype-1 infection (ATOMIC): an open-label, randomised, multicentre phase 2 trial显示文摘 | Kris V Kowdley Eric Lawitz Israel Crespo Tarek Hassanein Mitchell N Davis Michael DeMicco David E Bernstein Nezam Afdhal John M Vierling Stuart C Gordon Jane K Anderson Robert H Hyland Hadas Dvory-Sobol Di An Robert G Hindes Efsevia Albanis William T Symo | 2013 | The Lancet2013，，9883： | 3 |
| 5 | Akt Promotes Cell Survival by Phosphorylating and Inhibiting a Forkhead Transcription Factor显示文摘 | Anne Brunet Azad Bonni Michael J Zigmond Michael Z Lin Peter Juo Linda S Hu Michael J Anderson Karen C Arden John Blenis Michael E Greenberg | 1999 | Cell1999，，6： | 2 |
| 6 | Label-retaining liver cancer cells are relatively resistant to sorafenib显示文摘 | Hong-Wu Xin Chenwi M Ambe Danielle M Hari Gordon W Wiegand Tyler C Miller Jin-Qiu Chen Andrew J Anderson Satyajit Ray John E Mullinax Tomotake Koizumi Russell C Langan Douglas Burka Michelle A Herrmann Paul K Goldsmith Alexander Stojadinovic Udo Rudloff S | 2013 | Gut2013，，12： | 2 |
| 7 | PM 2.5 chemical source profiles for vehicle exhaust, vegetative burning, geological material, and coal burning in Northwestern Colorado during 1995显示文摘 | John G Watson Judith C Chow James E Houck | 2001 | Chemosphere2001，，8： | 2 |
| 8 | 由地震简正模式观测得到的内核各向异性区域变化显示文摘地球的固体内核被对流的液体外核包围,由此创建了驱动地球磁场的地核发电机。用压缩体波研究地震显示出内核各向异性结构的半球性变化,但由于受地震和接收器分布状况所限,这一结论还不够充分。本文中,利用大地震的简正模式分裂函数测定结果,并基于扩展交叉耦合理论,我们观测到了区域变化和内核中东、西两半球的各向异性。这一模式与地球磁场的相似性说明在固化或组构演变过程中由Maxwell应力引起的晶体排列的凝入是产生各向异性的根源。这些观测结果限制了内核超速旋转的总量,但与振荡相符。 | Arwen Deuss Jessica C E Irving John H Woodhouse 洪启宇(译) 左玉玲(校) | 2010 | 国际地震动态2010，，10： | 2 |
| 9 | Comparison of the Biocidal Efficiency of Alternative Disinfectons 显示文摘 | John C H Edivin E Gelderieh | 1981 | AWWA1981，73，1： | 1 |
| 10 | Successful treatment of experimental allergic encephalomyelitis with transforming growth factor β1 显示文摘 | Johns L D Flanders K C Ranges G E | 1991 | J Immunol1991，147，： | 1 |
| 11 | Numerical Modeling of Concrete Confined by Fiber-Reinforced Composites显示文摘 | Malvar L J Kenneth B M John E C | 2004 | Journal of Composites for Construction2004，8，4： | 1 |
| 12 | Plant-water relations and adaptation 显示文摘 | Turner N C John E B | 1981 | Plant and Soi11981，58，13： | 1 |
| 13 | Adaptation of HIV-1to human leukocyte antigen class I显示文摘 | Kawashima Y Pfafferott K Frater J Matthews P Payne R Addo M Gatanaga H Fujiwara M Hachiya A Koizumi H Kuse N Oka S Duda A Prendergast A Crawford H Leslie A Brumme Z Brumme C Allen T Brander C Kaslow R Tang J Hunter E Allen S Mulenga J Branch S Roach T John M Mallal S Ogwu A Shapiro R Prado J G Fidler S Weber J Pybus O G Klenerman P Ndung'u T Phillips R Heckerman D Harrigan P R Walker B D Takiguchi M Goulder P | 2009 | Nature2009，458，7238： | 1 |
| 14 | In vitro degradation of a novel poly (lactide-co-glycolide)75/ 25 foam显示文摘 | Holy C E Dang S M John E D | 1999 | Biomaterials1999，20，： | 1 |
| 15 | Transient expression and insertional mutagenesis of Puccinia triticina using biolistics显示文摘 | CRAIG A W LES J S GUUS B CLARKE G RICHARD C S MERLE E JOHN P F | 2005 | Functional & Integrative Genomics2005，12，： | 1 |
| 16 | Resistance of Rosa microtubule polymerization to colchicines results from a low-affinity interation of colchicine and tubulin显示文摘 | MORE JOHN L C BUREARU T E TOCCHI L P | 1987 | Planta1987，28，1： | 1 |
| 17 | Elemental fluorine Part 12 fluorination of 1,4 - disubstituted aromatic compounds显示文摘 | Richard D C John H Matthew E S | 2000 | J Fluorine Chem2000，102，12： | 1 |
| 18 | Evidence of a hairy at the surface of polystyrene latex particles显示文摘 | JILL E SEEBERGH JOHN C et a/ | 1995 | Colloids and Surfaces A:Physico- chemical and Engineering Aspects1995，100，： | 1 |
| 19 | An intertemporal general equilibrium model of asset prices and theory of the term struc- ture of interest rates显示文摘 | JOHN C JONATHAN E STEPHEN A | 1985 | Econometrica1985，53，2： | 1 |
| 20 | The versatile midface degloving approach显示文摘 | PRICE J C HOLLIDAY M J JOHNS M E | 1988 | Laryngoscope1988，98，： | 1 |
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