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| 1 | Immunotherapy for hepatocellular carcinoma:Current and future显示文摘Hepatocellular carcinoma(HCC)arises on the background of chronic liver disease.Despite the development of effective anti-viral therapeutics HCC is continuing to rise,in part driven by the epidemic of non-alcoholic fatty liver disease.Many patients present with advanced disease out with the criteria for transplant,resection or even locoregional therapy.Currently available therapeutics for HCC are effective in a small minority of individuals.However,there has been a major global interest in immunotherapies for cancer and although HCC has lagged behind other cancers,great opportunities now exist for treating HCC with newer and more sophisticated agents.Whilst checkpoint inhibitors are at the forefront of this revolution,other therapeutics such as inhibitory cytokine blockade,oncolytic viruses,adoptive cellular therapies and vaccines are emerging.Broadly these may be categorized as either boosting existing immune response or stimulating de novo immune response.Although some of these agents have shown promising results as monotherapy in early phase trials it may well be that their future role will be as combination therapy,either in combination with one another or in combination with treatment modalities such as locoregional therapy.Together these agents are likely to generate new and exciting opportunities for treating HCC,which are summarized in this review. | Michael P Johnston Salim I Khakoo | 2019 | World Journal of Gastroenterology2019,25,24: | 23 |
| 2 | Renewable Energy Policies and Technological Innovation: Evidence Based on Patent Counts显示文摘 | Nick Johnstone Ivan Ha??i? David Popp | 2010 | Environmental and Resource Economics2010,,1: | 2 |
| 3 | Use of Solid State Carbothermic Reduction in Production of Transition Metals and Their Carbides显示文摘Many transition metals are produced by pyrometallurgical procedures which require very considerable amounts of energy, commonly electrical. On the other hand, some transition metals are obtained by employing very complex hydrometallurgical process routes. Solid state carbothermic reduction offers an alternative route for the production of both the metals and their carbides for energy saving and process step elimination.
Consequently, it seemed worth to review the work carried out in this area The metals covered in this brief review are chromium, tungsten, titanium, manganese, niobium and molybdenum. Silicon is also mentioned although it is not a transition metal. | YANG Yin-dong SOMMERVILLE I D JOHNSTON R F McLEAN A | 2000 | Journal of Iron and Steel Research(International)2000,7,2: | 2 |
| 4 | Adapting to unknown smoothness via wavelet shrinkage显示文摘 | Donoho D L Johnstone I M | 1995 | Journal of the American Statistical Assoc1995,90,432: | 1 |
| 5 | Adapting to Unknown Smoothness via Wavelet Shrinkage显示文摘 | Donoho D L Johnstone I M | 1995 | Journal of the American Statistical Association1995,90,432: | 1 |
| 6 | Adipose stromal cells and platelet-rich plasma therapies synergistically increase revascularization during wound healing显示文摘 | BLANTON M W HADAD I JOHNSTONE B H | 2009 | Plast Reconstr Surg2009,123,2: | 1 |
| 7 | Ideal spatial adaptation via wavelet shrinkage显示文摘 | Donoho D L Johnstone I M | 1994 | Biometrika1994,81,12: | 1 |
| 8 | Wavelet shrinkage: asymptotia显示文摘 | DONOHO D L JOHNSTONE I M | 1995 | Journal of the Royal Statistical Society: Series (B)1995,7,2: | 1 |
| 9 | A firm's ability to managing in complex business networks : A review of concepts 显示文摘 | Ritter T Wilkinson I F Johnston W J | 2004 | Industrial Marketing Management2004,33,3: | 1 |
| 10 | Adapting to unknownsmoothness via wavelet shrinkage显示文摘 | Donoho D L Johnstone I M | 1995 | Journal of A-merican Statistical Association1995,,90: | 1 |
| 11 | Compucations of surgery for arteriovenous maiformation of the brain显示文摘 | Morgan M K Johnston I H Haulan J M | 1993 | J Neurosurg1993,78,: | 1 |
| 12 | Temperature acclimatisation of swimming performance in the European Queen Scallop 显示文摘 | Bailey D M Johnston I A | 2005 | J Therm Biol2005,30,: | 1 |
| 13 | Adapting to unknown smoothness via wavelet shrinkage显示文摘 | D L Donoho I M Johnstone | 1995 | Journal of the American Statistical Association1995,90,432: | 1 |
| 14 | Adipose stromal cells and platelet-rich plasma therapies synergistically increase revascularization during wound healing显示文摘 | Blanton MW Hadad I Johnstone BH | | 0,,2: | 1 |
| 15 | Empirical functional and efficient smoothing parameter selection (with discussion) 显示文摘 | Hall P Johnstone I | 1992 | Journal of the Royal Statistical Society Series B1992,54,2: | 1 |
| 16 | Density Estimation by Wavelet Thresholding显示文摘 | Donoho D L Johnstone I M Kerkyacharian G | 1996 | Annals of Statistics1996,24,2: | 1 |
| 17 | Ideal spatial adaptation by wavelet shrinkage 显示文摘 | Donoho D L Johnstone I M | 1994 | Biometrika1994,81,: | 1 |
| 18 | Measuring network competence: Some international evidence显示文摘 | WILKINSON I RITTER T JOHNSTON W | 2002 | The Journal of Business & Industrial Marketing2002,17,23: | 1 |
| 19 | Adapting to unknown smoothness via wavelet shrinkage 显示文摘 | Donoho D L Johnstone I M | 1995 | Journal of the American Statistical Association1995,90,12: | 1 |
| 20 | Least angle regression显示文摘 | Efron B Hastie T Johnstone I | 2004 | The Annals of Statistics2004,32,2: | 1 |