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| 1 | Cerebral small vessel disease or intracranial large vessel atherosclerosis may carry different risk for future strokes显示文摘Background The effect of cerebral small vessel disease(CSVD)and intracranial arterial stenosis(ICAS)on stroke outcomes remains unclear.Methods Data of 1045 patients with minor stroke or transient ischaemic attack(TIA)were obtained from 45 sites of the Clopidogrel in High-Risk Patients with Acute Non-disabling Cerebrovascular Events(CHANCE)trial.We assessed the associations of burdens of CSVD and ICAS with new strokes and bleeding events using multivariate Cox regression models and those with modified Rankin Scale(mRS)scores using ordinal logistic regression models.Results Among the 1045 patients,CSVD was present in 830 cases(79.4%)and ICAS in 460(44.0%).Patients with>1 ICAS segment showed the highest risk of new strokes(HR 2.03,95%CI 1.15 to 3.56,p=0.01).No association between CSVD and the occurrence of new strokes was found.The presence of severe CSVD(common OR(cOR)2.01,95%CI 1.40 to 2.89,p<0.001)and>1 ICAS segment(cOR 2.15,95%CI 1.57 to 2.93,p<0.001)was associated with higher mRS scores.Severe CSVD(HR 10.70,95%CI 1.16 to 99.04,p=0.04),but not ICAS,was associated with a higher risk of bleeding events.Six-point modified CSVD score improved the predictive power for bleeding events and disability.Interpretation CSVD is associated with more disability and bleeding events,and ICAS is associated with an increased risk of stroke and disability in patients with minor stroke and TIA at 3 months.CSVD and ICAS may represent different vascular pathologies and play distinct roles in stroke outcomes. | Huimin Chen Yuesong Pan Lixia Zong Jing Jing Xia Meng Yuyuan Xu Hongyi Yan Xingquan Zhao Liping Liu Hao Li S Claiborne Johnston Yongjun Wang Yilong Wang | 2020 | Stroke & Vascular Neurology2020，5，2： | 13 |
| 2 | Validation and refinement of scores to predict very early stroke risk after transient ischaemic attack显示文摘 | S Claiborne Johnston Peter M Rothwell Mai N Nguyen-Huynh Matthew F Giles Jacob S Elkins Allan L Bernstein Stephen Sidney | 2007 | 2007 (9558)2007，，9558： | 3 |
| 3 | 未处理或上游法处理后精子的DNA碎片能否预测使用赠卵ICSI后的妊娠?显示文摘本研究比较了未处理的精子和上游法处理后精子中的DNA碎片值(SDF)预测使用赠卵ICSI后妊娠的可能性。总共81例不孕女性接受通过夫精和赠卵ICSI后的胚胎移植。这种方式排除了目前公认的影响精子DNA修复的女方因素。在ICSI受精时,同时使用DNA碎片率检测试剂盒(Halosperm)进行盲法检测未处理的和上游法处理后精液中的精子DNA碎片。经上游法处理后的精液样本中SDF值呈显著下降。有趣的是,未处理的或上游法处理后精液样本中的SDF值均能预测妊娠。通过ROC曲线和其衍生的约登指数计算得出未处理前和上游法处理后精子sDF的临界值分别是24.8%和17.5%。未处理精子SDF预测妊娠的敏感性和特异性分别为75%和69%,而上游法处理后的精子SDF预测妊娠的敏感性和特异性分别是78%和73%。虽然SDF值增高与生育呈负相关,但我们发现在精子筛选降低sDF值后再与赠卵进行ICSI并不能保证获得妊娠。这表明目前的技术手段对于一些DNA损伤仍无法探及,从而相对影响辅助生殖成功的机率。因此,我们认为对目前的“冰山模式”作一些修饰后可以用来解释SDF在生育中的作用。 | Jaime Gosálvez Pedro Caballero Carmen López-Fernández Leonor Ortega José Andrés Guijarro José Luís FernAndez Stephen D Johnston Rocio Nufiez-Calonge | 2013 | Asian Journal of Andrology2013，15，6： | 3 |
| 4 | Validation and refinement of scores to predict very early stroke risk after transient ischaemic attack显示文摘 | S Claiborne Johnston Peter M Rothwell Mai N Nguyen-Huynh Matthew F Giles Jacob S Elkins Allan L Bernstein Stephen Sidney | 2007 | The Lancet . 2007 (9558)2007，，9558： | 2 |
| 5 | Mechanisms of asthma exacerbation显示文摘 | Johnston S L | 1998 | Clinl Exp Allergy1998，28，5： | 2 |
| 6 | Validation and refinement of scores to predict very early stroke risk after transient ischaemic attack显示文摘 | S Claiborne Johnston Peter M Rothwell Mai N Nguyen-Huynh Matthew F Giles Jacob S Elkins Allan L Bernstein Stephen Sidney | 2007 | The Lancet2007，，9558： | 2 |
| 7 | Color stability of dry earth pigmented maxillofacial silicone A- 2186 subjected to microwave energy exposure显示文摘 | Kiat-amnuay S Johnston DA Powers JM | 2005 | J Prosthedont2005，14，2： | 1 |
| 8 | Prognostic value of growth-differentiation factor-15 in patients with non ST elevation acute coronary syndrome 显示文摘 | Wollert K C Kempf T Peter T Olofsson S James S Johnston N | 2007 | Circulation2007，115，： | 1 |
| 9 | Probiotics for pediatric antibiotic-associated diarrhea: a meta-analysis of randomized placebocontrolled trials显示文摘 | JOHNSTON B C SUPINA A L VOHRA S | 2006 | Cmaj2006，175，4： | 1 |
| 10 | Bandlike and localized defect states in CuInSe2 solar cells显示文摘 | Jehad A M Shama A Johnston S Noufi R | 2005 | Journal of Physics and Chemistry of Solids2005，66，11： | 1 |
| 11 | High sensitivity surface plasmon resonance sensor based on phase detection显示文摘 | Nelson S G Johnston KS Yee S S | 1996 | Sensors and actuators B1996，3536，： | 1 |
| 12 | Chronic chlamydia pneumoniae infection and asthma exacerbations in children显示文摘 | CUNNINGHAM A F JOHNSTON S L JULIOUS S A | 1998 | Eur Respir J1998，11，2： | 1 |
| 13 | Short-term prognosis after emergency department diagnosis of TIA显示文摘 | Johnston S C Gress D R Browner W S | 2000 | JAMA2000，284，22： | 1 |
| 14 | Genetics of heifer puberty in two tropical beef geno- types in northern Australia and associations with heif- er- and steer-production traits 显示文摘 | JOHNSTON D J BARWICK S A CORBET N J | 2009 | Animal Production Science2009，49，6： | 1 |
| 15 | Targeting the EGFR pathway for cancer therapy显示文摘 | Johnston JB Navaratnam S Pitz MW | 2006 | Current medicinal chemistry2006，13，29： | 1 |
| 16 | Global variation in stroke burden and mortality: estimates from monitoring, surveillance,and modelling显示文摘 | Johnston SC Mendis S Mathers CD | 2009 | Lancet Neurol2009，8，4： | 1 |
| 17 | Community study of role of viral infections in exacerbations of asthma in 9-11 year old children显示文摘 | Pattemore P K Sanderson G | 1995 | BMJ1995，310，6898： | 1 |
| 18 | EECM improvement factors (EIF)显示文摘 | JOHNSTON S L | 1974 | Electronic Warfare Mag1974，6，3： | 1 |
| 19 | Clinical- and imaging-based prediction of stroke risk after transient ischemic attack: theCIP model显示文摘 | Ay H Arsava E M Johnston S C | 2009 | Stroke2009，40，： | 1 |
| 20 | Apolipoprotein(a) inhibits the conversion of Glu-plas-minogen to Lys-plasminogen : a novel mechanism forlipoprotein(a)-mediated inhibition of plasminogen ac-tivation 显示文摘 | FERIC N T BOFFA M B JOHNSTON S M | 2008 | J Thromb Haemost2008，6，： | 1 |
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