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| 1 | Cerebral small vessel disease or intracranial large vessel atherosclerosis may carry different risk for future strokes显示文摘Background The effect of cerebral small vessel disease(CSVD)and intracranial arterial stenosis(ICAS)on stroke outcomes remains unclear.Methods Data of 1045 patients with minor stroke or transient ischaemic attack(TIA)were obtained from 45 sites of the Clopidogrel in High-Risk Patients with Acute Non-disabling Cerebrovascular Events(CHANCE)trial.We assessed the associations of burdens of CSVD and ICAS with new strokes and bleeding events using multivariate Cox regression models and those with modified Rankin Scale(mRS)scores using ordinal logistic regression models.Results Among the 1045 patients,CSVD was present in 830 cases(79.4%)and ICAS in 460(44.0%).Patients with>1 ICAS segment showed the highest risk of new strokes(HR 2.03,95%CI 1.15 to 3.56,p=0.01).No association between CSVD and the occurrence of new strokes was found.The presence of severe CSVD(common OR(cOR)2.01,95%CI 1.40 to 2.89,p<0.001)and>1 ICAS segment(cOR 2.15,95%CI 1.57 to 2.93,p<0.001)was associated with higher mRS scores.Severe CSVD(HR 10.70,95%CI 1.16 to 99.04,p=0.04),but not ICAS,was associated with a higher risk of bleeding events.Six-point modified CSVD score improved the predictive power for bleeding events and disability.Interpretation CSVD is associated with more disability and bleeding events,and ICAS is associated with an increased risk of stroke and disability in patients with minor stroke and TIA at 3 months.CSVD and ICAS may represent different vascular pathologies and play distinct roles in stroke outcomes. | Huimin Chen Yuesong Pan Lixia Zong Jing Jing Xia Meng Yuyuan Xu Hongyi Yan Xingquan Zhao Liping Liu Hao Li S Claiborne Johnston Yongjun Wang Yilong Wang | 2020 | Stroke & Vascular Neurology2020，5，2： | 13 |
| 2 | Chinese Stroke Association guidelines for clinical management of cerebrovascular disorders:executive summary and 2019 update of the management of high-risk population显示文摘Aim Cerebrovascular disease is the leading cause of death and disability in China,causing a huge burden among patients and their families.Hence,stroke prevention is critical,especially in the high-risk population.Here,we present the evidence-based guideline suitable for the Chinese population.Methods Literature search of PubMed and Cochrane library(from January 1964 to June 2019)was done.After thorough discussion among the writing group members,recommendations were listed and summarised.This guideline was reviewed and discussed by the fellow writing committees of the Chinese Stroke Association’s Stroke.Results This evidence-based guideline was written in three parts:controlling the risk factors of stroke,utilisation of antiplatelet agents and assessing the risks of first-ever stroke.All recommendations were listed along with the recommending classes and levels of evidence.Conclusions This guideline provides recommendations for primary prevention of cerebrovascular disease among high-risk population in China.Controlling related risk factors,appropriately using antiplatelet agents,assessing the risk of developing first-ever stroke should help reduce the rate of cerebrovascular disease in China. | Yilong Wang Shangrong Han Haiqiang Qin Huaguang Zheng Bin Jiang Yong Cao Yuan Gao Ling Guan Qian Jia Yong Jiang Yuming Jiao Shuya Li Yapeng Li Zixiao Li Wei Liu Xiaojuan Ru Dongling Sun Haixin Sun Penglian Wang Tingting Wang Lixia Zong Lei Guo Xuewei Xie Yuming Xu Yuyuan Xu Xiaomeng Yang Yingying Yang Mengyuan Zhou Wenzhi Wang Chinese Stroke Association Stroke Council Guideline Writing Committee | 2020 | Stroke & Vascular Neurology2020，5，3： | 11 |
| 3 | Photocatalytic oxidation of phenol in aqueous solutions with oxygen catalyzed by supported metallophthalocyanine catalyst显示文摘In this paper, zinc tetraaminophthalocyanine (Zn-APc) was immobilized on cellulosic fiber by covalent bond to obtain a novel cellulosic fiber supported metallophthalocyanine, named Zn-TDTAPc-F. At pH 11, upon visible light irradiation for 6 h in the presence of O2, Zn-TDTAPc-F was found to be highly effective for the degradation of phenol in aqueous solution, and the degradation rate of phenol was more than 95%. HPLC was used to confirm formic acid, fumaric acid and maleic acid as its main degradation products. | CHEN WenXing CHEN ShiLiang LüShenShui YAO YuYuan XU MinHong | 2007 | Science China Chemistry2007，50，3： | 8 |
| 4 | Preparation and photoactivity of thermosensitive polymer supported metallophthalocyanine显示文摘A novel reactive metallophthalocyanine derivative,zinc tetra(2,4-dichloro-1,3,5-triazine)aminophthalo-cyanine(Zn-TDTAPc),was prepared and immobilized on poly(N-isopropylacrylamide)(PNIPAAm) by covalent bonding to obtain a thermosensitive polymer(Zn-TDTAPc-g-PNIPAAm).Compared with zinc tetraaminophthalocyanine(Zn-TAPc),Zn-TDTAPc-g-PNIPAAm exhibits excellent solubility in water and in most organic solvents.Furthermore,it has a special thermosensitive property in water and the lower critical solution temperature(LCST) is 34.1℃.It was found that both dissolved and precipitated Zn-TDTAPc-g-PNIPAAm present high photoactivity evidenced by the experiment of photocatalytic degra-dation of 1,3-diphenylisobenzofuran(DPBF) in the presence of Zn-TDTAPc-g-PNIPAAm.These proper-ties suggest that it can be used potentially in photodynamic therapy(PDT). | CHEN WenXing LIU Fan LU WangYang SHEN XiaoYuan YAO YuYuan XU MinHong | 2008 | Science China Chemistry2008，51，6： | 5 |
| 5 | Impact of Different Diets on Adult Tri-Spine Horseshoe Crab,Tachypleus tridentatus显示文摘Effective culture and management of adult tri-spine horseshoe crab,Tachypleus tridentatus can ensure that stock enhancement programs and aquaculture systems are maintained.To explore suitable feed for animals during the breeding season,Pacific oyster(Ostrea gigas)(oyster group;OG)and frozen sharpbelly fish(Hemiculter leucisculus)(frozen fish group;FG)were selected to feed 20 T.tridentatus male and female pairs,respectively.At the end of the experiment,intestinal samples were obtained to measure digestive enzymes activities.The intestinal flora were determined by 16S r DNA sequencing.No eggs were observed in the FG and one T.tridentatus adult died.No animals died in the OG,and 9.7×10;eggs were obtained.These results show that oysters are more suitable for the development and reproduction of adult T.tridentatus than frozen fish.Additionally,the digestive enzyme activity analysis revealed that animals in the OG exhibited higher protein digestibility than those in the FG,but no significant differences in lipid and carbohydrate uptake were observed between the groups.Furthermore,the intestinal flora analysis showed that operational taxonomic units(OTUs)and the Chao1 index were significantly higher in the OG than in the FG,but no significant difference was observed in the Shannon or Simpson indices between the groups.Our data indicate that the oyster diet improved the intestinal microbial diversity of T.tridentatus.We hypothesize that nutrients,such as oyster-based taurine,proteins,and highly unsaturated fatty acids,improve protease activity in the T.tridentatus digestive tract,alter the intestinal floral structure,and improve the reproductive performance of T.tridentatus. | YING Ziwei BAO Yuyuan LI Yinkang YE Guoling ZHANG Shuhuan XU Peng ZHU Junhua XIE Xiaoyong | 2022 | Journal of Ocean University of China2022，21，3： | 3 |
| 6 | Glucose metabolism controls humanγδ-cell-mediated tumor immunosurveillance in diabetes显示文摘Patients with type 2 diabetes mellitus(T2DM)have an increased risk of cancer.The effect of glucose metabolism onγδT cells and their impact on tumor surveillance remain unknown.Here,we showed that high glucose induced Warburg effect type of bioenergetic profle in Vy9vδ2 T cells,leading to excessive lactate accumulation,which further inhibited lytic granule secretion by impairing the traffcking of cytolytic machinery to the Vy9vδ2 T-cell-tumor synapse by suppressing AMPK activation and resulted in the loss of antitumor activity in vitro,in vivo and in patients.Strikingly,activating the AMPK pathway through glucose control or metformin treatment reversed the metabolic abnormalities and restored the antitumor activity of Vy9vδ2 T cells.These results suggest that the impaired antitumor activity of Vy9vδ2 T cells induced by dysregulated glucose metabolism may contribute to the increased cancer risk in T2DM patients and that metabolic reprogramming by targeting the AMPK pathway with metformin may improve tumor immunosurveillance. | Xiaofeng Mu Zheng Xiang Yan Xu Jing He Jianwen Lu Yuyuan Chen Xiwei Wang Chloe Ran Tu Yanme Wenyue Zhang Zhinan Yin Wing-hang Leung Yu-Lung Lau Yinping Liu Wenwei Tu | 2022 | Cellular & Molecular Immunology2022，19，8： | 2 |
| 7 | Frictional Loss Studiesand Experimental Performance of a New Synchronal Rotary Multiphase Pump显示文摘 | Yang Xu Qu Zongchang Wu Yuyuan | 2011 | Journal of Fluids Engineering- Transactions of the ASME2011，133，04： | 1 |
| 8 | Effect of Adding Surfaetant for Transforming Lignocellulose into Fermentable Sugars during Bioeatalysing 显示文摘 | Zhang Yuqing Xu Xuemin Zhang Yuyuan | 2011 | Biotechnology and Bioengineering2011，16，5： | 1 |
| 9 | Leakage analysis of a synchronal rotary multiphase pump 显示文摘 | Yang Xu Qu Zongchang Wu Yuyuan | 2012 | Advanced Materials Research2012，，562564： | 1 |
| 10 | Melatonin decreases GSDME mediated mesothelial cell pyroptosis and prevents peritoneal fibrosis and ultrafiltration failure显示文摘Peritoneal fibrosis together with increased capillaries is the primary cause of peritoneal dialysis failure.Mesothelial cell loss is an initiating event for peritoneal fibrosis.We find that the elevated glucose concentrations in peritoneal dialysate drive mesothelial cell pyroptosis in a manner dependent on caspase-3 and Gasdermin E,driving downstream inflammatory responses,including the activation of macrophages.Moreover,pyroptosis is associated with elevated vascular endothelial growth factor A and C,two key factors in vascular angiogenesis and lymphatic vessel formation.GSDME deficiency mice are protected from high glucose induced peritoneal fibrosis and ultrafiltration failure.Application of melatonin abrogates mesothelial cell pyroptosis through a MT1R-mediated action,and successfully reduces peritoneal fibrosis and angiogenesis in an animal model while preserving dialysis efficacy.Mechanistically,melatonin treatment maintains mitochondrial integrity in mesothelial cells,meanwhile activating m TOR signaling through an increase in the glycolysis product dihydroxyacetone phosphate.These effects together with quenching free radicals by melatonin help mesothelial cells maintain a relatively stable internal environment in the face of high-glucose stress.Thus,Melatonin treatment holds some promise in preserving mesothelium integrity and in decreasing angiogenesis to protect peritoneum function in patients undergoing peritoneal dialysis. | Hongxia Ruan Xuejuan Li Lina Zhou Zihan Zheng Rulin Hua Xu Wang Yuan Wang Yujie Fan Shuwen Guo Lihua Wang Shafiq ur Rahman Ziwei Wang Yuyuan Wei Shuangyan Yu Rongzhi Zhang Qian Cheng Jie Sheng Xue Li Xiaoyan Liu Ruqiang Yuan Xiaoyan Zhang Lihong Chen Guowang Xu Youfei Guan Jing Nie Hongqiang Qin Feng Zheng | 2024 | Science China(Life Sciences)2024，67，2： | 0 |
| 11 | Hydrogen inhibition effect of chitosan and sodium phosphate on ZK60 waste dust in a wet dust removal system:A feasible way to control hydrogen explosion显示文摘Wet dust removal systems used to control dust in the polishing or grinding process of Mg alloy products are frequently associated with potential hydrogen explosion caused by magnesium-water reaction.For purpose of avoiding hydrogen explosion risks,we try to use a combination of chitosan(CS)and sodium phosphate(SP)to inhibit the hydrogen evolution reaction between magnesium alloy waste dust and water.The hydrogen evolution curves and chemical kinetics modeling for ten different mixing ratios demonstrate that 0.4wt%CS+0.1wt%SP yields the best inhibition efficiency with hydrogen generation rate of almost zero.SEM and EDS analyses indicate that this composite inhibitor can create a uniform,smooth,tight protective film over the surface of the alloy dust particles.FTIR and XRD analysis of the chemical composition of the surface film show that this protective film contains CS and SP chemically adsorbed on the surface of ZK60 but no detectable Mg(OH)_(2),suggesting that magnesium-water reaction was totally blocked.Our new method offers a thorough solution to hydrogen explosion by inhibiting the hydrogen generation of magnesium alloy waste dust in a wet dust removal system. | Yuyuan Zhang Kaili Xu Jiahuan Li Bo Liu Ben Wang | 2023 | Journal of Magnesium and Alloys2023，11，8： | 0 |
| 12 | Differences in the prognostic value of tumor extent of resection among the molecular subgroups of medulloblastoma: A single centre study of 113 cases显示文摘Medulloblastoma(MB) is one of the most common pediatrics malignant tumors of the central nervous system. Studies in America and Europe have demonstrated significant differences in the prognostic value of medulloblastoma extent among molecular subgroups of medulloblastoma. However, studies focusing on the Chinese population are still lacking. A total of 113 patients with medulloblastoma who underwent surgical resection in Huashan Hospital between January 2002 and December 2013 were included in this study. Histological diagnoses were confirmed by 2 or more pathologists. Immunohistochemistry and CTNNB1 exon 3 mutation analysis were used to determine the different subgroups. Complete or incomplete resection was defined based on surgeons' reports and confirmed by postoperative computer tomography(CT). In this study, we included 113 patients with medulloblastoma(13 with WNT subgroup, 18 with SHH subgroup, and 82 with non-SHH/WNT subgroups) to assess their event-free and overall survival. We identified event-free survival and overall survival benefit for complete resection over incomplete resection. We found that for patients with NON-SHH/WNT medulloblastoma, incomplete resection was significantly associated with progression and overall survival compared with complete resection. To our best knowledge, the present study is the first to demonstrate the prognostic value of tumor extent of resection among the molecular subgroups of 113 medulloblastoma in the Chinese population.The prognostic benefit of the increased extent of resection for patients with medulloblastoma is attenuated after the molecular subgroups are taken into account. We still need further study to assess the benefit of surgical resection of small residual portions. | Yuyuan Wang Kay Kawai Li Ji Xiong Zhenyu Zhang Yang Wang Jian Xu Yin Wang Hokeung Ng Ping Zhong | 2017 | Translational Neuroscience and Clinics2017，3，2： | 0 |
| 13 | Conserved termini and adjacent variable region of Twortlikevirus Staphylococcus phages显示文摘Methicillin-resistant Staphylococcus aureus(MRSA) is an increasing cause of serious infection,both in the community and hospital settings. Despite sophisticated strategies and efforts, the antibiotic options for treating MRSA infection are narrowing because of the limited number of newly developed antimicrobials. Here, four newly-isolated MRSA-virulent phages, IME-SA1, IMESA2, IME-SA118 and IME-SA119, were sequenced and analyzed. Their genome termini were identified using our previously proposed 'termini analysis theory'. We provide evidence that remarkable conserved terminus sequences are found in IME-SA1/2/118/119, and, moreover, are widespread throughout Twortlikevirus Staphylococcus phage G1 and K species. Results also suggested that each phage of the two species has conserved 5′ terminus while the 3′ terminus is variable. More importantly, a variable region with a specific pattern was found to be present near the conserved terminus of Twortlikevirus S. phage G1 species. The clone with the longest variable region had variable terminus lengths in successive generations, while the clones with the shortest variable region and with the average length variable region maintained the same terminal length as themselves during successive generations. IME-SA1 bacterial infection experiments showed that the variation is not derived from adaptation of the phage to different host strains. This is the first study of the conserved terminus and variable region of Twortlikevirus S. phages. | Xianglilan Zhang Huaixing Kang Yuyuan Li Xiaodong Liu Yu Yang Shasha Li Guangqian Pei Qiang Sun Peng Shu Zhiqiang Mi Yong Huang Zhiyi Zhang Yannan Liu Xiaoping An Xiaolu Xu Yigang Tong | 2015 | Virologica Sinica2015，30，6： | 0 |
| 14 | Cultivation and Primary Processing of Medicinal Chrysanthemums显示文摘The morphological characteristics and growth habits of medicinal chrysanthemums are described,the cultivation techniques are summarized from the aspects of nursery,transplanting and field management,and the harvest and primary processing technology are introduced in detail. | Huashan GAO Mengke SONG Guanhua WANG Yulin MO Yuyuan XU Weishuang TONG | 2020 | Asian Agricultural Research2020，12，10： | 0 |
| 15 | Novel pegiviruses infecting wild birds and rodents显示文摘Pegivirus(family Flaviviridae)is a genus of small enveloped RNA viruses that mainly causes blood infections in various mammals including human.Herein,we carried out an extensive survey of pegiviruses from a wide range of wild animals mainly sampled in the Qinghai-Tibet Plateau of China.Three novel pegiviruses,namely Passer montanus pegivirus,Leucosticte brandti pegivirus and Montifringilla taczanowskii pegivirus,were identified from different wild birds,and one new rodent pegivirus,namely Phaiomys leucurus pegivirus,was identified from Blyth's vole.Interestingly,the pegiviruses of non-mammalian origin discovered in this study substantially broaden the host range of Pegivirus to avian species.Co-evolutionary analysis showed virus-host co-divergence over long evolutionary timescales,and indicated that pegiviruses largely followed a virus-host co-divergence relationship.Overall,this work extends the biodiversity of the Pegivirus genus to those infecting wild birds and hence revises the host range and evolutionary history of genus Pegivirus. | Wentao Zhu Jing Yang Shan Lu Yuyuan Huang Dong Jin Ji Pua Liyun Liu Zhenjun Li Mang Shi Jianguo Xu | 2022 | Virologica Sinica2022，37，2： | 0 |
| 16 | Co-alteration of Myc and RTK-RAS pathways defines a liver-metastatic propensity and immune-cold subgroup of pancreatic adenocarcinoma显示文摘Co-altered pathways refer to the phenomenon where multiple biological pathways exhibit aberrant changes simultaneously within the same tumor sample.This phenomenon can facilitate a better understanding of the mechanism and evolution of tumors and serve as a biological marker for diagnosing,classifying,and treating tumors.1 However,the nature of alteration occurrence and the impact on pancreatic adenocarcinoma(PAAD)remain elusive.The SELECT algorithm was originally designed to systematically assess the evolutionary dependencies and their impact between altered genes in cancer for anticipating drug resistance and proposing alternative strategies.Here,to better characterize the etiology of PAAD and develop an improved risk assessment strategy,2 by utilizing SELECT,we identified a co-altered pathway subgroup of PAAD that demonstrated an elevated risk for unfavorable prognosis,a propensity for liver metastasis,and an immunologically cold microenvironment. | Yuyuan Zhang Ziyang Zu Hui Xu Siyuan Weng Yuqing Ren Quan Cheng Peng Luo Jian Zhang Zaoqu Liu Xinwei Han | 2024 | Genes & Diseases2024，11，3： | 0 |
| 17 | Gene expression profiles contribute to robustly predicting prognosis in hepatocellular carcinoma显示文摘Hepatocellular carcinoma(HCC)is characterized by both inter-and intra-tumor heterogeneity and has distinct clinical outcomes.1 A promising clinical tool to perform patient stratification,prognosis evaluation,and treatment recommendations is indispensable.Here,we enrolled a total of 1595 tumor patients from 13 independent cohorts,including seven cohorts with survival data,four cohorts with immunotherapy information,and two cohorts with transcatheter arterial chemoembolization(TACE)and Sorafenib information,respectively(Table S1).Using 96 algorithms combinations derived from 10 popular machinelearning approaches,a novel framework was constructed and described in Figure S1.Firstly,a total of 26 stable consensus prognostic genes were screened in seven cohorts harboring complete survival information via univariate Cox regression analysis(Fig.S2A). | Long Liu Yuhui Wang Yuyuan Zhang Siyuan Weng Hui Xu Zaoqu Liu Xinwei Han | 2024 | Genes & Diseases2024，11，2： | 0 |
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