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| 1 | Impact of concomitant use of proton pump inhibitors and clopidogrel or ticagrelor on clinical outcomes in patients with acute coronary syndrome显示文摘BackgroundThere 是在质子泵禁止者(PPI ) 和 clopidogrel 之间的可能的不利相互作用上的大争论。另外, PPI 的使用是否少些影响 ticagrelor 遗体的临床的功效,知道。在经皮的冠的干预(一种总线标准) .MethodsWe 回顾地从 “ 分析了数据以后,我们试图与急性冠的症候群(交流)在病人在临床的结果上决定 PPI 和 clopidogrel 或 ticagrelor 的伴随物管理的影响;真实 world” ;,国际,在 2003 和 2014 之间的多中心登记( n = 15,401 )并且在1年的合成主要端点上估计了 PPI 和 clopidogrel 或 ticagrelor 的伴随物管理的影响(所有原因死亡收到 PPI 的病人更老,更经常女性,并且是更可能的有 comorbidities。没有协会为收到 clopidogrel 的病人在 PPI 使用和主要端点之间被观察(调整 HR:1.036;95% CI:0.903-1.189 ) 或 ticagrelor (调整 HR:2.320;95% CI:0.875-6.151 )(P 相互作用 = 0.2004 ) 。同样, PPI 的使用没与所有原因死亡,重新梗塞,或与交流后面的一种总线标准的为与任何一个 clopidogrel 对待的病人或 ticagrelor.ConclusionsIn 病人的严重流血的减少的风险的增加的风险被联系, PPI 的伴随物使用没在收到 clopidogrel 或 ticagrelor 的病人与不利结果的增加的风险被联系。我们的调查结果显示与 clopidogrel 或 ticagrelor 在联合使用 PPI 是合理的,特别在有胃肠的流血的更高的风险的病人。 | Yan YAN Xiao WANG Jing-Yao FAN Shao-Ping NIE Sergio Raposeiras-Roubin Emad Abu-Assi Jose P Simao Henriques Fabrizio D'Ascenzo Jorge Saucedo Jose R Gonzfilez-Juanatey Stephen B Wilton Wouter J Kikkert Ivlin Nufiez-Gil Albert Ariza-Sole Xian-Tao SONG Dimitrios Alexopoulos Christoph Liebetrau Tetsuma Kawaji Claudio Moretti Zenon Huczek Toshiharu Fujii Luis C Correia Masa-aki Kawashiril Sasko Kedev | 2016 | Journal of Geriatric Cardiology2016，13，3： | 12 |
| 2 | P2Y12受体抑制剂联合质子泵抑制剂对急性冠脉综合征患者缺血事件影响的临床分析显示文摘目的本研究旨在分析P2Y12受体抑制剂联合质子泵抑制剂(PPI)治疗对经皮冠状动脉介入(PCI)术后的急性冠脉综合征患者缺血事件的影响。方法基于国际多中心回顾性注册登记研究,纳入2003至2014年因急性冠脉综合征人院行PCI术的患者,分为PPI组及非PPI组并随访1年,主要临床终点为全因死亡/再发心肌梗死的复合终点。根据P2Y12受体抑制剂种类,将入组患者分为氯吡格雷组及替格瑞洛组,并比较不同药物与PPI联用发生临床终点事件的风险。结果研究入选9429例患者,PPI组占54.8%,具有更多高危因素。Cox回归结果提示PPI组较非PPI组全因死亡/再发心肌梗死复合事件的发生差异无统计学意义(HR1.00,95%CI 0.86—1.18)。根据P2Y12抑制剂种类不同分为氯吡格雷组和替格瑞洛组,不同P2Y12受体抑制剂联用PPI较未联用PPI患者的临床终点无差异,联用PPI的氯吡格雷组与替格瑞洛组的临床终点差异也无统计学意义。结论急性冠脉综合征患者PPI与P2Y12受体抑制剂联用不增加全因死亡和再发心肌梗死风险,尤其PPI联用氯吡格雷在患者的缺血事件上与替格瑞洛比较差异无统计学意义。 | 冯斯婷 严妍 范婧尧 王晓 郑文 聂绍平 Sergio Raposeiras-Roubin Emad Abu-Assi Jose P Simao Henriques Fabrizio D' Ascenzo Jorge Saucedo Jose R Conzalez-Juanatey Stephen B Wilton Wouter J Kikkert Ivan Nunez-Gil Albert Ariza-Sole Dimitrios Alexopoulos Christoph Liebetrau Tetsuma Kawaji Claudio Moretti Zenon Huczek Toshiharu Fujii Luis C Correia Masa-aki Kawashiri Sasko Kedev | 2016 | 中华医学杂志2016，96，33： | 6 |
| 3 | GISAID’s Role in Pandemic Response显示文摘GISAID is a global data science initiative and the primary source of genomic and associated metadata of all influenza viruses,Respiratory Syncytial Virus(RSV)and severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),the pandemic coronavirus causing coronavirus disease 2019(COVID-19).GISAID’s publicly accessible data sharing platform enables collaboration of over 42,000 participating researchers from 198 nations and data generators from over 3,500 institutions across the globe.Since the first wholegenome sequences were made available by China CDC through GISAID on January 10. | Shruti Khare Céline Gurry Lucas Freitas Mark B Schultz Gunter Bach Amadou Diallo Nancy Akite Joses Ho Raphael TC Lee Winston Yeo GISAID Core Curation Team Sebastian Maurer-Stroh | 2021 | China CDC weekly2021，3，49： | 3 |
| 4 | DNA damage induced by chronic inflammation contributes to colon carcinogenesis in mice显示文摘 | Meira Lisiane B Bugni James M Green Stephanie L Lee Chung-Wei Pang Bo Borenshtein Diana Rickman Barry H Rogers Arlin B Moroski-Erkul Catherine A McFaline Jose L Schauer David B Dedon Peter C Fox James G Samson Leona D | 2008 | Journal of Clinical Investigation2008，，7： | 2 |
| 5 | Controlled modification of acidity in cholecysto - kinin B receptor antagonists显示文摘 | JOSE L C RICHARD G B | 1996 | J Med Chem1996，39，： | 2 |
| 6 | Antibiotics and an- tibiotic resistance in water environments 显示文摘 | Femando B Jose L M Rafael C | 2008 | Current opinion in biotechnology2008，19，3： | 1 |
| 7 | Pasteurization of apple juice by using microwaves 显示文摘 | JUAN A C JOSE'E C JOHANNES D B | 2002 | Lebensmittel- Wissenschaft und-Technologie2002，35，5： | 1 |
| 8 | Optical techniques for real-time penetration monitoring for laser welding 显示文摘 | Fabfice B Adolfo C Jose M L H | 2005 | Applied Optics2005，44，19： | 1 |
| 9 | N-acyl-L-homoserine lactones: a class of bacterial quorum-sensing signals alter post-embryonic root de- velopment in Arabidopsis thaliana 显示文摘 | Randy O C Mignel M T Jose L B | 2008 | Plant Cell Environ2008，31，： | 1 |
| 10 | Quantum communication with po- larization-encoded qubit using quantum error correction 显示文摘 | Daniel B Jose C Rubens V | 2008 | IEEE Journal of Quantum Electronics2008，44，2： | 1 |
| 11 | Comparison of two methods for anteriorposterior isocenter localization in pelvic radiotherapy using electronic portal imaging显示文摘 | Greer P B Mortensen T M Jose C C | 1998 | Int J Radiat Oncol Biol Phys1998，41，： | 1 |
| 12 | Preparation, characterization and reactivity of V-and/or co-containing AlPO- 18 materials (VCoAPO-18) in the oxidative dehydrogenation of ethane 显示文摘 | PATRICIA C TERESA B JOSE M L N | 2004 | Micropor Mesopor Mater2004，67，23： | 1 |
| 13 | Pyrolysis of high-density polyethylene in free-fall reactors in series显示文摘 | Jose' F M Ce'sar B Jesu's C | 2006 | Energy & Fuels2006，20，： | 1 |
| 14 | Cloning, expression, and characterization ofavian reovirus guanylytransferase显示文摘 | Joseph H Jose M C Javier B | 2002 | Virology2002，296，2： | 1 |
| 15 | The improvement of maize (Zea mays L ) an- thers tissue culture by the addition of free amino acids in the culture medium 显示文摘 | RosauraR G Cecilla B PV Joaquin O C Jose D M G Remigio M L | 1998 | Cereal Research Communications1998，26，： | 1 |
| 16 | Confirmation of fluoroquinolones in catfish muscle by electrospray liquid chromatography / mass spectrometry显示文摘 | Sherri B T Calvin C W Jose E R | 1998 | J AOAC Iut1998，81，3： | 1 |
| 17 | Effect of dietary taurine sup- plementation on growth performance and feed selection of sea bass Dicentrarchus labrax fry fed with demand-feeders显示文摘 | Jose B M Stavros C Pascal D | 2004 | Fish- eries Science2004，70，： | 1 |
| 18 | Lipid profiling identifies a triacylglycerol signature of insulin resistance and improves diabetes prediction in humans显示文摘 | Rhee Eugene P Cheng Susan Larson Martin G Walford Geoffrey A Lewis Gregory D McCabe Elizabeth Yang Elaine Farrell Laurie Fox Caroline S O’Donnell Christopher J Carr Steven A Vasan Ramachandran S Florez Jose C Clish Clary B Wang Thomas J Ger | 2011 | Journal of Clinical Investigation2011，，4： | 1 |
| 19 | Docking and quantum mechanic studies on chlolinesterases and their inhibitiors 显示文摘 | Jose C B Cesar F S Jesus M C | 2007 | Eur J Medicinal Chem2007，42，1： | 1 |
| 20 | Moving targets processing in SAR spatial domain显示文摘 | Paulo A C Jose M and Dias B | 2007 | IEEE Transactions on Aerospace and Electronic Systems2007，43，3： | 1 |
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