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| 1 | Leptin signaling and cancer chemoresistance:Perspectives显示文摘Obesity is a major health problem and currently is endemic around the world. Obesity is a risk factor for several different types of cancer, significantly promoting cancer incidence, progression, poor prognosis and resistance to anti-cancer therapies. The study of this resistance is critical as development of chemoresistance is a serious drawback for the successful and effective drug-based treatments of cancer. There is increasing evidence that augmented adiposity can impact on chemotherapeutic treatment of cancer and the development of resistance to these treatments, particularly through one of its signature mediators, the adipokine leptin. Leptin is a pro-inflammatory, pro-angiogenic and pro-tumorigenic adipokine that has been implicated in many cancers promoting processes such as angiogenesis, metastasis, tumorigenesis and survival/resistance to apoptosis. Several possible mechanisms that could potentially be developed by cancer cells to elicit drug resistance have been suggested in the literature. Here, we summarize and discuss the current state of the literature on the role of obesity and leptin on chemoresistance, particularly as it relates to breast and pancreatic cancers. We focus on the role of leptin and its significance in possibly driving these proposed chemoresistance mechanisms, and examine its effects on cancer cell survival signals and expansion of the cancer stem cell sub-populations. | Pierre V Candelaria Antonio Rampoldi Adriana Harbuzariu Ruben R Gonzalez-Perez | 2017 | World Journal of Clinical Oncology2017，8，2： | 6 |
| 2 | Ramucirumab plus docetaxel versus placebo plus docetaxel for second-line treatment of stage IV non-small-cell lung cancer after disease progression on platinum-based therapy (REVEL): a multicentre, double-blind, randomised phase 3 trial显示文摘 | Edward B Garon Tudor-Eliade Ciuleanu Oscar Arrieta Kumar Prabhash Konstantinos N Syrigos Tuncay Goksel Keunchil Park Vera Gorbunova Ruben Dario Kowalyszyn Joanna Pikiel Grzegorz Czyzewicz Sergey V Orlov Conrad R Lewanski Michael Thomas Paolo Bidoli Shaker | 2014 | The Lancet2014，，： | 2 |
| 3 | Modeling and simulation of lithium-ion batteries 显示文摘 | ERNESTO M R RUBEN V M ANTONIO F T | 2011 | Computers and Chemical Engineering2011，35，1： | 1 |
| 4 | Quantum communication with po- larization-encoded qubit using quantum error correction 显示文摘 | Daniel B Jose C Rubens V | 2008 | IEEE Journal of Quantum Electronics2008，44，2： | 1 |
| 5 | Synthesis spectral and electrochemical properties of Al(Ⅲ)and Zn (Ⅱ)complexes with flavonoids显示文摘 | RUBENS F V D S WAGNER F D G | 2005 | Spectrochimica Acta Part A2005，61，： | 1 |
| 6 | Streptococcus suis serotype 2 interactions with human brain microvascular endothelial cells显示文摘 | CHARLAND N NIZET V RUBENS C E | 2000 | Infect Immun2000，68，2： | 1 |
| 7 | Genetics and electrophoretic karyotyping of wild-type and astaxanthin mutant strains of Phaffia rhodozyma显示文摘 | Víctor Cifuentes Germán Hermosilla Claudio Martínez Ruben León Guido Pincheira Antonio Jiménez | 1997 | Antonie van Leeuwenhoek1997，，2： | 1 |
| 8 | The effect of illumination on the xanthophyll composition of the photosystem Ⅱ light-harvesting complexes of spinachthylakoid membrane显示文摘 | Ruben A V Young A J Pancal A A | 1994 | Plant Physiology1994，104，： | 1 |
| 9 | Sonography of the scrotum显示文摘 | Dogra V S Gottlieb R H Oka M Rubens D J | 2003 | Radiology2003，227，1： | 1 |
| 10 | Streptococcussuis serotype 2 interactions with human brain microvascular endothelial cells显示文摘 | Charland N Nizet V Rubens C E | 2000 | Infect Immun2000，68，： | 1 |
| 11 | Synthesis,spectral and elec-trochemi cal properties of Al(羾)and Zn( H ) complexes with fla-vonoids显示文摘 | Rubens F V Souza D Wagner F | 2005 | Spectrochim Acta Part A2005，61，9： | 1 |
| 12 | Antioxidant properties of complexesof flavonoids with metal ions显示文摘 | RUBENS F V S WAGNER F G | 2004 | Redox Report2004，9，2： | 1 |
| 13 | Streptococcus suis serotype 2 interactions with human brain mierovascular endothelial celts显示文摘 | CHARLAND N NIZET V RUBENS C E | 2000 | Infection Immunity2000，68，2： | 1 |
| 14 | Rheological behavior and structural interpretation of waxy crude oil gels显示文摘 | Ruben F G V Romano L Emanuele V | 2005 | Langmuir2005，21，45： | 1 |
| 15 | Development of a harmonized phosphorus extraction procedure and certification of a sediment reference material 显示文摘 | Ruben V Lopez - Sanchez J F Pardon P | 2001 | Journal of Environmental Monito- ring2001，，3： | 1 |
| 16 | Streptococcus suis Serotype 2 Interactions with Human Brain Microvascular Endothelial Cells显示文摘 | CHARLAND N NIZET V RUBENS CE | 2000 | Infect Immun2000，68，： | 1 |
| 17 | Drug addiction: the neurobiology of disrupted self-control显示文摘 | Ruben D B Nora D V | 2000 | Trends in Molecular Medicine2000，12，12： | 1 |
| 18 | Differential voltagedependent K^+ channel responses during proliferation and activation in macrophages显示文摘 | Ruben V Artur E Mireia C | 2003 | The Journal of Biological Chemistry2003，278，46： | 1 |
| 19 | Streptococcus suilline interactions with human brain microvascular endothelial cells显示文摘 | Charland N Nizet V Rubens C | 2000 | Infect Immun2000，68，： | 1 |
| 20 | Acute effects of ehemieally dispersed crude oil on gill ion regulation, plasma ion levels and haematologieal parameters in tambaqui ( Colossoma macropomum) 显示文摘 | RAFAEL M D RUBENS T H ADALBERTO L V | 2010 | Aquatic Toxicology2010，2010，： | 1 |
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