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| 1 | Modulation of faecal metagenome in Crohn's disease:Role of microRNAs as biomarkers显示文摘BACKGROUND The gut microbiota plays a key role in the maintenance of intestinal homeostasis and the development and activation of the host immune system. It has been shown that commensal bacterial species can regulate the expression of host genes. 16 S rRNA gene sequencing has shown that the microbiota in inflammatory bowel disease(IBD) is abnormal and characterized by reduced diversity. Micro RNAs(miRNAs) have been explored as biomarkers and therapeutic targets, since they are able to regulate specific genes associated with Crohn's disease(CD). In this work, we aim to investigate the composition of gut microbiota of active treatment-na?ve adult CD patients, with miRNA profile from gut microbiota.AIM To investigate the composition of gut microbiota of active treatment-na?ve adult CD patients, with miRNA profile from gut microbiota.METHODS Patients attending the outpatient clinics at Valme University Hospital without relevant co-morbidities were matched according to age and gender. Faecal samples of newonset CD patients, free of treatment, and healthy controls were collected. Faecal samples were homogenized, and DNA was amplified by PCR using primers directed to the 16 S bacterial rRNA gene. Pyrosequencing was performed using GS-Junior platform. For sequence analysis, MGRAST server with the database Ribosomal Project was used. MiRNA profile and their relative abundance were analyzed by quantitative PCR.RESULTS Microbial community was characterized using 16 S rRNA gene sequencing in 29 samples(n = 13 CD patients, and n = 16 healthy controls). The mean Shannon diversity was higher in the healthy control population compared to CD group(5.5 vs 3.7). A reduction in Firmicutes and an increase in Bacteroidetes were found. Clostridia class was also significantly reduced in CD. Principal components analysis showed a grouping pattern, identified in most of the subjects in both groups, showing a marked difference between control and CD groups. A functional metabolic study showed that a lower metabolism of carbohydrates(P = 0.000) was found in CD group, while the metabolism of lipids was increased. In CD patients, three miRNAs were induced in affected mucosa: mir-144(6.2 ± 1.3 fold), mir-519(21.8 ± 3.1) and mir-211(2.3 ± 0.4). CONCLUSION Changes in microbial function in active non-treated CD subjects and three miRNAs in affected vs non-affected mucosa have been found. miRNAs profile may serve as a biomarker. | María Rojas-Feria Teresa Romero-García Jose Angel Fernández Caballero-Rico Helena Pastor Ramírez Marta Avilés-Recio Manuel Castro-Fernandez Natalia Chueca Porcuna Manuel Romero-Gomez Federico García Lourdes Grande JoséA Del Campo | 2018 | World Journal of Gastroenterology2018，24，46： | 7 |
| 2 | Heart Valve Injury Induced by Mediastinum Radiotherapy in Cancer Treatment显示文摘 | Patricia Fraga Paiva Alice Assumpcao Soares Guilherme Sotto Maior do Valle Pinheiro Carolina Fraga Paiva Gisele Maria Campos Fabri Emanoel Guimaraes Paiva Carlos M. Campos Jose Fabfi Junior | 2018 | Journal of Pharmacy and Pharmacology2018，6，6： | 2 |
| 3 | The Society of Thoracic Surgeons Expert Consensus for the Surgical Treatment of Hyperhidrosis显示文摘 | Robert J. Cerfolio Jose Ribas Milanez De Campos Ayesha S. Bryant Cliff P. Connery Daniel L. Miller Malcolm M. DeCamp Robert J. McKenna Mark J. Krasna | 2011 | The Annals of Thoracic Surgery2011，，5： | 2 |
| 4 | Association between the CYBA and NOX4 genes of NADPH oxidase and its relationship with metabolic syndrome in non-alcoholic fatty liver disease in Brazilian population显示文摘Background: Oxidative stress has been implicated in the progression of severe forms of non-alcoholic fatty liver disease(NAFLD). NADPH oxidase produces reactive oxygen species. In the present study, we investigated for the first time two single nucleotide polymorphisms(SNPs) in the regulatory region of genes encoding NADPH oxidase 4(NOX4) and p22 phox(CYBA) in NAFLD.Methods: A total of 207 biopsy-proven NAFLD patients [simple steatosis(n = 27); nonalcoholic steatohepatitis(NASH)(n = 180)] were evaluated. Genomic DNA was extracted from peripheral blood cells, and polymorphisms in CYBA(unregistered) and NOX4(rs3017887) were determined by direct sequencing of PCR.Results: Associations of CYBA-675 T/A with high-density lipoprotein(HDL)(TT vs TA vs AA; P < 0.01) and triglycerides(TGL)(TT vs XA; P < 0.01) were observed only in NASH patients. For polymorphisms in the NOX4 gene, NOX4(rs3017887) CA + AA genotypes was significant associated with alanine aminotransferase(ALT)(CA + AA vs CC; P = 0.02). However, there was no association of SNPs in the CYBA and NOX4 genes encoding the NADPH oxidase system proteins and the presence of NASH. Regarding the clinical results, it was observed that the most advanced degrees of fibrosis occurred in patients diagnosed with type 2 diabetes mellitus(66.9% vs 37.5%, P < 0.01) and those who were more obese(32.2 vs 29.0 kg/m2,P < 0.01). In addition, serum glucose and insulin levels increased significantly in the presence of NASH.Conclusions: There were associations between the presence of the allele A in the NOX4 SNP and a higher concentration of ALT in the NAFLD population; between the presence of the AA genotype in the polymorphism of the CYBA-675 T/A CYBA gene and a higher level of TGL and lower HDL in NASH patients. The presence of metabolic syndrome was associated with advanced degrees of fibrosis in NAFLD patients. | Fabiola Rabelo Jose Tadeu Stefano Ana Mercedes Cavaleiro Rodrigo Vieira Costa Lima Daniel Ferraz de Campos Mazo Flair Jose Carrilho Maria Lúcia Correa-Giannellac Claudia P.Oliveiraa | 2018 | Hepatobiliary & Pancreatic Diseases International2018，17，4： | 2 |
| 5 | Robust Kalman filter for descriptor systems显示文摘 | Ishihara Joao Y Terra Marco H Campos Jose C T | 2006 | IEEE Trans on Automatic Control2006，51，8： | 1 |
| 6 | Prognostic Value of Ambulatory Blood Pressure Monitoring in Refractory Hypertension: A Prospective Study显示文摘 | Josep Redon Carlos Campos Maria L. Narciso Jose L. Rodicio Jose M. Pascual Luis M. Ruilope | 1998 | Hypertension1998，，2： | 1 |
| 7 | Integrated risk management: a Petrobras application in offshore well construction safety to minimize critical emergency disconnections显示文摘In order to avoid mistakes and to save a great deal of time in analysis, an innovative methodology was developed that can analyze the well operations and rig characteristics involved to define the best emergency disconnect sequence(EDS)available. A solution was developed based on the characteristics of the rigs and blowout preventers(BOPs), and six variables were considered that directly affect the choice of EDS. All possible combinations of 64 scenarios were analyzed,and the priority of choice of the EDS was defined empirically. This paper presents an approach to EDS risk management and examples of exposure time(time without riser safety margin and shear capability) for the same well, which can be lowered from 13% to 0.1%. The impact of this reduction is related to the ability of the BOP to cut some of the heavy casings, in addition to improved availability of EDS modes. This implementation opened up many possibilities for the performance of risk exposure analysis, enabling comparison of several BOP configurations of contracted rigs and selection of the best options. This innovative approach allowed a better management of the rig schedules, prioritizing safety aspects and making it possible to allocate the fleet in a systematic way. | Claudio Benevenuto de Campos Lima Pedro Esteves Aranha Jose Francisco Tebaldi de Castro Gilson Brito Alves Lima Augusto Borella Hougaz Felipe de Souza Terra | 2018 | Petroleum Science2018，15，2： | 1 |
| 8 | Modeling aerobic granular SBR at variable COD/N ratios including accurate description of total solids concentration 显示文摘 | Jose Ramon Vazquez-Padin Anuska Mosquera-Corral Jose Luis Campos Ramon Mendez Julian Carrera Julio Perez | 2012 | Biochemical Engineering Journal2012，49，2： | 1 |
| 9 | Sustainable limits for golf course development in a tourist destination 显示文摘 | Francisco Jose Del Campo Gomis Mafia Ascension Molina Huertas Jose Miguel Sales Civera | 2006 | World Review of Science Technology and Sustainable Development2006，3，3： | 1 |
| 10 | Influence of purchase place and consumption frequency over quality wine preferences 显示文摘 | Laura Marti'nez - Carrasco Marti'nez Margarita Brugarolas Molla' - Bauza' Francisco Jose'Del Campo Gomis A'frica Marti'nez Pored | 2006 | Food Qllality and Preference2006，17，： | 1 |
| 11 | Fuzzy theory approach for temporal model-based: diagnosis: An application to medical domains 显示文摘 | Jose Palma Jose M Juarez Manuel Campos | 2006 | Artificial Intelligence in Medicine2006，38，： | 1 |
| 12 | Structural assessment under uncertain parameters via interval analysis 显示文摘 | Oscar Garcia Josep Vehia Jose Campos e Matos | 2008 | Journal of Computational and Applied Mathematics2008，，8： | 1 |
| 13 | Combustion-thermal-sprayed Recycled Poly(ethylene terephthalate)显示文摘 | Jose Roberto Tavares Branco Sthener Rodrigues Vieira Campos Luciana Tavares Duarte | 2004 | Journal of Applied Polymer Science2004，92，： | 1 |
| 14 | Temporomandibular joint and normal occlusion: Is there anything singular about it? A computed to- mographic evaluation 显示文摘 | Robert Wilier Farinazzo Vitral Marcio Jose da Silva Campos Andreia Fialho Rodrigues Marcelo Reis Fraga | 2011 | American Journal of Orthodontics and Dentofacial Orthopedics2011，140，1： | 1 |
| 15 | Development of alcoholic and malolactic fermentations in highly acidic and phenolic apple musts显示文摘 | Gloria del Campo lnaki Berregi Jose'Ignacio Santos Maite Duenas Ana Irastorza | 2008 | Bioresource Technology2008，，99： | 1 |
| 16 | HPC-oriented Canonical Workflows for Machine Learning Applications in Climate and Weather Prediction显示文摘Machine learning(ML)applications in weather and climate are gaining momentum as big data and the immense increase in High-performance computing(HPC)power are paving the way.Ensuring FAIR data and reproducible ML practices are significant challenges for Earth system researchers.Even though the FAIR principle is well known to many scientists,research communities are slow to adopt them.Canonical Workflow Framework for Research(CWFR)provides a platform to ensure the FAIRness and reproducibility of these practices without overwhelming researchers.This conceptual paper envisions a holistic CWFR approach towards ML applications in weather and climate,focusing on HPC and big data.Specifically,we discuss Fair Digital Object(FDO)and Research Object(RO)in the DeepRain project to achieve granular reproducibility.DeepRain is a project that aims to improve precipitation forecast in Germany by using ML.Our concept envisages the raster datacube to provide data harmonization and fast and scalable data access.We suggest the Juypter notebook as a single reproducible experiment.In addition,we envision JuypterHub as a scalable and distributed central platform that connects all these elements and the HPC resources to the researchers via an easy-to-use graphical interface. | Amirpasha Mozaffari Michael Langguth Bing Gong Jessica Ahring Adrian Rojas Campos Pascal Nieters Otoniel Jose Campos Escobar Martin Wittenbrink Peter Baumann Martin G.Schultz | 2022 | Data Intelligence2022，4，2： | 1 |
| 17 | Biological control of Bradysia matogrossensis (Diptera: Sciaridae) in mushroom cultivation with predatory mites显示文摘 | Renata Angelica Prado Freire Gilberto Jose Moraes Edmilson Santos Silva Alcione Cicera Vaz Raphael Campos Castilho | 2007 | Experimental and Applied Acarology2007，，2： | 1 |
| 18 | Consumer-perceived Risk Model for the Introduction of Genetically Modified Food in Spain显示文摘 | Martinez-Poveda Margarita Brugarolas Molla-Bauza Jose del Campo Gomis Laura Martinez-Carrasco Martinez | | 0，，06： | 1 |
| 19 | Why and When Do Government Initiate Public Enterprise Reform? 显示文摘 | Jose Edgardo Campos Hade Salehi Esfahani | 1996 | World Bank Economic Review1996，10，3： | 1 |
| 20 | A general review Uhla, of the Wilson plot method and its modifications to determine convection coefficients in heat exchange devices显示文摘 | Jose Fernan Jaime Sieres Antonio dez-Seara Francisco J Campo | 2007 | Applied Thermal Engineering2007，27，： | 1 |
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